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A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale.

McGuire JF, Piacentini J, Storch EA, Murphy TK, Ricketts EJ, Woods DW, Walkup JW, Peterson AL, Wilhelm S, Lewin AB, McCracken JT, Leckman JF, Scahill L.

Neurology. 2018 Apr 13. pii: 10.1212/WNL.0000000000005474. doi: 10.1212/WNL.0000000000005474. [Epub ahead of print]


Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial.

Bikic A, Leckman JF, Christensen TØ, Bilenberg N, Dalsgaard S.

Eur Child Adolesc Psychiatry. 2018 Apr 11. doi: 10.1007/s00787-018-1151-y. [Epub ahead of print]


Steps Toward Peace and Violence Prevention Across Generations: The Potential of Early Child Development in the Context of the 2030 Sustainable Development Goals.

Leckman JF, Britto PR.

New Dir Child Adolesc Dev. 2018 Mar;2018(159):5-12. doi: 10.1002/cad.20227. Review.


Genetic susceptibility in obsessive-compulsive disorder.

Fernandez TV, Leckman JF, Pittenger C.

Handb Clin Neurol. 2018;148:767-781. doi: 10.1016/B978-0-444-64076-5.00049-1.


Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry.

Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, Kuhn J, Huys D, Baldermann JC, Foltynie T, Hariz MI, Joyce EM, Zrinzo L, Kefalopoulou Z, Silburn P, Coyne T, Mogilner AY, Pourfar MH, Khandhar SM, Auyeung M, Ostrem JL, Visser-Vandewalle V, Welter ML, Mallet L, Karachi C, Houeto JL, Klassen BT, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Walter BL, Mari Z, Anderson WS, Changizi BK, Moro E, Zauber SE, Schrock LE, Zhang JG, Hu W, Rizer K, Monari EH, Foote KD, Malaty IA, Deeb W, Gunduz A, Okun MS.

JAMA Neurol. 2018 Mar 1;75(3):353-359. doi: 10.1001/jamaneurol.2017.4317.


DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.

Transl Psychiatry. 2018 Jan 10;8(1):15. doi: 10.1038/s41398-017-0063-9.


Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum.

Frick LR, Rapanelli M, Jindachomthong K, Grant P, Leckman JF, Swedo S, Williams K, Pittenger C.

Brain Behav Immun. 2018 Mar;69:304-311. doi: 10.1016/j.bbi.2017.12.004. Epub 2017 Dec 9.


A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.

Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H.

Mol Psychiatry. 2017 Nov 14. doi: 10.1038/mp.2017.215. [Epub ahead of print]


Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS).

Leon J, Hommer R, Grant P, Farmer C, D'Souza P, Kessler R, Williams K, Leckman JF, Swedo S.

Eur Child Adolesc Psychiatry. 2017 Nov 8. doi: 10.1007/s00787-017-1077-9. [Epub ahead of print]


What Are the Transgenerational Consequences of Maternal Childhood Adversity and Maternal Stress During Pregnancy?

Leckman JF.

J Am Acad Child Adolesc Psychiatry. 2017 Nov;56(11):914-915. doi: 10.1016/j.jaac.2017.09.421. No abstract available.


Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis.

Stuckelman ZD, Mulqueen JM, Ferracioli-Oda E, Cohen SC, Coughlin CG, Leckman JF, Bloch MH.

J Clin Psychiatry. 2017 Jun;78(6):e648-e655. doi: 10.4088/JCP.15r10601.


A double-blind randomized pilot trial comparing computerized cognitive exercises to Tetris in adolescents with attention-deficit/hyperactivity disorder.

Bikic A, Christensen TØ, Leckman JF, Bilenberg N, Dalsgaard S.

Nord J Psychiatry. 2017 Aug;71(6):455-464. doi: 10.1080/08039488.2017.1328070. Epub 2017 Jun 9.


Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome.

Meier SM, Dalsgaard S, Mortensen PB, Leckman JF, Plessen KJ.

Mov Disord. 2017 Apr;32(4):605-609. doi: 10.1002/mds.26939. Epub 2017 Mar 24.


Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case-Control Study.

Leslie DL, Kobre RA, Richmand BJ, Aktan Guloksuz S, Leckman JF.

Front Psychiatry. 2017 Jan 19;8:3. doi: 10.3389/fpsyt.2017.00003. eCollection 2017.


The Child Behavior Checklist-Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children.

Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG.

J Child Adolesc Psychopharmacol. 2017 May;27(4):342-348. doi: 10.1089/cap.2016.0125. Epub 2017 Feb 2.


Gilles de la Tourette syndrome.

Robertson MM, Eapen V, Singer HS, Martino D, Scharf JM, Paschou P, Roessner V, Woods DW, Hariz M, Mathews CA, Črnčec R, Leckman JF.

Nat Rev Dis Primers. 2017 Feb 2;3:16097. doi: 10.1038/nrdp.2016.97. Review.


Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders.

Guloksuz SA, Abali O, Aktas Cetin E, Bilgic Gazioglu S, Deniz G, Yildirim A, Kawikova I, Guloksuz S, Leckman JF.

Rev Bras Psiquiatr. 2017 Jul-Sep;39(3):195-200. doi: 10.1590/1516-4446-2015-1843. Epub 2017 Jan 12.


Systematic review of severity scales and screening instruments for tics: Critique and recommendations.

Martino D, Pringsheim TM, Cavanna AE, Colosimo C, Hartmann A, Leckman JF, Luo S, Munchau A, Goetz CG, Stebbins GT, Martinez-Martin P; Members of the MDS Committee on Rating Scales Development.

Mov Disord. 2017 Mar;32(3):467-473. doi: 10.1002/mds.26891. Epub 2017 Jan 10. Review.


Oxytocin response to youth-mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior.

Lebowitz ER, Silverman WK, Martino AM, Zagoory-Sharon O, Feldman R, Leckman JF.

Depress Anxiety. 2017 Feb;34(2):127-136. doi: 10.1002/da.22585. Epub 2017 Jan 3.


A preliminary study of movement intensity during a Go/No-Go task and its association with ADHD outcomes and symptom severity.

Li F, Zheng Y, Smith SD, Shic F, Moore CC, Zheng X, Qi Y, Liu Z, Leckman JF.

Child Adolesc Psychiatry Ment Health. 2016 Dec 12;10:47. doi: 10.1186/s13034-016-0135-2. eCollection 2016.


Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism.

Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA.

Sci Rep. 2016 Nov 15;6:35054. doi: 10.1038/srep35054.


Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder.

Fernandez TV, Leckman JF.

JAMA Psychiatry. 2016 Nov 1;73(11):1117-1118. doi: 10.1001/jamapsychiatry.2016.2092. No abstract available.


Nurturing care: promoting early childhood development.

Britto PR, Lye SJ, Proulx K, Yousafzai AK, Matthews SG, Vaivada T, Perez-Escamilla R, Rao N, Ip P, Fernald LCH, MacMillan H, Hanson M, Wachs TD, Yao H, Yoshikawa H, Cerezo A, Leckman JF, Bhutta ZA; Early Childhood Development Interventions Review Group, for the Lancet Early Childhood Development Series Steering Committee.

Lancet. 2017 Jan 7;389(10064):91-102. doi: 10.1016/S0140-6736(16)31390-3. Epub 2016 Oct 4. Review.


Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections.

Williams KA, Swedo SE, Farmer CA, Grantz H, Grant PJ, D'Souza P, Hommer R, Katsovich L, King RA, Leckman JF.

J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):860-867.e2. doi: 10.1016/j.jaac.2016.06.017. Epub 2016 Aug 3.


The Origins of Tourette Syndrome: Prenatal Risk Factors and the Promise of Birth Cohort Studies.

Leckman JF, Fernandez TV.

J Am Acad Child Adolesc Psychiatry. 2016 Sep;55(9):751-3. doi: 10.1016/j.jaac.2016.06.009. No abstract available.


The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?

Deeb W, Rossi PJ, Porta M, Visser-Vandewalle V, Servello D, Silburn P, Coyne T, Leckman JF, Foltynie T, Hariz M, Joyce EM, Zrinzo L, Kefalopoulou Z, Welter ML, Karachi C, Mallet L, Houeto JL, Shahed-Jimenez J, Meng FG, Klassen BT, Mogilner AY, Pourfar MH, Kuhn J, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Khandhar SM, Walter BL, Walter E, Mari Z, Changizi BK, Moro E, Baldermann JC, Huys D, Zauber SE, Schrock LE, Zhang JG, Hu W, Foote KD, Rizer K, Mink JW, Woods DW, Gunduz A, Okun MS.

Front Neurosci. 2016 Apr 25;10:170. doi: 10.3389/fnins.2016.00170. eCollection 2016.


A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD.

Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Aktan Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF.

J Atten Disord. 2016 May 13. pii: 1087054716647490. [Epub ahead of print]


Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).

Gaughan T, Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE.

J Clin Sleep Med. 2016 Jul 15;12(7):1027-32. doi: 10.5664/jcsm.5942.


Cross-generational influences on childhood anxiety disorders: pathways and mechanisms.

Lebowitz ER, Leckman JF, Silverman WK, Feldman R.

J Neural Transm (Vienna). 2016 Sep;123(9):1053-67. doi: 10.1007/s00702-016-1565-y. Epub 2016 May 4. Review.


N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial.

Bloch MH, Panza KE, Yaffa A, Alvarenga PG, Jakubovski E, Mulqueen JM, Landeros-Weisenberger A, Leckman JF.

J Child Adolesc Psychopharmacol. 2016 May;26(4):327-34. doi: 10.1089/cap.2015.0109. Epub 2016 Mar 30.


Understanding the covariation of tics, attention-deficit/hyperactivity, and obsessive-compulsive symptoms: A population-based adult twin study.

Pinto R, Monzani B, Leckman JF, Rück C, Serlachius E, Lichtenstein P, Mataix-Cols D.

Am J Med Genet B Neuropsychiatr Genet. 2016 Oct;171(7):938-47. doi: 10.1002/ajmg.b.32436. Epub 2016 Feb 27.


Deep Brain Stimulation for Tourette Syndrome: Lessons Learned and Future Directions.

Leckman JF.

Biol Psychiatry. 2016 Mar 1;79(5):343-344. doi: 10.1016/j.biopsych.2015.11.028. No abstract available.


Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation.

Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK.

Psychoneuroendocrinology. 2016 Mar;65:35-43. doi: 10.1016/j.psyneuen.2015.12.007. Epub 2015 Dec 14.


A Prospective Longitudinal Study of Perceived Infant Outcomes at 18-24 Months: Neural and Psychological Correlates of Parental Thoughts and Actions Assessed during the First Month Postpartum.

Kim P, Rigo P, Leckman JF, Mayes LC, Cole PM, Feldman R, Swain JE.

Front Psychol. 2015 Nov 20;6:1772. doi: 10.3389/fpsyg.2015.01772. eCollection 2015.


Violence, health, and South-North collaboration: Interdisciplinary research in light of the 2030 Agenda.

Lee BX, Leckman JF, Khoshnood K.

Soc Sci Med. 2015 Dec;146:236-42. doi: 10.1016/j.socscimed.2015.10.029. Epub 2015 Oct 23. No abstract available.


Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial.

Bikic A, Leckman JF, Lindschou J, Christensen TØ, Dalsgaard S.

Trials. 2015 Oct 24;16:480. doi: 10.1186/s13063-015-0975-8.


Meta-Analysis: Risk of Tics Associated With Psychostimulant Use in Randomized, Placebo-Controlled Trials.

Cohen SC, Mulqueen JM, Ferracioli-Oda E, Stuckelman ZD, Coughlin CG, Leckman JF, Bloch MH.

J Am Acad Child Adolesc Psychiatry. 2015 Sep;54(9):728-36. doi: 10.1016/j.jaac.2015.06.011. Epub 2015 Jul 2.


Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study.

Dalsgaard S, Leckman JF, Mortensen PB, Nielsen HS, Simonsen M.

Lancet Psychiatry. 2015 Aug;2(8):702-709. doi: 10.1016/S2215-0366(15)00271-0. Epub 2015 Jul 22.


Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.

Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, Leckman JF, Serlachius E, Larsson H, Lichtenstein P.

JAMA Psychiatry. 2015 Aug;72(8):787-93. doi: 10.1001/jamapsychiatry.2015.0627.


Obsessive-compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children.

Alvarenga PG, do Rosario MC, Cesar RC, Manfro GG, Moriyama TS, Bloch MH, Shavitt RG, Hoexter MQ, Coughlin CG, Leckman JF, Miguel EC.

Eur Child Adolesc Psychiatry. 2016 Feb;25(2):175-82. doi: 10.1007/s00787-015-0723-3. Epub 2015 May 27.


Maternal history of autoimmune disease and later development of tourette syndrome in offspring.

Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB.

J Am Acad Child Adolesc Psychiatry. 2015 Jun;54(6):495-501.e1. doi: 10.1016/j.jaac.2015.03.008. Epub 2015 Mar 17.


The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576).

Weisman O, Pelphrey KA, Leckman JF, Feldman R, Lu Y, Chong A, Chen Y, Monakhov M, Chew SH, Ebstein RP.

Psychoneuroendocrinology. 2015 Aug;58:23-32. doi: 10.1016/j.psyneuen.2015.04.007. Epub 2015 Apr 16.


Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome.

Landeros-Weisenberger A, Mantovani A, Motlagh MG, de Alvarenga PG, Katsovich L, Leckman JF, Lisanby SH.

Brain Stimul. 2015 May-Jun;8(3):574-81. doi: 10.1016/j.brs.2014.11.015. Epub 2014 Dec 3.


Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study.

Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG.

Lancet. 2015 May 30;385(9983):2190-6. doi: 10.1016/S0140-6736(14)61684-6. Epub 2015 Feb 26.


Oxytocin-augmented labor and risk for autism in males.

Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S.

Behav Brain Res. 2015 May 1;284:207-12. doi: 10.1016/j.bbr.2015.02.028. Epub 2015 Feb 20.


Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children.

Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC.

J Psychiatr Res. 2015 Mar;62:108-14. doi: 10.1016/j.jpsychires.2015.01.018. Epub 2015 Feb 12.


Successful Treatment of Tourette Syndrome With Electroconvulsive Therapy: A Case Report.

Guo JN, Kothari JS, Leckman JF, Ostroff RB.

Biol Psychiatry. 2016 Mar 1;79(5):e13-e14. doi: 10.1016/j.biopsych.2014.09.020. Epub 2014 Oct 5. No abstract available.


Tourette syndrome deep brain stimulation: a review and updated recommendations.

Schrock LE, Mink JW, Woods DW, Porta M, Servello D, Visser-Vandewalle V, Silburn PA, Foltynie T, Walker HC, Shahed-Jimenez J, Savica R, Klassen BT, Machado AG, Foote KD, Zhang JG, Hu W, Ackermans L, Temel Y, Mari Z, Changizi BK, Lozano A, Auyeung M, Kaido T, Agid Y, Welter ML, Khandhar SM, Mogilner AY, Pourfar MH, Walter BL, Juncos JL, Gross RE, Kuhn J, Leckman JF, Neimat JA, Okun MS; Tourette Syndrome Association International Deep Brain Stimulation (DBS) Database and Registry Study Group.

Mov Disord. 2015 Apr;30(4):448-71. doi: 10.1002/mds.26094. Epub 2014 Dec 5. Review.


Editorial commentary: "What does immunology have to do with brain development and neuropsychiatric disorders?".

Leckman JF, Vaccarino FM.

Brain Res. 2015 Aug 18;1617:1-6. doi: 10.1016/j.brainres.2014.09.052. Epub 2014 Oct 8. No abstract available.


Transcriptome Analysis of the Human Striatum in Tourette Syndrome.

Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM.

Biol Psychiatry. 2016 Mar 1;79(5):372-382. doi: 10.1016/j.biopsych.2014.07.018. Epub 2014 Jul 24.

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