Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 186


Leveraging a "Catch-Release" Logic Gate Process for the Synthesis and Nonchromatographic Purification of Thioether- or Amine-Bridged Macrocyclic Peptides.

Kheirabadi M, Creech GS, Qiao JX, Nirschl DS, Leahy DK, Boy KM, Carter PH, Eastgate MD.

J Org Chem. 2018 Apr 20;83(8):4323-4335. doi: 10.1021/acs.joc.7b03124. Epub 2018 Apr 3.


EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA.

Cell. 2017 Oct 19;171(3):683-695.e18. doi: 10.1016/j.cell.2017.09.017. Epub 2017 Oct 5.


Use of text messaging in general practice: a mixed methods investigation on GPs' and patients' views.

Leahy D, Lyons A, Dahm M, Quinlan D, Bradley C.

Br J Gen Pract. 2017 Nov;67(664):e744-e750. doi: 10.3399/bjgp17X693065. Epub 2017 Sep 25.


BOC is a modifier gene in holoprosencephaly.

Hong M, Srivastava K, Kim S, Allen BL, Leahy DJ, Hu P, Roessler E, Krauss RS, Muenke M.

Hum Mutat. 2017 Nov;38(11):1464-1470. doi: 10.1002/humu.23286. Epub 2017 Jul 21.


Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

Ye XY, Chen SY, Wu S, Yoon DS, Wang H, Hong Z, O'Connor SP, Li J, Li JJ, Kennedy LJ, Walker SJ, Nayeem A, Sheriff S, Camac DM, Ramamurthy V, Morin PE, Zebo R, Taylor JR, Morgan NN, Ponticiello RP, Harrity T, Apedo A, Golla R, Seethala R, Wang M, Harper TW, Sleczka BG, He B, Kirby M, Leahy DK, Li J, Hanson RL, Guo Z, Li YX, DiMarco JD, Scaringe R, Maxwell B, Moulin F, Barrish JC, Gordon DA, Robl JA.

J Med Chem. 2017 Jun 22;60(12):4932-4948. doi: 10.1021/acs.jmedchem.7b00211. Epub 2017 Jun 5.


Feasibility of alcohol screening among patients receiving opioid treatment in primary care.

Henihan AM, McCombe G, Klimas J, Swan D, Leahy D, Anderson R, Bury G, Dunne CP, Keenan E, Lambert JS, Meagher D, O'Gorman C, O'Toole TP, Saunders J, Shorter GW, Smyth BP, Kaner E, Cullen W.

BMC Fam Pract. 2016 Nov 5;17(1):153.


Commentary on Zeremski et al. (2016): Improvements in HCV-related Knowledge Among Substance Users on Opioid Agonist Therapy After an Educational Intervention.

McCombe G, Leahy D, Klimas J, Lambert JS, Cullen W, Henihan AM.

J Addict Med. 2016 Sep-Oct;10(5):363-4. doi: 10.1097/ADM.0000000000000244. No abstract available.


Laser induced mortality of Anopheles stephensi mosquitoes.

Keller MD, Leahy DJ, Norton BJ, Johanson T, Mullen ER, Marvit M, Makagon A.

Sci Rep. 2016 Feb 18;6:20936. doi: 10.1038/srep20936.


A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.

Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M.

Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339.


Role of the general practitioner in providing early intervention for youth mental health: a mixed methods investigation.

Leahy D, Schaffalitzky E, Saunders J, Armstrong C, Meagher D, Ryan P, Dooley B, McNicholas F, McGorry P, Cullen W.

Early Interv Psychiatry. 2018 Apr;12(2):202-216. doi: 10.1111/eip.12303. Epub 2015 Dec 22.


Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma.

Rook AH, Gelfand JM, Wysocka M, Troxel AB, Benoit B, Surber C, Elenitsas R, Buchanan MA, Leahy DS, Watanabe R, Kirsch IR, Kim EJ, Clark RA.

Blood. 2015 Sep 17;126(12):1452-61. doi: 10.1182/blood-2015-02-630335. Epub 2015 Jul 30. Erratum in: Blood. 2015 Dec 17;126(25):2765. Gelfand, Joel C [corrected to Gelfand, Joel M].


Immunoaffinity Purification of Proteins.

Kavran JM, Leahy DJ.

Methods Enzymol. 2015;559:27-36. doi: 10.1016/bs.mie.2014.11.006. Epub 2015 Mar 29.


Conscientiousness and adherence to the oral contraceptive pill: A prospective study.

Leahy D, Treacy K, Molloy GJ.

Psychol Health. 2015;30(11):1346-60. doi: 10.1080/08870446.2015.1062095. Epub 2015 Jul 21.


Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1.

Li W, Koutmou KS, Leahy DJ, Li M.

J Biol Chem. 2015 Jul 31;290(31):18904-13. doi: 10.1074/jbc.M115.658864. Epub 2015 Jun 11.


Structural basis of arc binding to synaptic proteins: implications for cognitive disease.

Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF.

Neuron. 2015 Apr 22;86(2):490-500. doi: 10.1016/j.neuron.2015.03.030. Epub 2015 Apr 9.


Smoothened goes molecular: new pieces in the hedgehog signaling puzzle.

McCabe JM, Leahy DJ.

J Biol Chem. 2015 Feb 6;290(6):3500-7. doi: 10.1074/jbc.R114.617936. Epub 2014 Dec 17. Review.


Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.

Ward MD, Leahy DJ.

J Biol Chem. 2015 Jan 16;290(3):1570-9. doi: 10.1074/jbc.M114.612085. Epub 2014 Dec 2.


Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.

Cleveland TE 4th, McCabe JM, Leahy DJ.

Protein Expr Purif. 2014 Dec;104:92-102. doi: 10.1016/j.pep.2014.09.012. Epub 2014 Sep 26.


How IGF-1 activates its receptor.

Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ.

Elife. 2014 Sep 25;3. pii: e03772. doi: 10.7554/eLife.03772.


Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.

Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA.

J Biol Chem. 2014 Nov 7;289(45):31361-72. doi: 10.1074/jbc.M114.597153. Epub 2014 Sep 23.


Youth mental health in deprived urban areas: a Delphi study on the role of the GP in early intervention.

Schaffalitzky E, Leahy D, Cullen W, Gavin B, Latham L, O'Connor R, Smyth BP, O'Dea E, Ryan S.

Ir J Med Sci. 2015 Dec;184(4):831-43. doi: 10.1007/s11845-014-1187-z. Epub 2014 Sep 6.


FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia.

Ma HS, Nguyen B, Duffield AS, Li L, Galanis A, Williams AB, Brown PA, Levis MJ, Leahy DJ, Small D.

Cancer Res. 2014 Sep 15;74(18):5206-17. doi: 10.1158/0008-5472.CAN-14-1028. Epub 2014 Jul 24.


Improving the efficiency of multisensory integration in older adults: audio-visual temporal discrimination training reduces susceptibility to the sound-induced flash illusion.

Setti A, Stapleton J, Leahy D, Walsh C, Kenny RA, Newell FN.

Neuropsychologia. 2014 Aug;61:259-68. doi: 10.1016/j.neuropsychologia.2014.06.027. Epub 2014 Jun 28.


'Nobody really gets it': a qualitative exploration of youth mental health in deprived urban areas.

Schaffalitzky E, Leahy D, Armstrong C, Gavin B, Latham L, McNicholas F, Meagher D, O'Connor R, O'Toole T, Smyth BP, Cullen W.

Early Interv Psychiatry. 2015 Oct;9(5):406-11. doi: 10.1111/eip.12165. Epub 2014 Jun 23.


Stroke in young women: An interpretative phenomenological analysis.

Leahy DM, Desmond D, Coughlan T, O'Neill D, Collins DR.

J Health Psychol. 2016 May;21(5):669-78. doi: 10.1177/1359105314535125. Epub 2014 May 27.


Cross-validation pitfalls when selecting and assessing regression and classification models.

Krstajic D, Buturovic LJ, Leahy DE, Thomas S.

J Cheminform. 2014 Mar 29;6(1):10. doi: 10.1186/1758-2946-6-10.


Silver staining of SDS-polyacrylamide gel.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;541:169-76. doi: 10.1016/B978-0-12-420119-4.00014-8.


Coupling antibody to cyanogen bromide-activated sepharose.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;541:27-34. doi: 10.1016/B978-0-12-420119-4.00003-3.


The FRET signatures of noninteracting proteins in membranes: simulations and experiments.

King C, Sarabipour S, Byrne P, Leahy DJ, Hristova K.

Biophys J. 2014 Mar 18;106(6):1309-17. doi: 10.1016/j.bpj.2014.01.039.


An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.

Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA.

J Am Chem Soc. 2014 Mar 5;136(9):3370-3. doi: 10.1021/ja5006674. Epub 2014 Feb 24.


Single cell cloning of a stable mammalian cell line.

Longo PA, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2014;536:165-72. doi: 10.1016/B978-0-12-420070-8.00014-3.


Lysis of mammalian and Sf9 cells.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;536:47-52. doi: 10.1016/B978-0-12-420070-8.00004-0.


Primary care and youth mental health in Ireland: qualitative study in deprived urban areas.

Leahy D, Schaffalitzky E, Armstrong C, Bury G, Cussen-Murphy P, Davis R, Dooley B, Gavin B, Keane R, Keenan E, Latham L, Meagher D, McGorry P, McNicholas F, O'Connor R, O'Dea E, O'Keane V, O'Toole TP, Reilly E, Ryan P, Sanci L, Smyth BP, Cullen W.

BMC Fam Pract. 2013 Dec 17;14:194. doi: 10.1186/1471-2296-14-194.


Enzymatic deglycosylation of glycoproteins.

Kim MS, Leahy D.

Methods Enzymol. 2013;533:259-63. doi: 10.1016/B978-0-12-420067-8.00019-2.


Automation of decision making in drug design.

Leahy DE, Sykora V.

Drug Discov Today Technol. 2013 Sep;10(3):e437-41. Review. No abstract available.


Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer.

Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK.

Mol Carcinog. 2014 Feb;53 Suppl 1:E169-80. doi: 10.1002/mc.22088. Epub 2013 Oct 22.


Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.

Best HA, Matthews JH, Heathcott RW, Hanna R, Leahy DC, Coorey NV, Bellows DS, Atkinson PH, Miller JH.

Mol Biosyst. 2013 Nov;9(11):2842-52. doi: 10.1039/c3mb70211a.


Transient mammalian cell transfection with polyethylenimine (PEI).

Longo PA, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2013;529:227-40. doi: 10.1016/B978-0-12-418687-3.00018-5.


Generating mammalian stable cell lines by electroporation.

A Longo P, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2013;529:209-26. doi: 10.1016/B978-0-12-418687-3.00017-3.


Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.

Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA.

ACS Chem Biol. 2013 Nov 15;8(11):2372-6. doi: 10.1021/cb4005707. Epub 2013 Sep 6.


Piecing together the extracellular puzzle.

Leahy DJ.

Cell. 2013 Jul 3;154(1):23-5. doi: 10.1016/j.cell.2013.06.014.


Magic bullets from llamas.

Leahy DJ.

Structure. 2013 Jul 2;21(7):1072-3. doi: 10.1016/j.str.2013.06.008.


Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.

Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y.

Mech Ageing Dev. 2013 Oct;134(10):478-85. doi: 10.1016/j.mad.2013.01.005. Epub 2013 Feb 1.


Branched-chain amino Acid plus glucose supplement reduces exercise-induced delayed onset muscle soreness in college-age females.

Leahy DT, Pintauro SJ.

ISRN Nutr. 2013 Mar 17;2013:921972. doi: 10.5402/2013/921972. eCollection 2013.


Dystroglycan organizes axon guidance cue localization and axonal pathfinding.

Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD.

Neuron. 2012 Dec 6;76(5):931-44. doi: 10.1016/j.neuron.2012.10.009.


Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm.

Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destrée A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL, Dietz HC.

Nat Genet. 2012 Nov;44(11):1249-54. doi: 10.1038/ng.2421. Epub 2012 Sep 30.


Efficient and scalable enantioselective synthesis of a CGRP antagonist.

Leahy DK, Fan Y, Desai LV, Chan C, Zhu J, Luo G, Chen L, Hanson RL, Sugiyama M, Rosner T, Cuniere N, Guo Z, Hsiao Y, Gao Q.

Org Lett. 2012 Sep 21;14(18):4938-41. Epub 2012 Sep 6.


Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors.

Williams AB, Nguyen B, Li L, Brown P, Levis M, Leahy D, Small D.

Leukemia. 2013 Jan;27(1):48-55. doi: 10.1038/leu.2012.191. Epub 2012 Jul 13.


Proteolytic processing of ErbB4 in breast cancer.

Hollmén M, Liu P, Kurppa K, Wildiers H, Reinvall I, Vandorpe T, Smeets A, Deraedt K, Vahlberg T, Joensuu H, Leahy DJ, Schöffski P, Elenius K.

PLoS One. 2012;7(6):e39413. doi: 10.1371/journal.pone.0039413. Epub 2012 Jun 22.

Supplemental Content

Support Center