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Items: 14

1.

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.

EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.

2.

Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.

Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5.

3.

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.

Lázaro DF, Pavlou MAS, Outeiro TF.

Exp Neurol. 2017 Dec;298(Pt B):162-171. doi: 10.1016/j.expneurol.2017.05.007. Epub 2017 May 16. Review.

PMID:
28526239
4.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

5.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

6.

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.

Lázaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF.

Acta Neuropathol Commun. 2016 Dec 9;4(1):128.

7.

Glycation potentiates neurodegeneration in models of Huntington's disease.

Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.

Sci Rep. 2016 Nov 18;6:36798. doi: 10.1038/srep36798.

8.

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.

Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH.

PLoS Genet. 2016 Jun 24;12(6):e1006098. doi: 10.1371/journal.pgen.1006098. eCollection 2016 Jun.

9.

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells.

Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J.

J Biol Chem. 2015 Nov 13;290(46):27582-93. doi: 10.1074/jbc.M114.636027. Epub 2015 Sep 22.

10.

Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium.

Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P.

ACS Chem Neurosci. 2015 Oct 21;6(10):1769-79. doi: 10.1021/acschemneuro.5b00093. Epub 2015 Aug 25.

PMID:
26284970
11.

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.

PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov.

12.

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells.

Perfeito R, Lázaro DF, Outeiro TF, Rego AC.

Mol Cell Neurosci. 2014 Sep;62:51-9. doi: 10.1016/j.mcn.2014.08.002. Epub 2014 Aug 7.

PMID:
25109238
13.

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.

Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.

Neurobiol Dis. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28.

PMID:
24983211
14.

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.

Wales P, Pinho R, Lázaro DF, Outeiro TF.

J Parkinsons Dis. 2013;3(4):415-59. doi: 10.3233/JPD-130216. Review.

PMID:
24270242

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