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White matter integrity and processing speed in sickle cell anemia.

Stotesbury H, Kirkham FJ, Kölbel M, Balfour P, Clayden JD, Sahota S, Sakaria S, Saunders DE, Howard J, Kesse-Adu R, Inusa B, Pelidis M, Chakravorty S, Rees DC, Awogbade M, Wilkey O, Layton M, Clark CA, Kawadler JM.

Neurology. 2018 May 11. pii: 10.1212/WNL.0000000000005644. doi: 10.1212/WNL.0000000000005644. [Epub ahead of print]


Engagement in online pain self-management improves pain in adults on medication-assisted behavioral treatment for opioid use disorders.

Wilson M, Finlay M, Orr M, Barbosa-Leiker C, Sherazi N, Roberts MLA, Layton M, Roll JM.

Addict Behav. 2018 Apr 27. pii: S0306-4603(18)30364-2. doi: 10.1016/j.addbeh.2018.04.019. [Epub ahead of print]


Sex differences in opioid use and medical issues during buprenorphine/naloxone treatment.

Barbosa-Leiker C, McPherson S, Layton ME, Burduli E, Roll JM, Ling W.

Am J Drug Alcohol Abuse. 2018;44(4):488-496. doi: 10.1080/00952990.2018.1458234. Epub 2018 Apr 19.


Pilot investigation: randomized-controlled analog trial for alcohol and tobacco smoking co-addiction using contingency management.

Orr MF, Lederhos Smith C, Finlay M, Martin SC, Brooks O, Oluwoye OA, Leickly E, McDonell M, Burduli E, Barbosa-Leiker C, Layton M, Roll JM, McPherson SM.

Behav Pharmacol. 2018 Mar 20. doi: 10.1097/FBP.0000000000000379. [Epub ahead of print]


Respiratory disease in ball pythons (Python regius) experimentally infected with ball python nidovirus.

Hoon-Hanks LL, Layton ML, Ossiboff RJ, Parker JSL, Dubovi EJ, Stenglein MD.

Virology. 2018 Apr;517:77-87. doi: 10.1016/j.virol.2017.12.008. Epub 2018 Jan 10.


Decreases in smoking during treatment for methamphetamine-use disorders: preliminary evidence.

McPherson S, Orr M, Lederhos C, McDonell M, Leickly E, Hirchak K, Oluwoye OA, Murphy SM, Layton M, Roll JM.

Behav Pharmacol. 2018 Jun;29(4):370-374. doi: 10.1097/FBP.0000000000000349.


Outbreak of Influenza A(H7N2) Among Cats in an Animal Shelter With Cat-to-Human Transmission-New York City, 2016.

Lee CT, Slavinski S, Schiff C, Merlino M, Daskalakis D, Liu D, Rakeman JL, Misener M, Thompson C, Leung YL, Varma JK, Fry A, Havers F, Davis T, Newbury S, Layton M; Influenza A(H7N2) Response Team.

Clin Infect Dis. 2017 Nov 13;65(11):1927-1929. doi: 10.1093/cid/cix668.


Lessons learned from a review of paroxysmal nocturnal haemoglobinuria (PNH) requests: a report from the UK PNH Network.

Griffin M, Neilly I, Nikolousis M, Narayanan S, Lowndes K, Koh M, Ros J, Ingram W, Couzens S, Karim R, Morgan L, McMullin M, Sharma N, Mitchell L, Layton M, Medd P, Chattree S, Hill A.

Br J Haematol. 2017 Aug 31. doi: 10.1111/bjh.14888. [Epub ahead of print] No abstract available.


Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons.

Stenglein MD, Sanchez-Migallon Guzman D, Garcia VE, Layton ML, Hoon-Hanks LL, Boback SM, Keel MK, Drazenovich T, Hawkins MG, DeRisi JL.

J Virol. 2017 Jul 12;91(15). pii: e00451-17. doi: 10.1128/JVI.00451-17. Print 2017 Aug 1.


Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis-generating Small Clinical Studies.

Gufford BT, Ainslie GR, White JR Jr, Layton ME, Padowski JM, Pollack GM, Paine MF.

Clin Transl Sci. 2017 Sep;10(5):380-386. doi: 10.1111/cts.12473. Epub 2017 May 23.


Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model.

Pero JE, Rossi MA, Lehman HDGF, Kelly MJ 3rd, Mulhearn JJ, Wolkenberg SE, Cato MJ, Clements MK, Daley CJ, Filzen T, Finger EN, Gregan Y, Henze DA, Jovanovska A, Klein R, Kraus RL, Li Y, Liang A, Majercak JM, Panigel J, Urban MO, Wang J, Wang YH, Houghton AK, Layton ME.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2683-2688. doi: 10.1016/j.bmcl.2017.04.040. Epub 2017 Apr 22.


Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.

Roecker AJ, Egbertson M, Jones KLG, Gomez R, Kraus RL, Li Y, Koser AJ, Urban MO, Klein R, Clements M, Panigel J, Daley C, Wang J, Finger EN, Majercak J, Santarelli V, Gregan I, Cato M, Filzen T, Jovanovska A, Wang YH, Wang D, Joyce LA, Sherer EC, Peng X, Wang X, Sun H, Coleman PJ, Houghton AK, Layton ME.

Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093. doi: 10.1016/j.bmcl.2017.03.085. Epub 2017 Mar 30.


A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation.

Miner PB Jr, Koltun WD, Wiener GJ, De La Portilla M, Prieto B, Shailubhai K, Layton MB, Barrow L, Magnus L, Griffin PH.

Am J Gastroenterol. 2017 Apr;112(4):613-621. doi: 10.1038/ajg.2016.611. Epub 2017 Feb 7.


Hepatitis A Cases Among Food Handlers: A Local Health Department Response-New York City, 2013.

Ridpath A, Reddy V, Layton M, Misener M, Scaccia A, Starr D, Stavinsky F, Varma JK, Waechter H, Zucker JR, Balter S.

J Public Health Manag Pract. 2017 Nov/Dec;23(6):571-576. doi: 10.1097/PHH.0000000000000526.


Communication Between Infectious Disease Physicians and US State and Local Public Health Agencies: Strengths, Challenges, and Opportunities.

Santibañez S, Polgreen PM, Beekmann SE, Cairns C, Filice GA, Layton M, Hughes JM.

Public Health Rep. 2016 Sep;131(5):666-670. doi: 10.1177/0033354916660083. Epub 2016 Aug 22.


Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition.

Chaudhry MS, Gilmour KC, House IG, Layton M, Panoskaltsis N, Sohal M, Trapani JA, Voskoboinik I.

Oncoimmunology. 2016 Jun 2;5(7):e1179415. doi: 10.1080/2162402X.2016.1179415. eCollection 2016 Jul.


3-minute smartphone-based and tablet-based psychomotor vigilance tests for the assessment of reduced alertness due to sleep deprivation.

Grant DA, Honn KA, Layton ME, Riedy SM, Van Dongen HPA.

Behav Res Methods. 2017 Jun;49(3):1020-1029. doi: 10.3758/s13428-016-0763-8.


SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt.

Cho G, Anie KA, Buckton J, Kiilu P, Layton M, Alexander L, Hemmaway C, Sutton D, Amos C, Doré CJ, Kahan B, Meredith S.

BMJ Open. 2016 Jun 9;6(6):e011276. doi: 10.1136/bmjopen-2016-011276.


Educating Psychiatry Residents to Practice in Smaller Communities: A Regional Residency Track Model.

Cowley DS, Keeble T, Jones J, Layton M, Murray SB, Williams K, Bakker C, Verhulst J.

Acad Psychiatry. 2016 Oct;40(5):846-9. doi: 10.1007/s40596-016-0558-3. Epub 2016 Apr 25. No abstract available.


Pharmacokinetic analysis and comparison of caffeine administered rapidly or slowly in coffee chilled or hot versus chilled energy drink in healthy young adults.

White JR Jr, Padowski JM, Zhong Y, Chen G, Luo S, Lazarus P, Layton ME, McPherson S.

Clin Toxicol (Phila). 2016;54(4):308-12. doi: 10.3109/15563650.2016.1146740.


Safety, tolerability, efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic lupus erythematosus.

Kahl L, Patel J, Layton M, Binks M, Hicks K, Leon G, Hachulla E, Machado D, Staumont-Sallé D, Dickson M, Condreay L, Schifano L, Zamuner S, van Vollenhoven RF; JAK115919 Study Team.

Lupus. 2016 Nov;25(13):1420-1430. doi: 10.1177/0961203316640910. Epub 2016 Jul 11.


Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

Pero JE, Rossi MA, Kelly MJ 3rd, Lehman HD, Layton ME, Garbaccio RM, O'Brien JA, Magliaro BC, Uslaner JM, Huszar SL, Fillgrove KL, Tang C, Kuo Y, Joyce LA, Sherer EC, Jacobson MA.

ACS Med Chem Lett. 2016 Jan 10;7(3):312-7. doi: 10.1021/acsmedchemlett.5b00459. eCollection 2016 Mar 10.


Quantitative prediction and clinical evaluation of an unexplored herb-drug interaction mechanism in healthy volunteers.

Gufford BT, Barr JT, González-Pérez V, Layton ME, White JR Jr, Oberlies NH, Paine MF.

CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):701-10. doi: 10.1002/psp4.12047. Epub 2015 Nov 28.


Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.

Finley M, Cassaday J, Kreamer T, Li X, Solly K, O'Donnell G, Clements M, Converso A, Cook S, Daley C, Kraus R, Lai MT, Layton M, Lemaire W, Staas D, Wang J.

J Biomol Screen. 2016 Jun;21(5):480-9. doi: 10.1177/1087057116629669. Epub 2016 Feb 9.


Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

Layton ME, Reif AJ, Hartingh TJ, Rodzinak K, Dudkin V, Wang C, Arrington K, Kelly MJ 3rd, Garbaccio RM, O'Brien JA, Magliaro BC, Uslaner JM, Huszar SL, Fillgrove KL, Tang C, Kuo Y, Jacobson MA.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1260-4. doi: 10.1016/j.bmcl.2016.01.021. Epub 2016 Jan 11.


Sleep and performance in simulated Navy watch schedules.

Skornyakov E, Shattuck NL, Winser MA, Matsangas P, Sparrow AR, Layton ME, Gabehart RJ, Van Dongen HP.

Accid Anal Prev. 2017 Feb;99(Pt B):422-427. doi: 10.1016/j.aap.2015.11.021. Epub 2015 Dec 12.


A critical overview of the current myofascial pain literature - October 2015.

Dommerholt J, Grieve R, Hooks T, Layton M.

J Bodyw Mov Ther. 2015 Oct;19(4):736-46. doi: 10.1016/j.jbmt.2015.09.003. Epub 2015 Oct 22. Review.


Examining Longitudinal Stimulant Use and Treatment Attendance as Parallel Outcomes in Two Contingency Management Randomized Clinical Trials.

McPherson S, Brooks O, Barbosa-Leiker C, Lederhos C, Lamp A, Murphy S, Layton M, Roll J.

J Subst Abuse Treat. 2016 Feb;61:18-25. doi: 10.1016/j.jsat.2015.08.008. Epub 2015 Sep 21.


Dry needling for the management of thoracic spine pain.

Fernández-de-Las-Peñas C, Layton M, Dommerholt J.

J Man Manip Ther. 2015 Jul;23(3):147-53.


A critical overview of the current myofascial pain literature - July 2015.

Dommerholt J, Hooks T, Grieve R, Layton M.

J Bodyw Mov Ther. 2015 Jul;19(3):482-93. doi: 10.1016/j.jbmt.2015.05.003. Epub 2015 May 30. Review.


Examining the factor structure of the Clinical Opiate Withdrawal Scale: A secondary data analysis from the National Drug Abuse Treatment Clinical Trials Network (CTN) 0003.

Barbosa-Leiker C, McPherson S, Mamey MR, Burns GL, Layton ME, Roll J, Ling W.

Drug Alcohol Depend. 2015 Jul 1;152:218-23. doi: 10.1016/j.drugalcdep.2015.03.036. Epub 2015 Apr 11.


A critical overview of current myofascial pain literature - March 2015.

Dommerholt J, Layton M, Hooks T, Grieve R.

J Bodyw Mov Ther. 2015 Apr;19(2):337-49. doi: 10.1016/j.jbmt.2015.01.003. Epub 2015 Jan 29. Review.


Ebola virus disease in a humanitarian aid worker - New York City, October 2014.

Yacisin K, Balter S, Fine A, Weiss D, Ackelsberg J, Prezant D, Wilson R, Starr D, Rakeman J, Raphael M, Quinn C, Toprani A, Clark N, Link N, Daskalakis D, Maybank A, Layton M, Varma JK; Centers for Disease Control and Prevention (CDC).

MMWR Morb Mortal Wkly Rep. 2015 Apr 3;64(12):321-3.


DRESS syndrome and reversible liver function abnormalities in patients with systemic lupus erythematosus treated with the highly selective JAK-1 inhibitor GSK2586184.

van Vollenhoven RF, Layton M, Kahl L, Schifano L, Hachulla E, Machado D, Staumont-Sallé D, Patel J; JAK115919 Study Team.

Lupus. 2015 May;24(6):648-9. doi: 10.1177/0961203315573347. Epub 2015 Feb 27. No abstract available.


An evidence-informed review of the current myofascial pain literature--January 2015.

Dommerholt J, Grieve R, Layton M, Hooks T.

J Bodyw Mov Ther. 2015 Jan;19(1):126-37. doi: 10.1016/j.jbmt.2014.11.006. Epub 2014 Nov 13. Review.


Colorectal cancer screening and surveillance.

Short MW, Layton MC, Teer BN, Domagalski JE.

Am Fam Physician. 2015 Jan 15;91(2):93-100.


Suspected hypercalcemia induced ST-segment elevation in a patient with sarcoidosis.

Braun MM, Petersen K, Hermann S, Overbeek-Wager E, Layton M, Trowbridge D.

Mil Med. 2015 Jan;180(1):e160-3. doi: 10.7205/MILMED-D-14-00252.


Surveillance and preparedness for Ebola virus disease -- New York City, 2014.

Benowitz I, Ackelsberg J, Balter SE, Baumgartner JC, Dentinger C, Fine AD, Harper SA, Jones LE, Laraque F, Lee EH, Merizalde G, Yacisin KA, Varma JK, Layton MC; Centers for Disease Control and Prevention (CDC).

MMWR Morb Mortal Wkly Rep. 2014 Oct 17;63(41):934-6.


Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells.

Layton MJ, Rynkiewicz NK, Ivetac I, Horan KA, Mitchell CA, Phillips WA.

Biosci Rep. 2014 Apr 1;34(2). pii: e00104. Print 2014 Apr 1.


Immunopurification of adenomatous polyposis coli (APC) proteins.

Elliott KL, Catimel B, Church NL, Coates JL, Burgess AW, Layton MJ, Faux MC.

BMC Res Notes. 2013 Oct 25;6:429. doi: 10.1186/1756-0500-6-429.


Planned variation in preanalytical conditions to evaluate biospecimen stability in the National Children's Study (NCS).

Mechanic L, Mendez A, Merrill L, Rogers J, Layton M, Todd D, Varanasi A, O'Brien B, Meyer Iii WA, Zhang M, Schleicher RL, Moye J.

Clin Chem Lab Med. 2013 Dec;51(12):2287-94. doi: 10.1515/cclm-2013-0454.


The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom.

Cabrita IZ, Mohammed A, Layton M, Ghorashian S, Gilmore A, Cho G, Howard J, Anie KA, Desforges L, Bassett P, Grapsa J, Howard L, Mahalingam G, Dawson D, Pinto FJ, Nihoyannopoulos P, Davies SC, Gibbs JS.

Br J Haematol. 2013 Aug;162(3):400-8. doi: 10.1111/bjh.12391. Epub 2013 May 29.


A quality of life survey of individuals with urinary incontinence who visit a self-help website: implications for those seeking healthcare information.

Rozensky RH, Tovian SM, Gartley CB, Nichols TR, Layton M.

J Clin Psychol Med Settings. 2013 Sep;20(3):275-83. doi: 10.1007/s10880-013-9361-4.


Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions.

Cameron JM, Howell DN, White JR, Andrenyak DM, Layton ME, Roll JM.

Tob Control. 2014 Jan;23(1):77-8. doi: 10.1136/tobaccocontrol-2012-050604. Epub 2013 Feb 13. No abstract available.


Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria.

Gargiulo L, Papaioannou M, Sica M, Talini G, Chaidos A, Richichi B, Nikolaev AV, Nativi C, Layton M, de la Fuente J, Roberts I, Luzzatto L, Notaro R, Karadimitris A.

Blood. 2013 Apr 4;121(14):2753-61. doi: 10.1182/blood-2012-11-469353. Epub 2013 Jan 31.


Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity.

Layton MJ, Saad M, Church NL, Pearson RB, Mitchell CA, Phillips WA.

BMC Biochem. 2012 Dec 27;13:30. doi: 10.1186/1471-2091-13-30.


Disparities in the severity of influenza illness: a descriptive study of hospitalized and nonhospitalized novel H1N1 influenza-positive patients in New York City: 2009-2010 influenza season.

Levy NS, Nguyen TQ, Westheimer E, Layton M.

J Public Health Manag Pract. 2013 Jan-Feb;19(1):16-24. doi: 10.1097/PHH.0b013e31824155a2.


Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine.

Keystone EC, Wang MM, Layton M, Hollis S, McInnes IB; D1520C00001 Study Team.

Ann Rheum Dis. 2012 Oct;71(10):1630-5. Erratum in: Ann Rheum Dis. 2012 Dec;71(12):2064.


A retrospective review of UroVysion fish interpretations over 8.6 years: a major shift in the patient test population.

Denice Smith G, Sangle NA, Wilson A, Chadwick BE, Bentz JS, Gopez EV, Pyne MT, Tripp SR, Layton M, Pasi A, Jarboe EA, Collins BT.

Diagn Cytopathol. 2013 May;41(5):437-47. doi: 10.1002/dc.22881. Epub 2012 Aug 4. Review.


Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

Layton ME, Kelly MJ 3rd, Rodzinak KJ, Sanderson PE, Young SD, Bednar RA, Dilella AG, McDonald TP, Wang H, Mosser SD, Fay JF, Cunningham ME, Reiss DR, Fandozzi C, Trainor N, Liang A, Lis EV, Seabrook GR, Urban MO, Yergey J, Koblan KS.

ACS Chem Neurosci. 2011 Jul 20;2(7):352-62. doi: 10.1021/cn200013d. Epub 2011 Apr 15.

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