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Items: 29

1.

A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.

Kramer J, Désor V, Brunst S, Wittmann SK, Lausen J, Heering J, Proschak A, Proschak E.

Anal Biochem. 2018 Apr 15;547:7-13. doi: 10.1016/j.ab.2018.01.023. Epub 2018 Feb 2.

PMID:
29410016
2.

Hematopoietic transcription factors and differential cofactor binding regulate PRKACB isoform expression.

Kuvardina ON, Herkt S, Meyer A, Schneider L, Yillah J, Kohrs N, Bonig H, Seifried E, Müller-Tidow C, Lausen J.

Oncotarget. 2017 Apr 24;8(42):71685-71698. doi: 10.18632/oncotarget.17386. eCollection 2017 Sep 22.

3.

Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells.

Herkt SC, Kuvardina ON, Herglotz J, Schneider L, Meyer A, Pommerenke C, Salinas-Riester G, Seifried E, Bonig H, Lausen J.

Haematologica. 2018 Jan;103(1):18-29. doi: 10.3324/haematol.2017.174516. Epub 2017 Oct 12.

4.

Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.

Schanda J, Lee CW, Wohlan K, Müller-Kuller U, Kunkel H, Coco IQ, Stein S, Metz A, Koch J, Lausen J, Platzbecker U, Medyouf H, Gohlke H, Heuser M, Eder M, Grez M, Scherr M, Wichmann C.

Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2. No abstract available.

5.

MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.

Kohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.

PLoS Genet. 2016 Mar 18;12(3):e1005946. doi: 10.1371/journal.pgen.1005946. eCollection 2016 Mar.

6.

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.

Kuvardina ON, Herglotz J, Kolodziej S, Kohrs N, Herkt S, Wojcik B, Oellerich T, Corso J, Behrens K, Kumar A, Hussong H, Urlaub H, Koch J, Serve H, Bonig H, Stocking C, Rieger MA, Lausen J.

Blood. 2015 Jun 4;125(23):3570-9. doi: 10.1182/blood-2014-11-610519. Epub 2015 Apr 24.

7.

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1.

Ponnusamy K, Kohrs N, Ptasinska A, Assi SA, Herold T, Hiddemann W, Lausen J, Bonifer C, Henschler R, Wichmann C.

Oncogenesis. 2015 Apr 13;4:e146. doi: 10.1038/oncsis.2015.6.

8.

A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.

Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M.

Nucleic Acids Res. 2015 Feb 18;43(3):1577-92. doi: 10.1093/nar/gkv019. Epub 2015 Jan 20.

9.

The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells.

Ponnusamy K, Chen-Wichmann L, Kuvardina ON, Lausen J, Henschler R, Wichmann C.

Haematologica. 2014 Dec;99(12):e253-6. doi: 10.3324/haematol.2014.106088. Epub 2014 Aug 8. No abstract available.

10.

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.

Kolodziej S, Kuvardina ON, Oellerich T, Herglotz J, Backert I, Kohrs N, Buscató El, Wittmann SK, Salinas-Riester G, Bonig H, Karas M, Serve H, Proschak E, Lausen J.

Nat Commun. 2014 May 29;5:3995. doi: 10.1038/ncomms4995.

11.

Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.

Ng KP, Hu Z, Ebrahem Q, Negrotto S, Lausen J, Saunthararajah Y.

Oncogenesis. 2013 Nov 4;2:e78. doi: 10.1038/oncsis.2013.41.

12.

The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis.

Courtial N, Mücke C, Herkt S, Kolodziej S, Hussong H, Lausen J.

PLoS One. 2013 Sep 26;8(9):e76637. doi: 10.1371/journal.pone.0076637. eCollection 2013.

13.

Contributions of the histone arginine methyltransferase PRMT6 to the epigenetic function of RUNX1.

Lausen J.

Crit Rev Eukaryot Gene Expr. 2013;23(3):265-74. Review.

PMID:
23879542
14.

Histone arginine methylation keeps RUNX1 target genes in an intermediate state.

Herglotz J, Kuvardina ON, Kolodziej S, Kumar A, Hussong H, Grez M, Lausen J.

Oncogene. 2013 May 16;32(20):2565-75. doi: 10.1038/onc.2012.274. Epub 2012 Jul 9.

PMID:
22777353
15.

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP.

Bangert A, Cristofanon S, Eckhardt I, Abhari BA, Kolodziej S, Häcker S, Vellanki SH, Lausen J, Debatin KM, Fulda S.

Oncogene. 2012 Nov 1;31(44):4677-88. doi: 10.1038/onc.2011.614. Epub 2012 Jan 23.

PMID:
22266862
16.

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.

Courtial N, Smink JJ, Kuvardina ON, Leutz A, Göthert JR, Lausen J.

FASEB J. 2012 Feb;26(2):523-32. doi: 10.1096/fj.11-190850. Epub 2011 Oct 11.

PMID:
21990371
17.

Molecular targeting of aberrant transcription factors in leukemia: strategies for RUNX1/ETO.

Wichmann C, Grez M, Lausen J.

Curr Drug Targets. 2010 Sep;11(9):1181-91. Review.

PMID:
20583973
18.

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity.

Wichmann C, Becker Y, Chen-Wichmann L, Vogel V, Vojtkova A, Herglotz J, Moore S, Koch J, Lausen J, Mäntele W, Gohlke H, Grez M.

Blood. 2010 Jul 29;116(4):603-13. doi: 10.1182/blood-2009-10-248047. Epub 2010 Apr 29.

19.

Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.

Lausen J, Pless O, Leonard F, Kuvardina ON, Koch B, Leutz A.

J Biol Chem. 2010 Feb 19;285(8):5338-46. doi: 10.1074/jbc.M109.030296. Epub 2009 Dec 22.

20.

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A.

J Biol Chem. 2008 Sep 26;283(39):26357-63. doi: 10.1074/jbc.M802132200. Epub 2008 Jul 21.

21.

A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.

Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH.

Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17.

PMID:
17572682
22.

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.

Erdmann S, Senkel S, Arndt T, Lucas B, Lausen J, Klein-Hitpass L, Ryffel GU, Thomas H.

Biol Chem. 2007 Jan;388(1):91-106.

PMID:
17214554
23.

ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.

Lausen J, Liu S, Fliegauf M, Lübbert M, Werner MH.

Oncogene. 2006 Mar 2;25(9):1349-57.

PMID:
16247445
24.

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.

Lucas B, Grigo K, Erdmann S, Lausen J, Klein-Hitpass L, Ryffel GU.

Oncogene. 2005 Sep 22;24(42):6418-31.

PMID:
16007190
25.

The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.

Lausen J, Cho S, Liu S, Werner MH.

J Biol Chem. 2004 Nov 19;279(47):49281-8. Epub 2004 Sep 17.

26.

Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.

Thomas H, Badenberg B, Bulman M, Lemm I, Lausen J, Kind L, Roosen S, Ellard S, Hattersley AT, Ryffel GU.

Biol Chem. 2002 Nov;383(11):1691-700.

PMID:
12530534
27.

Promoter analysis of pyk20, a gene from Arabidopsis thaliana.

Puzio PS, Lausen J, Heinen P, Grundler FM.

Plant Sci. 2000 Aug 22;157(2):245-255.

PMID:
10960738
28.

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.

Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hattersley AT, Ryffel GU.

Nucleic Acids Res. 2000 Jan 15;28(2):430-7.

29.

Isolation of a gene from Arabidopsis thaliana related to nematode feeding structures.

Puzio PS, Lausen J, Almeida-Engler J, Cai D, Gheysen G, Grundler FM.

Gene. 1999 Oct 18;239(1):163-72.

PMID:
10571046

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