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Whole-Body Distribution and Clinical Association of Telangiectases in Systemic Sclerosis.

Jouvray M, Launay D, Dubucquoi S, Sobanski V, Podevin C, Lambert M, Morell-Dubois S, Maillard H, Hatron PY, Hachulla E, Giovannelli J.

JAMA Dermatol. 2018 May 16. doi: 10.1001/jamadermatol.2018.0916. [Epub ahead of print]


Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis.

Launay D, Montani D, Hassoun PM, Cottin V, Le Pavec J, Clerson P, Sitbon O, Jaïs X, Savale L, Weatherald J, Sobanski V, Mathai SC, Shafiq M, Cordier JF, Hachulla E, Simonneau G, Humbert M.

PLoS One. 2018 May 15;13(5):e0197112. doi: 10.1371/journal.pone.0197112. eCollection 2018.


Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The OPuS-2 study.

Riedl MA, Aygören-Pürsün E, Baker J, Farkas H, Anderson J, Bernstein JA, Bouillet L, Busse P, Manning M, Magerl M, Gompels M, Huissoon AP, Longhurst H, Lumry W, Ritchie B, Shapiro R, Soteres D, Banerji A, Cancian M, Johnston DT, Craig TJ, Launay D, Li HH, Liebhaber M, Nickel T, Offenberger J, Rae W, Schrijvers R, Triggiani M, Wedner HJ, Dobo S, Cornpropst M, Clemons D, Fang L, Collis P, Sheridan WP, Maurer M.

Allergy. 2018 Apr 24. doi: 10.1111/all.13466. [Epub ahead of print]


Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review.

Thiebaut M, Launay D, Rivière S, Mahévas T, Bellakhal S, Hachulla E, Fain O, Mekinian A.

Autoimmun Rev. 2018 Jun;17(6):582-587. doi: 10.1016/j.autrev.2017.12.010. Epub 2018 Apr 7. Review.


Specialist Advice Support for Management of Severe Hereditary Angioedema Attacks: A Multicenter Cluster-Randomized Controlled Trial.

Javaud N, Fain O, Durand-Zaleski I, Launay D, Bouillet L, Gompel A, Sobel A, Woimant M, Rabetrano H, Petrovic T, Lapostolle F, Boccon-Gibod I, Reuter PG, Bertrand P, Mezaour M, Coppere B, Floccard B, Kanny G, Baker E, Martin L, Vicaut E, Adnet F.

Ann Emerg Med. 2018 Mar 2. pii: S0196-0644(18)30081-7. doi: 10.1016/j.annemergmed.2018.01.053. [Epub ahead of print]


Association between Rheumatoid Arthritis and Pulmonary Hypertension: Data from the French Pulmonary Hypertension Registry.

Montani D, Henry J, O'Connell C, Jaïs X, Cottin V, Launay D, Habib G, Bourdin A, Jevnikar M, Savale L, Rottat L, Simonneau G, Sitbon O, Humbert M, Allanore Y.

Respiration. 2018;95(4):244-250. doi: 10.1159/000485631. Epub 2018 Feb 28.


Remission of Refractory Systemic-Onset Juvenile Idiopathic Arthritis After Treatment With Siltuximab.

Leurs A, Launay D, Terriou L, Hatron PY, Quartier P, Hachulla E.

J Clin Rheumatol. 2018 Feb 27. doi: 10.1097/RHU.0000000000000716. [Epub ahead of print] No abstract available.


No specific imaging pattern can help differentiate IgG4-related disease from idiopathic retroperitoneal fibrosis: 18 histologically proven cases.

Forestier A, Buob D, Mirault T, Puech P, Gnemmi V, Launay D, Hachulla E, Hatron PY, Lambert M.

Clin Exp Rheumatol. 2018 May-Jun;36(3):371-375. Epub 2018 Feb 14.


Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.

Thompson AM, O'Connor PD, Marshall AJ, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA.

J Med Chem. 2018 Mar 22;61(6):2329-2352. doi: 10.1021/acs.jmedchem.7b01581. Epub 2018 Mar 6.


Reply to Gilchrist et al. and to Musher.

Lopez B, Boucher A, Bahuaud M, Mortuaire G, Melliez H, Launay D, Terriou L, Wemeau-Stervinou L, Wallaert B, Faure K, Wallet F, Hachulla E, Hatron PY, Dubucquoi S, Batteux F, Labalette M, Lefèvre G.

Clin Infect Dis. 2018 Feb 1;66(4):637-638. doi: 10.1093/cid/cix866. No abstract available.


Altered B lymphocyte homeostasis and functions in systemic sclerosis.

Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S.

Autoimmun Rev. 2018 Mar;17(3):244-255. doi: 10.1016/j.autrev.2017.10.015. Epub 2018 Jan 16. Review.


Value of the Overall Pneumococcal Polysaccharide Response in the Diagnosis of Primary Humoral Immunodeficiencies.

Lopez B, Bahuaud M, Fieschi C, Mehlal S, Jeljeli M, Rogeau S, Brabant S, Deleplancque AS, Dubucquoi S, Poizot S, Terriou L, Launay D, Batteux F, Labalette M, Lefèvre G.

Front Immunol. 2017 Dec 20;8:1862. doi: 10.3389/fimmu.2017.01862. eCollection 2017.


Proinflammatory B-cell profile in the early phases of MS predicts an active disease.

Guerrier T, Labalette M, Launay D, Lee-Chang C, Outteryck O, Lefèvre G, Vermersch P, Dubucquoi S, Zéphir H.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 22;5(2):e431. doi: 10.1212/NXI.0000000000000431. eCollection 2018 Mar.


Factors associated with the 6-minute walk distance in patients with systemic sclerosis.

Sanges S, Giovannelli J, Sobanski V, Morell-Dubois S, Maillard H, Lambert M, Podevin C, Lamblin N, De Groote P, Bervar JF, Perez T, Matran R, Rémy-Jardin M, Hatron PY, Hachulla É, Launay D.

Arthritis Res Ther. 2017 Dec 15;19(1):279. doi: 10.1186/s13075-017-1489-4.


Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.

Thompson AM, Marshall AJ, Maes L, Yarlett N, Bacchi CJ, Gaukel E, Wring SA, Launay D, Braillard S, Chatelain E, Mowbray CE, Denny WA.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):207-213. doi: 10.1016/j.bmcl.2017.10.067. Epub 2017 Oct 27.


Limited Exercise Capacity in Patients with Systemic Sclerosis: Identifying Contributing Factors with Cardiopulmonary Exercise Testing.

Martis N, Queyrel-Moranne V, Launay D, Neviere R, Fuzibet JG, Marquette CH, Leroy S.

J Rheumatol. 2018 Jan;45(1):95-102. doi: 10.3899/jrheum.161349. Epub 2017 Nov 1.


Combined measurement of carbon monoxide and nitric oxide lung transfer does not improve the identification of pulmonary hypertension in systemic sclerosis.

Degano B, Soumagne T, Delaye T, Berger P, Perez T, Guillien A, Pellegrin JL, Launay D, Magy-Bertrand N, Agard C, Tiev KP, Hua-Huy T, Tardiff C, Diaz V, Chambellan A, Dinh-Xuan AT.

Eur Respir J. 2017 Oct 19;50(4). pii: 1701008. doi: 10.1183/13993003.01008-2017. Print 2017 Oct.


TAFRO Syndrome in Caucasians: A Case Report and Review of the Literature.

Louis C, Vijgen S, Samii K, Chalandon Y, Terriou L, Launay D, Fajgenbaum DC, Seebach JD, Muller YD.

Front Med (Lausanne). 2017 Sep 22;4:149. doi: 10.3389/fmed.2017.00149. eCollection 2017.


Pulmonary hypertension in systemic sclerosis: different phenotypes.

Launay D, Sobanski V, Hachulla E, Humbert M.

Eur Respir Rev. 2017 Sep 27;26(145). pii: 170056. doi: 10.1183/16000617.0056-2017. Print 2017 Sep 30. Review.


Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus: Results From the French Pulmonary Hypertension Registry.

Hachulla E, Jais X, Cinquetti G, Clerson P, Rottat L, Launay D, Cottin V, Habib G, Prevot G, Chabanne C, Foïs E, Amoura Z, Mouthon L, Le Guern V, Montani D, Simonneau G, Humbert M, Sobanski V, Sitbon O; French Collaborators Recruiting Members(∗).

Chest. 2018 Jan;153(1):143-151. doi: 10.1016/j.chest.2017.08.014. Epub 2017 Aug 26.


Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis.

Avouac J, Guignabert C, Hoffmann-Vold AM, Ruiz B, Dorfmuller P, Pezet S, Amar O, Tu L, Van Wassenhove J, Sadoine J, Launay D, Elhai M, Cauvet A, Subramaniam A, Resnick R, Hachulla E, Molberg Ø, Kahan A, Humbert M, Allanore Y.

Arthritis Rheumatol. 2017 Nov;69(11):2209-2221. doi: 10.1002/art.40229. Epub 2017 Oct 17.


Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease.

Le Gouellec N, Duhamel A, Perez T, Hachulla AL, Sobanski V, Faivre JB, Morell-Dubois S, Lambert M, Hatron PY, Hachulla E, Béhal H, Matran R, Launay D, Remy-Jardin M.

PLoS One. 2017 Aug 1;12(8):e0181692. doi: 10.1371/journal.pone.0181692. eCollection 2017.


Anticoagulation withdrawal in antiphospholipid syndrome: a retrospective matched-control study.

Yelnik CM, Urbanski G, Drumez E, Caron C, Maillard H, Morell-Dubois S, Dubucquoi S, Launay D, Hachulla E, Hatron PY, Duhamel A, Lambert M.

Lupus. 2018 Mar;27(3):357-364. doi: 10.1177/0961203317721751. Epub 2017 Jul 20.


Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature.

André R, Cottin V, Saraux JL, Blaison G, Bienvenu B, Cathebras P, Dhote R, Foucher A, Gil H, Lapoirie J, Launay D, Loustau V, Maurier F, Pertuiset E, Zénone T, Seebach J, Costedoat-Chalumeau N, Puéchal X, Mouthon L, Guillevin L, Terrier B; French Vasculitis Study Group (FVSG).

Autoimmun Rev. 2017 Sep;16(9):963-969. doi: 10.1016/j.autrev.2017.07.007. Epub 2017 Jul 12. Review.


Biologics in myelodysplastic syndrome-related systemic inflammatory and autoimmune diseases: French multicenter retrospective study of 29 patients.

Mekinian A, Dervin G, Lapidus N, Kahn JE, Terriou L, Liozon E, Grignano E, Piette JC, Rauzy OB, Grobost V, Godmer P, Gillard J, Rossignol J, Launay D, Aouba A, Cardon T, Bouillet L, Broner J, Vinit J, Ades L, Carrat F, Salvado C, Toussirot E, Versini M, Costedoat-Chalumeau N, Fraison JB, Guilpain P, Fenaux P, Fain O; GFM, SNFMI, CRI and MINHEMON.

Autoimmun Rev. 2017 Sep;16(9):903-910. doi: 10.1016/j.autrev.2017.07.003. Epub 2017 Jul 10.


[Systemic sclerosis and occupational difficulties: Results of a prospective study].

Peres N, Morell-Dubois S, Hachulla E, Hatron PY, Duhamel A, Godard D, Tellart-Mamert AS, Lambert M, Launay D, Fantoni-Quinton S.

Rev Med Interne. 2017 Nov;38(11):718-724. doi: 10.1016/j.revmed.2017.06.006. Epub 2017 Jul 10. French.


[Pulmonary hypertension screening in systemic sclerosis: The best strategy remains to be defined].

Launay D, Sobanski V.

Rev Med Interne. 2017 Aug;38(8):499-501. doi: 10.1016/j.revmed.2017.05.003. Epub 2017 Jun 13. French. No abstract available.


Development of a Scalable Process for the Synthesis of DNDI-VL-2098: A Potential Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis.

Satam VS, Pedada SR, Kamaraj P, Antao N, Singh A, Hindupur RM, Pati HN, Thompson AM, Launay D, Martin D.

Org Process Res Dev. 2017 Jan 20;21(1):52-59. doi: 10.1021/acs.oprd.6b00331. Epub 2016 Dec 6. Review.


Haemodynamically proven pulmonary hypertension in a patient with GATA2 deficiency-associated pulmonary alveolar proteinosis and fibrosis.

Sanges S, Prévotat A, Fertin M, Terriou L, Lefèvre G, Quesnel B, Hatron PY, Hachulla É, Copin MC, Launay D.

Eur Respir J. 2017 May 11;49(5). pii: 1700178. doi: 10.1183/13993003.00178-2017. Print 2017 May. No abstract available.


6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.

Thompson AM, Blaser A, Palmer BD, Anderson RF, Shinde SS, Launay D, Chatelain E, Maes L, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2583-2589. doi: 10.1016/j.bmcl.2017.03.069. Epub 2017 Mar 27.


7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.

Thompson AM, O'Connor PD, Marshall AJ, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Franzblau SG, Wan B, Wang Y, Ma Z, Cooper CB, Denny WA.

J Med Chem. 2017 May 25;60(10):4212-4233. doi: 10.1021/acs.jmedchem.7b00034. Epub 2017 May 11.


Extensive levamisole-induced vasculitis.

Desvignes C, Becquart C, Launay D, Terriou L, Patenotre P, Deheul S, Peytavin G, Dupin N, Delaporte E, Staumont-Sallé D.

Clin Exp Dermatol. 2017 Apr 10. doi: 10.1111/ced.13085. [Epub ahead of print]


Specific Polysaccharide Antibody Deficiency Revealed by Severe Bacterial Infections in Adulthood: A Report on 11 Cases.

Lopez B, Boucher A, Bahuaud M, Mortuaire G, Melliez H, Launay D, Terriou L, Wemeau-Stervinou L, Wallaert B, Faure K, Wallet F, Hachulla E, Hatron PY, Dubucquoi S, Batteux F, Labalette M, Lefèvre G.

Clin Infect Dis. 2017 Jul 15;65(2):328-331. doi: 10.1093/cid/cix284.


Strains Responsible for Invasive Meningococcal Disease in Patients With Terminal Complement Pathway Deficiencies.

Rosain J, Hong E, Fieschi C, Martins PV, El Sissy C, Deghmane AE, Ouachée M, Thomas C, Launay D, de Pontual L, Suarez F, Moshous D, Picard C, Taha MK, Frémeaux-Bacchi V.

J Infect Dis. 2017 Apr 15;215(8):1331-1338. doi: 10.1093/infdis/jix143.


Normal PAI-2 level in French FXII-HAE patients.

Marlu R, Deroux A, Du-Thanh A, Boccon-Gibod I, Launay D, Bouillet L.

J Allergy Clin Immunol. 2017 May;139(5):1719-1720. doi: 10.1016/j.jaci.2016.12.982. Epub 2017 Mar 16. No abstract available.


[Usefulness of nuclear medicine in Erdheim-Chester disease: A Lille experience].

Adens A, Landy P, Terriou L, Baillet C, Beron A, Lambert M, Launay D, Huglo D.

Rev Med Interne. 2017 Apr;38(4):235-242. doi: 10.1016/j.revmed.2016.10.386. Epub 2017 Mar 3. French.


Hereditary angioedema with normal C1 inhibitor: clinical characteristics and treatment response with plasma-derived human C1 inhibitor concentrate (Berinert®) in a French cohort.

Bouillet L, Boccon-Gibod I, Gompel A, Floccard B, Martin L, Blanchard-Delaunay C, Launay D, Fain O.

Eur J Dermatol. 2017 Apr 1;27(2):155-159. doi: 10.1684/ejd.2016.2948.


Hereditary angioedema with normal C1 inhibitor in a French cohort: Clinical characteristics and response to treatment with icatibant.

Bouillet L, Boccon-Gibod I, Launay D, Gompel A, Kanny G, Fabien V, Fain O; IOS Study Group.

Immun Inflamm Dis. 2017 Jan 11;5(1):29-36. doi: 10.1002/iid3.137. eCollection 2017 Mar.


Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature.

Sanges S, Rivière S, Mekinian A, Martin T, Le Quellec A, Chatelus E, Lescoat A, Jego P, Cazalets C, Quéméneur T, Le Gouellec N, Senet P, Francès C, Deroux A, Imbert B, Fain O, Boukari L, Sené T, Deligny C, Mathian A, Agard C, Pugnet G, Speca S, Dubucquoi S, Hatron PY, Hachulla É, Launay D.

Autoimmun Rev. 2017 Apr;16(4):377-384. doi: 10.1016/j.autrev.2017.02.008. Epub 2017 Feb 13. Review.


B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis.

Sanges S, Jendoubi M, Kavian N, Hauspie C, Speca S, Crave JC, Guerrier T, Lefèvre G, Sobanski V, Savina A, Hachulla E, Hatron PY, Labalette M, Batteux F, Dubucquoi S, Launay D.

Front Immunol. 2017 Feb 7;8:53. doi: 10.3389/fimmu.2017.00053. eCollection 2017.


Self-efficacy for deprescribing: A survey for health care professionals using evidence-based deprescribing guidelines.

Farrell B, Richardson L, Raman-Wilms L, de Launay D, Alsabbagh MW, Conklin J.

Res Social Adm Pharm. 2018 Jan;14(1):18-25. doi: 10.1016/j.sapharm.2017.01.003. Epub 2017 Jan 28.


Diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection.

Sanges S, Wallet F, Blondiaux N, Theis D, Vérin I, Vachée A, Dessein R, Faure K, Viget N, Senneville E, Leroy O, Maury F, Just N, Poissy J, Mathieu D, Prévotat A, Chenivesse C, Scherpereel A, Smith G, Lopez B, Rosain J, Frémeaux-Bacchi V, Hachulla E, Hatron PY, Bahuaud M, Batteux F, Launay D, Labalette M, Lefèvre G.

Clin Microbiol Infect. 2017 Aug;23(8):576.e1-576.e5. doi: 10.1016/j.cmi.2017.02.005. Epub 2017 Feb 10.


Diagnosis and treatment of upper airway oedema caused by acute angio-oedema in the emergency department: a French consensus statement.

Floccard B, Javaud N, Deroux A, Boccon-Gibod I, Fain O, Amarger S, Blanchard-Delaunay C, Jeandel PY, Marmion N, Ollivier Y, Pralong P, Gayet S, Du-Thanh A, Pelletier F, Sailler L, Robinson P, Launay D, Bouillet L; French Reference Centre for Angioedema (CREAK).

Eur J Emerg Med. 2017 Oct;24(5):318-325. doi: 10.1097/MEJ.0000000000000446.


Special considerations in pregnant systemic sclerosis patients.

Sobanski V, Launay D, Depret S, Ducloy-Bouthors AS, Hachulla E.

Expert Rev Clin Immunol. 2016 Nov;12(11):1161-1173. Epub 2016 Jun 8. Review.


Reemergence of Splenectomy for ITP Second-line Treatment?

Chater C, Terriou L, Duhamel A, Launay D, Chambon JP, Pruvot FR, Rogosnitzky M, Zerbib P.

Ann Surg. 2016 Nov;264(5):772-777.


Pulmonary arterial hypertension in idiopathic inflammatory myopathies: Data from the French pulmonary hypertension registry and review of the literature.

Sanges S, Yelnik CM, Sitbon O, Benveniste O, Mariampillai K, Phillips-Houlbracq M, Pison C, Deligny C, Inamo J, Cottin V, Mouthon L, Launay D, Lambert M, Hatron PY, Rottat L, Humbert M, Hachulla E.

Medicine (Baltimore). 2016 Sep;95(39):e4911. doi: 10.1097/MD.0000000000004911. Review.


A New Era in the Treatment of Scleroderma-associated Interstitial Lung Disease?

Launay D.

J Rheumatol. 2016 Sep;43(9):1619-21. doi: 10.3899/jrheum.160887. No abstract available.


N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis.

Allanore Y, Komocsi A, Vettori S, Hachulla E, Hunzelmann N, Distler J, Avouac J, Gobeaux C, Launay D, Czirjak L, Kahan A, Meune C.

Int J Cardiol. 2016 Nov 15;223:385-389. doi: 10.1016/j.ijcard.2016.08.246. Epub 2016 Aug 13.


A nationwide study of acquired C1-inhibitor deficiency in France: Characteristics and treatment responses in 92 patients.

Gobert D, Paule R, Ponard D, Levy P, Frémeaux-Bacchi V, Bouillet L, Boccon-Gibod I, Drouet C, Gayet S, Launay D, Martin L, Mekinian A, Leblond V, Fain O.

Medicine (Baltimore). 2016 Aug;95(33):e4363. doi: 10.1097/MD.0000000000004363.


Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases.

Ghrenassia E, Mekinian A, Chapelon-Albric C, Levy P, Cosnes J, Sève P, Lefèvre G, Dhôte R, Launay D, Prendki V, Morell-Dubois S, Sadoun D, Mehdaoui A, Soussan M, Bourrier A, Ricard L, Benamouzig R, Valeyre D, Fain O; Groupe Sarcoïdose Francophone.

Medicine (Baltimore). 2016 Jul;95(29):e4279. doi: 10.1097/MD.0000000000004279.

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