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Items: 1 to 50 of 197

1.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride.

Plöger GF, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Parr A, Polli JE, Shah VP, Tajiri T, Dressman JB.

J Pharm Sci. 2018 Mar 20. pii: S0022-3549(18)30149-7. doi: 10.1016/j.xphs.2018.03.009. [Epub ahead of print]

PMID:
29571740
2.

Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide.

Henze LJ, Griffin BT, Christiansen M, Bundgaard C, Langguth P, Holm R.

Eur J Pharm Sci. 2018 Jun 15;118:183-190. doi: 10.1016/j.ejps.2018.03.017. Epub 2018 Mar 17.

PMID:
29559403
3.

Bioequivalence decision for nanoparticular iron complex drugs for parenteral administration based on their disposition.

Schnorr J, Fütterer S, Spicher K, Catarinolo M, Schlösser C, Enzmann H, Langguth P.

Regul Toxicol Pharmacol. 2018 Apr;94:293-298. doi: 10.1016/j.yrtph.2018.02.009. Epub 2018 Feb 15.

PMID:
29454888
4.

A time-scaled convolution approach to construct IVIVC for enteric-coated acetylsalicylic acid tablets.

Al-Gousous J, Langguth P.

Pharmazie. 2018 Feb 1;73(2):67-69. doi: 10.1691/ph.2018.7136.

PMID:
29442006
5.

IVIVC approach based on carbamazepine bioequivalence studies combination.

González-García I, Mangas-Sanjuan V, Merino-Sanjuán M, Álvarez-Álvarez C, Díaz-Garzón Marco J, Rodríguez-Bonnín MA, Langguth T, Torrado-Durán JJ, Langguth P, García-Arieta A, Bermejo M.

Pharmazie. 2017 Aug 1;72(8):449-455. doi: 10.1691/ph.2017.7011.

PMID:
29441903
6.

Dissolution/permeation: The importance of the experimental setup for the prediction of formulation effects on fenofibrate in vivo performance.

Forner K, Hidalgo I, Lin J, Ackermann M, Langguth P.

Pharmazie. 2017 Oct 1;72(10):581-586. doi: 10.1691/ph.2017.7066.

PMID:
29441882
7.

Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration.

Ziller A, Nogueira SS, Hühn E, Funari SS, Brezesinski G, Hartmann H, Sahin U, Haas H, Langguth P.

Mol Pharm. 2018 Feb 5;15(2):642-651. doi: 10.1021/acs.molpharmaceut.7b01022. Epub 2018 Jan 18.

PMID:
29232147
8.

Extreme widening of asymmetric giant cystic Virchow-Robin spaces.

Austein F, Langguth P, Lindner T.

Neuroradiology. 2018 Jan;60(1):3-5. doi: 10.1007/s00234-017-1951-7. Epub 2017 Nov 22. No abstract available.

PMID:
29167921
9.

Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets.

Zaheer K, Langguth P.

Drug Dev Ind Pharm. 2018 Mar;44(3):444-451. doi: 10.1080/03639045.2017.1397685. Epub 2017 Nov 10.

PMID:
29098885
10.

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Folic Acid.

Hofsäss MA, Souza J, Silva-Barcellos NM, Bellavinha KR, Abrahamsson B, Cristofoletti R, Groot DW, Parr A, Langguth P, Polli JE, Shah VP, Tajiri T, Mehta MU, Dressman JB.

J Pharm Sci. 2017 Dec;106(12):3421-3430. doi: 10.1016/j.xphs.2017.08.007. Epub 2017 Aug 24.

PMID:
28842299
11.

Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer.

Radu IC, Hudita A, Zaharia C, Stanescu PO, Vasile E, Iovu H, Stan M, Ginghina O, Galateanu B, Costache M, Langguth P, Tsatsakis A, Velonia K, Negrei C.

Front Pharmacol. 2017 Aug 2;8:508. doi: 10.3389/fphar.2017.00508. eCollection 2017.

12.

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA.

Dahlgren D, Roos C, Lundqvist A, Tannergren C, Langguth P, Sjöblom M, Sjögren E, Lennernäs H.

Mol Pharm. 2017 Dec 4;14(12):4243-4251. doi: 10.1021/acs.molpharmaceut.7b00353. Epub 2017 Aug 8.

PMID:
28737406
13.

Combined immunotherapy: CTLA-4 blockade potentiates anti-tumor response induced by transcutaneous immunization.

Rausch J, Lopez PA, Bialojan A, Denny M, Langguth P, Probst HC, Schild H, Radsak MP.

J Dermatol Sci. 2017 Sep;87(3):300-306. doi: 10.1016/j.jdermsci.2017.06.013. Epub 2017 Jun 16.

PMID:
28666747
14.

Transcutaneous immunization with a novel imiquimod nanoemulsion induces superior T cell responses and virus protection.

Lopez PA, Denny M, Hartmann AK, Alflen A, Probst HC, von Stebut E, Tenzer S, Schild H, Stassen M, Langguth P, Radsak MP.

J Dermatol Sci. 2017 Sep;87(3):252-259. doi: 10.1016/j.jdermsci.2017.06.012. Epub 2017 Jun 16.

PMID:
28655469
15.

In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy.

Ciciliani AM, Langguth P, Wachtel H.

Int J Chron Obstruct Pulmon Dis. 2017 May 26;12:1565-1577. doi: 10.2147/COPD.S115886. eCollection 2017.

16.

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

Thambavita D, Galappatthy P, Mannapperuma U, Jayakody L, Cristofoletti R, Abrahamsson B, Groot DW, Langguth P, Mehta M, Parr A, Polli JE, Shah VP, Dressman J.

J Pharm Sci. 2017 Oct;106(10):2930-2945. doi: 10.1016/j.xphs.2017.04.068. Epub 2017 May 5. Review.

PMID:
28483422
17.

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril.

Verbeeck RK, Kanfer I, Löbenberg R, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Polli JE, Parr A, Shah VP, Mehta M, Dressman JB.

J Pharm Sci. 2017 Aug;106(8):1933-1943. doi: 10.1016/j.xphs.2017.04.019. Epub 2017 Apr 21. Review.

PMID:
28435140
18.

Impaired oral absorption of methylphenidate after Roux-en-Y gastric bypass.

Azran C, Langguth P, Dahan A.

Surg Obes Relat Dis. 2017 Jul;13(7):1245-1247. doi: 10.1016/j.soard.2017.03.003. Epub 2017 Mar 9. Review.

PMID:
28420586
19.

Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial.

Burak C, Wolffram S, Zur B, Langguth P, Fimmers R, Alteheld B, Stehle P, Egert S.

Br J Nutr. 2017 Mar;117(5):698-711. doi: 10.1017/S0007114517000241. Epub 2017 Apr 3.

PMID:
28366181
20.

A survey on IVIVC/IVIVR development in the pharmaceutical industry - Past experience and current perspectives.

Nguyen MA, Flanagan T, Brewster M, Kesisoglou F, Beato S, Biewenga J, Crison J, Holm R, Li R, Mannaert E, McAllister M, Mueller-Zsigmondy M, Muenster U, Ojala K, Page S, Parr A, Rossenu S, Timmins P, Van Peer A, Vermeulen A, Langguth P.

Eur J Pharm Sci. 2017 May 1;102:1-13. doi: 10.1016/j.ejps.2017.02.029. Epub 2017 Feb 21. Review.

PMID:
28235611
21.

Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems.

Al-Gousous J, Tsume Y, Fu M, Salem II, Langguth P.

Mol Pharm. 2017 Dec 4;14(12):4209-4219. doi: 10.1021/acs.molpharmaceut.6b00877. Epub 2017 Feb 28.

PMID:
28199791
22.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Laplanche L, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:610-625. doi: 10.1016/j.ejps.2016.10.036. Epub 2016 Nov 2.

PMID:
27816631
23.

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs.

Forner K, Roos C, Dahlgren D, Kesisoglou F, Konerding MA, Mazur J, Lennernäs H, Langguth P.

Drug Dev Ind Pharm. 2017 Feb;43(2):338-346. doi: 10.1080/03639045.2016.1251449. Epub 2016 Nov 6.

PMID:
27762631
24.

Past, present and future of immunology in Mainz.

Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H, Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S, Langguth P, Decker H, van Zandbergen G, Schild H.

Cell Immunol. 2016 Oct;308:1-6. doi: 10.1016/j.cellimm.2016.09.001. No abstract available.

PMID:
27719802
25.

Translating nanoparticulate-personalized cancer vaccines into clinical applications: case study with RNA-lipoplexes for the treatment of melanoma.

Grabbe S, Haas H, Diken M, Kranz LM, Langguth P, Sahin U.

Nanomedicine (Lond). 2016 Oct;11(20):2723-2734. Review.

PMID:
27700619
26.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes.

Darwich AS, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:626-642. doi: 10.1016/j.ejps.2016.09.037. Epub 2016 Sep 28.

PMID:
27693299
27.

No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded, placebo-controlled crossover trial.

Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Stehle P, Egert S.

Eur J Nutr. 2017 Oct;56(7):2265-2275. doi: 10.1007/s00394-016-1267-0. Epub 2016 Jul 16.

PMID:
27423432
28.

A Novel Disintegration Tester for Solid Dosage Forms Enabling Adjustable Hydrodynamics.

Kindgen S, Rach R, Nawroth T, Abrahamsson B, Langguth P.

J Pharm Sci. 2016 Aug;105(8):2402-9. doi: 10.1016/j.xphs.2016.05.028. Epub 2016 Jul 13.

PMID:
27422086
29.

Oral drug therapy following bariatric surgery: an overview of fundamentals, literature and clinical recommendations.

Azran C, Wolk O, Zur M, Fine-Shamir N, Shaked G, Czeiger D, Sebbag G, Kister O, Langguth P, Dahan A.

Obes Rev. 2016 Nov;17(11):1050-1066. doi: 10.1111/obr.12434. Epub 2016 Jun 22. Review.

PMID:
27335140
30.

Solid nanoemulsion as antigen and immunopotentiator carrier for transcutaneous immunization.

Gogoll K, Stein P, Lee KD, Arnold P, Peters T, Schild H, Radsak M, Langguth P.

Cell Immunol. 2016 Oct;308:35-43. doi: 10.1016/j.cellimm.2016.06.001. Epub 2016 Jun 2.

PMID:
27318760
31.

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.

Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Hüsemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Türeci Ö, Sahin U.

Nature. 2016 Jun 16;534(7607):396-401. doi: 10.1038/nature18300. Epub 2016 Jun 1.

PMID:
27281205
32.

Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions.

Knopp MM, Chourak N, Khan F, Wendelboe J, Langguth P, Rades T, Holm R.

Eur J Pharm Biopharm. 2016 Aug;105:106-14. doi: 10.1016/j.ejpb.2016.05.017. Epub 2016 May 19.

PMID:
27212472
33.

Toward Biopredictive Dissolution for Enteric Coated Dosage Forms.

Al-Gousous J, Amidon GL, Langguth P.

Mol Pharm. 2016 Jun 6;13(6):1927-36. doi: 10.1021/acs.molpharmaceut.6b00077. Epub 2016 May 10.

PMID:
27139040
34.

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature.

Knopp MM, Gannon N, Porsch I, Rask MB, Olesen NE, Langguth P, Holm R, Rades T.

J Pharm Sci. 2016 Sep;105(9):2621-2624. doi: 10.1016/j.xphs.2016.02.017. Epub 2016 Mar 22.

PMID:
27012222
35.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

Goodarzi N, Barazesh Morgani A, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Polli JE, Shah VP, Dressman JB.

J Pharm Sci. 2016 Apr;105(4):1362-9. doi: 10.1016/j.xphs.2016.01.017. Epub 2016 Mar 5.

PMID:
26952879
36.

Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial.

Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Stehle P, Egert S.

Eur J Nutr. 2017 Apr;56(3):1347-1357. doi: 10.1007/s00394-016-1185-1. Epub 2016 Feb 29.

PMID:
26924303
37.

Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions.

Knopp MM, Nguyen JH, Becker C, Francke NM, Jørgensen EB, Holm P, Holm R, Mu H, Rades T, Langguth P.

Eur J Pharm Biopharm. 2016 Apr;101:145-51. doi: 10.1016/j.ejpb.2016.02.007. Epub 2016 Feb 17.

PMID:
26899127
38.

Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions.

Knopp MM, Nguyen JH, Mu H, Langguth P, Rades T, Holm R.

AAPS J. 2016 Mar;18(2):416-23. doi: 10.1208/s12248-016-9865-6. Epub 2016 Jan 14.

39.

Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.

Al-Gousous J, Langguth P.

J Pharm Sci. 2016 Feb;105(2):509-511. doi: 10.1002/jps.24700. Epub 2016 Jan 11.

PMID:
26523769
40.

Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans.

Burak C, Brüll V, Langguth P, Zimmermann BF, Stoffel-Wagner B, Sausen U, Stehle P, Wolffram S, Egert S.

Eur J Nutr. 2017 Feb;56(1):343-353. doi: 10.1007/s00394-015-1084-x. Epub 2015 Oct 20.

PMID:
26482244
41.

Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial.

Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Naaf S, Zimmermann BF, Stehle P, Egert S.

Br J Nutr. 2015 Oct 28;114(8):1263-77. doi: 10.1017/S0007114515002950. Epub 2015 Sep 2.

42.

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Nifedipine.

Gajendran J, Krämer J, Shah VP, Langguth P, Polli J, Mehta M, Groot DW, Cristofoletti R, Abrahamsson B, Dressman JB.

J Pharm Sci. 2015 Oct;104(10):3289-98. doi: 10.1002/jps.24560. Epub 2015 Jul 6.

PMID:
26149619
43.

Differences in tissue distribution of iron from various clinically used intravenous iron complexes in fetal avian heart and liver.

Spicher K, Brendler-Schwaab S, Schlösser C, Catarinolo M, Fütterer S, Langguth P, Enzmann H.

Regul Toxicol Pharmacol. 2015 Oct;73(1):65-72. doi: 10.1016/j.yrtph.2015.06.005. Epub 2015 Jun 23.

PMID:
26111606
44.

Gordon L. Amidon: Very Sustained Drug Absorption.

Donovan MD, Polli JE, Langguth P, Tamai I, Vig B, Yu LX.

J Pharm Sci. 2015 Sep;104(9):2650-63. doi: 10.1002/jps.24523. Epub 2015 Jun 5. No abstract available.

PMID:
26053319
45.

Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristics.

Kindgen S, Wachtel H, Abrahamsson B, Langguth P.

J Pharm Sci. 2015 Sep;104(9):2956-68. doi: 10.1002/jps.24511. Epub 2015 May 27.

PMID:
26017815
46.

The Influence of Single-Dose and Short-Term Administration of Quercetin on the Pharmacokinetics of Midazolam in Humans.

Nguyen MA, Staubach P, Wolffram S, Langguth P.

J Pharm Sci. 2015 Sep;104(9):3199-207. doi: 10.1002/jps.24500. Epub 2015 May 18.

PMID:
25988261
47.

Fasted-state simulated intestinal fluid "FaSSIF-C", a cholesterol containing intestinal model medium for in vitro drug delivery development.

Khoshakhlagh P, Johnson R, Langguth P, Nawroth T, Schmueser L, Hellmann N, Decker H, Szekely NK.

J Pharm Sci. 2015 Jul;104(7):2213-24. doi: 10.1002/jps.24470. Epub 2015 May 11.

PMID:
25964103
48.

Cellular uptake and in vitro antitumor efficacy of composite liposomes for neutron capture therapy.

Peters T, Grunewald C, Blaickner M, Ziegner M, Schütz C, Iffland D, Hampel G, Nawroth T, Langguth P.

Radiat Oncol. 2015 Feb 22;10:52. doi: 10.1186/s13014-015-0342-7.

49.

Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer.

Knopp MM, Olesen NE, Holm P, Langguth P, Holm R, Rades T.

J Pharm Sci. 2015 Sep;104(9):2905-12. doi: 10.1002/jps.24410. Epub 2015 Mar 3.

PMID:
25740567
50.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.

Petruševska M, Berglez S, Krisch I, Legen I, Megušar K, Peternel L, Abrahamsson B, Cristofoletti R, Groot DW, Kopp S, Langguth P, Mehta M, Polli JE, Shah VP, Dressman J.

J Pharm Sci. 2015 Sep;104(9):2676-87. doi: 10.1002/jps.24350. Epub 2015 Feb 6. Review.

PMID:
25663270

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