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Items: 1 to 50 of 67

1.

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.

Garcia EG, Iyer S, Garcia SP, Loontiens S, Sadreyev RI, Speleman F, Langenau DM.

Leukemia. 2018 Apr 18. doi: 10.1038/s41375-018-0130-0. [Epub ahead of print] No abstract available.

PMID:
29749398
2.

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

Hayes MN, McCarthy K, Jin A, Oliveira ML, Iyer S, Garcia SP, Sindiri S, Gryder B, Motala Z, Nielsen GP, Borg JP, van de Rijn M, Malkin D, Khan J, Ignatius MS, Langenau DM.

Cell Stem Cell. 2018 Mar 1;22(3):414-427.e6. doi: 10.1016/j.stem.2018.02.002.

PMID:
29499154
3.

Identification and characterization of T reg-like cells in zebrafish.

Kasheta M, Painter CA, Moore FE, Lobbardi R, Bryll A, Freiman E, Stachura D, Rogers AB, Houvras Y, Langenau DM, Ceol CJ.

J Exp Med. 2017 Dec 4;214(12):3519-3530. doi: 10.1084/jem.20162084. Epub 2017 Oct 24.

PMID:
29066577
4.

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM.

Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3.

PMID:
28974511
5.

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma.

Bharathy N, Svalina MN, Settelmeyer TP, Cleary MM, Berlow NE, Airhart SD, Xiang S, Keck J, Hayden JB, Shern JF, Mansoor A, Lathara M, Srinivasa G, Langenau DM, Keller C.

Oncotarget. 2017 Jun 16;8(38):62976-62983. doi: 10.18632/oncotarget.18520. eCollection 2017 Sep 8.

6.

Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing.

Tang Q, Iyer S, Lobbardi R, Moore JC, Chen H, Lareau C, Hebert C, Shaw ML, Neftel C, Suva ML, Ceol CJ, Bernards A, Aryee M, Pinello L, Drummond IA, Langenau DM.

J Exp Med. 2017 Oct 2;214(10):2875-2887. doi: 10.1084/jem.20170976. Epub 2017 Sep 6.

7.

The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma.

Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM.

Cell Rep. 2017 Jun 13;19(11):2304-2318. doi: 10.1016/j.celrep.2017.05.061.

8.

Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors.

Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI.

Zebrafish. 2017 Aug;14(4):379-382. doi: 10.1089/zeb.2017.1434. Epub 2017 May 30.

PMID:
28557653
9.

Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.

Berberoglu MA, Gallagher TL, Morrow ZT, Talbot JC, Hromowyk KJ, Tenente IM, Langenau DM, Amacher SL.

Dev Biol. 2017 Apr 15;424(2):162-180. doi: 10.1016/j.ydbio.2017.03.004. Epub 2017 Mar 7.

10.

Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma.

Hayes MN, Langenau DM.

Methods Cell Biol. 2017;138:525-561. doi: 10.1016/bs.mcb.2016.11.011. Epub 2017 Jan 3. Review.

PMID:
28129857
11.

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma.

Tenente IM, Hayes MN, Ignatius MS, McCarthy K, Yohe M, Sindiri S, Gryder B, Oliveira ML, Ramakrishnan A, Tang Q, Chen EY, Petur Nielsen G, Khan J, Langenau DM.

Elife. 2017 Jan 12;6. pii: e19214. doi: 10.7554/eLife.19214.

12.

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish.

Moore JC, Tang Q, Yordán NT, Moore FE, Garcia EG, Lobbardi R, Ramakrishnan A, Marvin DL, Anselmo A, Sadreyev RI, Langenau DM.

J Exp Med. 2016 Nov 14;213(12):2575-2589. Epub 2016 Oct 24.

13.

T cell immune deficiency in zap70 mutant zebrafish.

Moore JC, Mulligan TS, Torres Yordán N, Castranova D, Pham VN, Tang Q, Lobbardi R, Anselmo A, Liwski RS, Berman JN, Sadreyev RI, Weinstein BM, Langenau DM.

Mol Cell Biol. 2016 Sep 6. pii: MCB.00281-16. [Epub ahead of print]

14.

Allograft Cancer Cell Transplantation in Zebrafish.

Moore JC, Langenau DM.

Adv Exp Med Biol. 2016;916:265-87. doi: 10.1007/978-3-319-30654-4_12. Review.

PMID:
27165358
15.

In Vivo Imaging of Cancer in Zebrafish.

Ignatius MS, Hayes M, Langenau DM.

Adv Exp Med Biol. 2016;916:219-37. doi: 10.1007/978-3-319-30654-4_10. Review.

PMID:
27165356
16.

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.

Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM.

J Exp Med. 2016 May 30;213(6):979-92. doi: 10.1084/jem.20152013. Epub 2016 May 2.

17.

Clusters of circulating tumor cells traverse capillary-sized vessels.

Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52. doi: 10.1073/pnas.1524448113. Epub 2016 Apr 18.

18.

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.

Tang Q, Moore JC, Ignatius MS, Tenente IM, Hayes MN, Garcia EG, Torres Yordán N, Bourque C, He S, Blackburn JS, Look AT, Houvras Y, Langenau DM.

Nat Commun. 2016 Jan 21;7:10358. doi: 10.1038/ncomms10358.

19.

Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.

Langenau DM, Sweet-Cordero A, Wechsler-Reya R, Dyer MA.

Cancer Res. 2015 Dec 15;75(24):5176-5186. doi: 10.1158/0008-5472.CAN-15-1308. Epub 2015 Dec 1. Review.

20.

Normal and malignant muscle cell transplantation into immune compromised adult zebrafish.

Tenente IM, Tang Q, Moore JC, Langenau DM.

J Vis Exp. 2014 Dec 26;(94). doi: 10.3791/52597.

21.

Rhabdomyosarcoma: current challenges and their implications for developing therapies.

Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C.

Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a025650. doi: 10.1101/cshperspect.a025650. Review.

22.

Optimized cell transplantation using adult rag2 mutant zebrafish.

Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM.

Nat Methods. 2014 Aug;11(8):821-4. doi: 10.1038/nmeth.3031. Epub 2014 Jul 20.

23.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.

Genes Dev. 2014 Jul 15;28(14):1578-91. doi: 10.1101/gad.238733.114.

24.

Zebrafish as a model to assess cancer heterogeneity, progression and relapse.

Blackburn JS, Langenau DM.

Dis Model Mech. 2014 Jul;7(7):755-62. doi: 10.1242/dmm.015842. Review.

25.

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.

Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54. doi: 10.1073/pnas.1317731111. Epub 2014 Mar 24.

26.

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.

Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT.

Br J Haematol. 2014 Jul;166(1):84-90. doi: 10.1111/bjh.12851. Epub 2014 Apr 2.

27.

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.

Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM.

Cancer Cell. 2014 Mar 17;25(3):366-78. doi: 10.1016/j.ccr.2014.01.032. Epub 2014 Mar 6.

28.

Pten regulates zebrafish hematopoiesis.

Langenau DM.

Blood. 2014 Jan 9;123(2):149-50. doi: 10.1182/blood-2013-11-536136.

29.

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.

Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Chen JY, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM.

PLoS Genet. 2013 Aug;9(8):e1003727. doi: 10.1371/journal.pgen.1003727. Epub 2013 Aug 29.

30.

Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.

Storer NY, White RM, Uong A, Price E, Nielsen GP, Langenau DM, Zon LI.

Development. 2013 Jul;140(14):3040-50. doi: 10.1242/dev.087858.

31.

The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.

Albacker CE, Storer NY, Langdon EM, Dibiase A, Zhou Y, Langenau DM, Zon LI.

PLoS One. 2013 May 21;8(5):e64969. doi: 10.1371/journal.pone.0064969. Print 2013.

32.

Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.

Sokolowski E, Turina CB, Kikuchi K, Langenau DM, Keller C.

Oncogene. 2014 Apr 10;33(15):1877-89. doi: 10.1038/onc.2013.129. Epub 2013 May 13. Review.

PMID:
23665679
33.

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, DiBiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI.

Development. 2013 Jun;140(11):2354-64. doi: 10.1242/dev.088427. Epub 2013 Apr 24.

34.

Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish.

Moore FE, Langenau DM.

Adv Hematol. 2012;2012:478164. doi: 10.1155/2012/478164. Epub 2012 Jul 8.

35.

Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM.

PLoS One. 2012;7(5):e37877. doi: 10.1371/journal.pone.0037877. Epub 2012 May 24.

36.

In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.

Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM.

Cancer Cell. 2012 May 15;21(5):680-93. doi: 10.1016/j.ccr.2012.03.043.

37.

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.

Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM.

Leukemia. 2012 Sep;26(9):2069-78. doi: 10.1038/leu.2012.116. Epub 2012 Apr 27.

38.

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.

Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20002-7. doi: 10.1073/pnas.1111733108. Epub 2011 Nov 30.

39.

Fluorescent imaging of cancer in zebrafish.

Ignatius MS, Langenau DM.

Methods Cell Biol. 2011;105:437-59. doi: 10.1016/B978-0-12-381320-6.00019-9.

40.

Zebrafish models of rhabdomyosarcoma.

Chen EY, Langenau DM.

Methods Cell Biol. 2011;105:383-402. doi: 10.1016/B978-0-12-381320-6.00016-3.

41.

Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish.

Blackburn JS, Liu S, Langenau DM.

J Vis Exp. 2011 Jul 14;(53):e2790. doi: 10.3791/2790.

42.

High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.

Blackburn JS, Liu S, Raimondi AR, Ignatius MS, Salthouse CD, Langenau DM.

Nat Protoc. 2011 Feb;6(2):229-41. doi: 10.1038/nprot.2010.170. Epub 2011 Feb 3.

43.

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK.

Nat Methods. 2011 Jan;8(1):67-9. doi: 10.1038/nmeth.1542. Epub 2010 Dec 12.

44.

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.

Cancer Cell. 2010 Oct 19;18(4):353-66. doi: 10.1016/j.ccr.2010.09.009.

45.

aMAZe-ing tools for mosaic analysis in zebrafish.

Blackburn JS, Langenau DM.

Nat Methods. 2010 Mar;7(3):188-90. doi: 10.1038/nmeth0310-188. No abstract available.

46.

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.

Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM.

Blood. 2010 Apr 22;115(16):3296-303. doi: 10.1182/blood-2009-10-246488. Epub 2010 Jan 7.

47.

Zebrafish as a model for cancer self-renewal.

Ignatius MS, Langenau DM.

Zebrafish. 2009 Dec;6(4):377-87. doi: 10.1089/zeb.2009.0610.

48.

Construction and application of a zebrafish array comparative genomic hybridization platform.

Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C.

Genes Chromosomes Cancer. 2009 Feb;48(2):155-70. doi: 10.1002/gcc.20623.

49.

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.

Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A.

Cell Death Differ. 2008 Jun;15(6):1063-72. doi: 10.1038/cdd.2008.42. Epub 2008 Apr 11.

50.

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.

Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI.

Oncogene. 2008 Jul 10;27(30):4242-8. doi: 10.1038/onc.2008.56. Epub 2008 Mar 17.

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