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Items: 20

1.

CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN.

Lafarga V, Tapia O, Sharma S, Bengoechea R, Stoecklin G, Lafarga M, Berciano MT.

Cell Mol Life Sci. 2018 Feb;75(3):527-546. doi: 10.1007/s00018-017-2638-2. Epub 2017 Sep 6.

PMID:
28879433
2.

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Nov 17;539(7629):456. doi: 10.1038/nature19826. Epub 2016 Sep 28. No abstract available.

PMID:
27680696
3.

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.

Nogués L, Reglero C, Rivas V, Salcedo A, Lafarga V, Neves M, Ramos P, Mendiola M, Berjón A, Stamatakis K, Zhou XZ, Lu KP, Hardisson D, Mayor F Jr, Penela P.

EBioMedicine. 2016 Nov;13:132-145. doi: 10.1016/j.ebiom.2016.09.030. Epub 2016 Oct 1.

4.

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, Hubbard C, Armstrong SA, Nussenzweig A, Fernandez-Capetillo O.

Sci Signal. 2016 Sep 13;9(445):ra91. doi: 10.1126/scisignal.aad8243.

5.

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O.

Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643.

6.

Replication fork stability confers chemoresistance in BRCA-deficient cells.

Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Jul 21;535(7612):382-7. doi: 10.1038/nature18325. Erratum in: Nature. 2016 Nov 17;539(7629):456.

7.

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.

Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, Fernandez-Capetillo O.

Mol Cell. 2016 Apr 21;62(2):307-313. doi: 10.1016/j.molcel.2016.03.006. Epub 2016 Apr 7.

8.

Dynamic Behavior of the RNA Polymerase II and the Ubiquitin Proteasome System During the Neuronal DNA Damage Response to Ionizing Radiation.

Casafont I, Palanca A, Lafarga V, Mata-Garrido J, Berciano MT, Lafarga M.

Mol Neurobiol. 2016 Dec;53(10):6799-6808. Epub 2015 Dec 11.

PMID:
26660115
9.

The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis.

Tapia O, Lafarga V, Bengoechea R, Palanca A, Lafarga M, Berciano MT.

J Cell Sci. 2014 Mar 1;127(Pt 5):939-46. doi: 10.1242/jcs.138537. Epub 2014 Jan 10.

10.

The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility.

Lafarga V, Mayor F Jr, Penela P.

Cell Adh Migr. 2012 Nov-Dec;6(6):495-501. doi: 10.4161/cam.21585. Epub 2012 Oct 17.

11.

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.

García-Zaragoza E, Pérez-Tavarez R, Ballester A, Lafarga V, Jiménez-Reinoso A, Ramírez A, Murillas R, Gallego MI.

Dev Biol. 2012 Dec 1;372(1):28-44. doi: 10.1016/j.ydbio.2012.09.005. Epub 2012 Sep 20.

12.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
13.

A novel GRK2/HDAC6 interaction modulates cell spreading and motility.

Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P.

EMBO J. 2012 Feb 15;31(4):856-69. doi: 10.1038/emboj.2011.466. Epub 2011 Dec 23.

14.

Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle.

Casafont I, Palanca A, Lafarga V, Berciano MT, Lafarga M.

Acta Neuropathol. 2011 Oct;122(4):481-93. doi: 10.1007/s00401-011-0869-0. Epub 2011 Sep 14.

PMID:
21915754
15.

Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair.

Baltanás FC, Casafont I, Lafarga V, Weruaga E, Alonso JR, Berciano MT, Lafarga M.

J Biol Chem. 2011 Aug 12;286(32):28287-302. doi: 10.1074/jbc.M111.246041. Epub 2011 Jun 23.

16.

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.

Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr.

Br J Pharmacol. 2010 Jun;160(4):821-32. doi: 10.1111/j.1476-5381.2010.00727.x. Review.

17.

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.

Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Muñoz-Canoves P, Nebreda AR.

EMBO J. 2010 Jun 16;29(12):2014-25. doi: 10.1038/emboj.2010.85. Epub 2010 May 14.

18.

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint.

Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez-Capetillo O, Nebreda AR.

Mol Cell Biol. 2009 Aug;29(16):4341-51. doi: 10.1128/MCB.00210-09. Epub 2009 Jun 15.

19.

p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.

Lafarga V, Cuadrado A, Nebreda AR.

Cell Cycle. 2007 Oct 1;6(19):2319-22. Epub 2007 Jul 12.

PMID:
17700068
20.

A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.

Cuadrado A, Lafarga V, Cheung PC, Dolado I, Llanos S, Cohen P, Nebreda AR.

EMBO J. 2007 Apr 18;26(8):2115-26. Epub 2007 Mar 22.

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