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Items: 1 to 50 of 127

1.

Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.

Tian W, Yougnia R, Depauw S, Lansiaux A, David-Cordonnier MH, Pfeiffer B, Kraus-Berthier L, Léonce S, Pierré A, Dufat H, Michel S.

J Med Chem. 2014 Dec 26;57(24):10329-42. doi: 10.1021/jm500927d. Epub 2014 Dec 9.

PMID:
25360689
2.

S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.

Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Léonce S, Ferry G, Da Violante G, Bouzom F, Cattan V, Jacquet-Bescond A, Comoglio PM, Lockhart BP, Boutin JA, Cordi A, Ortuno JC, Pierré A, Hickman JA, Cruzalegui FH, Depil S.

Mol Cancer Ther. 2013 Sep;12(9):1749-62. doi: 10.1158/1535-7163.MCT-13-0075. Epub 2013 Jun 26.

3.

Antiproliferative and iron chelating efficiency of the new bis-8-hydroxyquinoline benzylamine chelator S1 in hepatocyte cultures.

Lescoat G, Léonce S, Pierré A, Gouffier L, Gaboriau F.

Chem Biol Interact. 2012 Jan 25;195(2):165-72. doi: 10.1016/j.cbi.2011.12.003. Epub 2011 Dec 13.

PMID:
22197641
4.

Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.

Ferry G, Studeny A, Bossard C, Kubara PM, Zeyer D, Renaud JP, Casara P, de Nanteuil G, Wierzbicki M, Pfeiffer B, Prudhomme M, Leonce S, Pierré A, Boutin JA, Golsteyn RM.

Life Sci. 2011 Aug 15;89(7-8):259-68. doi: 10.1016/j.lfs.2011.06.010. Epub 2011 Jun 29.

PMID:
21736880
5.

Synthesis and cytotoxic activity of benzo[a]acronycine and benzo[b]acronycine substituted on the A ring.

Gaslonde T, Covello F, Velazquez-Alonso L, Léonce S, Pierré A, Pfeiffer B, Michel S, Tillequin F.

Eur J Med Chem. 2011 May;46(5):1861-73. doi: 10.1016/j.ejmech.2011.02.050. Epub 2011 Feb 26.

PMID:
21411193
6.

Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.

Sancier F, Dumont A, Sirvent A, Paquay de Plater L, Edmonds T, David G, Jan M, de Montrion C, Cogé F, Léonce S, Burbridge M, Bruno A, Boutin JA, Lockhart B, Roche S, Cruzalegui F.

PLoS One. 2011 Feb 24;6(2):e17237. doi: 10.1371/journal.pone.0017237.

7.

Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives.

Verones V, Flouquet N, Farce A, Carato P, Leonce S, Pfeiffer B, Berthelot P, Lebegue N.

Eur J Med Chem. 2010 Dec;45(12):5678-84. doi: 10.1016/j.ejmech.2010.09.022. Epub 2010 Sep 17.

PMID:
20884092
8.

Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.

Ayerbe N, Routier S, Gillaizeau I, Maiereanu C, Caignard DH, Pierré A, Léonce S, Coudert G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4670-4. doi: 10.1016/j.bmcl.2010.05.088. Epub 2010 May 26.

PMID:
20566289
9.

Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.

Boutefnouchet S, Minh NT, Putrus R, Pfeiffer B, Léonce S, Pierré A, Michel S, Tillequin F, Lallemand MC.

Eur J Med Chem. 2010 Feb;45(2):581-7. doi: 10.1016/j.ejmech.2009.10.045. Epub 2009 Nov 4.

PMID:
19926174
10.

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.

Cahuzac N, Studény A, Marshall K, Versteege I, Wetenhall K, Pfeiffer B, Léonce S, Hickman JA, Pierré A, Golsteyn RM.

Cancer Lett. 2010 Mar 28;289(2):178-87. doi: 10.1016/j.canlet.2009.08.014. Epub 2009 Sep 15.

PMID:
19758748
11.

Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities.

Depauw S, Gaslonde T, Léonce S, Kraus-Berthier L, Laine W, Lenglet G, Chiaroni A, Pfeiffer B, Bailly C, Michel S, Tillequin F, Pierré A, David-Cordonnier MH.

Mol Pharmacol. 2009 Dec;76(6):1172-85. doi: 10.1124/mol.109.057554. Epub 2009 Sep 14.

12.

Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.

Do Q, Tian W, Yougnia R, Gaslonde T, Pfeiffer B, Pierré A, Léonce S, Kraus-Berthier L, David-Cordonnier MH, Depauw S, Lansiaux A, Mazinghien R, Koch M, Tillequin F, Michel S, Dufat H.

Bioorg Med Chem. 2009 Mar 1;17(5):1918-27. doi: 10.1016/j.bmc.2009.01.062. Epub 2009 Jan 31.

PMID:
19217791
13.

Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.

Gallet S, Flouquet N, Carato P, Pfeiffer B, Renard P, Léonce S, Pierré A, Berthelot P, Lebegue N.

Bioorg Med Chem. 2009 Feb 1;17(3):1132-8. doi: 10.1016/j.bmc.2008.12.039. Epub 2008 Dec 25.

PMID:
19162484
14.

Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.

Boutefnouchet S, Gaboriaud-Kolar N, Nguyen TM, Depauw S, David-Cordonnier MH, Pfeiffer B, Léonce S, Pierré A, Tillequin F, Lallemand MC, Michel S.

J Med Chem. 2008 Nov 27;51(22):7287-97. doi: 10.1021/jm8009487. Erratum in: J Med Chem. 2008 Dec 25;51(24):8179.

PMID:
18947222
15.

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.

Anizon F, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Eur J Med Chem. 2009 May;44(5):2234-8. doi: 10.1016/j.ejmech.2008.05.023. Epub 2008 Jul 3.

PMID:
18602198
16.

Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.

Lefoix M, Coudert G, Routier S, Pfeiffer B, Caignard DH, Hickman J, Pierré A, Golsteyn RM, Léonce S, Bossard C, Mérour JY.

Bioorg Med Chem. 2008 May 1;16(9):5303-21. doi: 10.1016/j.bmc.2008.02.086. Epub 2008 Mar 4.

PMID:
18342518
17.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.

Do Q, Thi Mai HD, Gaslonde T, Pfeiffer B, Léonce S, Pierré A, Michel S, Tillequin F, Dufat H.

Eur J Med Chem. 2008 Dec;43(12):2677-87. doi: 10.1016/j.ejmech.2008.01.033. Epub 2008 Feb 3.

PMID:
18342404
18.

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

Conchon E, Anizon F, Aboab B, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2008 Apr 15;16(8):4419-30. doi: 10.1016/j.bmc.2008.02.061. Epub 2008 Mar 5.

PMID:
18321713
19.

Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest.

Jolly C, Thoison O, Martin MT, Dumontet V, Gilbert A, Pfeiffer B, Léonce S, Sévenet T, Guéritte F, Litaudon M.

Phytochemistry. 2008 Jan;69(2):533-40. Epub 2007 Sep 7.

PMID:
17825854
20.

Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference.

Chomarat P, Cogé F, Guénin SP, Mailliet F, Vella F, Mallet C, Giraudet S, Nagel N, Leonce S, Ferry G, Delagrange P, Boutin JA.

Biochimie. 2007 Oct;89(10):1264-75. Epub 2007 Jul 15.

PMID:
17714848
21.

Sesquiterpenoids and cytotoxic lignans from the bark of Libocedrus chevalieri.

Zhang YJ, Litaudon M, Bousserouel H, Martin MT, Thoison O, Léonce S, Dumontet V, Sévenet T, Guéritte F.

J Nat Prod. 2007 Aug;70(8):1368-70. Epub 2007 Aug 4.

PMID:
17676899
22.

Synthesis and biological activities of isogranulatimide analogues.

Hugon B, Anizon F, Bailly C, Golsteyn RM, Pierré A, Léonce S, Hickman J, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2007 Sep 1;15(17):5965-80. Epub 2007 Jun 7.

PMID:
17582773
23.
24.

Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.

Lansiaux A, Léonce S, Kraus-Berthier L, Bal-Mahieu C, Mazinghien R, Didier S, David-Cordonnier MH, Hautefaye P, Lavielle G, Bailly C, Hickman JA, Pierré A.

Mol Pharmacol. 2007 Aug;72(2):311-9. Epub 2007 May 9.

25.

Synthesis and cytotoxic activity of dimeric analogs of acronycine in the benzo[b]pyrano[3,2-h]acridin-7-one series.

Gaslonde T, Michel S, Koch M, Pfeiffer B, Léonce S, Pierré A, Tillequin F.

Chem Pharm Bull (Tokyo). 2007 May;55(5):734-8.

26.

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

Hénon H, Messaoudi S, Anizon F, Aboab B, Kucharczyk N, Léonce S, Golsteyn RM, Pfeiffer B, Prudhomme M.

Eur J Pharmacol. 2007 Jan 12;554(2-3):106-12. Epub 2006 Oct 19.

PMID:
17134696
27.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.

Conchon E, Aboab B, Golsteyn RM, Cruzalegui F, Edmonds T, Léonce S, Pfeiffer B, Prudhomme M.

Eur J Med Chem. 2006 Dec;41(12):1470-7. Epub 2006 Sep 22.

PMID:
16996169
28.

Synthesis and primary cytotoxicity evaluation of arylmethylenenaphthofuranones derivatives.

Lardic M, Patry C, Duflos M, Guillon J, Massip S, Cruzalegui F, Edmonds T, Giraudet S, Marini L, Leonce S.

J Enzyme Inhib Med Chem. 2006 Jun;21(3):313-25.

PMID:
16918079
29.

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

Messaoudi S, Anizon F, Peixoto P, David-Cordonnier MH, Golsteyn RM, Léonce S, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2006 Nov 15;14(22):7551-62. Epub 2006 Aug 4.

PMID:
16889964
30.

Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.

Léonce S, Kraus-Berthier L, Golsteyn RM, David-Cordonnier MH, Tardy C, Lansiaux A, Poindessous V, Larsen AK, Pierré A.

Cancer Res. 2006 Jul 15;66(14):7203-10.

31.

Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment.

Borgne A, Versteege I, Mahé M, Studeny A, Léonce S, Naime I, Rodriguez M, Hickman JA, Meijer L, Golsteyn RM.

Oncogene. 2006 Nov 30;25(56):7361-72. Epub 2006 Jun 19.

PMID:
16785996
32.

Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine.

Nguyen TM, Sittisombut C, Boutefnouchet S, Lallemand MC, Michel S, Koch M, Tillequin F, Mazinghien R, Lansiaux A, David-Cordonnier MH, Pfeiffer B, Kraus-Berthier L, Léonce S, Pierré A.

J Med Chem. 2006 Jun 1;49(11):3383-94.

PMID:
16722658
33.

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

Hénon H, Anizon F, Golsteyn RM, Léonce S, Hofmann R, Pfeiffer B, Prudhomme M.

Bioorg Med Chem. 2006 Jun 1;14(11):3825-34. Epub 2006 Feb 3.

PMID:
16460946
34.

Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.

Guillaumel J, Léonce S, Pierré A, Renard P, Pfeiffer B, Arimondo PB, Monneret C.

Eur J Med Chem. 2006 Mar;41(3):379-86. Epub 2006 Jan 25.

PMID:
16442188
35.

Novel benzopyridothiadiazepines as potential active antitumor agents.

Lebegue N, Gallet S, Flouquet N, Carato P, Pfeiffer B, Renard P, Léonce S, Pierré A, Chavatte P, Berthelot P.

J Med Chem. 2005 Nov 17;48(23):7363-73.

PMID:
16279796
36.

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.

Bouissane L, El Kazzouli S, Léonce S, Pfeiffer B, Rakib EM, Khouili M, Guillaumet G.

Bioorg Med Chem. 2006 Feb 15;14(4):1078-88. Epub 2005 Nov 7.

PMID:
16274996
37.

Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.

Doan Thi Mai H, Gaslonde T, Michel S, Koch M, Tillequin F, Bailly C, David-Cordonnier MH, Pfeiffer B, Léonce S, Pierré A.

Chem Pharm Bull (Tokyo). 2005 Aug;53(8):919-22.

38.

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.

Messaoudi S, Anizon F, Léonce S, Pierré A, Pfeiffer B, Prudhomme M.

Eur J Med Chem. 2005 Oct;40(10):961-71.

PMID:
15907347
39.

Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.

Laronze M, Boisbrun M, Léonce S, Pfeiffer B, Renard P, Lozach O, Meijer L, Lansiaux A, Bailly C, Sapi J, Laronze JY.

Bioorg Med Chem. 2005 Mar 15;13(6):2263-83.

PMID:
15830466
40.

Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.

Duca M, Arimondo PB, Léonce S, Pierré A, Pfeiffer B, Monneret C, Dauzonne D.

Org Biomol Chem. 2005 Mar 21;3(6):1074-80. Epub 2005 Feb 18.

PMID:
15750651
41.

Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.

Routier S, Peixoto P, Mérour JY, Coudert G, Dias N, Bailly C, Pierré A, Léonce S, Caignard DH.

J Med Chem. 2005 Mar 10;48(5):1401-13.

PMID:
15743184
42.

Synthesis and cytotoxic activity of thiazolofluorenone derivatives.

Chabane H, Pierre A, Leonce S, Pfeiffer B, Renard P, Thiery V, Guillaumet G, Besson T.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):567-75.

PMID:
15662960
43.

Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

Duca M, Guianvarc'h D, Meresse P, Bertounesque E, Dauzonne D, Kraus-Berthier L, Thirot S, Léonce S, Pierré A, Pfeiffer B, Renard P, Arimondo PB, Monneret C.

J Med Chem. 2005 Jan 27;48(2):593-603.

PMID:
15658872
44.

Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues.

Guillonneau C, Nault A, Raimbaud E, Léonce S, Kraus-Berthier L, Pierré A, Goldstein S.

Bioorg Med Chem. 2005 Jan 3;13(1):175-84.

PMID:
15582462
45.

Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.

Bal C, Baldeyrou B, Moz F, Lansiaux A, Colson P, Kraus-Berthier L, Léonce S, Pierré A, Boussard MF, Rousseau A, Wierzbicki M, Bailly C.

Biochem Pharmacol. 2004 Nov 15;68(10):1911-22.

PMID:
15476662
46.

Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

Prado S, Michel S, Tillequin F, Koch M, Pfeiffer B, Pierré A, Léonce S, Colson P, Baldeyrou B, Lansiaux A, Bailly C.

Bioorg Med Chem. 2004 Jul 15;12(14):3943-53.

PMID:
15210161
47.

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.

Guianvarc'h D, Duca M, Boukarim C, Kraus-Berthier L, Léonce S, Pierré A, Pfeiffer B, Renard P, Arimondo PB, Monneret C, Dauzonne D.

J Med Chem. 2004 Apr 22;47(9):2365-74.

PMID:
15084135
48.

Analogues of antifungal tjipanazoles from rebeccamycin.

Voldoire A, Moreau P, Sancelme M, Matulova M, Léonce S, Pierré A, Hickman J, Pfeiffer B, Renard P, Dias N, Bailly C, Prudhomme M.

Bioorg Med Chem. 2004 Apr 15;12(8):1955-62.

PMID:
15051063
49.

Design of novel antitumor DNA alkylating agents: the benzacronycine series.

David-Cordonnier MH, Laine W, Gaslonde T, Michel S, Tillequin F, Koch M, Léonce S, Pierré A, Bailly C.

Curr Med Chem Anticancer Agents. 2004 Mar;4(2):83-92. Review.

PMID:
15032716
50.

Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents.

Lisowski V, Léonce S, Kraus-Berthier L, Sopková-de Oliveira Santos J, Pierré A, Atassi G, Caignard DH, Renard P, Rault S.

J Med Chem. 2004 Mar 11;47(6):1448-64.

PMID:
14998333

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