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Items: 1 to 50 of 115

1.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
2.

T cells specific for post-translational modifications escape intrathymic tolerance induction.

Raposo B, Merky P, Lundqvist C, Yamada H, Urbonaviciute V, Niaudet C, Viljanen J, Kihlberg J, Kyewski B, Ekwall O, Holmdahl R, Bäcklund J.

Nat Commun. 2018 Jan 24;9(1):353. doi: 10.1038/s41467-017-02763-y.

3.

Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.

Wang L, Winnewisser J, Federle C, Jessberger G, Nave KA, Werner HB, Kyewski B, Klein L, Hinterberger M.

Front Immunol. 2017 Nov 9;8:1511. doi: 10.3389/fimmu.2017.01511. eCollection 2017.

4.

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.

Michel C, Miller CN, Küchler R, Brors B, Anderson MS, Kyewski B, Pinto S.

J Immunol. 2017 Nov 15;199(10):3488-3503. doi: 10.4049/jimmunol.1700203. Epub 2017 Oct 9.

PMID:
28993517
5.

Dissecting and modeling the emergent murine TEC compartment during ontogeny.

Brunk F, Michel C, Holland-Letz T, Slynko A, Kopp-Schneider A, Kyewski B, Pinto S.

Eur J Immunol. 2017 Jul;47(7):1153-1159. doi: 10.1002/eji.201747006. Epub 2017 May 22.

PMID:
28439878
6.

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, Brenner L, Smedley C, Travis MA, Hofmann TG, Klingmüller U, Kyewski B.

Cell Rep. 2016 Oct 4;17(2):448-457. doi: 10.1016/j.celrep.2016.09.027.

7.

Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self-antigen in mice.

Lucca LE, Axisa PP, Aloulou M, Perals C, Ramadan A, Rufas P, Kyewski B, Derbinski J, Fazilleau N, Mars LT, Liblau RS.

Eur J Immunol. 2016 Sep;46(9):2247-59. doi: 10.1002/eji.201646416. Epub 2016 Jul 21.

8.

Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032-1039.

Derbinski J, Schulte A, Kyewski B, Klein L.

J Immunol. 2016 Apr 1;196(7):2915-22. No abstract available.

9.

Re-examining the Nature and Function of Self-Reactive T cells.

Richards DM, Kyewski B, Feuerer M.

Trends Immunol. 2016 Feb;37(2):114-25. doi: 10.1016/j.it.2015.12.005. Epub 2016 Jan 12. Review.

PMID:
26795134
10.

Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells.

Rattay K, Derbinski J, Hofmann TG, Kyewski B.

Genom Data. 2015 Aug 7;6:48-50. doi: 10.1016/j.gdata.2015.08.004. eCollection 2015 Dec.

11.

Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.

Brunk F, Augustin I, Meister M, Boutros M, Kyewski B.

J Immunol. 2015 Dec 1;195(11):5261-71. doi: 10.4049/jimmunol.1501265. Epub 2015 Oct 28.

12.

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

Rattay K, Meyer HV, Herrmann C, Brors B, Kyewski B.

J Autoimmun. 2016 Feb;67:65-75. doi: 10.1016/j.jaut.2015.10.001. Epub 2015 Oct 23.

13.

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression.

Pinto S, Stark HJ, Martin I, Boukamp P, Kyewski B.

J Vis Exp. 2015 Jul 30;(101):e52614. doi: 10.3791/52614.

14.

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells.

Brennecke P, Reyes A, Pinto S, Rattay K, Nguyen M, Küchler R, Huber W, Kyewski B, Steinmetz LM.

Nat Immunol. 2015 Sep;16(9):933-41. doi: 10.1038/ni.3246. Epub 2015 Aug 3.

15.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L.

Immunity. 2015 Jun 16;42(6):1048-61. doi: 10.1016/j.immuni.2015.05.013. Epub 2015 Jun 9.

16.

Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes.

Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Østerbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R.

Diabetes. 2015 Oct;64(10):3532-42. doi: 10.2337/db15-0024. Epub 2015 Apr 27.

17.

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

Alvarez I, Collado JA, Colobran R, Carrascal M, Ciudad MT, Canals F, James EA, Kwok WW, Gärtner M, Kyewski B, Pujol-Borrell R, Jaraquemada D.

J Autoimmun. 2015 Jun;60:12-9. doi: 10.1016/j.jaut.2015.03.004. Epub 2015 Apr 21.

PMID:
25911201
18.

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

Rattay K, Claude J, Rezavandy E, Matt S, Hofmann TG, Kyewski B, Derbinski J.

J Immunol. 2015 Feb 1;194(3):921-8. doi: 10.4049/jimmunol.1402694. Epub 2014 Dec 31.

19.

Love is in the Aire: mTECs share their assets.

Kyewski B, Feuerer M.

Immunity. 2014 Sep 18;41(3):343-345. doi: 10.1016/j.immuni.2014.08.013.

20.

Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.

Ucar A, Ucar O, Klug P, Matt S, Brunk F, Hofmann TG, Kyewski B.

Immunity. 2014 Aug 21;41(2):257-69. doi: 10.1016/j.immuni.2014.07.005.

21.

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

Pinto S, Sommermeyer D, Michel C, Wilde S, Schendel D, Uckert W, Blankenstein T, Kyewski B.

Eur J Immunol. 2014 Sep;44(9):2811-21. doi: 10.1002/eji.201444499. Epub 2014 Aug 18.

22.

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

Klein L, Kyewski B, Allen PM, Hogquist KA.

Nat Rev Immunol. 2014 Jun;14(6):377-91. doi: 10.1038/nri3667. Epub 2014 May 16. Review.

23.

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.

Pinto S, Michel C, Schmidt-Glenewinkel H, Harder N, Rohr K, Wild S, Brors B, Kyewski B.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3497-505. doi: 10.1073/pnas.1308311110. Epub 2013 Aug 26.

24.

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression.

Ucar O, Tykocinski LO, Dooley J, Liston A, Kyewski B.

Eur J Immunol. 2013 Jul;43(7):1769-78. doi: 10.1002/eji.201343343. Epub 2013 May 17.

25.

An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression.

Pinto S, Schmidt K, Egle S, Stark HJ, Boukamp P, Kyewski B.

J Immunol. 2013 Feb 1;190(3):1085-93. doi: 10.4049/jimmunol.1201843. Epub 2012 Dec 26.

26.

The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway.

Kyewski B, Haskins K.

Curr Opin Immunol. 2012 Feb;24(1):67-70. doi: 10.1016/j.coi.2012.01.013. Epub 2012 Feb 2. No abstract available.

PMID:
22305303
27.

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A.

Nat Immunol. 2011 Dec 18;13(2):181-7. doi: 10.1038/ni.2193.

28.

DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues.

Kont V, Murumägi A, Tykocinski LO, Kinkel SA, Webster KE, Kisand K, Tserel L, Pihlap M, Ströbel P, Scott HS, Marx A, Kyewski B, Peterson P.

Mol Immunol. 2011 Dec;49(3):518-26. doi: 10.1016/j.molimm.2011.09.022. Epub 2011 Oct 27.

PMID:
22036612
29.

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.

Colobran R, Armengol Mdel P, Faner R, Gärtner M, Tykocinski LO, Lucas A, Ruiz M, Juan M, Kyewski B, Pujol-Borrell R.

Hum Mol Genet. 2011 Sep 1;20(17):3415-23. doi: 10.1093/hmg/ddr247. Epub 2011 Jun 3.

PMID:
21642385
30.

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.

Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA.

J Clin Invest. 2011 Apr;121(4):1561-73. doi: 10.1172/JCI44583. Epub 2011 Mar 23.

31.

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Van de Walle I, De Smet G, Gärtner M, De Smedt M, Waegemans E, Vandekerckhove B, Leclercq G, Plum J, Aster JC, Bernstein ID, Guidos CJ, Kyewski B, Taghon T.

Blood. 2011 Apr 28;117(17):4449-59. doi: 10.1182/blood-2010-06-290049. Epub 2011 Mar 3.

32.

Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.

Tykocinski LO, Sinemus A, Rezavandy E, Weiland Y, Baddeley D, Cremer C, Sonntag S, Willecke K, Derbinski J, Kyewski B.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19426-31. doi: 10.1073/pnas.1009265107. Epub 2010 Oct 21.

33.

How thymic antigen presenting cells sample the body's self-antigens.

Derbinski J, Kyewski B.

Curr Opin Immunol. 2010 Oct;22(5):592-600. doi: 10.1016/j.coi.2010.08.003. Epub 2010 Sep 9. Review.

PMID:
20832274
34.

Chronic inflammation is regarded as a strong promoter of tumorigenesis.

Kyewski B, Romero P.

Int J Cancer. 2010 Aug 15;127(4):747. doi: 10.1002/ijc.25487. No abstract available.

35.

Aire, master of many trades.

Kyewski B, Peterson P.

Cell. 2010 Jan 8;140(1):24-6. doi: 10.1016/j.cell.2009.12.036.

36.

Antigen presentation in the thymus for positive selection and central tolerance induction.

Klein L, Hinterberger M, Wirnsberger G, Kyewski B.

Nat Rev Immunol. 2009 Dec;9(12):833-44. doi: 10.1038/nri2669. Review.

PMID:
19935803
37.

Obligation for cell line authentication: appeal for concerted action.

Lichter P, Allgayer H, Bartsch H, Fusenig N, Hemminki K, von Knebel Doeberitz M, Kyewski B, Miller AB, zur Hausen H.

Int J Cancer. 2010 Jan 1;126(1):1. doi: 10.1002/ijc.24985. No abstract available.

38.

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.

Koble C, Kyewski B.

J Exp Med. 2009 Jul 6;206(7):1505-13. doi: 10.1084/jem.20082449. Epub 2009 Jun 29.

39.

The thymus medulla slowly yields its secrets.

Tykocinski LO, Sinemus A, Kyewski B.

Ann N Y Acad Sci. 2008 Nov;1143:105-22. doi: 10.1196/annals.1443.018. Review.

PMID:
19076347
40.

Immunology. A breath of Aire for the periphery.

Kyewski B.

Science. 2008 Aug 8;321(5890):776-7. doi: 10.1126/science.1162966. No abstract available.

PMID:
18687943
41.

How promiscuity promotes tolerance: the case of myasthenia gravis.

Kyewski B, Taubert R.

Ann N Y Acad Sci. 2008;1132:157-62. doi: 10.1196/annals.1405.026.

PMID:
18567865
42.

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.

Derbinski J, Pinto S, Rösch S, Hexel K, Kyewski B.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):657-62. doi: 10.1073/pnas.0707486105. Epub 2008 Jan 7.

43.

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

Gäbler J, Arnold J, Kyewski B.

Eur J Immunol. 2007 Dec;37(12):3363-72.

44.

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.

Giraud M, Taubert R, Vandiedonck C, Ke X, Lévi-Strauss M, Pagani F, Baralle FE, Eymard B, Tranchant C, Gajdos P, Vincent A, Willcox N, Beeson D, Kyewski B, Garchon HJ.

Nature. 2007 Aug 23;448(7156):934-7. Epub 2007 Aug 8.

PMID:
17687331
45.
46.
47.

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.

Klamp T, Sahin U, Kyewski B, Schwendemann J, Dhaene K, Türeci O.

Immunol Lett. 2006 Aug 15;106(2):172-9. Epub 2006 Jul 28.

PMID:
16876259
48.

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.

Cabarrocas J, Cassan C, Magnusson F, Piaggio E, Mars L, Derbinski J, Kyewski B, Gross DA, Salomon BL, Khazaie K, Saoudi A, Liblau RS.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8453-8. Epub 2006 May 18.

49.

A central role for central tolerance.

Kyewski B, Klein L.

Annu Rev Immunol. 2006;24:571-606. Review.

PMID:
16551260
50.

Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer.

zur Hausen H, Bartsch H, Fusenig N, Doeberitz Mv, Kyewski B, Lichter P, Miller A.

Int J Cancer. 2006 Jun 15;118(12):2919. No abstract available.

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