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Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.

Veatch JR, Lee SM, Fitzgibbon M, Chow IT, Jesernig B, Schmitt T, Kong YY, Kargl J, Houghton AM, Thompson JA, McIntosh M, Kwok WW, Riddell SR.

J Clin Invest. 2018 Mar 12. pii: 98689. doi: 10.1172/JCI98689. [Epub ahead of print]


Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans.

Muehling LM, Turner RB, Brown KB, Wright PW, Patrie JT, Lahtinen SJ, Lehtinen MJ, Kwok WW, Woodfolk JA.

J Infect Dis. 2018 Jan 17;217(3):381-392. doi: 10.1093/infdis/jix514.


C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18.


Synchronous immune alterations mirror clinical response during allergen immunotherapy.

Renand A, Shamji MH, Harris KM, Qin T, Wambre E, Scadding GW, Wurtzen PA, Till SJ, Togias A, Nepom GT, Kwok WW, Durham SR.

J Allergy Clin Immunol. 2017 Nov 9. pii: S0091-6749(17)31735-9. doi: 10.1016/j.jaci.2017.09.041. [Epub ahead of print]


Lanthanide-Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry.

Wu X, DeGottardi Q, Wu IC, Yu J, Wu L, Ye F, Kuo CT, Kwok WW, Chiu DT.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14908-14912. doi: 10.1002/anie.201708463. Epub 2017 Oct 12.


A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9171. doi: 10.1126/scitranslmed.aam9171.


Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS.

J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31.


Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

Yang J, Wen X, Xu H, Torres-Chinn N, Speake C, Greenbaum CJ, Nepom GT, Kwok WW.

J Immunol. 2017 Jul 1;199(1):91-96. doi: 10.4049/jimmunol.1601570. Epub 2017 May 26.


αS1-Casein elucidate major T-cell responses in cow's milk allergy.

Archila LD, Khan FS, Bhatnagar N, Robinson D, Farrington ML, Kwok WW.

J Allergy Clin Immunol. 2017 Sep;140(3):854-857.e6. doi: 10.1016/j.jaci.2017.02.028. Epub 2017 Mar 23. No abstract available.


Tetramer-Guided Epitope Mapping: A Rapid Approach to Identify HLA-Restricted T-Cell Epitopes from Composite Allergens.

Archila LL, Kwok WW.

Methods Mol Biol. 2017;1592:199-209. doi: 10.1007/978-1-4939-6925-8_16.


Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M.

Diabetes. 2017 Mar;66(3):722-734. doi: 10.2337/db16-1025. Epub 2016 Dec 5.


Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.

Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD.

Sci Transl Med. 2016 Oct 5;8(359):359ra132.


Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

Muehling LM, Mai DT, Kwok WW, Heymann PW, Pomés A, Woodfolk JA.

J Immunol. 2016 Oct 15;197(8):3214-3224. Epub 2016 Sep 2.


Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining.

Uchtenhagen H, Rims C, Blahnik G, Chow IT, Kwok WW, Buckner JH, James EA.

Nat Commun. 2016 Aug 30;7:12614. doi: 10.1038/ncomms12614.


A Comparative Analysis of the Peptide Repertoires of HLA-DR Molecules Differentially Associated With Rheumatoid Arthritis.

Scholz E, Mestre-Ferrer A, Daura X, García-Medel N, Carrascal M, James EA, Kwok WW, Canals F, Álvarez I.

Arthritis Rheumatol. 2016 Oct;68(10):2412-21. doi: 10.1002/art.39736.


Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4(+) T cell epitopes with other tree nuts.

Archila LD, Chow IT, McGinty JW, Renand A, Jeong D, Robinson D, Farrington ML, Kwok WW.

Clin Exp Allergy. 2016 Jun;46(6):871-83. doi: 10.1111/cea.12746.



Renand A, Robinson D, Kwok WW.

J Allergy Clin Immunol. 2016 May;137(5):1622-3. doi: 10.1016/j.jaci.2015.11.046. Epub 2016 Mar 11. No abstract available.


Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.

James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW.

PLoS Pathog. 2016 Jan 21;12(1):e1005375. doi: 10.1371/journal.ppat.1005375. eCollection 2016 Jan.


Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity.

Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A.

Clin Exp Allergy. 2016 May;46(5):705-19. doi: 10.1111/cea.12692.


Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

Renand A, Archila LD, McGinty J, Wambre E, Robinson D, Hales BJ, Thomas WR, Kwok WW.

J Allergy Clin Immunol. 2015 Dec;136(6):1627-1635.e13. doi: 10.1016/j.jaci.2015.07.031. Epub 2015 Sep 11.


Modulation of Peanut-specific humoral and cellular responses pre- and post-oral immunotherapy.

Kwok WW.

Clin Exp Allergy. 2015 Jul;45(7):1146-9. doi: 10.1111/cea.12552. No abstract available.


Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA.

Sci Transl Med. 2015 May 13;7(287):287ra74. doi: 10.1126/scitranslmed.aaa8038.


Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

Alvarez I, Collado JA, Colobran R, Carrascal M, Ciudad MT, Canals F, James EA, Kwok WW, Gärtner M, Kyewski B, Pujol-Borrell R, Jaraquemada D.

J Autoimmun. 2015 Jun;60:12-9. doi: 10.1016/j.jaut.2015.03.004. Epub 2015 Apr 21.


Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.

Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Murali-Krishna K, Koelle DM.

Tuberculosis (Edinb). 2015 May;95(3):275-87. doi: 10.1016/ Epub 2015 Mar 27.


Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.

Archila LD, Jeong D, Pascal M, Bartra J, Juan M, Robinson D, Farrington ML, Kwok WW.

J Allergy Clin Immunol. 2015 Oct;136(4):983-92.e7. doi: 10.1016/j.jaci.2015.01.029. Epub 2015 Mar 13.


Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.

Chow IT, Yang J, Gates TJ, James EA, Mai DT, Greenbaum C, Kwok WW.

PLoS One. 2014 Nov 18;9(11):e112882. doi: 10.1371/journal.pone.0112882. eCollection 2014.


Circulating Type-1 Anti-Tumor CD4(+) T Cells are Preferentially Pro-Apoptotic in Cancer Patients.

Wesa AK, Mandic M, Taylor JL, Moschos S, Kirkwood JM, Kwok WW, Finke JH, Storkus WJ.

Front Oncol. 2014 Sep 29;4:266. doi: 10.3389/fonc.2014.00266. eCollection 2014.


Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.


Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells.

Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW.

J Allergy Clin Immunol. 2014 Dec;134(6):1456-1459.e7. doi: 10.1016/j.jaci.2014.07.048. Epub 2014 Sep 12. No abstract available.


Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine.

Zaleska A, Eiwegger T, Soyer O, van de Veen W, Rhyner C, Soyka MB, Bekpen C, Demiröz D, Treis A, Söllner S, Palomares O, Kwok WW, Rose H, Senti G, Kündig TM, Ozoren N, Jutel M, Akdis CA, Crameri R, Akdis M.

Allergy. 2014 Sep;69(9):1162-70. doi: 10.1111/all.12461. Epub 2014 Jul 12. Erratum in: Allergy. 2016 Jan;71(1):129.


Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.

Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW.

Clin Exp Allergy. 2014 Jul;44(7):986-98. doi: 10.1111/cea.12324.


Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.

McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA.

Diabetes. 2014 Sep;63(9):3033-40. doi: 10.2337/db13-1952. Epub 2014 Apr 4.


Ruminative and catastrophizing cognitive styles mediate the association between daily hassles and high anxiety in Hong Kong adolescents.

Chan SM, Chan SK, Kwok WW.

Child Psychiatry Hum Dev. 2015 Feb;46(1):57-66. doi: 10.1007/s10578-014-0451-9.


Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection.

Johnston C, Zhu J, Jing L, Laing KJ, McClurkan CM, Klock A, Diem K, Jin L, Stanaway J, Tronstein E, Kwok WW, Huang ML, Selke S, Fong Y, Magaret A, Koelle DM, Wald A, Corey L.

J Virol. 2014 May;88(9):4921-31. doi: 10.1128/JVI.03285-13. Epub 2014 Feb 19.


Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner.

Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW.

J Allergy Clin Immunol. 2014 Mar;133(3):872-9.e7. doi: 10.1016/j.jaci.2013.10.054. Epub 2013 Dec 25.


Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation.

Till SJ, Raynsford EJ, Reynolds CJ, Quigley KJ, Grzybowska-Kowalczyk A, Saggar LR, Goldstone A, Maillere B, Kwok WW, Altmann DM, Durham SR, Boyton RJ.

Thorax. 2014 Apr;69(4):335-45. doi: 10.1136/thoraxjnl-2013-204324. Epub 2013 Nov 20.


Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins.

James EA, LaFond RE, Gates TJ, Mai DT, Malhotra U, Kwok WW.

J Virol. 2013 Dec;87(23):12794-804. doi: 10.1128/JVI.01160-13. Epub 2013 Sep 18.


Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1.

Kailaanmäki A, Kinnunen T, Kwok WW, Rytkönen-Nissinen M, Randell J, Virtanen T.

Immunology. 2014 Jan;141(1):52-60. doi: 10.1111/imm.12166.


Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.

Chow IT, James EA, Gates TJ, Tan V, Moustakas AK, Papadopoulos GK, Kwok WW.

J Immunol. 2013 May 1;190(9):4516-24. doi: 10.4049/jimmunol.1202445. Epub 2013 Mar 29.


CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination.

Yang J, James E, Gates TJ, DeLong JH, LaFond RE, Malhotra U, Kwok WW.

Int Immunol. 2013 Aug;25(8):447-57. doi: 10.1093/intimm/dxt005. Epub 2013 Mar 22.


Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.

Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A.

PLoS Pathog. 2013 Jan;9(1):e1003130. doi: 10.1371/journal.ppat.1003130. Epub 2013 Jan 24.


CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.

Yang J, James EA, Sanda S, Greenbaum C, Kwok WW.

Immunology. 2013 Mar;138(3):269-79. doi: 10.1111/imm.12034.


Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy.

Bonvalet M, Moussu H, Wambre E, Ricarte C, Horiot S, Rimaniol AC, Kwok WW, Horak F, de Beaumont O, Baron-Bodo V, Moingeon P.

Clin Exp Allergy. 2012 Dec;42(12):1745-55. doi: 10.1111/cea.12015.


Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.

Aarntzen EH, De Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, Schreibelt G, Mus R, De Wilt JH, Haanen JB, Schadendorf D, Croockewit A, Blokx WA, Van Rossum MM, Kwok WW, Adema GJ, Punt CJ, Figdor CG.

Cancer Res. 2013 Jan 1;73(1):19-29. doi: 10.1158/0008-5472.CAN-12-1127. Epub 2012 Oct 18.


Characterization of CD4+ T cell subsets in allergy.

Wambre E, James EA, Kwok WW.

Curr Opin Immunol. 2012 Dec;24(6):700-6. doi: 10.1016/j.coi.2012.07.009. Epub 2012 Aug 10. Review.


An evaluation of a web-based diabetes education program designed to enhance self-management among patients living with diabetes.

Chau JP, Chung LC, Wong RY, Loo KM, Lo SH, So TT, Lau MS, Yeung TH, Leung BS, Tong ML, Li CY, Kwok WW, Thompson DR, Lee DT.

Comput Inform Nurs. 2012 Dec;30(12):672-9. doi: 10.1097/NXN.0b013e318261f1d2.


HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term.

Vingert B, Benati D, Lambotte O, de Truchis P, Slama L, Jeannin P, Galperin M, Perez-Patrigeon S, Boufassa F, Kwok WW, Lemaître F, Delfraissy JF, Thèze J, Chakrabarti LA.

J Virol. 2012 Oct;86(19):10661-74. doi: 10.1128/JVI.00056-12. Epub 2012 Jul 25.


Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ).

Arlehamn CS, Sidney J, Henderson R, Greenbaum JA, James EA, Moutaftsi M, Coler R, McKinney DM, Park D, Taplitz R, Kwok WW, Grey H, Peters B, Sette A.

J Immunol. 2012 May 15;188(10):5020-31. doi: 10.4049/jimmunol.1103556. Epub 2012 Apr 13.


Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

Kwok WW, Tan V, Gillette L, Littell CT, Soltis MA, LaFond RB, Yang J, James EA, DeLong JH.

J Immunol. 2012 Mar 15;188(6):2537-44. doi: 10.4049/jimmunol.1102190. Epub 2012 Feb 10.


Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence.

Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM.

J Exp Med. 2012 Jan 16;209(1):61-75. doi: 10.1084/jem.20100388. Epub 2012 Jan 2.

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