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Items: 31


The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery.

Kwan JC.

mSystems. 2018 Mar 13;3(2). pii: e00186-17. doi: 10.1128/mSystems.00186-17. eCollection 2018 Mar-Apr.


Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont.

Lopera J, Miller IJ, McPhail KL, Kwan JC.

mSystems. 2017 Nov 21;2(6). pii: e00096-17. doi: 10.1128/mSystems.00096-17. eCollection 2017 Nov-Dec.


Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.

Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01418-17. doi: 10.1128/AEM.01418-17. Print 2017 Dec 1.


Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.

Miller IJ, Chevrette MG, Kwan JC.

Mar Drugs. 2017 Jun 6;15(6). pii: E165. doi: 10.3390/md15060165. Review.


Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont "Candidatus Endobugula sertula".

Miller IJ, Vanee N, Fong SS, Lim-Fong GE, Kwan JC.

Appl Environ Microbiol. 2016 Oct 27;82(22):6573-6583. Print 2016 Nov 15.


Single sample resolution of rare microbial dark matter in a marine invertebrate metagenome.

Miller IJ, Weyna TR, Fong SS, Lim-Fong GE, Kwan JC.

Sci Rep. 2016 Sep 29;6:34362. doi: 10.1038/srep34362.


PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113. Epub 2016 Apr 4.


Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis.

Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW.

Appl Environ Microbiol. 2016 May 31;82(12):3450-60. doi: 10.1128/AEM.00860-16. Print 2016 Jun 15.


Cardio-protective signalling by glyceryl trinitrate and cariporide in a model of donor heart preservation.

Kwan JC, Gao L, Macdonald PS, Hicks M.

Heart Lung Circ. 2015 Mar;24(3):306-18. doi: 10.1016/j.hlc.2014.10.001. Epub 2014 Oct 14.


Species specificity of symbiosis and secondary metabolism in ascidians.

Tianero MD, Kwan JC, Wyche TP, Presson AP, Koch M, Barrows LR, Bugni TS, Schmidt EW.

ISME J. 2015 Mar;9(3):615-28. doi: 10.1038/ismej.2014.152. Epub 2014 Aug 29.


Evaluation of class I HDAC isoform selectivity of largazole analogues.

Kim B, Park H, Salvador LA, Serrano PE, Kwan JC, Zeller SL, Chen QY, Ryu S, Liu Y, Byeon S, Luesch H, Hong J.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3728-31. doi: 10.1016/j.bmcl.2014.07.006. Epub 2014 Jul 9.


Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella.

Kwan JC, Tianero MD, Donia MS, Wyche TP, Bugni TS, Schmidt EW.

PLoS One. 2014 May 2;9(5):e95850. doi: 10.1371/journal.pone.0095850. eCollection 2014.


Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation.

Kwan JC, Liu Y, Ratnayake R, Hatano R, Kuribara A, Morimoto C, Ohnuma K, Paul VJ, Ye T, Luesch H.

Chembiochem. 2014 Apr 14;15(6):799-804. doi: 10.1002/cbic.201300762. Epub 2014 Mar 3.


Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism.

Kwan JC, Schmidt EW.

PLoS One. 2013 Dec 4;8(12):e80822. doi: 10.1371/journal.pone.0080822. eCollection 2013.


A bacterial source for mollusk pyrone polyketides.

Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM, Schmidt EW.

Chem Biol. 2013 Jan 24;20(1):73-81. doi: 10.1016/j.chembiol.2012.10.019.


Genome streamlining and chemical defense in a coral reef symbiosis.

Kwan JC, Donia MS, Han AW, Hirose E, Haygood MG, Schmidt EW.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20655-60. doi: 10.1073/pnas.1213820109. Epub 2012 Nov 26.


Structure and biosynthesis of the antibiotic bottromycin D.

Hou Y, Tianero MD, Kwan JC, Wyche TP, Michel CR, Ellis GA, Vazquez-Rivera E, Braun DR, Rose WE, Schmidt EW, Bugni TS.

Org Lett. 2012 Oct 5;14(19):5050-3. doi: 10.1021/ol3022758. Epub 2012 Sep 17.


Cleaning up polyketide synthases.

Kwan JC, Schmidt EW.

Chem Biol. 2012 Mar 23;19(3):309-11. doi: 10.1016/j.chembiol.2012.03.003.


Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa.

Kwan JC, Meickle T, Ladwa D, Teplitski M, Paul V, Luesch H.

Mol Biosyst. 2011 Apr;7(4):1205-16. doi: 10.1039/c0mb00180e. Epub 2011 Jan 24.


Biological effects of Byrsocarpus coccineus in vitro.

Akindele AJ, Eksioglu EA, Kwan JC, Adeyemi OO, Liu C, Luesch H, James MO.

Pharm Biol. 2011 Feb;49(2):152-60. doi: 10.3109/13880209.2010.504967. Epub 2010 Nov 26.


Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides.

Kwan JC, Ratnayake R, Abboud KA, Paul VJ, Luesch H.

J Org Chem. 2010 Dec 3;75(23):8012-23. doi: 10.1021/jo1013564. Epub 2010 Nov 4.


Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

Kwan JC, Luesch H.

Chemistry. 2010 Nov 22;16(44):13020-9. doi: 10.1002/chem.201001562.


Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

Liu Y, Salvador LA, Byeon S, Ying Y, Kwan JC, Law BK, Hong J, Luesch H.

J Pharmacol Exp Ther. 2010 Nov;335(2):351-61. doi: 10.1124/jpet.110.172387. Epub 2010 Aug 25.


Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula.

Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H.

J Nat Prod. 2010 Mar 26;73(3):463-6. doi: 10.1021/np900614n.


Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.

Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ.

J Nat Prod. 2010 Mar 26;73(3):459-62. doi: 10.1021/np900603f.


Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.

Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H.

J Med Chem. 2009 Sep 24;52(18):5732-47. doi: 10.1021/jm9009394.


Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin.

Kwan JC, Rocca JR, Abboud KA, Paul VJ, Luesch H.

Org Lett. 2008 Mar 6;10(5):789-92. doi: 10.1021/ol702946d. Epub 2008 Jan 26.


Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of phosphatidylinositol 3-kinase Akt pathway.

Gao L, Kwan JC, Macdonald PS, Yang L, Preiss T, Hicks M.

Transplantation. 2007 Aug 15;84(3):380-6.


AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells.

Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, Dhakshinamoorthy S, Porter A.

EMBO J. 2005 Aug 3;24(15):2815-26. Epub 2005 Jul 7.

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