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Items: 8


Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.

Kurimchak AM, Shelton C, Duncan KE, Johnson KJ, Brown J, O'Brien S, Gabbasov R, Fink LS, Li Y, Lounsbury N, Abou-Gharbia M, Childers WE, Connolly DC, Chernoff J, Peterson JR, Duncan JS.

Cell Rep. 2016 Aug 2;16(5):1273-1286. doi: 10.1016/j.celrep.2016.06.091. Epub 2016 Jul 21.


PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Kurimchak A, Graña X.

Cell Cycle. 2015;14(1):18-30. doi: 10.4161/15384101.2014.985069. Review.


Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X.

Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17.


PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates.

Kurimchak A, Graña X.

Gene. 2012 May 10;499(1):1-7. doi: 10.1016/j.gene.2012.02.015. Epub 2012 Feb 22. Review.


B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X.

J Biol Chem. 2010 Sep 24;285(39):29863-73. doi: 10.1074/jbc.M110.162354. Epub 2010 Jul 27.


Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

Sotillo E, Garriga J, Padgaonkar A, Kurimchak A, Cook JG, Graña X.

J Biol Chem. 2009 May 22;284(21):14126-35. doi: 10.1074/jbc.M900687200. Epub 2009 Mar 25.


Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.

Sotillo E, Garriga J, Kurimchak A, Graña X.

J Biol Chem. 2008 Apr 25;283(17):11280-92. doi: 10.1074/jbc.M709055200. Epub 2008 Feb 14.

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