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Items: 1 to 50 of 300

1.

Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction.

Inanobe A, Itamochi H, Kurachi Y.

Mol Pharmacol. 2018 Apr 12. pii: mol.117.111377. doi: 10.1124/mol.117.111377. [Epub ahead of print]

2.

Rebuttal from Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi and Hiroaki Miki.

Funato Y, Furutani K, Kurachi Y, Miki H.

J Physiol. 2018 Mar 1;596(5):751. doi: 10.1113/JP275706. Epub 2018 Jan 31. No abstract available.

PMID:
29383723
3.

CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption.

Funato Y, Furutani K, Kurachi Y, Miki H.

J Physiol. 2018 Mar 1;596(5):743-746. doi: 10.1113/JP275248. Epub 2018 Jan 31. No abstract available.

PMID:
29383719
4.

Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes.

Kinboshi M, Mukai T, Nagao Y, Matsuba Y, Tsuji Y, Tanaka S, Tokudome K, Shimizu S, Ito H, Ikeda A, Inanobe A, Kurachi Y, Inoue S, Ohno Y.

Front Mol Neurosci. 2017 Dec 7;10:408. doi: 10.3389/fnmol.2017.00408. eCollection 2017.

5.
6.

Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

Nin F, Yoshida T, Murakami S, Ogata G, Uetsuka S, Choi S, Doi K, Sawamura S, Inohara H, Komune S, Kurachi Y, Hibino H.

NPJ Syst Biol Appl. 2017 Aug 25;3:24. doi: 10.1038/s41540-017-0025-0. eCollection 2017.

7.

Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.

Numata T, Tsumoto K, Yamada K, Kurokawa T, Hirose S, Nomura H, Kawano M, Kurachi Y, Inoue R, Mori Y.

Sci Rep. 2017 Aug 29;7(1):9760. doi: 10.1038/s41598-017-10357-3.

8.
9.

HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research.

Furutani K, Tsumoto K, Kurachi Y; for HD physiology project investigators.

NPJ Syst Biol Appl. 2017 Jan 16;3:1. doi: 10.1038/s41540-016-0001-0. eCollection 2017.

10.

The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study.

Nitta H, Katagiri S, Nagasawa T, Izumi Y, Ishikawa I, Izumiyama H, Uchimura I, Kanazawa M, Chiba H, Matsuo A, Utsunomiya K, Tanabe H, Takei I, Asanami S, Kajio H, Ono T, Hayashi Y, Ueki K, Tsuji M, Kurachi Y, Yamanouchi T, Ichinokawa Y, Inokuchi T, Fukui A, Miyazaki S, Miyauchi T, Kawahara R, Ogiuchi H, Yoshioka N, Negishi J, Mori M, Mogi K, Saito Y, Tanzawa H, Nishikawa T, Takada N, Nanjo K, Morita N, Nakamura N, Kanamura N, Makino H, Nishimura F, Kobayashi K, Higuchi Y, Sakata T, Yanagisawa S, Tei C, Ando Y, Hanada N, Inoue S.

J Diabetes Investig. 2017 Sep;8(5):677-686. doi: 10.1111/jdi.12633. Epub 2017 May 8.

11.

The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.

Nin F, Yoshida T, Sawamura S, Ogata G, Ota T, Higuchi T, Murakami S, Doi K, Kurachi Y, Hibino H.

Pflugers Arch. 2016 Oct;468(10):1637-49. doi: 10.1007/s00424-016-1871-0. Epub 2016 Aug 27. Review.

12.

The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus.

Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y.

eNeuro. 2016 Jul 20;3(3). pii: ENEURO.0138-16.2016. doi: 10.1523/ENEURO.0138-16.2016. eCollection 2016 May-Jun.

13.

The unique ion permeability profile of cochlear fibrocytes and its contribution to establishing their positive resting membrane potential.

Yoshida T, Nin F, Murakami S, Ogata G, Uetsuka S, Choi S, Nakagawa T, Inohara H, Komune S, Kurachi Y, Hibino H.

Pflugers Arch. 2016 Sep;468(9):1609-19. doi: 10.1007/s00424-016-1853-2. Epub 2016 Jun 25.

PMID:
27344659
14.

Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system.

Kawada H, Inanobe A, Kurachi Y.

Neuropharmacology. 2016 Oct;109:18-28. doi: 10.1016/j.neuropharm.2016.05.016. Epub 2016 May 26.

PMID:
27236080
15.

Theoretical and experimental analysis of ototoxic mechanism in the spiral ligament fibrocytes by multi-level simulation with ion transports in the cochlea.

Nin F, Yoshida T, Murakami S, Uetsuka S, Ogata G, Kurachi Y, Hibino H.

Nihon Yakurigaku Zasshi. 2016 Feb;147(2):80-3. doi: 10.1254/fpj.147.80. Japanese. No abstract available.

PMID:
26860646
16.

Mechanisms of astrocytic K(+) clearance and swelling under high extracellular K(+) concentrations.

Murakami S, Kurachi Y.

J Physiol Sci. 2016 Mar;66(2):127-42. doi: 10.1007/s12576-015-0404-5. Epub 2015 Oct 27.

PMID:
26507417
17.

Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology.

Amemiya T, Honma M, Kariya Y, Ghosh S, Kitano H, Kurachi Y, Fujita KI, Sasaki Y, Homma Y, Abernethy DR, Kume H, Suzuki H.

NPJ Syst Biol Appl. 2015 Sep 28;1:15005. doi: 10.1038/npjsba.2015.5. eCollection 2015.

18.

An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels.

Inanobe A, Tsuzuki C, Kurachi Y.

Cell Physiol Biochem. 2015;36(5):1847-61.

19.

Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain.

Fujita A, Inanobe A, Hibino H, Nielsen S, Ottersen OP, Kurachi Y.

Cell Tissue Res. 2015 Feb;359(2):627-634. doi: 10.1007/s00441-014-2030-6. Epub 2014 Nov 8.

PMID:
25380566
20.

Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs: a simulation study.

Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y.

PLoS One. 2014 Oct 3;9(10):e109271. doi: 10.1371/journal.pone.0109271. eCollection 2014.

21.

NKCCs in the fibrocytes of the spiral ligament are silent on the unidirectional K⁺ transport that controls the electrochemical properties in the mammalian cochlea.

Yoshida T, Nin F, Ogata G, Uetsuka S, Kitahara T, Inohara H, Akazawa K, Komune S, Kurachi Y, Hibino H.

Pflugers Arch. 2015 Jul;467(7):1577-1589. doi: 10.1007/s00424-014-1597-9. Epub 2014 Aug 22.

PMID:
25143138
22.

RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.

Chen IS, Furutani K, Inanobe A, Kurachi Y.

J Physiol. 2014 Mar 15;592(6):1237-48. doi: 10.1113/jphysiol.2013.269803. Epub 2014 Jan 13.

23.

Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.

Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, Kurachi Y, Omori Y, Furukawa T, Tsuda T, Kuwabata S, Mizukami S, Kikuchi K, Miki H.

PLoS Genet. 2013;9(12):e1003983. doi: 10.1371/journal.pgen.1003983. Epub 2013 Dec 5.

24.

Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels.

Inanobe A, Nakagawa A, Kurachi Y.

PLoS One. 2013 Nov 11;8(11):e79844. doi: 10.1371/journal.pone.0079844. eCollection 2013.

25.

A versatile platform for multilevel modeling of physiological systems: template/instance framework for large-scale modeling and simulation.

Asai Y, Abe T, Oka H, Okita M, Okuyama T, Hagihara K, Ghosh S, Matsuoka Y, Kurachi Y, Kitano H.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5529-32. doi: 10.1109/EMBC.2013.6610802.

PMID:
24110989
26.

Short-term desensitization of muscarinic K+ current in the heart.

Murakami S, Inanobe A, Kurachi Y.

Biophys J. 2013 Sep 17;105(6):1515-25. doi: 10.1016/j.bpj.2013.08.009.

27.

Membrane channels as integrators of G-protein-mediated signaling.

Inanobe A, Kurachi Y.

Biochim Biophys Acta. 2014 Feb;1838(2):521-31. doi: 10.1016/j.bbamem.2013.08.018. Epub 2013 Sep 9. Review.

28.

[Mechanism of electrical potential dynamics of lymph fluid in inner ear].

Hibino H, Nin F, Murakami S, Doi K, Suzuki T, Hisa Y, Kurachi Y.

Nihon Jibiinkoka Gakkai Kaiho. 2013 Feb;116(2):60-8. Review. Japanese. No abstract available.

PMID:
24015419
29.

The mechanism underlying maintenance of the endocochlear potential by the K+ transport system in fibrocytes of the inner ear.

Adachi N, Yoshida T, Nin F, Ogata G, Yamaguchi S, Suzuki T, Komune S, Hisa Y, Hibino H, Kurachi Y.

J Physiol. 2013 Sep 15;591(18):4459-72. doi: 10.1113/jphysiol.2013.258046. Epub 2013 Jul 8.

30.

Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER).

Harada Y, Nagao Y, Shimizu S, Serikawa T, Terada R, Fujimoto M, Okuda A, Mukai T, Sasa M, Kurachi Y, Ohno Y.

Brain Res. 2013 Jun 23;1517:141-9. doi: 10.1016/j.brainres.2013.04.009. Epub 2013 Apr 17.

PMID:
23603404
31.

[Computational model reproduces electrochemical properties of the mammalian cochlea].

Nin F, Hibino H, Kurachi Y.

Nihon Yakurigaku Zasshi. 2013 Apr;141(4):224. Review. Japanese. No abstract available.

PMID:
23575430
32.

Computational model of a circulation current that controls electrochemical properties in the mammalian cochlea.

Nin F, Hibino H, Murakami S, Suzuki T, Hisa Y, Kurachi Y.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9191-6. doi: 10.1073/pnas.1120067109. Epub 2012 May 22.

33.

Physiology without borders 2.

Noble D, Kurachi Y, Hunter P, Wang X, Gordon M, Boron W.

Physiology (Bethesda). 2012 Feb;27(1):2. doi: 10.1152/physiol.00045.2011. No abstract available.

34.

Pharmacophore modeling for hERG channel facilitation.

Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y.

Biochem Biophys Res Commun. 2012 Feb 3;418(1):161-6. doi: 10.1016/j.bbrc.2011.12.153. Epub 2012 Jan 8.

PMID:
22244872
35.

A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents.

Furutani K, Yamakawa Y, Inanobe A, Iwata M, Ohno Y, Kurachi Y.

Biochem Biophys Res Commun. 2011 Nov 11;415(1):141-6. doi: 10.1016/j.bbrc.2011.10.034. Epub 2011 Oct 12.

PMID:
22020101
36.

Interactions of cations with the cytoplasmic pores of inward rectifier K(+) channels in the closed state.

Inanobe A, Nakagawa A, Kurachi Y.

J Biol Chem. 2011 Dec 2;286(48):41801-11. doi: 10.1074/jbc.M111.278531. Epub 2011 Oct 9.

37.

Inverse agonist-like action of cadmium on G-protein-gated inward-rectifier K(+) channels.

Inanobe A, Matsuura T, Nakagawa A, Kurachi Y.

Biochem Biophys Res Commun. 2011 Apr 8;407(2):366-71. doi: 10.1016/j.bbrc.2011.03.025. Epub 2011 Mar 17.

PMID:
21396912
38.

Roles of subcellular Na+ channel distributions in the mechanism of cardiac conduction.

Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y.

Biophys J. 2011 Feb 2;100(3):554-63. doi: 10.1016/j.bpj.2010.12.3716.

39.

Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study).

Yamashita T, Inoue H, Okumura K, Kodama I, Aizawa Y, Atarashi H, Ohe T, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Koretsune Y, Saikawa T, Sakurai M, Sato T, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E, Ogawa S; J-RHYTHM II Investigators.

Europace. 2011 Apr;13(4):473-9. doi: 10.1093/europace/euq439. Epub 2010 Dec 10.

PMID:
21148662
40.

Transmural dispersion of repolarization determines scroll wave behavior during ventricular tachyarrhythmias.

Haraguchi R, Ashihara T, Namba T, Tsumoto K, Murakami S, Kurachi Y, Ikeda T, Nakazawa K.

Circ J. 2011;75(1):80-8. Epub 2010 Nov 16.

41.

A structural determinant for the control of PIP2 sensitivity in G protein-gated inward rectifier K+ channels.

Inanobe A, Nakagawa A, Matsuura T, Kurachi Y.

J Biol Chem. 2010 Dec 3;285(49):38517-23. doi: 10.1074/jbc.M110.161703. Epub 2010 Sep 29.

42.

Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation.

Mitsuma T, Tani K, Hiroaki Y, Kamegawa A, Suzuki H, Hibino H, Kurachi Y, Fujiyoshi Y.

J Mol Biol. 2010 Oct 1;402(4):669-81. doi: 10.1016/j.jmb.2010.07.060. Epub 2010 Aug 13.

PMID:
20709083
43.

ANG II inhibits insulin-mediated production of PI 3,4,5-trisphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes.

Ikushima M, Ishii M, Ohishi M, Yamamoto K, Ogihara T, Rakugi H, Kurachi Y.

Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H680-9. doi: 10.1152/ajpheart.00220.2009. Epub 2010 Jul 2.

44.

Cellular modelling: experiments and simulation to develop a physiological model of G-protein control of muscarinic K+ channels in mammalian atrial cells.

Murakami S, Suzuki S, Ishii M, Inanobe A, Kurachi Y.

Philos Trans A Math Phys Eng Sci. 2010 Jun 28;368(1921):2983-3000. doi: 10.1098/rsta.2010.0093.

45.

On calcium-buffer dynamics within the excess buffer regime.

Ait-Haddou R, Kurachi Y, Nomura T.

J Theor Biol. 2010 May 7;264(1):55-65. doi: 10.1016/j.jtbi.2010.01.017. Epub 2010 Jan 20.

PMID:
20093125
46.

Inwardly rectifying potassium channels: their structure, function, and physiological roles.

Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y.

Physiol Rev. 2010 Jan;90(1):291-366. doi: 10.1152/physrev.00021.2009. Review.

47.

How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus.

Hibino H, Nin F, Tsuzuki C, Kurachi Y.

Pflugers Arch. 2010 Mar;459(4):521-33. doi: 10.1007/s00424-009-0754-z. Epub 2009 Dec 11. Review.

PMID:
20012478
48.

A platform for in silico modeling of physiological systems III.

Suzuki Y, Asai Y, Oka H, Heien E, Urai T, Okamoto T, Yumikura Y, Tominaga K, Kido Y, Nakanishi M, Hagihara K, Kurachi Y, Nomura T.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2803-6. doi: 10.1109/IEMBS.2009.5333775.

PMID:
19964264
49.

Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel.

Furutani K, Ohno Y, Inanobe A, Hibino H, Kurachi Y.

Mol Pharmacol. 2009 Jun;75(6):1287-95. doi: 10.1124/mol.108.052936. Epub 2009 Mar 5. Erratum in: Mol Pharmacol. 2009 Aug;76(2):451.

50.

A platform for in silico modeling of physiological systems II. CellML compatibility and other extended capabilities.

Suzuki Y, Asai Y, Kawazu T, Nakanishi M, Taniguchi Y, Heien E, Hagihara K, Kurachi Y, Nomura T.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:573-6. doi: 10.1109/IEMBS.2008.4649217.

PMID:
19162720

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