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Role of novel histone modifications in cancer.

Shanmugam MK, Arfuso F, Arumugam S, Chinnathambi A, Jinsong B, Warrier S, Wang LZ, Kumar AP, Ahn KS, Sethi G, Lakshmanan M.

Oncotarget. 2017 Dec 17;9(13):11414-11426. doi: 10.18632/oncotarget.23356. eCollection 2018 Feb 16. Review.


Corrigendum to "Tocotrienls: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics" [Drug Discov. Today 22 (December (12)) (2017) 1765-1781].

Kanchi MM, Shanmugam MK, Rane G, Sethi G, Kumar AP.

Drug Discov Today. 2018 Mar 7. pii: S1359-6446(18)30089-8. doi: 10.1016/j.drudis.2018.02.010. [Epub ahead of print] No abstract available.


Molecular cloning, characterization and expression profiling of galectin-9 gene from Labeo rohita (Hamilton, 1822).

Mushtaq Z, Krishnan R, Prasad KP, Bedekar MK, Kumar AP.

Fish Shellfish Immunol. 2018 Mar 13;76:287-292. doi: 10.1016/j.fsi.2018.02.037. [Epub ahead of print]


Molecular targets and anti-cancer potential of escin.

Cheong DHJ, Arfuso F, Sethi G, Wang L, Hui KM, Kumar AP, Tran T.

Cancer Lett. 2018 Feb 21;422:1-8. doi: 10.1016/j.canlet.2018.02.027. [Epub ahead of print]


Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.

Chakravarthy D, Muñoz AR, Su A, Hwang RF, Keppler BR, Chan DE, Halff G, Ghosh R, Kumar AP.

Cancer Lett. 2018 Apr 10;419:103-115. doi: 10.1016/j.canlet.2018.01.057.


Pancreatic cancer: Current status and Challenges.

Muñoz AR, Chakravarthy D, Gong J, Halff GA, Ghosh R, Kumar AP.

Curr Pharmacol Rep. 2017 Dec;3(6):396-408. doi: 10.1007/s40495-017-0112-3. Epub 2017 Oct 11.


Corrigendum on "Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer" [Cancer Lett. 363 (1) (2015) 28-36].

Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G.

Cancer Lett. 2018 Apr 28;420:259. doi: 10.1016/j.canlet.2018.01.003. Epub 2018 Jan 17. No abstract available.


Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment.

Moraes LA, Kar S, Foo SL, Gu T, Toh YQ, Ampomah PB, Sachaphibulkij K, Yap G, Zharkova O, Lukman HM, Fairhurst AM, Kumar AP, Lim LHK.

Sci Rep. 2017 Dec 20;7(1):17925. doi: 10.1038/s41598-017-17622-5.


Dual role of autophagy in hallmarks of cancer.

Singh SS, Vats S, Chia AY, Tan TZ, Deng S, Ong MS, Arfuso F, Yap CT, Goh BC, Sethi G, Huang RY, Shen HM, Manjithaya R, Kumar AP.

Oncogene. 2018 Mar;37(9):1142-1158. doi: 10.1038/s41388-017-0046-6. Epub 2017 Dec 19. Review.


Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.

Banik K, Harsha C, Bordoloi D, Lalduhsaki Sailo B, Sethi G, Leong HC, Arfuso F, Mishra S, Wang L, Kumar AP, Kunnumakkara AB.

Cancer Lett. 2018 Mar 1;416:75-86. doi: 10.1016/j.canlet.2017.12.014. Epub 2017 Dec 13.


Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites.

Kumar AP, Nguyen MN, Verma C, Lukman S.

Proteins. 2018 Mar;86(3):301-321. doi: 10.1002/prot.25440. Epub 2018 Jan 3.


Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response.

Horning AM, Wang Y, Lin CK, Louie AD, Jadhav RR, Hung CN, Wang CM, Lin CL, Kirma NB, Liss MA, Kumar AP, Sun L, Liu Z, Chao WT, Wang Q, Jin VX, Chen CL, Huang TH.

Cancer Res. 2018 Feb 15;78(4):853-864. doi: 10.1158/0008-5472.CAN-17-1924. Epub 2017 Dec 12.


The Role of Resveratrol in Cancer Therapy.

Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Bishayee A, Ahn KS.

Int J Mol Sci. 2017 Dec 1;18(12). pii: E2589. doi: 10.3390/ijms18122589. Review.


Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G.

Pharmacol Res. 2018 Mar;129:357-364. doi: 10.1016/j.phrs.2017.11.023. Epub 2017 Nov 21. Review.


Triple negative breast cancer in Asia: An insider's view.

Wang C, Kar S, Lai X, Cai W, Arfuso F, Sethi G, Lobie PE, Goh BC, Lim LHK, Hartman M, Chan CW, Lee SC, Tan SH, Kumar AP.

Cancer Treat Rev. 2018 Jan;62:29-38. doi: 10.1016/j.ctrv.2017.10.014. Epub 2017 Nov 10. Review.


SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma.

Sethi G, Shanmugam MK, Kumar AP.

Biosci Rep. 2017 Dec 15;37(6). pii: BSR20171270. doi: 10.1042/BSR20171270. Print 2017 Dec 22. Review.


Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells.

Thirunavukkarasan M, Wang C, Rao A, Hind T, Teo YR, Siddiquee AA, Goghari MAI, Kumar AP, Herr DR.

PLoS One. 2017 Oct 19;12(10):e0186334. doi: 10.1371/journal.pone.0186334. eCollection 2017.


Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma.

Abbhi V, Saini L, Mishra S, Sethi G, Kumar AP, Piplani P.

Bioorg Med Chem. 2017 Nov 1;25(21):6071-6085. doi: 10.1016/j.bmc.2017.09.045. Epub 2017 Oct 4.


PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.

Chen L, Yuan Y, Kar S, Kanchi MM, Arora S, Kim JE, Koh PF, Yousef E, Samy RP, Shanmugam MK, Tan TZ, Shin SW, Arfuso F, Shen HM, Yang H, Goh BC, Park JI, Gaboury L, Lobie PE, Sethi G, Lim LHK, Kumar AP.

Mol Cancer Ther. 2017 Nov;16(11):2528-2542. doi: 10.1158/1535-7163.MCT-16-0739. Epub 2017 Aug 15.


Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators.

Bhuvanalakshmi G, Arfuso F, Kumar AP, Dharmarajan A, Warrier S.

Stem Cell Res Ther. 2017 Aug 14;8(1):185. doi: 10.1186/s13287-017-0638-7.


Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics.

Kanchi MM, Shanmugam MK, Rane G, Sethi G, Kumar AP.

Drug Discov Today. 2017 Dec;22(12):1765-1781. doi: 10.1016/j.drudis.2017.08.001. Epub 2017 Aug 5. Review. Erratum in: Drug Discov Today. 2018 Mar 7;:.


'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.

Ong MS, Cai W, Yuan Y, Leong HC, Tan TZ, Mohammad A, You ML, Arfuso F, Goh BC, Warrier S, Sethi G, Tolwinski NS, Lobie PE, Yap CT, Hooi SC, Huang RY, Kumar AP.

Br J Pharmacol. 2017 Dec;174(24):4684-4700. doi: 10.1111/bph.13958. Epub 2017 Aug 23. Review.


Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

Shanmugam MK, Warrier S, Kumar AP, Sethi G, Arfuso F.

Curr Vasc Pharmacol. 2017;15(6):503-519. doi: 10.2174/1570161115666170713094319.


Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial.

Mahendran R, Rawtaer I, Fam J, Wong J, Kumar AP, Gandhi M, Jing KX, Feng L, Kua EH.

Trials. 2017 Jul 12;18(1):324. doi: 10.1186/s13063-017-2080-7.


ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.

Jahn A, Rane G, Paszkowski-Rogacz M, Sayols S, Bluhm A, Han CT, Draškovič I, Londoño-Vallejo JA, Kumar AP, Buchholz F, Butter F, Kappei D.

EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.


Combination of Nexrutine and docetaxel suppresses NFκB-mediated activation of c-FLIP.

Zhang Y, Li L, Wang J, Cheng W, Zhang J, Li X, Zhang Z, Gong J, Ghosh R, Kumar AP, Xie J.

Mol Carcinog. 2017 Oct;56(10):2200-2209. doi: 10.1002/mc.22673. Epub 2017 Jun 15.


Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.

Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G.

Adv Protein Chem Struct Biol. 2017;108:199-225. doi: 10.1016/bs.apcsb.2017.01.001. Epub 2017 Feb 15. Review.


Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4.

Bhuvanalakshmi G, Basappa, Rangappa KS, Dharmarajan A, Sethi G, Kumar AP, Warrier S.

Front Pharmacol. 2017 Mar 20;8:124. doi: 10.3389/fphar.2017.00124. eCollection 2017.


Wnt signaling in triple-negative breast cancer.

Pohl SG, Brook N, Agostino M, Arfuso F, Kumar AP, Dharmarajan A.

Oncogenesis. 2017 Apr 3;6(4):e310. doi: 10.1038/oncsis.2017.14. Review.


Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer.

Kumavath R, Azad M, Devarapalli P, Tiwari S, Kar S, Barh D, Azevedo V, Kumar AP.

Bioinformation. 2016 Oct 10;12(6):324-331. doi: 10.6026/97320630012324. eCollection 2016.


Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.

Cai W, Chen ZX, Rane G, Singh SS, Choo Z, Wang C, Yuan Y, Tan TZ, Arfuso F, Yap CT, Pongor LS, Yang H, Lee MB, Goh BC, Sethi G, Benoukraf T, Tergaonkar V, Kumar AP.

J Natl Cancer Inst. 2017 Jan 25;109(6). pii: djw278. doi: 10.1093/jnci/djw278. Print 2017 Jan. Review.


A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma.

Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G.

Oncotarget. 2017 Feb 21;8(8):12831-12842. doi: 10.18632/oncotarget.14606.


Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer.

Zhang J, Sikka S, Siveen KS, Lee JH, Um JY, Kumar AP, Chinnathambi A, Alharbi SA, Basappa, Rangappa KS, Sethi G, Ahn KS.

Apoptosis. 2017 Jan;22(1):158-168. doi: 10.1007/s10495-016-1313-7.


Identification of natural peptides as a new class of antimalarial drugs by in silico approaches.

Samy RP, Foo SL, Franco OL, Stiles BG, Kumar AP, Sethi G, Lim LH.

Front Biosci (Schol Ed). 2017 Jan 1;9:88-110. Review.


TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts.

Huang G, Osmulski PA, Bouamar H, Mahalingam D, Lin CL, Liss MA, Kumar AP, Chen CL, Thompson IM, Sun LZ, Gaczynska ME, Huang TH.

Oncotarget. 2016 Nov 22;7(47):77124-77137. doi: 10.18632/oncotarget.12808.


Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.

Dai X, Ahn KS, Wang LZ, Kim C, Deivasigamni A, Arfuso F, Um JY, Kumar AP, Chang YC, Kumar D, Kundu GC, Magae J, Goh BC, Hui KM, Sethi G.

Mol Cancer Ther. 2016 Dec;15(12):2966-2976. Epub 2016 Oct 7.


Comparative study between platelets infusion and IV corticosteroids in patients with Dengue fever and thrombocytopenia.

Kumar AP, Soy D, Sharma D, Lugun N.

J Assoc Physicians India. 2016 Jan;64(1):121. No abstract available.


An azaspirane derivative suppresses growth and induces apoptosis of ER-positive and ER-negative breast cancer cells through the modulation of JAK2/STAT3 signaling pathway.

Sulaiman NB, Mohan CD, Basappa S, Pandey V, Rangappa S, Bharathkumar H, Kumar AP, Lobie PE, Rangappa KS.

Int J Oncol. 2016 Sep;49(3):1221-9. doi: 10.3892/ijo.2016.3615. Epub 2016 Jul 6.


Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma.

Loo SY, Hirpara JL, Pandey V, Tan TZ, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S, Clément MV, Kumar AP.

Antioxid Redox Signal. 2016 Aug 20;25(6):283-99. doi: 10.1089/ars.2015.6524.


Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

Hussain SS, Kumar AP, Ghosh R.

Semin Cancer Biol. 2016 Oct;40-41:233-246. doi: 10.1016/j.semcancer.2016.06.002. Epub 2016 Jul 7. Review.


Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion.

Tochhawng L, Deng S, Pugalenthi G, Kumar AP, Lim KH, Tan TZ, Yang H, Hooi SC, Goh YC, Maciver SK, Pervaiz S, Yap CT.

Oncotarget. 2016 Aug 16;7(33):52832-52848. doi: 10.18632/oncotarget.10451.


Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.

Kothapalli R, Sivaraman Siveen K, Tan TZ, Paul Thiery J, Kumar AP, Sethi G, Swaminathan K.

Biosci Biotechnol Biochem. 2016 Jun 29:1-10. [Epub ahead of print]


RNA helicase DP103 and TAK1: a new connection in cancer.

Shin EM, Osato M, Kumar AP, Tergaonkar V.

Mol Cell Oncol. 2015 Jan 26;2(3):e985911. doi: 10.4161/23723556.2014.985911. eCollection 2015 Jul-Sep. No abstract available.


CD44 Expression Level and Isoform Contributes to Pancreatic Cancer Cell Plasticity, Invasiveness, and Response to Therapy.

Zhao S, Chen C, Chang K, Karnad A, Jagirdar J, Kumar AP, Freeman JW.

Clin Cancer Res. 2016 Nov 15;22(22):5592-5604. doi: 10.1158/1078-0432.CCR-15-3115. Epub 2016 Jun 7.


Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells.

Gong J, Muñoz AR, Pingali S, Payton-Stewart F, Chan DE, Freeman JW, Ghosh R, Kumar AP.

Mol Carcinog. 2017 Feb;56(2):402-411. doi: 10.1002/mc.22503. Epub 2016 May 25.


ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation.

Yuan Y, Anbalagan D, Lee LH, Samy RP, Shanmugam MK, Kumar AP, Sethi G, Lobie PE, Lim LH.

Oncotarget. 2016 May 10;7(19):27007-20. doi: 10.18632/oncotarget.8875.


The potential role of boswellic acids in cancer prevention and treatment.

Roy NK, Deka A, Bordoloi D, Mishra S, Kumar AP, Sethi G, Kunnumakkara AB.

Cancer Lett. 2016 Jul 10;377(1):74-86. doi: 10.1016/j.canlet.2016.04.017. Epub 2016 Apr 14. Review.


Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma.

Huang B, Deng S, Loo SY, Datta A, Yap YL, Yan B, Ooi CH, Dinh TD, Zhuo J, Tochhawng L, Gopinadhan S, Jegadeesan T, Tan P, Salto-Tellez M, Yong WP, Soong R, Yeoh KG, Goh YC, Lobie PE, Yang H, Kumar AP, Maciver SK, So JB, Yap CT.

Oncotarget. 2016 May 3;7(18):25391-407. doi: 10.18632/oncotarget.8603.


Major Protein of Carcinoembryonic Antigen Gene Family - CD66c, A Novel Marker in Colon Carcinoma.

Nataraj SM, Prema CL, Vimalambike MG, Shivalingaiah SC, Sundaram S, Kumar AP, Math AK, Prashant A.

J Clin Diagn Res. 2016 Feb;10(2):XC01-XC04. doi: 10.7860/JCDR/2016/17180.7286. Epub 2016 Feb 1.


Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.

Shanmugam MK, Lee JH, Chai EZ, Kanchi MM, Kar S, Arfuso F, Dharmarajan A, Kumar AP, Ramar PS, Looi CY, Mustafa MR, Tergaonkar V, Bishayee A, Ahn KS, Sethi G.

Semin Cancer Biol. 2016 Oct;40-41:35-47. doi: 10.1016/j.semcancer.2016.03.005. Epub 2016 Mar 30. Review.


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