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Items: 1 to 50 of 336

1.

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1.

Meyer Zu Horste G, Przybylski D, Schramm MA, Wang C, Schnell A, Lee Y, Sobel R, Regev A, Kuchroo VK.

Immunity. 2018 Mar 20;48(3):556-569.e7. doi: 10.1016/j.immuni.2018.03.008.

PMID:
29562202
2.

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH.

J Immunol. 2018 Apr 15;200(8):2592-2602. doi: 10.4049/jimmunol.1701231. Epub 2018 Mar 12.

PMID:
29531164
3.

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM.

Nat Med. 2018 May;24(4):417-426. doi: 10.1038/nm.4501. Epub 2018 Mar 5.

PMID:
29505031
4.

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N.

J Immunol. 2018 Apr 15;200(8):3000-3007. doi: 10.4049/jimmunol.1700407. Epub 2018 Mar 2.

PMID:
29500245
5.

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells.

Nakashima H, Alayo QA, Penaloza-MacMaster P, Freeman GJ, Kuchroo VK, Reardon DA, Fernandez S, Caligiuri M, Chiocca EA.

Sci Rep. 2018 Jan 9;8(1):208. doi: 10.1038/s41598-017-18540-2.

6.

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.

Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018.

PMID:
29308307
7.

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.

Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL.

Nat Commun. 2017 Nov 17;8(1):1600. doi: 10.1038/s41467-017-01571-8.

8.

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC.

Cell. 2017 Nov 16;171(5):1221-1223. doi: 10.1016/j.cell.2017.11.006. No abstract available.

9.

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Nov 30;551(7682):658. doi: 10.1038/nature24480. Epub 2017 Nov 15.

PMID:
29143821
10.

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.

Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius M.

Cardiovasc Res. 2018 Jan 1;114(1):158-167. doi: 10.1093/cvr/cvx181.

PMID:
29016728
11.

Predictors of responses to immune checkpoint blockade in advanced melanoma.

Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Ternès N, Jegou S, Woods DM, Sodré AL, Hansen M, Meirow Y, Sade-Feldman M, Burra A, Kwek SS, Flament C, Messaoudene M, Duong CPM, Chen L, Kwon BS, Anderson AC, Kuchroo VK, Weide B, Aubin F, Borg C, Dalle S, Beatrix O, Ayyoub M, Balme B, Tomasic G, Di Giacomo AM, Maio M, Schadendorf D, Melero I, Dréno B, Khammari A, Dummer R, Levesque M, Koguchi Y, Fong L, Lotem M, Baniyash M, Schmidt H, Svane IM, Kroemer G, Marabelle A, Michiels S, Cavalcanti A, Smyth MJ, Weber JS, Eggermont AM, Zitvogel L.

Nat Commun. 2017 Sep 19;8(1):592. doi: 10.1038/s41467-017-00608-2.

12.

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Sep 21;549(7672):351-356. doi: 10.1038/nature24029. Epub 2017 Sep 13. Erratum in: Nature. 2017 Nov 15;:.

13.

Tim-3, Lag-3, and TIGIT.

Joller N, Kuchroo VK.

Curr Top Microbiol Immunol. 2017;410:127-156. doi: 10.1007/82_2017_62.

14.

Podoplanin is a negative regulator of Th17 inflammation.

Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA.

JCI Insight. 2017 Sep 7;2(17). pii: 92321. doi: 10.1172/jci.insight.92321. [Epub ahead of print]

15.

TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

Ding Q, Mohib K, Kuchroo VK, Rothstein DM.

J Immunol. 2017 Oct 1;199(7):2585-2595. doi: 10.4049/jimmunol.1602107. Epub 2017 Aug 28.

PMID:
28848066
16.

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production.

Brauner S, Folkersen L, Kvarnström M, Meisgen S, Petersen S, Franzén-Malmros M, Mofors J, Brokstad KA, Klareskog L, Jonsson R, Westerberg LS, Trollmo C, Malmström V, Ambrosi A, Kuchroo VK, Nordmark G, Wahren-Herlenius M.

Ann Rheum Dis. 2017 Oct;76(10):1755-1763. doi: 10.1136/annrheumdis-2016-210509. Epub 2017 Jul 31.

17.

Phagocytosis imprints heterogeneity in tissue-resident macrophages.

A-Gonzalez N, Quintana JA, García-Silva S, Mazariegos M, González de la Aleja A, Nicolás-Ávila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A.

J Exp Med. 2017 May 1;214(5):1281-1296. doi: 10.1084/jem.20161375. Epub 2017 Apr 21.

18.

Tim-3 and its role in regulating anti-tumor immunity.

Das M, Zhu C, Kuchroo VK.

Immunol Rev. 2017 Mar;276(1):97-111. doi: 10.1111/imr.12520. Review.

19.

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.

Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK.

Nat Immunol. 2017 Apr;18(4):412-421. doi: 10.1038/ni.3683. Epub 2017 Feb 6.

20.

IL-17 Blockade in Psoriasis.

Burkett PR, Kuchroo VK.

Cell. 2016 Dec 15;167(7):1669. doi: 10.1016/j.cell.2016.11.044.

21.

Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.

Kishi Y, Kondo T, Xiao S, Yosef N, Gaublomme J, Wu C, Wang C, Chihara N, Regev A, Joller N, Kuchroo VK.

J Exp Med. 2016 Oct 17;213(11):2489-2501. Epub 2016 Sep 26.

22.

T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia.

Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE.

J Immunol. 2016 Dec 1;197(11):4403-4412. Epub 2016 Oct 24.

23.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.

Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3.

24.

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.

Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC.

Cell. 2016 Sep 8;166(6):1500-1511.e9. doi: 10.1016/j.cell.2016.08.052. Erratum in: Cell. 2017 Nov 16;171(5):1221-1223.

25.

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.

Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS.

J Exp Med. 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376. Epub 2016 Aug 22.

26.

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.

Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK.

Cell Rep. 2016 Jul 12;16(2):392-404. doi: 10.1016/j.celrep.2016.05.088. Epub 2016 Jun 23.

27.

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi: 10.1073/pnas.1600934113. Epub 2016 Jun 16.

28.

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

Anderson AC, Joller N, Kuchroo VK.

Immunity. 2016 May 17;44(5):989-1004. doi: 10.1016/j.immuni.2016.05.001. Review.

29.

Differentiation and Characterization of Tr1 Cells.

Chihara N, Madi A, Karwacz K, Awasthi A, Kuchroo VK.

Curr Protoc Immunol. 2016 Apr 1;113:3.27.1-3.27.10. doi: 10.1002/0471142735.im0327s113.

PMID:
27038462
30.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

31.

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM.

PLoS Pathog. 2016 Mar 11;12(3):e1005490. doi: 10.1371/journal.ppat.1005490. eCollection 2016 Mar.

32.

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.

Patel DD, Kuchroo VK.

Immunity. 2015 Dec 15;43(6):1040-51. doi: 10.1016/j.immuni.2015.12.003. Review.

33.

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A.

Cell. 2015 Dec 3;163(6):1400-12. doi: 10.1016/j.cell.2015.11.009. Epub 2015 Nov 19.

34.

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.

Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK.

Cell. 2015 Dec 3;163(6):1413-27. doi: 10.1016/j.cell.2015.10.068. Epub 2015 Nov 19.

35.

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA.

J Clin Invest. 2015 Nov 2;125(11):4212-22. doi: 10.1172/JCI81151. Epub 2015 Oct 20.

36.

Oct1 and OCA-B are selectively required for CD4 memory T cell function.

Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D.

J Exp Med. 2015 Nov 16;212(12):2115-31. doi: 10.1084/jem.20150363. Epub 2015 Oct 19.

37.

TIGIT predominantly regulates the immune response via regulatory T cells.

Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC.

J Clin Invest. 2015 Nov 2;125(11):4053-62. doi: 10.1172/JCI81187. Epub 2015 Sep 28.

38.

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.

Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK.

J Clin Invest. 2015 Nov 2;125(11):4011-20. doi: 10.1172/JCI75933. Epub 2015 Sep 28.

39.

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling.

Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C.

J Immunol. 2015 Nov 1;195(9):4144-53. doi: 10.4049/jimmunol.1302246. Epub 2015 Sep 25.

40.

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH.

J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14.

41.

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.

Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J.

Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025.

42.

Effector T cell differentiation: are master regulators of effector T cells still the masters?

Wang C, Collins M, Kuchroo VK.

Curr Opin Immunol. 2015 Dec;37:6-10. doi: 10.1016/j.coi.2015.08.001. Epub 2015 Aug 27. Review.

PMID:
26319196
43.

Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.

Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK.

Nat Commun. 2015 Jul 8;6:7657. doi: 10.1038/ncomms8657. No abstract available.

PMID:
26153760
44.

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ.

Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.

45.

Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment.

Andersson KM, Cavallini NF, Hu D, Brisslert M, Cialic R, Valadi H, Erlandsson MC, Silfverswärd S, Pullerits R, Kuchroo VK, Weiner HL, Bokarewa MI.

Mol Med. 2015 Jun 4;21:536-43. doi: 10.2119/molmed.2015.00057.

46.

Physical attraction of Th9 cells is skin deep.

Dardalhon V, Collins M, Kuchroo VK.

Ann Transl Med. 2015 Apr;3(6):74. doi: 10.3978/j.issn.2305-5839.2015.01.28. No abstract available.

47.

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity.

Burkett PR, Meyer zu Horste G, Kuchroo VK.

J Clin Invest. 2015 Jun;125(6):2211-9. doi: 10.1172/JCI78085. Epub 2015 May 11. Review.

48.

A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.

Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK.

J Autoimmun. 2015 May;59:38-42. doi: 10.1016/j.jaut.2015.02.001. Epub 2015 Feb 26.

49.

Ezh2 lines up the chromatin in T regulatory cells.

Wu C, Chen Z, Kuchroo VK.

Immunity. 2015 Feb 17;42(2):201-203. doi: 10.1016/j.immuni.2015.01.019.

50.

TIM-1 signaling is required for maintenance and induction of regulatory B cells.

Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM.

Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2.

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