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Items: 1 to 50 of 57

1.

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

Hénon H, Messaoudi S, Anizon F, Aboab B, Kucharczyk N, Léonce S, Golsteyn RM, Pfeiffer B, Prudhomme M.

Eur J Pharmacol. 2007 Jan 12;554(2-3):106-12. Epub 2006 Oct 19.

PMID:
17134696
2.

Solid-phase synthesis of alpha-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP inhibitors.

Chollet AM, Le Diguarher T, Kucharczyk N, Loynel A, Bertrand M, Tucker G, Guilbaud N, Burbridge M, Pastoureau P, Fradin A, Sabatini M, Fauchère JL, Casara P.

Bioorg Med Chem. 2002 Mar;10(3):531-44.

PMID:
11814839
3.

From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors.

Henlin JM, Boutin JA, Kucharczyk N, Desmet-Beaufort C, Loynel A, Bertrand M, Genton A, Tucker GC, Atassi G, Fauchére JL.

J Pept Res. 2001 Feb;57(2):85-96.

PMID:
11168892
4.

Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.

Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchère JL, Boutin JA.

J Biol Chem. 2000 Mar 24;275(12):8794-805. Erratum in: J Biol Chem 2000 Dec 15;275(50):39799.

5.

A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists.

Jacoby E, Boudon A, Kucharczyk N, Michel A, Fauchère JL.

J Recept Signal Transduct Res. 1997 Nov;17(6):855-73.

PMID:
9365934
6.

A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.

Bonnet J, Kucharczyk N, Robineau P, Lonchampt M, Dacquet C, Regoli D, Fauchère JL, Canet E.

Eur J Pharmacol. 1996 Aug 22;310(1):37-46.

PMID:
8880065
7.

Synthesis and conformational analysis by 1H NMR and restrained molecular dynamics simulations of the cyclic decapeptide [Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly].

Buono RA, Kucharczyk N, Neuenschwander M, Kemmink J, Hwang LY, Fauchère JL, Venanzi CA.

J Comput Aided Mol Des. 1996 Jun;10(3):213-32.

PMID:
8808738
8.

Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation.

Sabatini M, Lesur C, Pacherie M, Pastoureau P, Kucharczyk N, Fauchère JL, Bonnet J.

Bone. 1996 Jan;18(1):59-65.

PMID:
8717538
9.

Distribution of felbamate in brain.

Cornford EM, Truong HV, Sofia RD, Kucharczyk N.

Epilepsia. 1996 Jan;37(1):15-8.

PMID:
8603617
10.

In vitro and in vivo pharmacology of S 16474, a novel dual tachykinin NK1 and NK2 receptor antagonist.

Robineau P, Lonchampt M, Kucharczyk N, Krause JE, Regoli D, Fauchere JL, Prost JF, Canet E.

Eur J Pharmacol. 1995 Dec 29;294(2-3):677-84.

PMID:
8750733
11.

Estimation of blood levels of endothelin and neurokinin receptor antagonists at the rat portal and jugular veins after oral administration as a tool in peptide drug design.

Paladino J, Kucharczyk N, Morris AD, Thibault-Naze M, Mahieu JP, Serkiz B, Volland JP, Autissier C, Fauchere JL.

Drug Des Discov. 1994 Nov;12(2):121-8.

PMID:
9116167
12.

Determination of valproate in the presence of felbamate in human plasma by narrow bore capillary gas chromatography.

Romanyshyn LA, Wagner MC, Wichmann JK, Kucharczyk N, Sofia RD.

Epilepsia. 1994 Mar-Apr;35(2):406-10.

PMID:
8156966
14.

Simultaneous determination of felbamate and three metabolites in human plasma by high-performance liquid chromatography.

Romanyshyn LA, Wichmann JK, Kucharczyk N, Sofia RD.

Ther Drug Monit. 1994 Feb;16(1):83-9.

PMID:
8160261
15.

Drug concentrations in human brain tissue samples from epileptic patients treated with felbamate.

Adusumalli VE, Wichmann JK, Kucharczyk N, Kamin M, Sofia RD, French J, Sperling M, Bourgeois B, Devinsky O, Dreifuss FE, et al.

Drug Metab Dispos. 1994 Jan-Feb;22(1):168-70. No abstract available.

PMID:
8149879
16.

Simultaneous determination of felbamate and three metabolites in rat and dog plasmas by high-performance liquid chromatography.

Romanyshyn LA, Wichmann JK, Kucharczyk N, Sofia RD.

J Chromatogr. 1993 Dec 22;622(2):229-34.

PMID:
8150870
17.

Simultaneous determination of felbamate and four metabolites in rat cerebrospinal fluid by high-performance liquid chromatography.

Romanyshyn LA, Wichmann JK, Kucharczyk N, Sofia RD.

J Chromatogr. 1993 Dec 22;622(2):223-8.

PMID:
8150869
18.

Distribution of the anticonvulsant felbamate to cerebrospinal fluid and brain tissue of adult and neonatal rats.

Adusumalli VE, Wichmann JK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1079-85.

PMID:
7905387
19.

Synthesis and in vitro activities of new tryptophan-modified and thiomethylene-containing pseudopeptide antagonists of the neurokinins.

Paladino J, Thurieau C, Morris AD, Kucharczyk N, Rouissi N, Regoli D, Fauchère JL.

Int J Pept Protein Res. 1993 Sep;42(3):284-93.

PMID:
8225784
20.

Isolation and identification of 3-carbamoyloxy-2-phenylpropionic acid as a major human urinary metabolite of felbamate.

Adusumalli VE, Choi YM, Romanyshyn LA, Sparadoski RE Jr, Wichmann JK, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1993 Jul-Aug;21(4):710-6.

PMID:
8104132
21.

Tetrapeptide tachykinin antagonists: synthesis and modulation of the physicochemical and pharmacological properties of a new series of partially cyclic analogs.

Kucharczyk N, Thurieau C, Paladino J, Morris AD, Bonnet J, Canet E, Krause JE, Regoli D, Couture R, Fauchère JL.

J Med Chem. 1993 May 28;36(11):1654-61.

PMID:
8388471
22.

Determination of the anticonvulsant felbamate and its three metabolites in brain and heart tissue of rats.

Jacala A, Adusumalli VE, Kucharczyk N, Sofia RD.

J Chromatogr. 1993 May 5;614(2):285-92.

PMID:
8314941
23.

Pharmacokinetics of the new antiasthma and antiallergy drug, azelastine, in pediatric and adult beagle dogs.

Adusumalli VE, Wichmann JK, Wong KK, Kucharczyk N, Sofia RD.

Biopharm Drug Dispos. 1993 Apr;14(3):233-44.

PMID:
8098227
24.

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.

McCabe RT, Wasterlain CG, Kucharczyk N, Sofia RD, Vogel JR.

J Pharmacol Exp Ther. 1993 Mar;264(3):1248-52.

PMID:
8383742
26.

Pharmacodynamic and pharmacokinetic studies with azelastine in the guinea pig: evidence for preferential distribution into the lung.

Chand N, Adusumalli VE, Nolan K, Diamantis W, Wichmann JK, Pivonka J, Langevin CN, Wong KK, Kucharczyk N, Sofia RD.

Allergy. 1993 Jan;48(1):19-24.

PMID:
8096126
27.

High performance liquid chromatographic determination of azelastine and desmethylazelastine in guinea pig plasma and lung tissue.

Langevin CN, Pivonka J, Wichmann JK, Kucharczyk N, Sofia RD.

Biomed Chromatogr. 1993 Jan-Feb;7(1):7-11.

PMID:
8094306
28.

Pharmacokinetics of felbamate in pediatric and adult beagle dogs.

Adusumalli VE, Gilchrist JR, Wichmann JK, Kucharczyk N, Sofia RD.

Epilepsia. 1992 Sep-Oct;33(5):955-60.

PMID:
1396441
29.

Metabolism of [14C]azelastine in guinea pigs.

Yang JT, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1992 Jul-Aug;20(4):536-40.

PMID:
1356731
30.

Pharmacokinetics of azelastine and its active metabolite, desmethylazelastine, in guinea pigs.

Adusumalli VE, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1992 Jul-Aug;20(4):530-5.

PMID:
1356730
31.

Tissue distribution and lung localization of [14C]azelastine in guinea pigs.

Wong KK, Yang JT, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1992 Jul-Aug;20(4):525-9.

PMID:
1356729
32.

Determination of the anticonvulsant felbamate in beagle dog plasma by high-performance liquid chromatography.

Clark LA, Wichmann JK, Kucharczyk N, Sofia RD.

J Chromatogr. 1992 Jan 3;573(1):113-9.

PMID:
1564088
33.

Felbamate metabolism in pediatric and adult beagle dogs.

Yang JT, Morris M, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1992 Jan-Feb;20(1):84-8.

PMID:
1347002
34.

Felbamate in vitro metabolism by rat liver microsomes.

Adusumalli VE, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1991 Nov-Dec;19(6):1135-8.

PMID:
1687021
35.

Felbamate metabolism in the rat, rabbit, and dog.

Yang JT, Adusumalli VE, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1991 Nov-Dec;19(6):1126-34.

PMID:
1687020
36.

Felbamate pharmacokinetics in the rat, rabbit, and dog.

Adusumalli VE, Yang JT, Wong KK, Kucharczyk N, Sofia RD.

Drug Metab Dispos. 1991 Nov-Dec;19(6):1116-25.

PMID:
1687019
37.
38.

Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography.

Pivonka J, Segelman FH, Hartman CA, Segl WE, Kucharczyk N, Sofia RD.

J Chromatogr. 1987 Sep 4;420(1):89-98.

PMID:
2889747
39.

Gas chromatographic determination of carisoprodol in human plasma.

Kucharczyk N, Segelman FH, Kelton E, Summers J, Sofia RD, Mahrous H, Heath R.

J Chromatogr. 1986 Apr 25;377:384-90. No abstract available.

PMID:
3711232
40.

The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats.

Segelman FH, Kelton E, Terzi RM, Kucharczyk N, Sofia RD.

Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):467-70.

PMID:
4023427
41.

Drug level monitoring of antiasthmatic drugs.

Kucharczyk N, Segelman FH.

J Chromatogr. 1985 May 10;340:243-71. Review.

PMID:
2862156
42.

The formaldehyde-donating activity of N5,N10-methylene tetrahydrofolic acid in xenobiotic biotransformation.

Kucharczyk N, Yang JT, Wong KK, Sofia RD.

Xenobiotica. 1984 Aug;14(8):667-76.

PMID:
6495760
43.

Study on in vivo decarboxylation of D-penicillamine in rats.

Kucharczyk N, Wong KK, Yang JT, Sofia RD.

Arzneimittelforschung. 1984;34(2):211-2.

PMID:
6426483
44.

Determination of methyclothiazide in human plasma by high-performance liquid chromatography.

Hartman CA, Kucharczyk N, Sofia RD, Perhach JL Jr.

J Chromatogr. 1981 Dec 11;226(2):510-3. No abstract available.

PMID:
7320181
45.

Biotransformation of reproterol in the intestinal tract of the rat.

Kucharczyk N, Yang JT, Sofia RD.

Arzneimittelforschung. 1981;31(12):2085-8.

PMID:
7199302
46.

An overview of assay methods for D-penicillamine.

Kucharczyk N, Shahinian S.

J Rheumatol Suppl. 1981 Jan-Feb;7:28-34.

PMID:
6939884
47.

Simultaneous determination of dyphylline and theophylline in human plasma by high-performance liquid chromatography.

Valia KH, Hartman CA, Kucharczyk N, Sofia RD.

J Chromatogr. 1980 Nov 14;221(1):170-5. No abstract available.

PMID:
7451620
48.

Metabolites of 2-(3-trifluoromethylphenyl)tetrahydro-1,4-oxazine (CERM) 1841) in rats and dogs.

Kucharczyk N, Yang JT, Valia KH, Stiefel FJ, Sofia RD.

Xenobiotica. 1979 Nov;9(11):703-11.

PMID:
532219
49.

N5,N10-Methylene tetrahydrofolic acid as a formaldehyde donor in drug biotransformation.

Kucharczyk N, Yang J, Sofia RD.

Biochem Pharmacol. 1979 Jul 15;28(14):2219-22. No abstract available.

PMID:
574015
50.

The disposition of 3-methyl-2,3-dihydro-9H-isoxazolo[3,2-b]-quinazolin-9-one (W-2451).

Kucharczyk N, Ballard F, Yang J, Myers G, Sofia RD.

Arch Int Pharmacodyn Ther. 1979 Jun;239(2):180-94.

PMID:
114130

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