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Items: 45

1.

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.

Schlütke L, Immer M, Preu L, Totzke F, Schächtele C, Kubbutat MHG, Kunick C.

Eur J Pharm Biopharm. 2018 May;126:89-94. doi: 10.1016/j.ejpb.2017.03.011. Epub 2017 Mar 15.

PMID:
28315448
2.

Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.

Wätjen W, Ebada SS, Bergermann A, Chovolou Y, Totzke F, Kubbutat MH, Lin W, Proksch P.

Arch Toxicol. 2017 Mar;91(3):1485-1495. doi: 10.1007/s00204-016-1787-7. Epub 2016 Jul 29.

PMID:
27473261
3.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

Barbosa ML, Lima LM, Tesch R, Sant'Anna CM, Totzke F, Kubbutat MH, Schächtele C, Laufer SA, Barreiro EJ.

Eur J Med Chem. 2014 Jan;71:1-14. doi: 10.1016/j.ejmech.2013.10.058. Epub 2013 Oct 31.

PMID:
24269511
4.

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells.

Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, Kubbutat MH, Chovolou Y, Proksch P, Wätjen W.

J Pharm Pharmacol. 2013 Sep;65(9):1393-408. doi: 10.1111/jphp.12107. Epub 2013 Jul 31.

PMID:
23927478
5.

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Dimova D, Iyer P, Vogt M, Totzke F, Kubbutat MH, Schächtele C, Laufer S, Bajorath J.

J Med Chem. 2012 Dec 27;55(24):11067-71. doi: 10.1021/jm3014508. Epub 2012 Dec 11.

PMID:
23210446
6.

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C.

Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14.

PMID:
22560627
7.

Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.

Abu Thaher B, Arnsmann M, Totzke F, Ehlert JE, Kubbutat MH, Schächtele C, Zimmermann MO, Koch P, Boeckler FM, Laufer SA.

J Med Chem. 2012 Jan 26;55(2):961-5. doi: 10.1021/jm201391u. Epub 2012 Jan 17.

PMID:
22185282
8.

Generation of a conditionally transformed murine embryonic fibroblast cell line using doxycycline-dependent IGF-1R overexpression.

Graeser R, Vrignaud P, Esser N, Umber S, Zirrgiebel U, Chiron M, Schaechtele C, Kubbutat MH.

J Biomol Screen. 2012 Mar;17(3):339-49. doi: 10.1177/1087057111424310. Epub 2011 Oct 14.

PMID:
22002421
9.

Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.

Ebada SS, Schulz B, Wray V, Totzke F, Kubbutat MH, Müller WE, Hamacher A, Kassack MU, Lin W, Proksch P.

Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. doi: 10.1016/j.bmc.2011.06.013. Epub 2011 Jul 6.

PMID:
21741249
10.

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.

Schmidt S, Preu L, Lemcke T, Totzke F, Schächtele C, Kubbutat MH, Kunick C.

Eur J Med Chem. 2011 Jul;46(7):2759-69. doi: 10.1016/j.ejmech.2011.03.065. Epub 2011 Apr 6.

PMID:
21524503
11.

Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening.

Lemcke T, Dreher J, Rarey M, Totzke F, Schächtele C, Kubbutat MH, Kunick C.

Mol Inform. 2011 Mar 14;30(2-3):145-50. doi: 10.1002/minf.201000138. Epub 2011 Mar 17. No abstract available.

PMID:
27466768
12.

A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis.

Pérez de Castro I, Aguirre-Portolés C, Martin B, Fernández-Miranda G, Klotzbucher A, Kubbutat MH, Megías D, Arlot-Bonnemains Y, Malumbres M.

Front Oncol. 2011 Dec 14;1:50. doi: 10.3389/fonc.2011.00050. eCollection 2011.

13.

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.

Egert-Schmidt AM, Dreher J, Dunkel U, Kohfeld S, Preu L, Weber H, Ehlert JE, Mutschler B, Totzke F, Schächtele C, Kubbutat MH, Baumann K, Kunick C.

J Med Chem. 2010 Mar 25;53(6):2433-42. doi: 10.1021/jm901388c.

PMID:
20170163
14.

Workflow comparison for label-free, quantitative secretome proteomics for cancer biomarker discovery: method evaluation, differential analysis, and verification in serum.

Piersma SR, Fiedler U, Span S, Lingnau A, Pham TV, Hoffmann S, Kubbutat MH, Jiménez CR.

J Proteome Res. 2010 Apr 5;9(4):1913-22. doi: 10.1021/pr901072h.

PMID:
20085282
15.

Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa.

Shi C, Xu MJ, Bayer M, Deng ZW, Kubbutat MH, Wätjen W, Proksch P, Lin WH.

Phytochemistry. 2010 Mar;71(4):435-42. doi: 10.1016/j.phytochem.2009.11.008. Epub 2009 Dec 18. Erratum in: Phytochemistry. 2010 Jun;71(8-9):1025. Waejen, Wim [corrected to Wätjen, Wim].

PMID:
20022347
16.

A novel roscovitine derivative potently induces G1-phase arrest in platelet-derived growth factor-BB-activated vascular smooth muscle cells.

Sroka IM, Heiss EH, Havlicek L, Totzke F, Aristei Y, Pechan P, Kubbutat MH, Strnad M, Dirsch VM.

Mol Pharmacol. 2010 Feb;77(2):255-61. doi: 10.1124/mol.109.060327. Epub 2009 Nov 10.

17.

Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.

Tasler S, Müller O, Wieber T, Herz T, Pegoraro S, Saeb W, Lang M, Krauss R, Totzke F, Zirrgiebel U, Ehlert JE, Kubbutat MH, Schächtele C.

Bioorg Med Chem. 2009 Sep 15;17(18):6728-37. doi: 10.1016/j.bmc.2009.07.047. Epub 2009 Jul 25.

PMID:
19692247
18.

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kappaB signalling in H4IIE cells.

Wätjen W, Putz A, Chovolou Y, Kampkötter A, Totzke F, Kubbutat MH, Proksch P, Konuklugil B.

J Pharm Pharmacol. 2009 Jul;61(7):919-24. doi: 10.1211/jpp/61.07.0011.

PMID:
19589234
19.

Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.

Debbab A, Aly AH, Edrada-Ebel R, Wray V, Müller WE, Totzke F, Zirrgiebel U, Schächtele C, Kubbutat MH, Lin WH, Mosaddak M, Hakiki A, Proksch P, Ebel R.

J Nat Prod. 2009 Apr;72(4):626-31. doi: 10.1021/np8004997.

PMID:
19271717
20.

N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.

Tasler S, Müller O, Wieber T, Herz T, Krauss R, Totzke F, Kubbutat MH, Schächtele C.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1349-56. doi: 10.1016/j.bmcl.2009.01.054. Epub 2009 Jan 22.

PMID:
19211246
21.

Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.

Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MH, Proksch P.

Mol Nutr Food Res. 2009 Apr;53(4):431-40. doi: 10.1002/mnfr.200700428.

PMID:
19065580
22.

Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.

Danilenko VN, Simonov AY, Lakatosh SA, Kubbutat MH, Totzke F, Schächtele C, Elizarov SM, Bekker OB, Printsevskaya SS, Luzikov YN, Reznikova MI, Shtil AA, Preobrazhenskaya MN.

J Med Chem. 2008 Dec 25;51(24):7731-6. doi: 10.1021/jm800758s.

PMID:
19053831
23.

A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries.

Oehmig A, Klotzbücher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat MH, Joos TO, Volkmer H.

BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.

24.

Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.

Aly AH, Edrada-Ebel R, Indriani ID, Wray V, Müller WE, Totzke F, Zirrgiebel U, Schächtele C, Kubbutat MH, Lin WH, Proksch P, Ebel R.

J Nat Prod. 2008 Jun;71(6):972-80. doi: 10.1021/np070447m. Epub 2008 May 22.

PMID:
18494522
25.

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.

Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L.

Cancer Res. 2007 Sep 1;67(17):8325-34.

26.

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.

Kohfeld S, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C.

Eur J Med Chem. 2007 Nov-Dec;42(11-12):1317-24. Epub 2007 Mar 1.

PMID:
17448574
27.

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones.

Kunick C, Bleeker C, Prühs C, Totzke F, Schächtele C, Kubbutat MH, Link A.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2148-53. Epub 2006 Feb 7.

PMID:
16464582
28.

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

Kunick C, Zeng Z, Gussio R, Zaharevitz D, Leost M, Totzke F, Schächtele C, Kubbutat MH, Meijer L, Lemcke T.

Chembiochem. 2005 Mar;6(3):541-9.

PMID:
15696597
29.

Regulation of HDM2 activity by the ribosomal protein L11.

Lohrum MA, Ludwig RL, Kubbutat MH, Hanlon M, Vousden KH.

Cancer Cell. 2003 Jun;3(6):577-87.

30.

Apoptosis and its relevance in cancer therapy.

Ehlert JE, Kubbutat MH.

Onkologie. 2001 Oct;24(5):433-40. Review.

PMID:
11694769
31.

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization.

Lohrum MA, Ashcroft M, Kubbutat MH, Vousden KH.

Curr Biol. 2000 May 4;10(9):539-42.

32.

Identification of a cryptic nucleolar-localization signal in MDM2.

Lohrum MA, Ashcroft M, Kubbutat MH, Vousden KH.

Nat Cell Biol. 2000 Mar;2(3):179-81. No abstract available.

PMID:
10707090
33.

Cause and consequence of becoming persistentPersistent viral infections edited by R. Ahmed and I.S.Y. chen

Kubbutat MH.

Trends Microbiol. 1999 Sep;7(9):382. No abstract available.

PMID:
10470048
34.

Analysis of the degradation function of Mdm2.

Kubbutat MH, Ludwig RL, Levine AJ, Vousden KH.

Cell Growth Differ. 1999 Feb;10(2):87-92.

35.

Regulation of p53 function and stability by phosphorylation.

Ashcroft M, Kubbutat MH, Vousden KH.

Mol Cell Biol. 1999 Mar;19(3):1751-8.

36.

Assignment1 of the murine Ki-67 gene (Mki67) to chromosome band 7F3-F5 by in situ hybridization.

Traut W, Scholzen T, Winking H, Kubbutat MH, Gerdes J.

Cytogenet Cell Genet. 1998;83(1-2):12-3. No abstract available.

PMID:
9925911
37.

Regulation of Mdm2-directed degradation by the C terminus of p53.

Kubbutat MH, Ludwig RL, Ashcroft M, Vousden KH.

Mol Cell Biol. 1998 Oct;18(10):5690-8.

38.

Keeping an old friend under control: regulation of p53 stability.

Kubbutat MH, Vousden KH.

Mol Med Today. 1998 Jun;4(6):250-6. Review.

PMID:
9679243
39.

New HPV E6 binding proteins: dangerous liaisons?

Kubbutat MH, Vousden KH.

Trends Microbiol. 1998 May;6(5):173-5. Review. No abstract available.

PMID:
9614337
40.

Regulation of p53 stability by Mdm2.

Kubbutat MH, Jones SN, Vousden KH.

Nature. 1997 May 15;387(6630):299-303.

PMID:
9153396
41.
43.

Cell proliferation-associated nuclear antigen defined by antibody Ki-67: a new kind of cell cycle-maintaining proteins.

Duchrow M, Schlüter C, Key G, Kubbutat MH, Wohlenberg C, Flad HD, Gerdes J.

Arch Immunol Ther Exp (Warsz). 1995;43(2):117-21. Review.

PMID:
8744726
44.
45.

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