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Items: 38

1.

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC.

Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8.

PMID:
29118061
2.

Auer Rods.

Gordon SW, Krystal GW.

N Engl J Med. 2017 May 25;376(21):2065. doi: 10.1056/NEJMicm1612344. No abstract available.

3.

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer.

Nakajima W, Sharma K, Hicks MA, Le N, Brown R, Krystal GW, Harada H.

Cancer Biol Ther. 2016;17(1):27-35. doi: 10.1080/15384047.2015.1108485.

4.

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.

Nakajima W, Hicks MA, Tanaka N, Krystal GW, Harada H.

Cell Death Dis. 2014 Feb 13;5:e1052. doi: 10.1038/cddis.2014.6.

5.

Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer.

Krystal GW, Alesi E, Tatum JL.

Mol Cancer Ther. 2012 Jul;11(7):1385-8. doi: 10.1158/1535-7163.MCT-12-0011. Epub 2012 May 4.

6.

Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737.

Krystal GW.

Cancer Biol Ther. 2010 Nov 1;10(9):930-2. Epub 2010 Nov 1. No abstract available.

PMID:
20935462
7.

Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines.

Xu H, Krystal GW.

Clin Cancer Res. 2010 Sep 1;16(17):4392-400. doi: 10.1158/1078-0432.CCR-10-0640. Epub 2010 Aug 23.

8.

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

Hauck P, Chao BH, Litz J, Krystal GW.

Mol Cancer Ther. 2009 Apr;8(4):883-92. doi: 10.1158/1535-7163.MCT-08-1118.

9.

Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt.

Yeh J, Litz J, Hauck P, Ludwig DL, Krystal GW.

Lung Cancer. 2008 May;60(2):166-74. Epub 2007 Nov 14.

PMID:
18006183
10.

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G.

Nat Chem Biol. 2007 Aug;3(8):498-507. Epub 2007 Jul 1.

PMID:
17603540
12.

Receptor tyrosine kinase mutations: molecular indicators for therapeutic response or signposts marking important signaling pathways?

Krystal GW.

Cancer Biol Ther. 2005 Dec;4(12):1417-8. Epub 2005 Dec 29. No abstract available.

PMID:
16322688
13.

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, Hylemon PB.

Biochem Pharmacol. 2005 Nov 25;70(11):1685-96. Epub 2005 Oct 3.

PMID:
16207485
14.

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy.

Warshamana-Greene GS, Litz J, Buchdunger E, García-Echeverría C, Hofmann F, Krystal GW.

Clin Cancer Res. 2005 Feb 15;11(4):1563-71.

15.

The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression.

Litz J, Sakuntala Warshamana-Greene G, Sulanke G, Lipson KE, Krystal GW.

Lung Cancer. 2004 Dec;46(3):283-91.

PMID:
15541812
16.
17.

Imatinib mesylate (STI571) for myeloid malignancies other than CML.

Krystal GW.

Leuk Res. 2004 May;28 Suppl 1:S53-9. Review.

PMID:
15036942
18.
19.

Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.

Litz J, Carlson P, Warshamana-Greene GS, Grant S, Krystal GW.

Clin Cancer Res. 2003 Oct 1;9(12):4586-94.

21.

Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes.

Angchaisuksiri P, Grigus SR, Carlson PL, Krystal GW, Dessypris EN.

Blood. 2002 Jan 1;99(1):130-6.

22.
23.

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

Krystal GW, Honsawek S, Kiewlich D, Liang C, Vasile S, Sun L, McMahon G, Lipson KE.

Cancer Res. 2001 May 1;61(9):3660-8.

24.

A novel assay for the measurement of Raf-1 kinase activity.

Bondzi C, Grant S, Krystal GW.

Oncogene. 2000 Oct 12;19(43):5030-3.

25.

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

Krystal GW, Honsawek S, Litz J, Buchdunger E.

Clin Cancer Res. 2000 Aug;6(8):3319-26.

27.
28.

Activating c-kit gene mutations in human germ cell tumors.

Tian Q, Frierson HF Jr, Krystal GW, Moskaluk CA.

Am J Pathol. 1999 Jun;154(6):1643-7.

29.

Selective Sp1 binding is critical for maximal activity of the human c-kit promoter.

Park GH, Plummer HK 3rd, Krystal GW.

Blood. 1998 Dec 1;92(11):4138-49.

31.
32.

Identification of novel human tumor cell-specific CaMK-II variants.

Tombes RM, Krystal GW.

Biochim Biophys Acta. 1997 Mar 1;1355(3):281-92.

33.
34.

Coexpression of the c-kit and stem cell factor genes in breast carcinomas.

Hines SJ, Organ C, Kornstein MJ, Krystal GW.

Cell Growth Differ. 1995 Jun;6(6):769-79.

35.
36.

N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.

Krystal GW, Armstrong BC, Battey JF.

Mol Cell Biol. 1990 Aug;10(8):4180-91.

37.

Phosphorylation of cleavage stage histone H1 in mitotic and prematurely condensed chromosomes.

Krystal GW, Poccia DL.

Exp Cell Res. 1981 Jul;134(1):41-8. No abstract available.

PMID:
6265251
38.

Control of chromosome condensation in the sea urchin egg.

Krystal GW, Poccia D.

Exp Cell Res. 1979 Oct 15;123(2):207-19. No abstract available.

PMID:
574089

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