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Items: 1 to 50 of 81

1.

Modeling hepatitis virus infections and treatment strategies in humanized mice.

Kremsdorf D, Strick-Marchand H.

Curr Opin Virol. 2017 Aug;25:119-125. doi: 10.1016/j.coviro.2017.07.029. Epub 2017 Aug 31. Review.

PMID:
28858692
2.

Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver.

Dusséaux M, Masse-Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, Beaumont E, Moreau P, Rivière L, Neuveut C, Soussan P, Roingeard P, Kremsdorf D, Di Santo JP, Strick-Marchand H.

Gastroenterology. 2017 Dec;153(6):1647-1661.e9. doi: 10.1053/j.gastro.2017.08.034. Epub 2017 Aug 26.

3.

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity.

Duriez M, Mandouri Y, Lekbaby B, Wang H, Schnuriger A, Redelsperger F, Guerrera CI, Lefevre M, Fauveau V, Ahodantin J, Quetier I, Chhuon C, Gourari S, Boissonnas A, Gill U, Kennedy P, Debzi N, Sitterlin D, Maini MK, Kremsdorf D, Soussan P.

J Hepatol. 2017 Oct;67(4):687-699. doi: 10.1016/j.jhep.2017.05.025. Epub 2017 Jun 7.

PMID:
28600137
4.

A novel mouse model for stable engraftment of a human immune system and human hepatocytes.

Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff E, Ahodantin J, Weijer K, Spits H, Kremsdorf D, Di Santo JP.

PLoS One. 2015 Mar 17;10(3):e0119820. doi: 10.1371/journal.pone.0119820. eCollection 2015.

5.

Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stimulated signaling pathways and limits the extent of liver inflammation.

Pol JG, Lekbaby B, Redelsperger F, Klamer S, Mandouri Y, Ahodantin J, Bieche I, Lefevre M, Souque P, Charneau P, Gadessaud N, Kremsdorf D, Soussan P.

FASEB J. 2015 May;29(5):1879-89. doi: 10.1096/fj.14-258715. Epub 2015 Jan 28.

PMID:
25630972
6.

C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis.

Quetier I, Brezillon N, Revaud J, Ahodantin J, DaSilva L, Soussan P, Kremsdorf D.

J Gen Virol. 2015 Mar;96(Pt 3):614-25. doi: 10.1099/vir.0.070680-0. Epub 2014 Dec 17.

PMID:
25519169
7.

Regulation of interleukin-6 in head and neck squamous cell carcinoma is related to papillomavirus infection.

Guerrera IC, Quetier I, Fetouchi R, Moreau F, Vauloup-Fellous C, Lekbaby B, Rousselot C, Chhuon C, Edelman A, Lefevre M, Nicolas JC, Kremsdorf D, Lacau Saint Guily J, Soussan P.

J Proteome Res. 2014 Feb 7;13(2):1002-11. doi: 10.1021/pr401009f. Epub 2014 Jan 10.

PMID:
24405156
8.

Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice.

Quétier I, Brezillon N, Duriez M, Massinet H, Giang E, Ahodantin J, Lamant C, Brunelle MN, Soussan P, Kremsdorf D.

J Hepatol. 2013 Aug;59(2):285-91. doi: 10.1016/j.jhep.2013.03.021. Epub 2013 Mar 28.

PMID:
23542345
9.

Detection and genotyping of human papillomavirus by real-time PCR assay.

Moreau F, Fetouchi R, Micalessi I, Brejeon V, Bacon N, Jannes G, Le Pendeven C, Lekbaby B, Kremsdorf D, Lacau Saint Guily J, Soussan P.

J Clin Virol. 2013 Mar;56(3):244-9. doi: 10.1016/j.jcv.2012.11.003. Epub 2012 Nov 22.

PMID:
23182775
10.

Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress.

Williams V, Brichler S, Khan E, Chami M, Dény P, Kremsdorf D, Gordien E.

J Viral Hepat. 2012 Oct;19(10):744-53. doi: 10.1111/j.1365-2893.2012.01597.x. Epub 2012 Apr 22.

PMID:
22967106
11.

Production of hepatitis B defective particles is dependent on liver status.

Redelsperger F, Lekbaby B, Mandouri Y, Giang E, Duriez M, Desire N, Roque Afonso AM, Brichler S, Dubreuil P, Dobrin A, Perlemuter G, Prevot S, Bacon N, Grange JD, Zatla F, Le Pendeven C, Pol S, Strick-Marchand H, Di Santo J, Kremsdorf D, Soussan P.

Virology. 2012 Sep 15-30;431(1-2):21-8. doi: 10.1016/j.virol.2012.05.008. Epub 2012 Jun 2.

12.

Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice.

Brezillon N, Brunelle MN, Massinet H, Giang E, Lamant C, DaSilva L, Berissi S, Belghiti J, Hannoun L, Puerstinger G, Wimmer E, Neyts J, Hantz O, Soussan P, Morosan S, Kremsdorf D.

PLoS One. 2011;6(12):e25096. doi: 10.1371/journal.pone.0025096. Epub 2011 Dec 5.

13.

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. doi: 10.1073/pnas.1019167108. Epub 2011 Mar 28.

14.

Inhibition of hepatitis B virus DNA replication by a thermostable interferon-γ variant.

Brunelle MN, Saboulard D, Massinet H, Lamant C, Soussan P, Brezillon N, Kremsdorf D.

Antivir Ther. 2010;15(6):861-9. doi: 10.3851/IMP1639.

PMID:
20834098
15.

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms.

Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, Paterlini-Brechot P, Tiollais P.

Pathol Biol (Paris). 2010 Aug;58(4):278-87. doi: 10.1016/j.patbio.2010.05.001. Epub 2010 Jul 27. Review.

PMID:
20667665
16.

Role of the hepatitis B virus proteins in pro- and anti-apoptotic processes.

Assrir N, Soussan P, Kremsdorf D, Rossignol JM.

Front Biosci (Landmark Ed). 2010 Jan 1;15:12-24. Review.

PMID:
20036802
17.

Hepatitis delta virus proteins repress hepatitis B virus enhancers and activate the alpha/beta interferon-inducible MxA gene.

Williams V, Brichler S, Radjef N, Lebon P, Goffard A, Hober D, Fagard R, Kremsdorf D, Dény P, Gordien E.

J Gen Virol. 2009 Nov;90(Pt 11):2759-67. doi: 10.1099/vir.0.011239-0. Epub 2009 Jul 22.

PMID:
19625466
18.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.

19.

Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens.

Brezillon N, Kremsdorf D, Weiss MC.

Dis Model Mech. 2008 Sep-Oct;1(2-3):113-30. doi: 10.1242/dmm.000463.

20.

Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes.

Brezillon NM, DaSilva L, L'Hôte D, Bernex F, Piquet J, Binart N, Morosan S, Kremsdorf D.

Cell Transplant. 2008;17(7):803-12.

PMID:
19044207
21.

Prospective comparison of Abbott RealTime HBV DNA and Versant HBV DNA 3.0 assays for hepatitis B DNA quantitation: impact on HBV genotype monitoring.

Pol J, Le Pendeven C, Beby-Defaux A, Rabut E, Jais JP, Pilloux M, Osada C, Zatla F, Assami H, Grange JD, Kremsdorf D, Nicolas JC, Soussan P.

J Virol Methods. 2008 Dec;154(1-2):1-6. doi: 10.1016/j.jviromet.2008.09.014. Epub 2008 Nov 4.

PMID:
18929599
22.

Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells.

Hayhurst GP, Strick-Marchand H, Mulet C, Richard AF, Morosan S, Kremsdorf D, Weiss MC.

J Hepatol. 2008 Sep;49(3):384-95. doi: 10.1016/j.jhep.2008.04.024. Epub 2008 Jun 5.

23.

Expression of defective hepatitis B virus particles derived from singly spliced RNA is related to liver disease.

Soussan P, Pol J, Garreau F, Schneider V, Le Pendeven C, Nalpas B, Lacombe K, Bonnard P, Pol S, Kremsdorf D.

J Infect Dis. 2008 Jul 15;198(2):218-25. doi: 10.1086/589623.

PMID:
18532883
24.

Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice.

Sidorkiewicz M, Jais JP, Tralhao G, Morosan S, Giannini C, Brezillon N, Soussan P, Delpuech O, Kremsdorf D.

World J Gastroenterol. 2008 Jan 28;14(4):574-81.

25.

Transplanted hepatocytes over-expressing FoxM1B efficiently repopulate chronically injured mouse liver independent of donor age.

Brezillon N, Lambert-Blot M, Morosan S, Couton D, Mitchell C, Kremsdorf D, Costa RH, Gilgenkrantz H, Guidotti JE.

Mol Ther. 2007 Sep;15(9):1710-5. Epub 2007 Jun 12.

26.

New animal models for hepatitis C viral infection and pathogenesis studies.

Kremsdorf D, Brezillon N.

World J Gastroenterol. 2007 May 7;13(17):2427-35. Review.

27.

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

Cerec V, Glaise D, Garnier D, Morosan S, Turlin B, Drenou B, Gripon P, Kremsdorf D, Guguen-Guillouzo C, Corlu A.

Hepatology. 2007 Apr;45(4):957-67.

PMID:
17393521
28.

Hepatitis B virus splice-generated protein induces T-cell responses in HLA-transgenic mice and hepatitis B virus-infected patients.

Mancini-Bourgine M, Bayard F, Soussan P, Deng Q, Lone YC, Kremsdorf D, Michel ML.

J Virol. 2007 May;81(10):4963-72. Epub 2007 Mar 14.

29.

Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo.

Fougère-Deschatrette C, Imaizumi-Scherrer T, Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, Faust DM, Weiss MC.

Stem Cells. 2006 Sep;24(9):2098-109.

30.

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis.

Kremsdorf D, Soussan P, Paterlini-Brechot P, Brechot C.

Oncogene. 2006 Jun 26;25(27):3823-33. Review.

PMID:
16799624
31.

Liver-stage development of Plasmodium falciparum, in a humanized mouse model.

Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Van Rooijen N, Battaglia S, Blanc C, Eling W, Sauerwein R, Hannoun L, Belghiti J, Brechot C, Kremsdorf D, Druilhe P.

J Infect Dis. 2006 Apr 1;193(7):996-1004. Epub 2006 Feb 28.

PMID:
16518762
32.

Human MxA protein participates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice.

Peltekian C, Gordien E, Garreau F, Meas-Yedid V, Soussan P, Willams V, Chaix ML, Olivo-Marin JC, Bréchot C, Kremsdorf D.

J Hepatol. 2005 Dec;43(6):965-72. Epub 2005 Jul 14.

PMID:
16168514
33.

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes.

Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, Weiss MC.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8360-5. Epub 2004 May 20.

34.

Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection.

Iavarone M, Trabut JB, Delpuech O, Carnot F, Colombo M, Kremsdorf D, Bréchot C, Thiers V.

J Hepatol. 2003 Aug;39(2):253-61.

PMID:
12873823
35.

A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector.

Giannini C, Morosan S, Tralhao JG, Guidotti JE, Battaglia S, Mollier K, Hannoun L, Kremsdorf D, Gilgenkrantz H, Charneau P.

Hepatology. 2003 Jul;38(1):114-22.

PMID:
12829993
36.

The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis.

Soussan P, Tuveri R, Nalpas B, Garreau F, Zavala F, Masson A, Pol S, Brechot C, Kremsdorf D.

J Hepatol. 2003 Mar;38(3):343-8.

PMID:
12586301
37.

Hepatitis C virus core protein expression in human B-cell lines does not significantly modify main proliferative and apoptosis pathways.

Giannini C, Caini P, Giannelli F, Fontana F, Kremsdorf D, Bréchot C, Zignego AL.

J Gen Virol. 2002 Jul;83(Pt 7):1665-71.

PMID:
12075085
38.

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis.

Tralhao JG, Roudier J, Morosan S, Giannini C, Tu H, Goulenok C, Carnot F, Zavala F, Joulin V, Kremsdorf D, Bréchot C.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6991-6.

39.
40.

Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues.

Tu H, Bonura C, Giannini C, Mouly H, Soussan P, Kew M, Paterlini-Bréchot P, Bréchot C, Kremsdorf D.

Cancer Res. 2001 Nov 1;61(21):7803-10.

41.

Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein.

Delhem N, Sabile A, Gajardo R, Podevin P, Abadie A, Blaton MA, Kremsdorf D, Beretta L, Brechot C.

Oncogene. 2001 Sep 13;20(41):5836-45.

42.

Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"?

Bréchot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Bréchot P.

Hepatology. 2001 Jul;34(1):194-203. Review. No abstract available.

PMID:
11431751
43.

Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein.

Gordien E, Rosmorduc O, Peltekian C, Garreau F, Bréchot C, Kremsdorf D.

J Virol. 2001 Mar;75(6):2684-91.

44.

Vaccination of chronic hepatitis B virus carriers with preS2/S envelope protein is not associated with the emergence of envelope escape mutants.

Soussan P, Pol S, Garreau F, Bréchot C, Kremsdorf D.

J Gen Virol. 2001 Feb;82(Pt 2):367-71.

PMID:
11161275
45.

In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA.

Soussan P, Garreau F, Zylberberg H, Ferray C, Brechot C, Kremsdorf D.

J Clin Invest. 2000 Jan;105(1):55-60.

46.

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Bréchot C.

Oncogene. 1999 Aug 26;18(34):4848-59.

47.

Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.

Weil R, Sirma H, Giannini C, Kremsdorf D, Bessia C, Dargemont C, Bréchot C, Israël A.

Mol Cell Biol. 1999 Sep;19(9):6345-54.

48.

Inhibition of interferon-inducible MxA protein expression by hepatitis B virus capsid protein.

Rosmorduc O, Sirma H, Soussan P, Gordien E, Lebon P, Horisberger M, Bréchot C, Kremsdorf D.

J Gen Virol. 1999 May;80 ( Pt 5):1253-62.

PMID:
10355772
49.

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome.

Sirma H, Weil R, Rosmorduc O, Urban S, Israël A, Kremsdorf D, Bréchot C.

Oncogene. 1998 Apr 23;16(16):2051-63.

50.

Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection.

Brind A, Jiang J, Samuel D, Gigou M, Feray C, Bréchot C, Kremsdorf D.

J Hepatol. 1997 Feb;26(2):228-35.

PMID:
9059940

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