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Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.

Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2204-2209. doi: 10.1073/pnas.1717363115. Epub 2018 Feb 12.


The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment.

Urabe F, Kosaka N, Yoshioka Y, Egawa S, Ochiya T.

Clin Transl Med. 2017 Dec 13;6(1):45. doi: 10.1186/s40169-017-0176-z. Review.


Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians.

Abnave P, Aboukhatwa E, Kosaka N, Thompson J, Hill MA, Aboobaker AA.

Development. 2017 Oct 1;144(19):3440-3453. doi: 10.1242/dev.154971. Epub 2017 Sep 11.


Evaluation of obliteration of arteriovenous malformations after stereotactic radiosurgery with arterial spin labeling MR imaging.

Kodera T, Arai Y, Arishima H, Higashino Y, Isozaki M, Tsunetoshi K, Matsuda K, Kitai R, Shimizu K, Kosaka N, Yamamoto T, Shioura H, Kimura H, Kikuta KI.

Br J Neurosurg. 2017 Dec;31(6):641-647. doi: 10.1080/02688697.2017.1365818. Epub 2017 Aug 22.


The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells.

Lai AG, Kosaka N, Abnave P, Sahu S, Aboobaker AA.

Dev Biol. 2018 Jan 15;433(2):218-226. doi: 10.1016/j.ydbio.2017.07.023. Epub 2017 Jul 28.


Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review.

Kosaka N, Hasegawa K, Kiuchi K, Ochiai S, Nagai T, Machida H, Imai Y, Fukasawa I.

Acta Cytol. 2017;61(2):165-171. doi: 10.1159/000458750. Epub 2017 Mar 25. Review.


miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma.

Kubota D, Kosaka N, Fujiwara T, Yoshida A, Arai Y, Qiao Z, Takeshita F, Ochiya T, Kawai A, Kondo T.

Sarcoma. 2016;2016:1390571. Epub 2016 Nov 21.


Simultaneous acquisition of high-contrast and quantitative liver T1 images using 3D phase-sensitive inversion recovery: a feasibility study.

Fujiwara Y, Maruyama H, Kosaka N, Ishimori Y.

Acta Radiol. 2017 Aug;58(8):899-905. doi: 10.1177/0284185116678273. Epub 2016 Nov 21.


Concomitant Evaluation of a Panel of Exosome Proteins and MiRs for Qualification of Cultured Human Corneal Endothelial Cells.

Ueno M, Asada K, Toda M, Nagata K, Sotozono C, Kosaka N, Ochiya T, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4393-402. doi: 10.1167/iovs.16-19805.


Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging.

Shimizu K, Kosaka N, Fujiwara Y, Matsuda T, Yamamoto T, Tsuchida T, Tsuchiyama K, Oyama N, Kimura H.

Magn Reson Med Sci. 2017 Jan 10;16(1):38-44. doi: 10.2463/ Epub 2016 May 9.


Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection.

Sasaki H, Yoshiike M, Nozawa S, Usuba W, Katsuoka Y, Aida K, Kitajima K, Kudo H, Hoshikawa M, Yoshioka Y, Kosaka N, Ochiya T, Chikaraishi T.

Clin Genitourin Cancer. 2016 Oct;14(5):e493-e499. doi: 10.1016/j.clgc.2016.04.002. Epub 2016 Apr 9.


Uterine cervical adenocarcinoma metastasizing concurrently to eutopic and ectopic ovaries: A case report.

Kiuchi K, Hasegawa K, Nagai T, Watanabe M, Kosaka N, Machida H, Imai Y, Fukasawa I.

J Obstet Gynaecol Res. 2016 Jul;42(7):899-904. doi: 10.1111/jog.12977. Epub 2016 Mar 23.


Versatile roles of extracellular vesicles in cancer.

Kosaka N, Yoshioka Y, Fujita Y, Ochiya T.

J Clin Invest. 2016 Apr 1;126(4):1163-72. doi: 10.1172/JCI81130. Epub 2016 Mar 14. Review.


Levonorgestrel-releasing intrauterine system placement for severe uterine cervical stenosis after conization: two case reports.

Motegi E, Hasegawa K, Kawai S, Kiuchi K, Kosaka N, Mochizuki Y, Fukasawa I.

J Med Case Rep. 2016 Mar 9;10:56. doi: 10.1186/s13256-016-0831-9.


Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection.

Fujiwara Y, Matsuda T, Kanamoto M, Tsuchida T, Tsuji K, Kosaka N, Adachi T, Kimura H.

Acta Radiol. 2017 Jan;58(1):84-90. Epub 2016 Feb 17.


Decoding the Secret of Cancer by Means of Extracellular Vesicles.

Kosaka N.

J Clin Med. 2016 Feb 4;5(2). pii: E22. doi: 10.3390/jcm5020022. Review.


PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.

Hirahata M, Osaki M, Kanda Y, Sugimoto Y, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Kawai A, Ito H, Ochiya T, Okada F.

Cancer Med. 2016 May;5(5):892-902. doi: 10.1002/cam4.651. Epub 2016 Jan 28.


Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles.

Hagiwara K, Katsuda T, Gailhouste L, Kosaka N, Ochiya T.

FEBS Lett. 2015 Dec 21;589(24 Pt B):4071-8. doi: 10.1016/j.febslet.2015.11.036. Epub 2015 Nov 26.


Facial Recognition in a Group-Living Cichlid Fish.

Kohda M, Jordan LA, Hotta T, Kosaka N, Karino K, Tanaka H, Taniyama M, Takeyama T.

PLoS One. 2015 Nov 25;10(11):e0142552. doi: 10.1371/journal.pone.0142552. eCollection 2015.


Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.

Fujita Y, Araya J, Ito S, Kobayashi K, Kosaka N, Yoshioka Y, Kadota T, Hara H, Kuwano K, Ochiya T.

J Extracell Vesicles. 2015 Nov 11;4:28388. doi: 10.3402/jev.v4.28388. eCollection 2015.


A robust screening method for dietary agents that activate tumour-suppressor microRNAs.

Hagiwara K, Gailhouste L, Yasukawa K, Kosaka N, Ochiya T.

Sci Rep. 2015 Oct 1;5:14697. doi: 10.1038/srep14697.


Extracellular vesicles in lung microenvironment and pathogenesis.

Fujita Y, Kosaka N, Araya J, Kuwano K, Ochiya T.

Trends Mol Med. 2015 Sep;21(9):533-42. doi: 10.1016/j.molmed.2015.07.004. Epub 2015 Jul 28. Review.


Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer.

Tokuhisa M, Ichikawa Y, Kosaka N, Ochiya T, Yashiro M, Hirakawa K, Kosaka T, Makino H, Akiyama H, Kunisaki C, Endo I.

PLoS One. 2015 Jul 24;10(7):e0130472. doi: 10.1371/journal.pone.0130472. eCollection 2015.


On-chip immunoelectrophoresis of extracellular vesicles released from human breast cancer cells.

Akagi T, Kato K, Kobayashi M, Kosaka N, Ochiya T, Ichiki T.

PLoS One. 2015 Apr 30;10(4):e0123603. doi: 10.1371/journal.pone.0123603. eCollection 2015.


Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga N, Kosaka N, Ono M, Katsuda T, Yoshioka Y, Tamura K, Lötvall J, Nakagama H, Ochiya T.

Nat Commun. 2015 Apr 1;6:6716. doi: 10.1038/ncomms7716.


Profiling of circulating microRNAs for prostate cancer biomarker discovery.

Haldrup C, Kosaka N, Ochiya T, Borre M, Høyer S, Orntoft TF, Sorensen KD.

Drug Deliv Transl Res. 2014 Feb;4(1):19-30. doi: 10.1007/s13346-013-0169-4.


Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo.

Asanuma D, Sakabe M, Kamiya M, Yamamoto K, Hiratake J, Ogawa M, Kosaka N, Choyke PL, Nagano T, Kobayashi H, Urano Y.

Nat Commun. 2015 Mar 13;6:6463. doi: 10.1038/ncomms7463.


Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages.

Izumi H, Tsuda M, Sato Y, Kosaka N, Ochiya T, Iwamoto H, Namba K, Takeda Y.

J Dairy Sci. 2015 May;98(5):2920-33. doi: 10.3168/jds.2014-9076. Epub 2015 Feb 26.


Serial changes of (18)F-FDG PET/CT findings in ischiopubic synchondrosis: comparison with contrast-enhanced MRI.

Tsuji K, Tsuchida T, Kosaka N, Tanizawa A, Kimura H.

Hell J Nucl Med. 2015 Jan-Apr;18(1):66-7. doi: 10.1967/s002449910166. Epub 2015 Feb 13.


[Development of an magnetic resonance imaging safety management system for metallic biomedical products using an magnetic resonance compatibility database and inquiry-based patient records].

Fujiwara Y, Kata T, Fujimoto S, Yachida T, Kanamoto M, Nanbu Y, Seki K, Kosaka N, Kimura H, Adachi T.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2014 Dec;70(12):1413-9. doi: 10.6009/jjrt.2014_JSRT_70.12.1413. Japanese.


The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer.

Fujita Y, Yagishita S, Hagiwara K, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Tsuta K, Nokihara H, Tamura T, Asamura H, Kawaishi M, Kuwano K, Ochiya T.

Mol Ther. 2015 Apr;23(4):717-27. doi: 10.1038/mt.2015.10. Epub 2015 Jan 19.


Fat-subtracted three-dimensional time-of-flight MR angiography of the neck by use of fat-only images with the two-point Dixon technique.

Fujiwara Y, Ishimori Y, Yamaguchi I, Kosaka N, Kimura H, Adachi T.

Radiol Phys Technol. 2015 Jul;8(2):193-9. doi: 10.1007/s12194-015-0307-4. Epub 2015 Jan 11.


Development of aseptic subcutaneous abscess after tocilizumab therapy in a patient with SAPHO syndrome complicated by amyloid A amyloidosis.

Fujita S, Kosaka N, Mito T, Hayashi H, Morita Y.

Int J Rheum Dis. 2015 May;18(4):476-9. doi: 10.1111/1756-185X.12525. Epub 2014 Dec 25. No abstract available.


Standardized uptake value differences between primary and metastatic lesions in ¹⁸F-FDG PET/CT of patients with lung cancer.

Kosaka N, Tsuchida T, Tsuji K, Shimizu K, Kimura H.

Acta Radiol. 2015 Nov;56(11):1329-35. doi: 10.1177/0284185114556705. Epub 2014 Nov 14.


RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis.

Fujiwara T, Takahashi RU, Kosaka N, Nezu Y, Kawai A, Ozaki T, Ochiya T.

Mol Ther Nucleic Acids. 2014 Sep 2;3:e189. doi: 10.1038/mtna.2014.35.


Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K, Ochiya T.

Sci Signal. 2014 Jul 1;7(332):ra63. doi: 10.1126/scisignal.2005231.


RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.

Tominaga N, Hagiwara K, Kosaka N, Honma K, Nakagama H, Ochiya T.

Mol Cancer. 2014 May 31;13:134. doi: 10.1186/1476-4598-13-134.


Arterial spin labeling perfusion-weighted MRI for long-term follow-up of a cerebral arteriovenous malformation after stereotactic radiosurgery.

Shimizu K, Kosaka N, Yamamoto T, Shioura H, Kodera T, Kikuta K, Kimura H.

Acta Radiol Short Rep. 2014 Jan 3;3(1):2047981613510160. doi: 10.1177/2047981613510160. eCollection 2014 Jan.


Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy.

Kosaka N, Yoshioka Y, Tominaga N, Hagiwara K, Katsuda T, Ochiya T.

Future Oncol. 2014 Mar;10(4):671-81. doi: 10.2217/fon.13.222. Review.


Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.

Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai A, Ozaki T, Ochiya T.

Stem Cells. 2014 Apr;32(4):959-73. doi: 10.1002/stem.1618.


Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen.

Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T.

Nat Commun. 2014 Apr 7;5:3591. doi: 10.1038/ncomms4591.


CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes.

Yoshitane H, Ozaki H, Terajima H, Du NH, Suzuki Y, Fujimori T, Kosaka N, Shimba S, Sugano S, Takagi T, Iwasaki W, Fukada Y.

Mol Cell Biol. 2014 May;34(10):1776-87. doi: 10.1128/MCB.01465-13. Epub 2014 Mar 3.


Assessment of tumor blood flow and its correlation with histopathologic features in skull base meningiomas and schwannomas by using pseudo-continuous arterial spin labeling images.

Yamamoto T, Takeuchi H, Kinoshita K, Kosaka N, Kimura H.

Eur J Radiol. 2014 May;83(5):817-23. doi: 10.1016/j.ejrad.2014.01.023. Epub 2014 Feb 6.


A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications.

Hagiwara K, Ochiya T, Kosaka N.

Drug Deliv Transl Res. 2014;4(1):31-7. doi: 10.1007/s13346-013-0180-9. Review.


Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey.

Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M.

PLoS One. 2014 Feb 12;9(2):e88843. doi: 10.1371/journal.pone.0088843. eCollection 2014.


The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers.

Katsuda T, Kosaka N, Ochiya T.

Proteomics. 2014 Mar;14(4-5):412-25. doi: 10.1002/pmic.201300389. Review.


Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application.

Katsuda T, Ikeda S, Yoshioka Y, Kosaka N, Kawamata M, Ochiya T.

Biol Chem. 2014 Apr;395(4):365-73. doi: 10.1515/hsz-2013-0222. Review.


Circulating microRNAs in drug safety assessment for hepatic and cardiovascular toxicity: the latest biomarker frontier?

Osaki M, Kosaka N, Okada F, Ochiya T.

Mol Diagn Ther. 2014 Apr;18(2):121-6. doi: 10.1007/s40291-013-0065-0.


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