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Items: 31

1.

Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma.

Akasaki Y, Kikuchi T, Homma S, Koido S, Ohkusa T, Tasaki T, Hayashi K, Komita H, Watanabe N, Suzuki Y, Yamamoto Y, Mori R, Arai T, Tanaka T, Joki T, Yanagisawa T, Murayama Y.

Cancer Immunol Immunother. 2016 Dec;65(12):1499-1509. Epub 2016 Sep 29.

PMID:
27688162
2.

Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells.

Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Nagasaki E, Homma S.

BMC Cancer. 2015 Oct 16;15:726. doi: 10.1186/s12885-015-1772-1.

3.

Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors.

Komita H, Koido S, Hayashi K, Kan S, Ito M, Kamata Y, Suzuki M, Homma S.

Oncol Rep. 2015 Oct;34(4):2099-105. doi: 10.3892/or.2015.4149. Epub 2015 Jul 24.

PMID:
26239720
4.

Gemcitabine treatment enhances HER2 expression in low HER2-expressing breast cancer cells and enhances the antitumor effects of trastuzumab emtansine.

Kan S, Koido S, Okamoto M, Hayashi K, Ito M, Kamata Y, Komita H, Ishidao T, Nagasaki E, Homma S.

Oncol Rep. 2015 Jul;34(1):504-10. doi: 10.3892/or.2015.3974. Epub 2015 May 12.

PMID:
25976081
5.

Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine.

Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H.

World J Gastroenterol. 2014 Oct 21;20(39):14420-9. doi: 10.3748/wjg.v20.i39.14420.

6.

Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer.

Koido S, Homma S, Okamoto M, Takakura K, Mori M, Yoshizaki S, Tsukinaga S, Odahara S, Koyama S, Imazu H, Uchiyama K, Kajihara M, Arakawa H, Misawa T, Toyama Y, Yanagisawa S, Ikegami M, Kan S, Hayashi K, Komita H, Kamata Y, Ito M, Ishidao T, Yusa S, Shimodaira S, Gong J, Sugiyama H, Ohkusa T, Tajiri H.

Clin Cancer Res. 2014 Aug 15;20(16):4228-39. doi: 10.1158/1078-0432.CCR-14-0314. Epub 2014 Jul 23.

7.

Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells.

Koido S, Ito M, Sagawa Y, Okamoto M, Hayashi K, Nagasaki E, Kan S, Komita H, Kamata Y, Homma S.

Cancer Immunol Immunother. 2014 May;63(5):459-68. doi: 10.1007/s00262-014-1531-1. Epub 2014 Mar 14.

PMID:
24627093
8.

Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer.

Nishida S, Koido S, Takeda Y, Homma S, Komita H, Takahara A, Morita S, Ito T, Morimoto S, Hara K, Tsuboi A, Oka Y, Yanagisawa S, Toyama Y, Ikegami M, Kitagawa T, Eguchi H, Wada H, Nagano H, Nakata J, Nakae Y, Hosen N, Oji Y, Tanaka T, Kawase I, Kumanogoh A, Sakamoto J, Doki Y, Mori M, Ohkusa T, Tajiri H, Sugiyama H.

J Immunother. 2014 Feb-Mar;37(2):105-14. doi: 10.1097/CJI.0000000000000020.

9.

Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions.

Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Kamata Y, Ito M, Ohkusa T, Gong J, Tajiri H.

Oncoimmunology. 2013 Sep 1;2(9):e25994. Epub 2013 Sep 12. Review.

10.

Fusions between dendritic cells and whole tumor cells as anticancer vaccines.

Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.

Oncoimmunology. 2013 May 1;2(5):e24437.

11.

Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production.

Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Kajihara M, Uchiyama K, Arihiro S, Imazu H, Arakawa H, Kan S, Hayashi K, Komita H, Kamata Y, Ito M, Hara E, Ohkusa T, Gong J, Tajiri H.

PLoS One. 2013 May 24;8(5):e63498. doi: 10.1371/journal.pone.0063498. Print 2013.

12.

Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes.

Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.

PLoS One. 2013;8(3):e59280. doi: 10.1371/journal.pone.0059280. Epub 2013 Mar 15.

13.

Vaccines targeting tumor blood vessel antigens promote CD8(+) T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice.

Zhao X, Bose A, Komita H, Taylor JL, Chi N, Lowe DB, Okada H, Cao Y, Mukhopadhyay D, Cohen PA, Storkus WJ.

J Immunol. 2012 Feb 15;188(4):1782-8. doi: 10.4049/jimmunol.1101644. Epub 2012 Jan 13.

14.

Immunotherapy synergizes with chemotherapy targeting pancreatic cancer.

Koido S, Homma S, Takahara A, Namiki Y, Komita H, Uchiyama K, Ito M, Gong J, Ohkusa T, Tajiri H.

Immunotherapy. 2012 Jan;4(1):5-7. doi: 10.2217/imt.11.150. No abstract available.

PMID:
22149993
15.

Current immunotherapeutic approaches in pancreatic cancer.

Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, Uchiyama K, Satoh K, Ito M, Komita H, Arakawa H, Ohkusa T, Gong J, Tajiri H.

Clin Dev Immunol. 2011;2011:267539. doi: 10.1155/2011/267539. Epub 2011 Sep 14. Review.

16.

Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response.

Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, Mineno J, Shiku H, Nishida S, Sugiyama H, Tajiri H, Homma S.

Cancer Immunol Immunother. 2011 Sep;60(9):1289-97. doi: 10.1007/s00262-011-1033-3. Epub 2011 May 24.

PMID:
21607557
17.

Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines.

Koido S, Homma S, Takahara A, Namiki Y, Komita H, Nagasaki E, Ito M, Nagatsuma K, Uchiyama K, Satoh K, Ohkusa T, Gong J, Tajiri H.

J Biomed Biotechnol. 2011;2011:910836. doi: 10.1155/2011/910836. Epub 2011 Apr 26. Review.

18.

Intratumoral IL-12 gene therapy results in the crosspriming of Tc1 cells reactive against tumor-associated stromal antigens.

Zhao X, Bose A, Komita H, Taylor JL, Kawabe M, Chi N, Spokas L, Lowe DB, Goldbach C, Alber S, Watkins SC, Butterfield LH, Kalinski P, Kirkwood JM, Storkus WJ.

Mol Ther. 2011 Apr;19(4):805-14. doi: 10.1038/mt.2010.295. Epub 2010 Dec 28.

19.

Regulation of tumor immunity by tumor/dendritic cell fusions.

Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, Tajiri H.

Clin Dev Immunol. 2010;2010:516768. doi: 10.1155/2010/516768. Epub 2010 Oct 26. Review.

20.

Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions.

Koido S, Hara E, Homma S, Namiki Y, Komita H, Takahara A, Nagasaki E, Ito M, Sagawa Y, Mitsunaga M, Uchiyama K, Satoh K, Arihiro S, Ohkusa T, Gong J, Tajiri H.

Clin Immunol. 2010 Jun;135(3):384-400. doi: 10.1016/j.clim.2010.02.003. Epub 2010 Mar 11.

PMID:
20226739
21.

Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity.

Komita H, Zhao X, Katakam AK, Kumar P, Kawabe M, Okada H, Braughler JM, Storkus WJ.

Cancer Gene Ther. 2009 Dec;16(12):883-91. doi: 10.1038/cgt.2009.33. Epub 2009 May 15.

22.

Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity.

Homma S, Koido S, Sagawa Y, Suzuki H, Komita H, Nagasaki E, Takahara A, Horiguchi-Yamada J, Tajiri H, Zeldin DC, Obata T.

Clin Exp Immunol. 2009 May;156(2):344-52. doi: 10.1111/j.1365-2249.2009.03900.x. Epub 2009 Mar 2.

23.

[Diagnosis of Helicobacter pylori infection: comparison with gold standard].

Koido S, Odahara S, Mitsunaga M, Aizawa M, Itoh S, Uchiyama K, Komita H, Satoh K, Kuniyasu Y, Yamane T, Ohkusa T.

Rinsho Byori. 2008 Nov;56(11):1007-13. Review. Japanese.

PMID:
19086456
24.

CD8+ T-cell responses against hemoglobin-beta prevent solid tumor growth.

Komita H, Zhao X, Taylor JL, Sparvero LJ, Amoscato AA, Alber S, Watkins SC, Pardee AD, Wesa AK, Storkus WJ.

Cancer Res. 2008 Oct 1;68(19):8076-84. doi: 10.1158/0008-5472.CAN-08-0387.

25.

In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells.

Koido S, Homma S, Hara E, Mitsunaga M, Namiki Y, Takahara A, Nagasaki E, Komita H, Sagawa Y, Ohkusa T, Fujise K, Gong J, Tajiri H.

J Transl Med. 2008 Sep 15;6:51. doi: 10.1186/1479-5876-6-51.

26.

Mechanism of antitumor effect on mouse hepatocellular carcinoma by intratumoral injection of OK-432, a streptococcal preparation.

Homma S, Sagawa Y, Komita H, Koido S, Nagasaki E, Ryoma Y, Okamoto M.

Cancer Immunol Immunother. 2007 Aug;56(8):1265-74. Epub 2007 Jan 12.

PMID:
17219148
27.

Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma.

Komita H, Homma S, Saotome H, Zeniya M, Ohno T, Toda G.

J Hepatol. 2006 Nov;45(5):662-72. Epub 2006 Jul 7.

PMID:
16935390
28.

Autoimmune hepatic inflammation by vaccination of mice with dendritic cells loaded with well-differentiated hepatocellular carcinoma cells and administration of interleukin-12.

Tamaki S, Homma S, Enomoto Y, Komita H, Zeniya M, Ohno T, Toda G.

Clin Immunol. 2005 Dec;117(3):280-93. Epub 2005 Oct 24.

PMID:
16246626
30.

Repeated administration of cytokines improve the ex-vivo generation of human dendritic cells.

Takeda A, Komita H, Takagi Y, Kikuchi T, Homma S, Hoshi Y, Ohno T, Horiguchi-Yamada J.

J Exp Clin Cancer Res. 2004 Dec;23(4):617-23.

PMID:
15743032
31.

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