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Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.

Kim IK, Kim K, Lee E, Oh DS, Park CS, Park S, Yang JM, Kim JH, Kim HS, Shima DT, Kim JH, Hong SH, Cho YH, Kim YH, Park JB, Koh GY, Ju YS, Lee HK, Lee S, Kim I.

J Exp Med. 2018 Mar 5;215(3):963-983. doi: 10.1084/jem.20170123. Epub 2018 Feb 14.


Organ-specific lymphatic vasculature: From development to pathophysiology.

Petrova TV, Koh GY.

J Exp Med. 2018 Jan 2;215(1):35-49. doi: 10.1084/jem.20171868. Epub 2017 Dec 14. Review.


HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2.

Yang H, Lee MH, Park I, Jeon H, Choi J, Seo S, Kim SW, Koh GY, Park KS, Lee DH.

Cancer Lett. 2017 Dec 28;411:19-26. doi: 10.1016/j.canlet.2017.09.040. Epub 2017 Oct 4.


Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.

Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY.

J Clin Invest. 2017 Oct 2;127(10):3877-3896. doi: 10.1172/JCI94668. Epub 2017 Sep 18.


YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.

Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, Koh GY.

J Clin Invest. 2017 Sep 1;127(9):3441-3461. doi: 10.1172/JCI93825. Epub 2017 Aug 14.


Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology.

Augustin HG, Koh GY.

Science. 2017 Aug 25;357(6353). pii: eaal2379. doi: 10.1126/science.aal2379. Epub 2017 Aug 3. Review.


Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice.

Wu X, Pfalzer AC, Koh GY, Tang S, Crott JW, Thomas MJ, Meydani M, Mason JB.

J Agric Food Chem. 2017 Aug 23;65(33):7200-7209. doi: 10.1021/acs.jafc.7b02648. Epub 2017 Aug 11.


Plastic roles of pericytes in the blood-retinal barrier.

Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, Koh GY.

Nat Commun. 2017 May 16;8:15296. doi: 10.1038/ncomms15296.


Resistant starch as a novel dietary strategy to maintain kidney health in diabetes mellitus.

Koh GY, Rowling MJ.

Nutr Rev. 2017 May 1;75(5):350-360. doi: 10.1093/nutrit/nux006. Review.


VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY.

EMBO Mol Med. 2017 Jun;9(6):750-769. doi: 10.15252/emmm.201607341.


Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells.

Hong SP, Song S, Cho SW, Lee S, Koh BI, Bae H, Kim KH, Park JS, Do HS, Im I, Heo HJ, Ko TH, Park JH, Youm JB, Kim SJ, Kim I, Han J, Han YM, Koh GY.

Sci Rep. 2017 Feb 6;7:41840. doi: 10.1038/srep41840.


Taking aim at Sox18.

Kim I, Koh GY.

Elife. 2017 Jan 31;6. pii: e24238. doi: 10.7554/eLife.24238.


Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

Park JS, Kim IK, Han S, Park I, Kim C, Bae J, Oh SJ, Lee S, Kim JH, Woo DC, He Y, Augustin HG, Kim I, Lee D, Koh GY.

Cancer Cell. 2017 Jan 9;31(1):157-158. doi: 10.1016/j.ccell.2016.12.009. No abstract available.


Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.

Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y.

Elife. 2016 Dec 22;5. pii: e21032. doi: 10.7554/eLife.21032.


Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.

Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG.

J Clin Invest. 2017 Feb 1;127(2):457-471. doi: 10.1172/JCI85145. Epub 2016 Dec 19.


Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

Park JS, Kim IK, Han S, Park I, Kim C, Bae J, Oh SJ, Lee S, Kim JH, Woo DC, He Y, Augustin HG, Kim I, Lee D, Koh GY.

Cancer Cell. 2016 Dec 12;30(6):953-967. doi: 10.1016/j.ccell.2016.10.018. Erratum in: Cancer Cell. 2017 Jan 9;31(1):157-158.


Consumption of Dietary Resistant Starch Partially Corrected the Growth Pattern Despite Hyperglycemia and Compromised Kidney Function in Streptozotocin-Induced Diabetic Rats.

Koh GY, Rowling MJ, Schalinske KL, Grapentine K, Loo YT.

J Agric Food Chem. 2016 Oct 12;64(40):7540-7545. Epub 2016 Sep 30.


Coordinated lymphangiogenesis is critical in lymph node development and maturation.

Lee YG, Koh GY.

Dev Dyn. 2016 Dec;245(12):1189-1197. doi: 10.1002/dvdy.24456. Epub 2016 Oct 3.


Tie1 controls angiopoietin function in vascular remodeling and inflammation.

Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P.

J Clin Invest. 2016 Sep 1;126(9):3495-510. doi: 10.1172/JCI84923. Epub 2016 Aug 22.


SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling.

Kim K, Kim IK, Yang JM, Lee E, Koh BI, Song S, Park J, Lee S, Choi C, Kim JW, Kubota Y, Koh GY, Kim I.

Circ Res. 2016 Sep 16;119(7):839-52. doi: 10.1161/CIRCRESAHA.116.308483. Epub 2016 Aug 15.


PEGylation and HAylation via catechol: α-Amine-specific reaction at N-terminus of peptides and proteins.

Song IT, Lee M, Lee H, Han J, Jang JH, Lee MS, Koh GY, Lee H.

Acta Biomater. 2016 Oct 1;43:50-60. doi: 10.1016/j.actbio.2016.07.018. Epub 2016 Jul 14.


Correction: Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring.

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW.

PLoS One. 2016 Apr 28;11(4):e0154979. doi: 10.1371/journal.pone.0154979. eCollection 2016.


Amelioration of sepsis by TIE2 activation-induced vascular protection.

Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim YI, Kim P, Kim I, Koh GY.

Sci Transl Med. 2016 Apr 20;8(335):335ra55. doi: 10.1126/scitranslmed.aad9260.


Circulating adiponectin concentrations are increased by dietary resistant starch and correlate with serum 25-hydroxycholecalciferol concentrations and kidney function in Zucker diabetic fatty rats.

Koh GY, Derscheid R, Fuller KNZ, Valentine RJ, Leow SE, Reed L, Wisecup E, Schalinske KL, Rowling MJ.

Nutr Res. 2016 Apr;36(4):311-319. doi: 10.1016/j.nutres.2015.12.006. Epub 2015 Dec 8.


Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring.

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW.

PLoS One. 2016 Mar 11;11(3):e0151579. doi: 10.1371/journal.pone.0151579. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0154979.


Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.

Kim Y, Nam HJ, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H, Koh GY, Baek SH.

Nat Commun. 2016 Jan 13;7:10347. doi: 10.1038/ncomms10347.


Whole Egg Consumption Prevents Diminished Serum 25-Hydroxycholecalciferol Concentrations in Type 2 Diabetic Rats.

Jones SK, Koh GY, Rowling MJ, Schalinske KL.

J Agric Food Chem. 2016 Jan 13;64(1):120-4. doi: 10.1021/acs.jafc.5b04347. Epub 2015 Dec 31.


Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.

Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Rossaint J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D.

J Exp Med. 2015 Dec 14;212(13):2267-87. doi: 10.1084/jem.20150718. Epub 2015 Dec 7.


AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.

Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG.

J Cell Biol. 2015 Nov 9;211(3):619-37. doi: 10.1083/jcb.201503113.


A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner.

Oh N, Kim K, Kim SJ, Park I, Lee JE, Seo YS, An HJ, Kim HM, Koh GY.

Sci Rep. 2015 Oct 19;5:15291. doi: 10.1038/srep15291.


Intravital imaging of intestinal lacteals unveils lipid drainage through contractility.

Choe K, Jang JY, Park I, Kim Y, Ahn S, Park DY, Hong YK, Alitalo K, Koh GY, Kim P.

J Clin Invest. 2015 Nov 2;125(11):4042-52. doi: 10.1172/JCI76509. Epub 2015 Oct 5.


Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.

Cahoon JM, Rai RR, Carroll LS, Uehara H, Zhang X, O'Neil CL, Medina RJ, Das SK, Muddana SK, Olson PR, Nielson S, Walker K, Flood MM, Messenger WB, Archer BJ, Barabas P, Krizaj D, Gibson CC, Li DY, Koh GY, Gao G, Stitt AW, Ambati BK.

Diabetes. 2015 Dec;64(12):4247-59. doi: 10.2337/db14-1030. Epub 2015 Sep 4.


Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion.

Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, Cho ES, Kim H, Adams RH, Yoo OJ, Koh GY.

Development. 2015 Aug 1;142(15):2623-32. doi: 10.1242/dev.125336.


Mouse Hepatic Tumor Vascular Imaging by Experimental Selective Angiography.

Kim SK, Kim H, Koh GY, Lim DS, Yu DY, Kim MD, Park MS, Lim JS.

PLoS One. 2015 Jul 1;10(7):e0131687. doi: 10.1371/journal.pone.0131687. eCollection 2015.


Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers.

Yun SJ, Jeong P, Kang HW, Kim YH, Kim EA, Yan C, Choi YK, Kim D, Kim JM, Kim SK, Kim SY, Kim ST, Kim WT, Lee OJ, Koh GY, Moon SK, Kim IY, Kim J, Choi YH, Kim WJ.

Int Neurourol J. 2015 Jun;19(2):74-84. doi: 10.5213/inj.2015.19.2.74. Epub 2015 Jun 29.


The pericyte as a cellular regulator of penile erection and a novel therapeutic target for erectile dysfunction.

Yin GN, Das ND, Choi MJ, Song KM, Kwon MH, Ock J, Limanjaya A, Ghatak K, Kim WJ, Hyun JS, Koh GY, Ryu JK, Suh JK.

Sci Rep. 2015 Jun 5;5:10891. doi: 10.1038/srep10891.


Bioluminescence-activated deep-tissue photodynamic therapy of cancer.

Kim YR, Kim S, Choi JW, Choi SY, Lee SH, Kim H, Hahn SK, Koh GY, Yun SH.

Theranostics. 2015 Apr 18;5(8):805-17. doi: 10.7150/thno.11520. eCollection 2015.


Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts.

Syrjälä SO, Nykänen AI, Tuuminen R, Raissadati A, Keränen MA, Arnaudova R, Krebs R, Koh GY, Alitalo K, Lemström KB.

Am J Transplant. 2015 Aug;15(8):2075-84. doi: 10.1111/ajt.13296. Epub 2015 May 1.


Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization.

Kim BH, Lee J, Choi JS, Park DY, Song HY, Park TK, Cho CH, Ye SK, Joo CK, Koh GY, Kim TY.

Br J Pharmacol. 2015 Aug;172(15):3875-89. doi: 10.1111/bph.13177. Epub 2015 Jun 26.


COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway.

Moon HE, Byun K, Park HW, Kim JH, Hur J, Park JS, Jun JK, Kim HS, Paek SL, Kim IK, Hwang JH, Kim JW, Kim DG, Sung YC, Koh GY, Song CW, Lee B, Paek SH.

Exp Neurobiol. 2015 Mar;24(1):55-70. doi: 10.5607/en.2015.24.1.55. Epub 2015 Mar 13.


Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse.

Ryu JK, Kim WJ, Koh YJ, Piao S, Jin HR, Lee SW, Choi MJ, Shin HY, Kwon MH, Jung K, Koh GY, Suh JK.

Sci Rep. 2015 Mar 18;5:9222. doi: 10.1038/srep09222.


Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.

Lee S, Kim IK, Ahn JS, Woo DC, Kim ST, Song S, Koh GY, Kim HS, Jeon BH, Kim I.

Circulation. 2015 Mar 17;131(11):995-1005. doi: 10.1161/CIRCULATIONAHA.114.012568. Epub 2015 Jan 16.


Novel glycosylated VEGF decoy receptor fusion protein, VEGF-Grab, efficiently suppresses tumor angiogenesis and progression.

Lee JE, Kim C, Yang H, Park I, Oh N, Hua S, Jeong H, An HJ, Kim SC, Lee GM, Koh GY, Kim HM.

Mol Cancer Ther. 2015 Feb;14(2):470-9. doi: 10.1158/1535-7163.MCT-14-0968-T. Epub 2014 Dec 22.


Angiopoietin-1 blocks neurotoxic zinc entry into cortical cells via PIP2 hydrolysis-mediated ion channel inhibition.

Lim JS, Koh GY, Koh JY.

Neurobiol Dis. 2015 Sep;81:203-13. doi: 10.1016/j.nbd.2014.11.001. Epub 2014 Nov 9.


Cytotoxic and antiangiogenic paclitaxel solubilized and permeation-enhanced by natural product nanoparticles.

Liu Z, Zhang F, Koh GY, Dong X, Hollingsworth J, Zhang J, Russo PS, Yang P, Stout RW.

Anticancer Drugs. 2015 Feb;26(2):167-79. doi: 10.1097/CAD.0000000000000173.


Dietary resistant starch prevents urinary excretion of vitamin D metabolites and maintains circulating 25-hydroxycholecalciferol concentrations in Zucker diabetic fatty rats.

Koh GY, Whitley EM, Mancosky K, Loo YT, Grapentine K, Bowers E, Schalinske KL, Rowling MJ.

J Nutr. 2014 Nov;144(11):1667-73. doi: 10.3945/jn.114.198200. Epub 2014 Aug 27.


Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.

Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I.

Nat Commun. 2014 Jul 29;5:4552. doi: 10.1038/ncomms5552.


Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.

Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY.

J Clin Invest. 2014 Sep;124(9):3960-74. doi: 10.1172/JCI75392. Epub 2014 Jul 25.


Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse.

Yin GN, Choi MJ, Kim WJ, Kwon MH, Song KM, Park JM, Das ND, Kwon KD, Batbold D, Oh GT, Koh GY, Kim KW, Ryu JK, Suh JK.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2731-40. doi: 10.1073/pnas.1403471111. Epub 2014 Jun 16.

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