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Items: 1 to 50 of 867

1.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

PMID:
29676732
2.

A Pseudo-Kinase Double Act.

Preuß F, Mathea S, Knapp S.

Structure. 2018 Apr 3;26(4):527-528. doi: 10.1016/j.str.2018.03.008.

PMID:
29617648
3.

Genome-Wide Association Mapping Uncovers Fw1, a Dominant Gene Conferring Resistance to Fusarium Wilt in Strawberry.

Pincot DDA, Poorten TJ, Hardigan MA, Harshman JM, Acharya CB, Cole GS, Gordon TR, Stueven M, Edger PP, Knapp SJ.

G3 (Bethesda). 2018 Mar 30. pii: g3.200129.2018. doi: 10.1534/g3.118.200129. [Epub ahead of print]

4.

Halogen-aromatic π-interactions modulate inhibitor residence time.

Heroven C, Georgi V, Ganotra GK, Brennan PE, Wolfreys F, Wade RC, Fernández-Montalván AE, Chaikuad A, Knapp S.

Angew Chem Int Ed Engl. 2018 Mar 30. doi: 10.1002/anie.201801666. [Epub ahead of print]

PMID:
29601130
5.

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.

Bowkett D, Talon R, Tallant C, Schofield C, von Delft F, Knapp S, Bruton G, Brennan PE.

ChemMedChem. 2018 Mar 26. doi: 10.1002/cmdc.201800030. [Epub ahead of print]

PMID:
29578648
6.

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells.

Wroblewski M, Scheller-Wendorff M, Udonta F, Bauer R, Schlichting J, Zhao L, Ben Batalla I, Gensch V, Päsler S, Wu L, Wanior M, Taipaleenmäki H, Bolamperti S, Najafova Z, Pantel K, Bokemeyer C, Qi J, Hesse E, Knapp S, Johnsen S, Loges S.

Haematologica. 2018 Mar 22. pii: haematol.2017.181354. doi: 10.3324/haematol.2017.181354. [Epub ahead of print]

7.

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.

Moustakim M, Riedel K, Schuller M, Gehring AP, Monteiro OP, Martin SP, Fedorov O, Heer J, Dixon DJ, Elkins JM, Knapp S, Bracher F, Brennan PE.

Bioorg Med Chem. 2018 Mar 12. pii: S0968-0896(18)30337-7. doi: 10.1016/j.bmc.2018.03.020. [Epub ahead of print]

8.

Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.

Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV.

Biochemistry. 2018 Apr 10;57(14):2140-2149. doi: 10.1021/acs.biochem.8b00150. Epub 2018 Mar 28.

PMID:
29558110
9.

New opportunities for kinase drug repurposing and target discovery.

Knapp S.

Br J Cancer. 2018 Apr;118(7):936-937. doi: 10.1038/s41416-018-0045-6. Epub 2018 Mar 16.

PMID:
29545596
10.

A new commelinid monocot seed fossil from the early Eocene previously identified as Solanaceae.

Särkinen T, Kottner S, Stuppy W, Ahmed F, Knapp S.

Am J Bot. 2018 Jan;105(1):95-107. doi: 10.1002/ajb2.1009. Epub 2018 Feb 12.

11.

θ-Defensins-A Magic Bullet for Acute Lung Injury?

Knapp S.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):277-278. doi: 10.1165/rcmb.2017-0368ED. No abstract available.

PMID:
29493326
12.

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.

Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Felici M, Behrends C, Klinger FG, Dötsch V.

Nat Struct Mol Biol. 2018 Mar;25(3):261-269. doi: 10.1038/s41594-018-0035-7. Epub 2018 Feb 26.

PMID:
29483652
13.

Computational assessment of thioether isosteres.

Barrows RD, Blacklock KM, Rablen PR, Khare SD, Knapp S.

J Mol Graph Model. 2018 Mar;80:282-292. doi: 10.1016/j.jmgm.2018.01.018. Epub 2018 Feb 1.

PMID:
29414047
14.

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.

Zheng Y, Sethi R, Mangala LS, Taylor C, Goldsmith J, Wang M, Masuda K, Karaminejadranjbar M, Mannion D, Miranda F, Herrero-Gonzalez S, Hellner K, Chen F, Alsaadi A, Albukhari A, Fotso DC, Yau C, Jiang D, Pradeep S, Rodriguez-Aguayo C, Lopez-Berestein G, Knapp S, Gray NS, Campo L, Myers KA, Dhar S, Ferguson D, Bast RC Jr., Sood AK, von Delft F, Ahmed AA.

Nat Commun. 2018 Feb 2;9(1):476. doi: 10.1038/s41467-017-02811-7.

15.

Digest: Shape-shifting in Solanaceae flowers: The influence of pollinators.

Dodsworth S, Orejuela A, Pérez-Escobar OA, Särkinen T, Knapp S.

Evolution. 2018 Mar;72(3):717-718. doi: 10.1111/evo.13437. Epub 2018 Mar 1. No abstract available.

PMID:
29380354
16.

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.

Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jimenez-Agüero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O, Mann DA.

Gut. 2018 Jan 27. pii: gutjnl-2017-314107. doi: 10.1136/gutjnl-2017-314107. [Epub ahead of print]

17.

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E.

PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018.

18.

Stereochemistry and Reactivity of the HPA-Imine Mannich Intermediate.

Polyak D, Phung N, Liu J, Barrows R, Emge TJ, Knapp S.

Tetrahedron Lett. 2017 Oct 4;58(40):3879-3883. doi: 10.1016/j.tetlet.2017.08.070. Epub 2017 Aug 31.

PMID:
29276314
19.

Single-molecule sequencing and optical mapping yields an improved genome of woodland strawberry (Fragaria vesca) with chromosome-scale contiguity.

Edger PP, VanBuren R, Colle M, Poorten TJ, Wai CM, Niederhuth CE, Alger EI, Ou S, Acharya CB, Wang J, Callow P, McKain MR, Shi J, Collier C, Xiong Z, Mower JP, Slovin JP, Hytönen T, Jiang N, Childs KL, Knapp SJ.

Gigascience. 2018 Feb 1;7(2):1-7. doi: 10.1093/gigascience/gix124.

20.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.

Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB.

Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22.

21.

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM.

Bioorg Med Chem. 2018 Jan 1;26(1):25-36. doi: 10.1016/j.bmc.2017.10.042. Epub 2017 Nov 4.

PMID:
29170024
22.

Precious plants.

Knapp S.

Nat Plants. 2017 Nov;3(11):836. doi: 10.1038/s41477-017-0054-0. No abstract available.

PMID:
29116225
23.

The Type 1 Diabetes-Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice.

Whitener RL, Gallo Knight L, Li J, Knapp S, Zhang S, Annamalai M, Pliner VM, Fu D, Radichev I, Amatya C, Savinov A, Yurdagul A Jr, Yuan S, Glawe J, Kevil CG, Chen J, Stimpson SE, Mathews CE.

J Immunol. 2017 Dec 15;199(12):3991-4000. doi: 10.4049/jimmunol.1602037. Epub 2017 Nov 6.

PMID:
29109122
24.

Heme and hemolysis in innate immunity: adding insult to injury.

Martins R, Knapp S.

Curr Opin Immunol. 2018 Feb;50:14-20. doi: 10.1016/j.coi.2017.10.005. Epub 2017 Nov 5. Review.

PMID:
29107115
25.

Estimating the potential biodiversity impact of redeveloping small urban spaces: the Natural History Museum's grounds.

Phillips HRP, Knapp S, Purvis A.

PeerJ. 2017 Oct 30;5:e3914. doi: 10.7717/peerj.3914. eCollection 2017.

26.

Pharmacoproteomic characterisation of human colon and rectal cancer.

Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.

Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701.

27.

Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor.

Dutra LA, Heidenreich D, Silva GDBD, Man Chin C, Knapp S, Santos JLD.

Nutrients. 2017 Oct 27;9(11). pii: E1172. doi: 10.3390/nu9111172.

28.

The Shenzhen Declaration on Plant Sciences: Too late or just in time?

Kress WJ, Knapp S.

PhytoKeys. 2017 Sep 18;(86):1-2. doi: 10.3897/phytokeys.86.20712. eCollection 2017. No abstract available.

29.

A revision of the Solanum elaeagnifolium clade (Elaeagnifolium clade; subgenus Leptostemonum, Solanaceae).

Knapp S, Sagona E, Carbonell AKZ, Chiarini F.

PhytoKeys. 2017 Aug 7;(84):1-104. doi: 10.3897/phytokeys.84.12695. eCollection 2017.

30.

The Cysteinome of Protein Kinases as a Target in Drug Development.

Chaikuad A, Koch P, Laufer SA, Knapp S.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4372-4385. doi: 10.1002/anie.201707875. Epub 2018 Feb 2. Review.

PMID:
28994500
31.

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S.

ACS Chem Biol. 2017 Nov 17;12(11):2866-2874. doi: 10.1021/acschembio.7b00445. Epub 2017 Oct 19.

PMID:
28991428
32.

Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.

Wang BD, Ceniccola K, Hwang S, Andrawis R, Horvath A, Freedman JA, Olender J, Knapp S, Ching T, Garmire L, Patel V, Garcia-Blanco MA, Patierno SR, Lee NH.

Nat Commun. 2017 Sep 27;8:16161. doi: 10.1038/ncomms16161.

33.

18 F-FDG-PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin.

Grobman M, Cohn L, Knapp S, Bryan JN, Reinero C.

Vet Radiol Ultrasound. 2018 Jan;59(1):107-115. doi: 10.1111/vru.12562. Epub 2017 Sep 18.

PMID:
28925085
34.

Amazon plant diversity revealed by a taxonomically verified species list.

Cardoso D, Särkinen T, Alexander S, Amorim AM, Bittrich V, Celis M, Daly DC, Fiaschi P, Funk VA, Giacomin LL, Goldenberg R, Heiden G, Iganci J, Kelloff CL, Knapp S, Cavalcante de Lima H, Machado AFP, Dos Santos RM, Mello-Silva R, Michelangeli FA, Mitchell J, Moonlight P, de Moraes PLR, Mori SA, Nunes TS, Pennington TD, Pirani JR, Prance GT, de Queiroz LP, Rapini A, Riina R, Rincon CAV, Roque N, Shimizu G, Sobral M, Stehmann JR, Stevens WD, Taylor CM, Trovó M, van den Berg C, van der Werff H, Viana PL, Zartman CE, Forzza RC.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10695-10700. doi: 10.1073/pnas.1706756114. Epub 2017 Sep 18.

35.

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.

Kosack L, Gawish R, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S, Bergthaler A.

Sci Rep. 2017 Sep 12;7(1):11289. doi: 10.1038/s41598-017-10637-y.

36.

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.

ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. doi: 10.1021/acschembio.7b00481. Epub 2017 Sep 12.

37.

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension.

Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP.

Eur Respir J. 2017 Aug 24;50(2). pii: 1700764. doi: 10.1183/13993003.00764-2017. Print 2017 Aug. No abstract available.

38.

Characterization of a highly selective inhibitor of the Aurora kinases.

Ferguson FM, Doctor ZM, Chaikuad A, Sim T, Kim ND, Knapp S, Gray NS.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4405-4408. doi: 10.1016/j.bmcl.2017.08.016. Epub 2017 Aug 10.

PMID:
28818446
39.

Statistical Analysis on the Performance of Molecular Mechanics Poisson-Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study.

Aldeghi M, Bodkin MJ, Knapp S, Biggin PC.

J Chem Inf Model. 2017 Sep 25;57(9):2203-2221. doi: 10.1021/acs.jcim.7b00347. Epub 2017 Aug 24.

40.

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.

PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.

41.

19 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.

Dalvit C, Knapp S.

Magn Reson Chem. 2017 Dec;55(12):1091-1095. doi: 10.1002/mrc.4640. Epub 2017 Aug 24.

PMID:
28762528
42.

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.

Abu Jhaisha S, Widowati EW, Kii I, Sonamoto R, Knapp S, Papadopoulos C, Becker W.

Sci Rep. 2017 Jul 25;7(1):6420. doi: 10.1038/s41598-017-06874-w.

43.

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.

Igoe N, Bayle ED, Tallant C, Fedorov O, Meier JC, Savitsky P, Rogers C, Morias Y, Scholze S, Boyd H, Cunoosamy D, Andrews DM, Cheasty A, Brennan PE, Müller S, Knapp S, Fish PV.

J Med Chem. 2017 Aug 24;60(16):6998-7011. doi: 10.1021/acs.jmedchem.7b00611. Epub 2017 Aug 10.

PMID:
28714688
44.

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.

Melo-Hanchuk TD, Slepicka PF, Meirelles GV, Basei FL, Lovato DV, Granato DC, Pauletti BA, Domingues RR, Leme AFP, Pelegrini AL, Lenz G, Knapp S, Elkins JM, Kobarg J.

Sci Rep. 2017 Jul 14;7(1):5445. doi: 10.1038/s41598-017-05325-w.

45.

Erratum to: Impact of e-publication changes in the International Code of Nomenclature for algae, fungi and plants (Melbourne Code, 2012) - did we need to "run for our lives"?

Nicolson N, Challis K, Tucker A, Knapp S.

BMC Evol Biol. 2017 Jul 3;17(1):156. doi: 10.1186/s12862-017-1009-9. No abstract available.

46.

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.

Wang BD, Ceniccola K, Hwang S, Andrawis R, Horvath A, Freedman JA, Olender J, Knapp S, Ching T, Garmire L, Patel V, Garcia-Blanco MA, Patierno SR, Lee NH.

Nat Commun. 2017 Jun 30;8:15921. doi: 10.1038/ncomms15921. Erratum in: Nat Commun. 2017 Sep 27;8:16161.

47.

Taxonomy: naming algae, fungi, plants.

Funk VA, Herendeen P, Knapp S.

Nature. 2017 Jun 28;546(7660):599. doi: 10.1038/546599c. No abstract available.

PMID:
28658217
48.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.

49.

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E, Feng FY, Nelson PS, Saatcioglu F, Knudsen KE, Tammela TLJ, Sauter G, Schlomm T, Nykter M, Visakorpi T, Mills IG.

Cell Rep. 2017 Jun 6;19(10):2045-2059. doi: 10.1016/j.celrep.2017.05.049.

50.

Metabolic Impact of Rapamycin (Sirolimus) and B-Estradiol Using Mouse Embryonic Fibroblasts as a Model for Lymphangioleiomyomatosis.

Marsh KM, Schipper D, Ferng AS, Johnson K, Fisher J, Knapp S, Dicken D, Khalpey Z.

Lung. 2017 Aug;195(4):425-430. doi: 10.1007/s00408-017-0016-3. Epub 2017 Jun 2.

PMID:
28577037

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