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Items: 28

1.

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.

Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:42-49. doi: 10.1016/j.jchromb.2018.02.006. Epub 2018 Feb 8.

PMID:
29477066
2.

A multifunctional catalyst that stereoselectively assembles prodrugs.

DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW.

Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936.

PMID:
28450641
3.

Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189.

Simmons B, Liu Z, Klapars A, Bellomo A, Silverman SM.

Org Lett. 2017 May 5;19(9):2218-2221. doi: 10.1021/acs.orglett.7b00469. Epub 2017 Apr 18.

PMID:
28418681
4.

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM.

Org Lett. 2016 Nov 18;18(22):5888-5891. Epub 2016 Nov 1.

PMID:
27802043
5.

Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-Alkylation.

Chung JY, Shevlin M, Klapars A, Journet M.

Org Lett. 2016 Apr 15;18(8):1812-5. doi: 10.1021/acs.orglett.6b00548. Epub 2016 Mar 25.

PMID:
27015542
6.

A highly efficient asymmetric synthesis of vernakalant.

Limanto J, Ashley ER, Yin J, Beutner GL, Grau BT, Kassim AM, Kim MM, Klapars A, Liu Z, Strotman HR, Truppo MD.

Org Lett. 2014 May 16;16(10):2716-9. doi: 10.1021/ol501002a. Epub 2014 May 1.

PMID:
24786635
7.

Enantioselective synthesis of an HCV NS5a antagonist.

Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I.

Org Lett. 2014 May 2;16(9):2310-3. doi: 10.1021/ol500971c. Epub 2014 Apr 11.

PMID:
24724971
8.

Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.

Barker G, McGrath JL, Klapars A, Stead D, Zhou G, Campos KR, O'Brien P.

J Org Chem. 2011 Aug 5;76(15):5936-53. doi: 10.1021/jo2011347. Epub 2011 Jul 8.

PMID:
21714542
9.

Enantioselective, biocatalytic reduction of 3-substituted cyclopentenones: application to the asymmetric synthesis of an hNK-1 receptor antagonist.

Campos KR, Klapars A, Kohmura Y, Pollard D, Ishibashi H, Kato S, Takezawa A, Waldman JH, Wallace DJ, Chen CY, Yasuda N.

Org Lett. 2011 Mar 4;13(5):1004-7. doi: 10.1021/ol1030348. Epub 2011 Feb 8.

PMID:
21302901
10.

Identification and structural elucidation of process impurities generated in the end-game synthesis of taranabant (MK-0364) via cyanuric chloride.

Chen YW, Liu Y, Novak T, Frey L, Campos K, Klapars A, Chen CY, Phenix B.

J Pharm Biomed Anal. 2009 Apr 5;49(3):702-10. doi: 10.1016/j.jpba.2009.01.003. Epub 2009 Jan 9.

PMID:
19188037
11.

Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

Klapars A, Campos KR, Waldman JH, Zewge D, Dormer PG, Chen CY.

J Org Chem. 2008 Jul 4;73(13):4986-93. doi: 10.1021/jo8006804. Epub 2008 May 29.

PMID:
18507444
12.

N-silyl protecting groups for labile aziridines: application toward the synthesis of N-H aziridinomitosenes.

Warner DL, Hibberd AM, Kalman M, Klapars A, Vedejs E.

J Org Chem. 2007 Oct 26;72(22):8519-22. Epub 2007 Oct 2.

PMID:
17910500
13.

Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine.

Campos KR, Klapars A, Waldman JH, Dormer PG, Chen CY.

J Am Chem Soc. 2006 Mar 22;128(11):3538-9.

PMID:
16536525
14.

Mild and practical method for the alpha-arylation of nitriles with heteroaryl halides.

Klapars A, Waldman JH, Campos KR, Jensen MS, McLaughlin M, Chung JY, Cvetovich RJ, Chen CY.

J Org Chem. 2005 Nov 25;70(24):10186-9.

PMID:
16292870
15.

Sequence-specific DNA interstrand cross-linking by an aziridinomitosene in the absence of exogenous reductant.

Rink SM, Warner DL, Klapars A, Vedejs E.

Biochemistry. 2005 Oct 25;44(42):13981-6.

PMID:
16229487
16.

Preparation of enamides via palladium-catalyzed amidation of enol tosylates.

Klapars A, Campos KR, Chen CY, Volante RP.

Org Lett. 2005 Mar 17;7(6):1185-8.

PMID:
15760170
17.

Synthesis of medium ring nitrogen heterocycles via a tandem copper-catalyzed C-N bond formation-ring-expansion process.

Klapars A, Parris S, Anderson KW, Buchwald SL.

J Am Chem Soc. 2004 Mar 24;126(11):3529-33.

PMID:
15025480
18.

Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies.

Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H.

J Am Chem Soc. 2003 Dec 24;125(51):15796-806.

PMID:
14677970
19.

Copper-catalyzed coupling of amides and carbamates with vinyl halides.

Jiang L, Job GE, Klapars A, Buchwald SL.

Org Lett. 2003 Oct 2;5(20):3667-9.

PMID:
14507200
20.

Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions.

Huang X, Anderson KW, Zim D, Jiang L, Klapars A, Buchwald SL.

J Am Chem Soc. 2003 Jun 4;125(22):6653-5. Erratum in: J Am Chem Soc. 2003 Sep 3;125(35):10767.

PMID:
12769573
21.

Copper-catalyzed domino halide exchange-cyanation of aryl bromides.

Zanon J, Klapars A, Buchwald SL.

J Am Chem Soc. 2003 Mar 12;125(10):2890-1.

PMID:
12617652
22.

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.

Klapars A, Buchwald SL.

J Am Chem Soc. 2002 Dec 18;124(50):14844-5.

PMID:
12475315
23.

The copper-catalyzed N-arylation of indoles.

Antilla JC, Klapars A, Buchwald SL.

J Am Chem Soc. 2002 Oct 2;124(39):11684-8.

PMID:
12296734
24.

A general and efficient copper catalyst for the amidation of aryl halides.

Klapars A, Huang X, Buchwald SL.

J Am Chem Soc. 2002 Jun 26;124(25):7421-8.

PMID:
12071751
25.

Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere.

Kwong FY, Klapars A, Buchwald SL.

Org Lett. 2002 Feb 21;4(4):581-4.

PMID:
11843596
26.

Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides.

Wolter M, Klapars A, Buchwald SL.

Org Lett. 2001 Nov 15;3(23):3803-5.

PMID:
11700143
27.

Reductive deprotection of N-tritylaziridines.

Vedejs E, Klapars A, Warner DL, Weiss AH.

J Org Chem. 2001 Nov 2;66(22):7542-6. No abstract available.

PMID:
11681978
28.

A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles.

Klapars A, Antilla JC, Huang X, Buchwald SL.

J Am Chem Soc. 2001 Aug 8;123(31):7727-9. No abstract available.

PMID:
11481007

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