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Items: 1 to 50 of 140

1.

High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides.

de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS.

Sci Transl Med. 2018 May 9;10(440). pii: eaar5894. doi: 10.1126/scitranslmed.aar5894.

PMID:
29743350
2.

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing αβ T cell clones.

Matos TR, O'Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA.

J Clin Invest. 2017 Nov 1;127(11):4031-4041. doi: 10.1172/JCI93396. Epub 2017 Sep 25.

3.

The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications.

Anderson KC, Auclair D, Kelloff GJ, Sigman CC, Avet-Loiseau H, Farrell AT, Gormley NJ, Kumar SK, Landgren O, Munshi NC, Cavo M, Davies FE, Di Bacco A, Dickey JS, Gutman SI, Higley HR, Hussein MA, Jessup JM, Kirsch IR, Little RF, Loberg RD, Lohr JG, Mukundan L, Omel JL, Pugh TJ, Reaman GH, Robbins MD, Sasser AK, Valente N, Zamagni E.

Clin Cancer Res. 2017 Aug 1;23(15):3980-3993. doi: 10.1158/1078-0432.CCR-16-2895. Epub 2017 Apr 20.

PMID:
28428191
4.

Eosinophil-Rich Acute Febrile Neutrophilic Dermatosis in a Patient With Enteropathy-Associated T-cell Lymphoma, Type 1.

Soon CW, Kirsch IR, Connolly AJ, Kwong BY, Kim J.

Am J Dermatopathol. 2016 Sep;38(9):704-8. doi: 10.1097/DAD.0000000000000549.

PMID:
27097333
5.

TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL.

Kirsch IR, Watanabe R, O'Malley JT, Williamson DW, Scott LL, Elco CP, Teague JE, Gehad A, Lowry EL, LeBoeuf NR, Krueger JG, Robins HS, Kupper TS, Clark RA.

Sci Transl Med. 2015 Oct 7;7(308):308ra158. doi: 10.1126/scitranslmed.aaa9122.

6.

Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma.

Rook AH, Gelfand JM, Wysocka M, Troxel AB, Benoit B, Surber C, Elenitsas R, Buchanan MA, Leahy DS, Watanabe R, Kirsch IR, Kim EJ, Clark RA.

Blood. 2015 Sep 17;126(12):1452-61. doi: 10.1182/blood-2015-02-630335. Epub 2015 Jul 30. Erratum in: Blood. 2015 Dec 17;126(25):2765. Gelfand, Joel C [corrected to Gelfand, Joel M].

7.

An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency.

Bailis JM, Gordon ML, Gurgel JL, Komor AC, Barton JK, Kirsch IR.

PLoS One. 2013 Oct 29;8(10):e78726. doi: 10.1371/journal.pone.0078726. eCollection 2013.

8.

Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.

Klorin G, Rozenblum E, Glebov O, Walker RL, Park Y, Meltzer PS, Kirsch IR, Kaye FJ, Roschke AV.

Cancer Genet. 2013 May;206(5):191-205. doi: 10.1016/j.cancergen.2013.04.006. Epub 2013 Jul 5.

9.

The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

Castiel A, Danieli MM, David A, Moshkovitz S, Aplan PD, Kirsch IR, Brandeis M, Krämer A, Izraeli S.

J Cell Sci. 2011 Feb 15;124(Pt 4):532-9. doi: 10.1242/jcs.079731. Epub 2011 Jan 18.

10.

Colonoscopy use following mutation detection in Lynch syndrome: exploring a role for cancer screening in adaptation.

Hadley DW, Ashida S, Jenkins JF, Calzone KA, Kirsch IR, Koehly LM.

Clin Genet. 2011 Apr;79(4):321-8. doi: 10.1111/j.1399-0004.2010.01622.x. Epub 2011 Jan 19.

11.

Generation after generation: exploring the psychological impact of providing genetic services through a cascading approach.

Hadley DW, Ashida S, Jenkins JF, Martin JC, Calzone KA, Kuhn NR, McBride CM, Kirsch IR, Koehly LM.

Genet Med. 2010 Dec;12(12):808-15. doi: 10.1097/GIM.0b013e3181f69dbb.

PMID:
20921894
12.

Targeting karyotypic complexity and chromosomal instability of cancer cells.

Roschke AV, Kirsch IR.

Curr Drug Targets. 2010 Oct;11(10):1341-50. Review.

14.

Perceptions of cancer risks and predictors of colon and endometrial cancer screening in women undergoing genetic testing for Lynch syndrome.

Hadley DW, Jenkins JF, Steinberg SM, Liewehr D, Moller S, Martin JC, Calzone KA, Soballe PW, Kirsch IR.

J Clin Oncol. 2008 Feb 20;26(6):948-54. doi: 10.1200/JCO.2007.13.0575.

PMID:
18281669
15.

Predictive value of microsatellite instability-high remains controversial.

Kim GP, Colangelo LH, Paik S, O'Connell MJ, Kirsch IR, Allegra C, Wolmark N.

J Clin Oncol. 2007 Oct 20;25(30):4857; author reply 4857-8. No abstract available.

PMID:
17947740
16.

Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.

Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR.

Mol Endocrinol. 2007 Dec;21(12):3013-27. Epub 2007 Aug 23.

PMID:
17717072
17.

Randomized comparison of phone versus in-person BRCA1/2 predisposition genetic test result disclosure counseling.

Jenkins J, Calzone KA, Dimond E, Liewehr DJ, Steinberg SM, Jourkiv O, Klein P, Soballe PW, Prindiville SA, Kirsch IR.

Genet Med. 2007 Aug;9(8):487-95.

PMID:
17700386
18.

Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study.

Kim GP, Colangelo LH, Wieand HS, Paik S, Kirsch IR, Wolmark N, Allegra CJ; National Cancer Institute.

J Clin Oncol. 2007 Mar 1;25(7):767-72. Epub 2007 Jan 16.

PMID:
17228023
19.

Gene expression patterns distinguish colonoscopically isolated human aberrant crypt foci from normal colonic mucosa.

Glebov OK, Rodriguez LM, Soballe P, DeNobile J, Cliatt J, Nakahara K, Kirsch IR.

Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2253-62.

20.

DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators.

Hart JR, Glebov O, Ernst RJ, Kirsch IR, Barton JK.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15359-63. Epub 2006 Oct 9.

21.

Linking the human cytogenetic map with nucleotide sequence: the CCAP clone set.

Jang W, Yonescu R, Knutsen T, Brown T, Reppert T, Sirotkin K, Schuler GD, Ried T, Kirsch IR.

Cancer Genet Cytogenet. 2006 Jul 15;168(2):89-97.

PMID:
16843097
22.

Celecoxib treatment alters the gene expression profile of normal colonic mucosa.

Glebov OK, Rodriguez LM, Lynch P, Patterson S, Lynch H, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, Denobile J, Soballe P, Gallinger S, Buchbinder A, Gordon G, Hawk E, Kirsch IR.

Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1382-91.

23.

Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population.

Joshi N, Johnson LL, Wei WQ, Abnet CC, Dong ZW, Taylor PR, Limburg PJ, Dawsey SM, Hawk ET, Qiao YL, Kirsch IR.

Cancer Res. 2006 Jul 1;66(13):6851-60.

24.

Selenomethionine treatment does not alter gene expression in normal squamous esophageal mucosa in a high-risk Chinese population.

Joshi N, Johnson LL, Wei WQ, Abnet CC, Dong ZW, Taylor PR, Limburg PJ, Dawsey SM, Hawk ET, Qiao YL, Kirsch IR.

Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1046-7.

25.

Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells.

Wallqvist A, Huang R, Covell DG, Roschke AV, Gelhaus KS, Kirsch IR.

Mol Cancer Ther. 2005 Oct;4(10):1559-68.

26.

Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.

Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, Kirsch IR, Kaye FJ.

Cancer Res. 2005 Aug 15;65(16):7137-44.

27.

Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.

Campaner S, Kaldis P, Izraeli S, Kirsch IR.

Mol Cell Biol. 2005 Aug;25(15):6660-72.

28.

The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence.

Knutsen T, Gobu V, Knaus R, Padilla-Nash H, Augustus M, Strausberg RL, Kirsch IR, Sirotkin K, Ried T.

Genes Chromosomes Cancer. 2005 Sep;44(1):52-64.

29.

Randomized comparison of group versus individual genetic education and counseling for familial breast and/or ovarian cancer.

Calzone KA, Prindiville SA, Jourkiv O, Jenkins J, DeCarvalho M, Wallerstedt DB, Liewehr DJ, Steinberg SM, Soballe PW, Lipkowitz S, Klein P, Kirsch IR.

J Clin Oncol. 2005 May 20;23(15):3455-64.

PMID:
15908654
30.

A phase II and pharmacologic study of fluorouracil given by a 1-hour infusion daily for 5 days with leucovorin and interferon alpha-2a in adenocarcinoma of the large bowel.

Ismail AS, Quinn MG, Wright MA, Ernst A, Kao V, Grogan L, Parr A, Grollman F, Kirsch IR, Grem JL.

Oncol Rep. 2005 Jun;13(6):1145-52.

PMID:
15870935
31.

Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability.

Roschke AV, Kirsch IR.

Cell Cycle. 2005 May;4(5):679-82. Epub 2005 May 25.

PMID:
15846096
32.

Karyotypic "state" as a potential determinant for anticancer drug discovery.

Roschke AV, Lababidi S, Tonon G, Gehlhaus KS, Bussey K, Weinstein JN, Kirsch IR.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2964-9. Epub 2005 Feb 9.

33.

Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.

Hahn Y, Bera TK, Gehlhaus K, Kirsch IR, Pastan IH, Lee B.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13257-61. Epub 2004 Aug 23.

34.

Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas.

Tonon G, Gehlhaus KS, Yonescu R, Kaye FJ, Kirsch IR.

Cancer Genet Cytogenet. 2004 Jul 1;152(1):15-22.

PMID:
15193437
35.

Sil overexpression in lung cancer characterizes tumors with increased mitotic activity.

Erez A, Perelman M, Hewitt SM, Cojacaru G, Goldberg I, Shahar I, Yaron P, Muler I, Campaner S, Amariglio N, Rechavi G, Kirsch IR, Krupsky M, Kaminski N, Izraeli S.

Oncogene. 2004 Jul 8;23(31):5371-7.

PMID:
15107824
36.

Genetics and cytogenetics of multiple myeloma: a workshop report.

Fonseca R, Barlogie B, Bataille R, Bastard C, Bergsagel PL, Chesi M, Davies FE, Drach J, Greipp PR, Kirsch IR, Kuehl WM, Hernandez JM, Minvielle S, Pilarski LM, Shaughnessy JD Jr, Stewart AK, Avet-Loiseau H.

Cancer Res. 2004 Feb 15;64(4):1546-58.

37.

Karyotypic complexity of the NCI-60 drug-screening panel.

Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN, Kirsch IR.

Cancer Res. 2003 Dec 15;63(24):8634-47.

38.

Microsatellite instability in colon cancer.

Allegra CJ, Kim G, Kirsch IR.

N Engl J Med. 2003 Oct 30;349(18):1774-6; author reply 1774-6. No abstract available.

39.

Distinguishing right from left colon by the pattern of gene expression.

Glebov OK, Rodriguez LM, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, DeNobile J, Soballe P, Simon R, Wright G, Lynch P, Patterson S, Lynch H, Gallinger S, Buchbinder A, Gordon G, Hawk E, Kirsch IR.

Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):755-62.

40.

Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.

Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN.

Cancer Res. 2003 Mar 1;63(5):1000-11.

41.

A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition.

Junicke H, Hart JR, Kisko J, Glebov O, Kirsch IR, Barton JK.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3737-42. Epub 2003 Feb 27.

42.

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ.

Nat Genet. 2003 Feb;33(2):208-13. Epub 2003 Jan 21. Erratum in: Nat Genet. 2003 Mar;33(3):430.

PMID:
12539049
43.

Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.

Cogliati T, Good DJ, Haigney M, Delgado-Romero P, Eckhaus MA, Koch WJ, Kirsch IR.

Mol Cell Biol. 2002 Jul;22(14):4977-83.

44.
45.

Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.

Izraeli S, Lowe LA, Bertness VL, Campaner S, Hahn H, Kirsch IR, Kuehn MR.

Genesis. 2001 Oct;31(2):72-7.

PMID:
11668681
46.

Biomarker correlations of urinary 2,4-D levels in foresters: genomic instability and endocrine disruption.

Garry VF, Tarone RE, Kirsch IR, Abdallah JM, Lombardi DP, Long LK, Burroughs BL, Barr DB, Kesner JS.

Environ Health Perspect. 2001 May;109(5):495-500.

47.

Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints.

Raghavan SC, Kirsch IR, Lieber MR.

J Biol Chem. 2001 Aug 3;276(31):29126-33. Epub 2001 Jun 4.

48.

Integration of cytogenetic landmarks into the draft sequence of the human genome.

Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen XN, Furey TS, Kim UJ, Kuo WL, Olivier M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailey JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Han CS, Herrick S, Lee J, Ligon AH, Lowry S, Morley M, Narasimhan S, Osoegawa K, Peng Z, Plajzer-Frick I, Quade BJ, Scott D, Sirotkin K, Thorpe AA, Gray JW, Hudson J, Pinkel D, Ried T, Rowen L, Shen-Ong GL, Strausberg RL, Birney E, Callen DF, Cheng JF, Cox DR, Doggett NA, Carter NP, Eichler EE, Haussler D, Korenberg JR, Morton CC, Albertson D, Schuler G, de Jong PJ, Trask BJ; BAC Resource Consortium.

Nature. 2001 Feb 15;409(6822):953-8.

PMID:
11237021
49.

A high-resolution map of human chromosome 12.

Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R.

Nature. 2001 Feb 15;409(6822):945-6.

PMID:
11237017
50.

A physical map of the human genome.

McPherson JD, Marra M, Hillier L, Waterston RH, Chinwalla A, Wallis J, Sekhon M, Wylie K, Mardis ER, Wilson RK, Fulton R, Kucaba TA, Wagner-McPherson C, Barbazuk WB, Gregory SG, Humphray SJ, French L, Evans RS, Bethel G, Whittaker A, Holden JL, McCann OT, Dunham A, Soderlund C, Scott CE, Bentley DR, Schuler G, Chen HC, Jang W, Green ED, Idol JR, Maduro VV, Montgomery KT, Lee E, Miller A, Emerling S, Kucherlapati, Gibbs R, Scherer S, Gorrell JH, Sodergren E, Clerc-Blankenburg K, Tabor P, Naylor S, Garcia D, de Jong PJ, Catanese JJ, Nowak N, Osoegawa K, Qin S, Rowen L, Madan A, Dors M, Hood L, Trask B, Friedman C, Massa H, Cheung VG, Kirsch IR, Reid T, Yonescu R, Weissenbach J, Bruls T, Heilig R, Branscomb E, Olsen A, Doggett N, Cheng JF, Hawkins T, Myers RM, Shang J, Ramirez L, Schmutz J, Velasquez O, Dixon K, Stone NE, Cox DR, Haussler D, Kent WJ, Furey T, Rogic S, Kennedy S, Jones S, Rosenthal A, Wen G, Schilhabel M, Gloeckner G, Nyakatura G, Siebert R, Schlegelberger B, Korenberg J, Chen XN, Fujiyama A, Hattori M, Toyoda A, Yada T, Park HS, Sakaki Y, Shimizu N, Asakawa S, Kawasaki K, Sasaki T, Shintani A, Shimizu A, Shibuya K, Kudoh J, Minoshima S, Ramser J, Seranski P, Hoff C, Poustka A, Reinhardt R, Lehrach H; International Human Genome Mapping Consortium.

Nature. 2001 Feb 15;409(6822):934-41.

PMID:
11237014

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