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White matter integrity and processing speed in sickle cell anemia.

Stotesbury H, Kirkham FJ, Kölbel M, Balfour P, Clayden JD, Sahota S, Sakaria S, Saunders DE, Howard J, Kesse-Adu R, Inusa B, Pelidis M, Chakravorty S, Rees DC, Awogbade M, Wilkey O, Layton M, Clark CA, Kawadler JM.

Neurology. 2018 May 11. pii: 10.1212/WNL.0000000000005644. doi: 10.1212/WNL.0000000000005644. [Epub ahead of print]


Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia: Results from a multiple-inflow-time arterial spin labelling study.

Kawadler JM, Hales PW, Barker S, Cox TCS, Kirkham FJ, Clark CA.

NMR Biomed. 2018 Mar 30:e3915. doi: 10.1002/nbm.3915. [Epub ahead of print]


Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial.

Cox SE, Ellins EA, Marealle AI, Newton CR, Soka D, Sasi P, Luca Di Tanna G, Johnson W, Makani J, Prentice AM, Halcox JP, Kirkham FJ.

Lancet Haematol. 2018 Apr;5(4):e147-e160. doi: 10.1016/S2352-3026(18)30020-6. Epub 2018 Mar 13.


Children with sickle cell anemia with normal transcranial Doppler ultrasounds and without silent infarcts have a low incidence of new strokes.

Jordan LC, Roberts Williams DO, Rodeghier MJ, Covert Greene BV, Ponisio MR, Casella JF, McKinstry RC, Noetzel MJ, Kirkham FJ, Meier ER, Fuh B, McNaull M, Sarnaik S, Majumdar S, McCavit TL, DeBaun MR.

Am J Hematol. 2018 Mar 9. doi: 10.1002/ajh.25085. [Epub ahead of print]


The promise of noninvasive cerebral hemodynamic assessment in sickle cell anemia.

Stotesbury H, Hales PW, Kirkham FJ.

Neurology. 2018 Mar 27;90(13):585-586. doi: 10.1212/WNL.0000000000005236. Epub 2018 Mar 2. No abstract available.


Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial).

Galadanci NA, Umar Abdullahi S, Vance LD, Musa Tabari A, Ali S, Belonwu R, Salihu A, Amal Galadanci A, Wudil Jibir B, Bello-Manga H, Neville K, Kirkham FJ, Shyr Y, Phillips S, Covert BV, Kassim AA, Jordan LC, Aliyu MH, DeBaun MR.

Am J Hematol. 2018 Mar;93(3):E83. doi: 10.1002/ajh.25012. Epub 2018 Feb 2. No abstract available.


Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.

Willen SM, Rodeghier M, Strunk RC, Bacharier LB, Rosen CL, Kirkham FJ, DeBaun MR, Cohen RT.

Br J Haematol. 2018 Feb;180(4):571-577. doi: 10.1111/bjh.15076. Epub 2018 Jan 24.


Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.

Howard J, Slee AE, Skene S, Inusa B, Kawadler J, Downes M, Gavlak J, Koelbel M, Stotesbury H, Chorozoglou M, Tebbs S, Chakravorty S, Awogbade M, Rees DC, Gupta A, Murphy PB, Hart N, Sahota S, Nwosu C, Gwam M, Saunders D, Muthurangu V, Barber N, Ako E, Thein SL, Marshall M, Reading IC, Cheng MYE, Kirkham FJ, Liossi C.

Trials. 2018 Jan 22;19(1):55. doi: 10.1186/s13063-017-2419-0.


Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.

Vigevano F, Kirkham FJ, Wilken B, Raspall-Chaure M, Grebla R, Lee D, Werner-Kiechle T, Lagae L.

Eur J Paediatr Neurol. 2018 Jan;22(1):56-63. doi: 10.1016/j.ejpn.2017.07.017. Epub 2017 Aug 2.


Nocturnal oxyhemoglobin desaturation and arteriopathy in a pediatric sickle cell disease cohort.

Dlamini N, Saunders DE, Bynevelt M, Trompeter S, Cox TC, Bucks RS, Kirkham FJ.

Neurology. 2017 Dec 12;89(24):2406-2412. doi: 10.1212/WNL.0000000000004728. Epub 2017 Nov 8.


Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease.

Downes M, Kirkham FJ, Telfer PT, de Haan M.

J Pediatr Psychol. 2017 Sep 18. doi: 10.1093/jpepsy/jsx115. [Epub ahead of print]


Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania.

Nkya S, Mgaya J, Urio F, Makubi A, Thein SL, Menzel S, Cox SE, Newton CR, Kirkham FJ, Mmbando BP, Makani J.

EBioMedicine. 2017 Sep;23:146-149. doi: 10.1016/j.ebiom.2017.08.006. Epub 2017 Aug 8.


Airway Hyperresponsiveness Does Not Predict Morbidity in Children with Sickle Cell Anemia.

Willen SM, Rodeghier M, Strunk RC, Rosen CL, Kirkham FJ, Field JJ, DeBaun MR, Cohen RT.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1533-1534. doi: 10.1164/rccm.201610-1970LE. No abstract available.


Task utility and norms for the Preschool Executive Task Assessment (PETA).

Downes M, Berg C, Kirkham FJ, Kischkel L, McMurray I, de Haan M.

Child Neuropsychol. 2017 May 31:1-15. doi: 10.1080/09297049.2017.1333092. [Epub ahead of print]


Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial).

Galadanci NA, Umar Abdullahi S, Vance LD, Musa Tabari A, Ali S, Belonwu R, Salihu A, Amal Galadanci A, Wudil Jibir B, Bello-Manga H, Neville K, Kirkham FJ, Shyr Y, Phillips S, Covert BV, Kassim AA, Jordan LC, Aliyu MH, DeBaun MR.

Am J Hematol. 2017 Aug;92(8):780-788. doi: 10.1002/ajh.24770. Epub 2017 Jun 15. Erratum in: Am J Hematol. 2018 Mar;93(3):E83.


Neurocognitive outcomes for acute global acquired brain injury in children.

Kirkham FJ.

Curr Opin Neurol. 2017 Apr;30(2):148-155. doi: 10.1097/WCO.0000000000000427. Review.



Kirkham FJ.

Curr Opin Neurol. 2017 Apr;30(2):125-126. doi: 10.1097/WCO.0000000000000428. No abstract available.


Stroke and Hypertension in Children and Adolescents.

Kupferman JC, Zafeiriou DI, Lande MB, Kirkham FJ, Pavlakis SG.

J Child Neurol. 2017 Mar;32(4):408-417. doi: 10.1177/0883073816685240. Epub 2016 Dec 26. Review.


Parent reported sleep problems in preschool children with sickle cell anemia and controls in East London.

Downes M, de Haan M, Kirkham FJ, Telfer PT.

Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26337. Epub 2016 Nov 15.


Stroke in sickle cell anaemia is more than stenosis and thrombosis: the role of anaemia and hyperemia in ischaemia.

Dowling MM, Kirkham FJ.

Br J Haematol. 2017 Jan;176(2):151-153. doi: 10.1111/bjh.14422. Epub 2016 Nov 11. No abstract available.


Exhaled nitric oxide: Not associated with asthma, symptoms, or spirometry in children with sickle cell anemia.

Cohen RT, Rodeghier M, Kirkham FJ, Rosen CL, Kirkby J, DeBaun MR, Strunk RC.

J Allergy Clin Immunol. 2016 Nov;138(5):1338-1343.e4. doi: 10.1016/j.jaci.2016.06.043. Epub 2016 Aug 9.


Indications for the performance of neuroimaging in children.

Kirkham FJ.

Handb Clin Neurol. 2016;136:1275-90. doi: 10.1016/B978-0-444-53486-6.00065-X. Review.


Pattern of Lung Function Is Not Associated with Prior or Future Morbidity in Children with Sickle Cell Anemia.

Cohen RT, Strunk RC, Rodeghier M, Rosen CL, Kirkham FJ, Kirkby J, DeBaun MR.

Ann Am Thorac Soc. 2016 Aug;13(8):1314-23. doi: 10.1513/AnnalsATS.201510-706OC.


Brain atrophy in paediatric sickle cell anaemia: findings from the silent infarct transfusion (SIT) trial.

Kawadler JM, Clark CA, McKinstry RC, Kirkham FJ.

Br J Haematol. 2017 Apr;177(1):151-153. doi: 10.1111/bjh.14039. Epub 2016 Apr 7. No abstract available.


Intelligence quotient in paediatric sickle cell disease: a systematic review and meta-analysis.

Kawadler JM, Clayden JD, Clark CA, Kirkham FJ.

Dev Med Child Neurol. 2016 Jul;58(7):672-9. doi: 10.1111/dmcn.13113. Epub 2016 Mar 31. Review.


Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development.

Hill CM, Baya A, Gavlak J, Carroll A, Heathcote K, Dimitriou D, L'Esperance V, Webster R, Holloway J, Virues-Ortega J, Kirkham FJ, Bucks RS, Hogan AM.

Sleep. 2016 May 1;39(5):1001-8. doi: 10.5665/sleep.5740.


Outcome and recurrence one year after paediatric arterial ischaemic stroke in a population-based cohort.

Mallick AA, Ganesan V, Kirkham FJ, Fallon P, Hedderly T, McShane T, Parker AP, Wassmer E, Wraige E, Amin S, Edwards HB, Cortina-Borja M, O'Callaghan FJ.

Ann Neurol. 2016 Mar 1. doi: 10.1002/ana.24626. [Epub ahead of print]


Central nervous system complications and management in sickle cell disease.

DeBaun MR, Kirkham FJ.

Blood. 2016 Feb 18;127(7):829-38. doi: 10.1182/blood-2015-09-618579. Epub 2016 Jan 12. Review.


Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study.

L'Esperance VS, Ekong T, Cox SE, Makani J, Newton CR, Soka D, Komba A, Kirkham FJ, Hill CM.

Arch Dis Child. 2016 Apr;101(4):352-5. doi: 10.1136/archdischild-2014-306468. Epub 2015 Dec 23.


New option for primary stroke prevention in sickle cell anaemia.

DeBaun MR, Kirkham FJ.

Lancet. 2016 Feb 13;387(10019):626-7. doi: 10.1016/S0140-6736(15)01130-7. Epub 2015 Dec 6. No abstract available.


A general model to calculate the spin-lattice (T1) relaxation time of blood, accounting for haematocrit, oxygen saturation and magnetic field strength.

Hales PW, Kirkham FJ, Clark CA.

J Cereb Blood Flow Metab. 2016 Feb;36(2):370-4. doi: 10.1177/0271678X15605856. Epub 2015 Sep 30.


Prevention of Morbidity in sickle cell disease--qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol for a randomised controlled trial.

Howard J, Inusa B, Liossi C, Jacob E, Murphy PB, Hart N, Gavlak J, Sahota S, Chorozoglou M, Nwosu C, Gwam M, Gupta A, Rees DC, Thein SL, Reading IC, Kirkham FJ, Cheng MY.

Trials. 2015 Aug 25;16:376. doi: 10.1186/s13063-015-0883-y.


Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania.

Makani J, Mgaya J, Balandya E, Msami K, Soka D, Cox SE, Komba AN, Rwezaula S, Meda E, Muturi D, Kitundu J, Fegan G, Kirkham FJ, Newton CR, Snow RW, Lowe B.

Br J Haematol. 2015 Jun 17. doi: 10.1111/bjh.13553. [Epub ahead of print]


White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts.

Kawadler JM, Kirkham FJ, Clayden JD, Hollocks MJ, Seymour EL, Edey R, Telfer P, Robins A, Wilkey O, Barker S, Cox TC, Clark CA.

Stroke. 2015 Jul;46(7):1793-9. doi: 10.1161/STROKEAHA.115.008721. Epub 2015 May 12.


Abnormal intra-aural pressure waves associated with death in African children with acute nontraumatic coma.

Gwer S, Kazungu M, Chengo E, Ohuma EO, Idro R, Birch T, Marchbanks R, Kirkham FJ, Newton CR.

Pediatr Res. 2015 Jul;78(1):38-43. doi: 10.1038/pr.2015.57. Epub 2015 Mar 19.


Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort.

Vance LD, Rodeghier M, Cohen RT, Rosen CL, Kirkham FJ, Strunk RC, DeBaun MR.

Am J Hematol. 2015 May;90(5):371-5. doi: 10.1002/ajh.23959. Epub 2015 Mar 30.


Left ventricular rotational mechanics in Tanzanian children with sickle cell disease.

Di Maria MV, Hsu HH, Al-Naami G, Gruenwald J, Kirby KS, Kirkham FJ, Cox SE, Younoszai AK.

J Am Soc Echocardiogr. 2015 Mar;28(3):340-6. doi: 10.1016/j.echo.2014.11.014. Epub 2014 Dec 30.


Diagnostic delays in paediatric stroke.

Mallick AA, Ganesan V, Kirkham FJ, Fallon P, Hedderly T, McShane T, Parker AP, Wassmer E, Wraige E, Amin S, Edwards HB, O'Callaghan FJ.

J Neurol Neurosurg Psychiatry. 2015 Aug;86(8):917-21. doi: 10.1136/jnnp-2014-309188. Epub 2014 Oct 23.


Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study.

Ichord RN, Benedict SL, Chan AK, Kirkham FJ, Nowak-Göttl U; International Paediatric Stroke Study Group.

Arch Dis Child. 2015 Feb;100(2):174-9. doi: 10.1136/archdischild-2014-306382. Epub 2014 Oct 6.


Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.

DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS Jr, Hirtz D, Casella JF.

N Engl J Med. 2014 Aug 21;371(8):699-710. doi: 10.1056/NEJMoa1401731.


Factors predicting future ACS episodes in children with sickle cell anemia.

DeBaun MR, Rodeghier M, Cohen R, Kirkham FJ, Rosen CL, Roberts I, Cooper B, Stocks J, Wilkey O, Inusa B, Warner JO, Strunk RC.

Am J Hematol. 2014 Nov;89(11):E212-7. doi: 10.1002/ajh.23819. Epub 2014 Aug 27.


Silent cerebral infarction, income, and grade retention among students with sickle cell anemia.

King AA, Rodeghier MJ, Panepinto JA, Strouse JJ, Casella JF, Quinn CT, Dowling MM, Sarnaik SA, Thompson AA, Woods GM, Minniti CP, Redding-Lallinger RC, Kirby-Allen M, Kirkham FJ, McKinstry R, Noetzel MJ, White DA, Kwiatkowski JK, Howard TH, Kalinyak KA, Inusa B, Rhodes MM, Heiny ME, Fuh B, Fixler JM, Gordon MO, DeBaun MR.

Am J Hematol. 2014 Oct;89(10):E188-92. doi: 10.1002/ajh.23805. Epub 2014 Aug 4.


Obstructive sleep apnea and sickle cell anemia.

Rosen CL, Debaun MR, Strunk RC, Redline S, Seicean S, Craven DI, Gavlak JC, Wilkey O, Inusa B, Roberts I, Goodpaster RL, Malow B, Rodeghier M, Kirkham FJ.

Pediatrics. 2014 Aug;134(2):273-81. doi: 10.1542/peds.2013-4223. Epub 2014 Jul 14.


Executive function and sleep problems in childhood epilepsy.

Holley S, Whitney A, Kirkham FJ, Freeman A, Nelson L, Whitlingum G, Hill CM.

Epilepsy Behav. 2014 Aug;37:20-5. doi: 10.1016/j.yebeh.2014.05.022. Epub 2014 Jun 20.


Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.

Cox SE, Makani J, Soka D, L'Esperence VS, Kija E, Dominguez-Salas P, Newton CR, Birch AA, Prentice AM, Kirkham FJ.

Br J Haematol. 2014 Jun;165(5):699-706. doi: 10.1111/bjh.12791. Epub 2014 Feb 21.


Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction.

Dowling MM, Noetzel MJ, Rodeghier MJ, Quinn CT, Hirtz DG, Ichord RN, Kwiatkowski JL, Roach ES, Kirkham FJ, Casella JF, DeBaun MR.

J Pediatr. 2014 May;164(5):1175-1180.e1. doi: 10.1016/j.jpeds.2014.01.001. Epub 2014 Feb 13.


Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies.

Hales PW, Kawadler JM, Aylett SE, Kirkham FJ, Clark CA.

J Cereb Blood Flow Metab. 2014 May;34(5):776-84. doi: 10.1038/jcbfm.2014.17. Epub 2014 Feb 5.


Tricuspid regurgitant jet velocity and hospitalization in Tanzanian children with sickle cell anemia.

Cox SE, Soka D, Kirkham FJ, Newton CR, Prentice AM, Makani J, Younoszai AK.

Haematologica. 2014 Jan;99(1):e1-4. doi: 10.3324/haematol.2013.089235. No abstract available.


Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia.

Strunk RC, Cohen RT, Cooper BP, Rodeghier M, Kirkham FJ, Warner JO, Stocks J, Kirkby J, Roberts I, Rosen CL, Craven DI, DeBaun MR; Sleep Asthma Cohort Investigative Team.

J Pediatr. 2014 Apr;164(4):821-826.e1. doi: 10.1016/j.jpeds.2013.11.034. Epub 2013 Dec 31.


Childhood arterial ischaemic stroke incidence, presenting features, and risk factors: a prospective population-based study.

Mallick AA, Ganesan V, Kirkham FJ, Fallon P, Hedderly T, McShane T, Parker AP, Wassmer E, Wraige E, Amin S, Edwards HB, Tilling K, O'Callaghan FJ.

Lancet Neurol. 2014 Jan;13(1):35-43. doi: 10.1016/S1474-4422(13)70290-4. Epub 2013 Dec 2.


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