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Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression.

Nguyen MN, Su Y, Kiriazis H, Yang Y, Gao XM, McMullen JR, Dart AM, Du XJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 9. doi: 10.1152/ajpheart.00337.2017. [Epub ahead of print]


Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.

Bernardo BC, Weeks KL, Pongsukwechkul T, Gao X, Kiriazis H, Cemerlang N, Boey EJH, Tham YK, Johnson CJ, Qian H, Du XJ, Gregorevic P, McMullen JR.

Clin Sci (Lond). 2018 Feb 8;132(3):381-397. doi: 10.1042/CS20171269. Print 2018 Feb 14.


Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1).

Li J, Huynh P, Dai A, Wu T, Tu Y, Chow B, Kiriazis H, Du XJ, Bach LA, Wilkinson-Berka JL, Biros E, Walker P, Nataatmadja M, West M, Golledge J, Allen TJ, Cooper ME, Chai Z.

Diabetes. 2018 Jan 8. pii: db170134. doi: 10.2337/db17-0134. [Epub ahead of print]


N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.

Giam B, Kuruppu S, Chu PY, Smith AI, Marques FZ, Fiedler A, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Sci Rep. 2017 Dec 18;7(1):17718. doi: 10.1038/s41598-017-17927-5.


Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.

Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ, McMullen JR.

Biochim Biophys Acta. 2018 Mar;1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. Epub 2017 Dec 6.


Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.

Qin CX, Finlayson SB, Ai-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du XJ, Gao XM, Ritchie RH.

Sci Rep. 2017 Nov 30;7(1):16615. doi: 10.1038/s41598-017-16317-1.


High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaam6084. doi: 10.1126/scitranslmed.aam6084.


Platelet-Targeted Delivery of Peripheral Blood Mononuclear Cells to the Ischemic Heart Restores Cardiac Function after Ischemia-Reperfusion Injury.

Ziegler M, Wang X, Lim B, Leitner E, Klingberg F, Ching V, Yao Y, Huang D, Gao XM, Kiriazis H, Du XJ, Haigh JJ, Bobik A, Hagemeyer CE, Ahrens I, Peter K.

Theranostics. 2017 Jul 22;7(13):3192-3206. doi: 10.7150/thno.19698. eCollection 2017.


Cardiac Fibrosis and Arrhythmogenesis.

Nguyen MN, Kiriazis H, Gao XM, Du XJ.

Compr Physiol. 2017 Jun 18;7(3):1009-1049. doi: 10.1002/cphy.c160046.


Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat.

Tate M, Deo M, Cao AH, Hood SG, Huynh K, Kiriazis H, Du XJ, Julius TL, Figtree GA, Dusting GJ, Kaye DM, Ritchie RH.

Diab Vasc Dis Res. 2017 Sep;14(5):423-433. doi: 10.1177/1479164117710390. Epub 2017 May 31.


Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.

Prakoso D, De Blasio MJ, Qin C, Rosli S, Kiriazis H, Qian H, Du XJ, Weeks KL, Gregorevic P, McMullen JR, Ritchie RH.

Clin Sci (Lond). 2017 Jun 7;131(12):1345-1360. doi: 10.1042/CS20170063. Print 2017 Jun 1.


Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry, and magnetic resonance imaging.

Gao XM, Wu QZ, Kiriazis H, Su Y, Han LP, Pearson JT, Taylor AJ, Du XJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1068-H1075. doi: 10.1152/ajpheart.00073.2017. Epub 2017 Mar 24.


Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture.

Gao XM, Tsai A, Al-Sharea A, Su Y, Moore S, Han LP, Kiriazis H, Dart AM, Murphy AJ, Du XJ.

Cardiovasc Drugs Ther. 2017 Apr;31(2):145-156. doi: 10.1007/s10557-017-6717-2.


Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs.

Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC, McMullen JR.

J Physiol. 2016 Oct 15;594(20):5959-5974. doi: 10.1113/JP272512. Epub 2016 Jul 20.


Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction.

Gao XM, Moore XL, Liu Y, Wang XY, Han LP, Su Y, Tsai A, Xu Q, Zhang M, Lambert GW, Kiriazis H, Gao W, Dart AM, Du XJ.

Clin Sci (Lond). 2016 Jul 1;130(13):1089-104. doi: 10.1042/CS20160234. Epub 2016 Apr 5.


N-acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure.

Giam B, Chu PY, Kuruppu S, Smith AI, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Physiol Rep. 2016 Apr;4(7). pii: e12757. doi: 10.14814/phy2.12757. Epub 2016 Apr 13.


Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload.

Bernardo BC, Nguyen SS, Gao XM, Tham YK, Ooi JY, Patterson NL, Kiriazis H, Su Y, Thomas CJ, Lin RC, Du XJ, McMullen JR.

Sci Rep. 2016 Mar 1;6:22442. doi: 10.1038/srep22442.


Expressing an inhibitor of PLCβ1b sustains contractile function following pressure overload.

Grubb DR, Gao XM, Kiriazis H, Matsumoto A, McMullen JR, Du XJ, Woodcock EA.

J Mol Cell Cardiol. 2016 Apr;93:12-7. doi: 10.1016/j.yjmcc.2016.02.015. Epub 2016 Feb 18.


Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.

Bernardo BC, Sapra G, Patterson NL, Cemerlang N, Kiriazis H, Ueyama T, Febbraio MA, McMullen JR.

PLoS One. 2015 Dec 14;10(12):e0145173. doi: 10.1371/journal.pone.0145173. eCollection 2015.


Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.

Lacey D, Hickey P, Arhatari BD, O'Reilly LA, Rohrbeck L, Kiriazis H, Du XJ, Bouillet P.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9698-703. doi: 10.1073/pnas.1508399112. Epub 2015 Jul 20.


Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis.

Nguyen MN, Kiriazis H, Ruggiero D, Gao XM, Su Y, Jian A, Han LP, McMullen JR, Du XJ.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H946-57. doi: 10.1152/ajpheart.00405.2015. Epub 2015 Jun 26.


Augmented endothelial l-arginine transport ameliorates pressure-overload-induced cardiac hypertrophy.

Rajapakse NW, Johnston T, Kiriazis H, Chin-Dusting JP, Du XJ, Kaye DM.

Exp Physiol. 2015 Jul 1;100(7):796-804. doi: 10.1113/EP085250.


Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling.

De Blasio MJ, Huynh K, Qin C, Rosli S, Kiriazis H, Ayer A, Cemerlang N, Stocker R, Du XJ, McMullen JR, Ritchie RH.

Free Radic Biol Med. 2015 Oct;87:137-47. doi: 10.1016/j.freeradbiomed.2015.04.028. Epub 2015 Apr 30.


The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.

Grubb DR, Crook B, Ma Y, Luo J, Qian HW, Gao XM, Kiriazis H, Du XJ, Gregorevic P, Woodcock EA.

J Mol Cell Cardiol. 2015 Jul;84:95-103. doi: 10.1016/j.yjmcc.2015.04.016. Epub 2015 Apr 25.


Pathological hypertrophy reverses β2-adrenergic receptor-induced angiogenesis in mouse heart.

Xu Q, Jennings NL, Sim K, Chang L, Gao XM, Kiriazis H, Lee YY, Nguyen MN, Woodcock EA, Zhang YY, El-Osta A, Dart AM, Du XJ.

Physiol Rep. 2015 Mar;3(3). pii: e12340. doi: 10.14814/phy2.12340.


Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo.

Cao N, Wong YG, Rosli S, Kiriazis H, Huynh K, Qin C, Du XJ, Kemp-Harper BK, Ritchie RH.

Circ Heart Fail. 2015 May;8(3):572-81. doi: 10.1161/CIRCHEARTFAILURE.114.001699. Epub 2015 Mar 3.


The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.

Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR.

Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705.


Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy.

Bernardo BC, Nguyen SS, Winbanks CE, Gao XM, Boey EJ, Tham YK, Kiriazis H, Ooi JY, Porrello ER, Igoor S, Thomas CJ, Gregorevic P, Lin RC, Du XJ, McMullen JR.

FASEB J. 2014 Dec;28(12):5097-110. doi: 10.1096/fj.14-253856. Epub 2014 Aug 21.


Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR.

PLoS One. 2014 Feb 27;9(2):e90337. doi: 10.1371/journal.pone.0090337. eCollection 2014.


Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction.

White DA, Su Y, Kanellakis P, Kiriazis H, Morand EF, Bucala R, Dart AM, Gao XM, Du XJ.

J Mol Cell Cardiol. 2014 Apr;69:32-42. doi: 10.1016/j.yjmcc.2014.01.015. Epub 2014 Feb 5.


Pro-inflammatory action of MIF in acute myocardial infarction via activation of peripheral blood mononuclear cells.

White DA, Fang L, Chan W, Morand EF, Kiriazis H, Duffy SJ, Taylor AJ, Dart AM, Du XJ, Gao XM.

PLoS One. 2013 Oct 1;8(10):e76206. doi: 10.1371/journal.pone.0076206. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/6e24b7bb-83c7-4887-9621-96b64acfb1c1.


Chronic activation of the low affinity site of β1-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling.

Kiriazis H, Tugiono N, Xu Q, Gao XM, Jennings NL, Ming Z, Su Y, Klenowski P, Summers RJ, Kaumann A, Molenaar P, Du XJ.

Br J Pharmacol. 2013 Sep;170(2):352-65. doi: 10.1111/bph.12272.


Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice.

Huynh K, Kiriazis H, Du XJ, Love JE, Gray SP, Jandeleit-Dahm KA, McMullen JR, Ritchie RH.

Free Radic Biol Med. 2013 Jul;60:307-17. doi: 10.1016/j.freeradbiomed.2013.02.021. Epub 2013 Feb 26.


No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy.

Cooley N, Ouyang K, McMullen JR, Kiriazis H, Sheikh F, Wu W, Mu Y, Du XJ, Chen J, Woodcock EA.

Circ Heart Fail. 2013 Mar;6(2):318-25. doi: 10.1161/CIRCHEARTFAILURE.112.972158. Epub 2012 Dec 20.


Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.


Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.

Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR.

Diabetologia. 2012 Dec;55(12):3369-81. doi: 10.1007/s00125-012-2720-0. Epub 2012 Sep 22.


Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease.

Kiriazis H, Jennings NL, Davern P, Lambert G, Su Y, Pang T, Du X, La Greca L, Head GA, Hannan AJ, Du XJ.

J Physiol. 2012 Nov 15;590(22):5845-60. doi: 10.1113/jphysiol.2012.238113. Epub 2012 Aug 13.


Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.

Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR.

Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15.


Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes.

Tikellis C, Pickering R, Tsorotes D, Du XJ, Kiriazis H, Nguyen-Huu TP, Head GA, Cooper ME, Thomas MC.

Clin Sci (Lond). 2012 Oct;123(8):519-29. doi: 10.1042/CS20110668.


Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes.

Huynh K, Kiriazis H, Du XJ, Love JE, Jandeleit-Dahm KA, Forbes JM, McMullen JR, Ritchie RH.

Diabetologia. 2012 May;55(5):1544-53. doi: 10.1007/s00125-012-2495-3. Epub 2012 Feb 29.


Arterial remodelling following pressure overload by aortic constriction: an overlooked and potentially fertile research area.

Du XJ, Kiriazis H, Dart AM.

Clin Exp Pharmacol Physiol. 2011 Sep;38(9):559-61. doi: 10.1111/j.1440-1681.2011.05558.x. No abstract available.


CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess.

Chu PY, Zatta A, Kiriazis H, Chin-Dusting J, Du XJ, Marshall T, Kaye DM.

Circ Heart Fail. 2011 Sep;4(5):651-8. doi: 10.1161/CIRCHEARTFAILURE.110.960831. Epub 2011 Jun 17.


Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities.

Chang L, Kiriazis H, Gao XM, Du XJ, El-Osta A.

Epigenetics. 2011 Jun;6(6):760-8. Epub 2011 Jun 1.


Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction.

Liu Y, Gao XM, Fang L, Jennings NL, Su Y, Q X, Samson AL, Kiriazis H, Wang XF, Shan L, Sturgeon SA, Medcalf RL, Jackson SP, Dart AM, Du XJ.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):834-41. doi: 10.1161/ATVBAHA.110.220467. Epub 2011 Jan 20.


Relaxin remodels fibrotic healing following myocardial infarction.

Samuel CS, Cendrawan S, Gao XM, Ming Z, Zhao C, Kiriazis H, Xu Q, Tregear GW, Bathgate RA, Du XJ.

Lab Invest. 2011 May;91(5):675-90. doi: 10.1038/labinvest.2010.198. Epub 2011 Jan 10.


Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation.

Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, Kiriazis H, Xu Q, Jennings N, Bobik A, Febbraio MA, Kingwell BA, Bucala R, Fingerle-Rowson G, Dart AM, Morand EF, Du XJ.

J Mol Cell Cardiol. 2011 Jun;50(6):991-9. doi: 10.1016/j.yjmcc.2010.12.022. Epub 2011 Jan 6.


Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.

Du XJ, Shan L, Gao XM, Kiriazis H, Liu Y, Lobo A, Head GA, Dart AM.

Thromb Haemost. 2011 Feb;105(2):356-64. doi: 10.1160/TH10-07-0449. Epub 2010 Nov 5.


Myocardial oxidative stress contributes to transgenic β₂-adrenoceptor activation-induced cardiomyopathy and heart failure.

Xu Q, Dalic A, Fang L, Kiriazis H, Ritchie RH, Sim K, Gao XM, Drummond G, Sarwar M, Zhang YY, Dart AM, Du XJ.

Br J Pharmacol. 2011 Mar;162(5):1012-28. doi: 10.1111/j.1476-5381.2010.01043.x.


PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):724-32. doi: 10.1161/ATVBAHA.109.201988.

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