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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B.

Immunity. 2018 Feb 20;48(2):380-395.e6. doi: 10.1016/j.immuni.2018.01.011. Epub 2018 Feb 6.


Sex, Gut, and Microglia.

Louveau A, Kipnis J.

Dev Cell. 2018 Jan 22;44(2):137-138. doi: 10.1016/j.devcel.2018.01.003.


Immune system: The "seventh sense".

Kipnis J.

J Exp Med. 2018 Feb 5;215(2):397-398. doi: 10.1084/jem.20172295. Epub 2018 Jan 16. Review.


Neuroimmunology in 2017: The central nervous system: privileged by immune connections.

Kipnis J, Filiano AJ.

Nat Rev Immunol. 2018 Feb;18(2):83-84. doi: 10.1038/nri.2017.152. Epub 2017 Dec 27. No abstract available.


Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI.

Absinta M, Ha SK, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS.

Elife. 2017 Oct 3;6. pii: e29738. doi: 10.7554/eLife.29738.


Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J.

J Clin Invest. 2017 Sep 1;127(9):3210-3219. doi: 10.1172/JCI90603. Epub 2017 Sep 1. Review.


Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat.

Jung E, Gardner D, Choi D, Park E, Jin Seong Y, Yang S, Castorena-Gonzalez J, Louveau A, Zhou Z, Lee GK, Perrault DP, Lee S, Johnson M, Daghlian G, Lee M, Jin Hong Y, Kato Y, Kipnis J, Davis MJ, Wong AK, Hong YK.

Sci Rep. 2017 Jul 17;7(1):5577. doi: 10.1038/s41598-017-06031-3.


Myeloid Cells in the Central Nervous System.

Herz J, Filiano AJ, Smith A, Yogev N, Kipnis J.

Immunity. 2017 Jun 20;46(6):943-956. doi: 10.1016/j.immuni.2017.06.007. Review.


DAMed in (Trem) 2 Steps.

Da Mesquita S, Kipnis J.

Cell. 2017 Jun 15;169(7):1172-1174. doi: 10.1016/j.cell.2017.05.039.


How and why do T cells and their derived cytokines affect the injured and healthy brain?

Filiano AJ, Gadani SP, Kipnis J.

Nat Rev Neurosci. 2017 Jun;18(6):375-384. doi: 10.1038/nrn.2017.39. Epub 2017 Apr 27. Review.


Microbiota alteration is associated with the development of stress-induced despair behavior.

Marin IA, Goertz JE, Ren T, Rich SS, Onengut-Gumuscu S, Farber E, Wu M, Overall CC, Kipnis J, Gaultier A.

Sci Rep. 2017 Mar 7;7:43859. doi: 10.1038/srep43859.


Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice.

Cronk JC, Herz J, Kim TS, Louveau A, Moser EK, Sharma AK, Smirnov I, Tung KS, Braciale TJ, Kipnis J.

JCI Insight. 2017 Jan 26;2(2):e88257. doi: 10.1172/jci.insight.88257.


Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury.

Gadani SP, Smirnov I, Smith AT, Overall CC, Kipnis J.

J Exp Med. 2017 Feb;214(2):285-296. doi: 10.1084/jem.20161982. Epub 2016 Dec 19.


Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?

Louveau A, Da Mesquita S, Kipnis J.

Neuron. 2016 Sep 7;91(5):957-973. doi: 10.1016/j.neuron.2016.08.027. Review.


Multifaceted interactions between adaptive immunity and the central nervous system.

Kipnis J.

Science. 2016 Aug 19;353(6301):766-71. doi: 10.1126/science.aag2638. Review.


How Do Meningeal Lymphatic Vessels Drain the CNS?

Raper D, Louveau A, Kipnis J.

Trends Neurosci. 2016 Sep;39(9):581-586. doi: 10.1016/j.tins.2016.07.001. Epub 2016 Jul 25. Review.


Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour.

Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, Peerzade SN, Chen H, Lee KS, Scott MM, Beenhakker MP, Litvak V, Kipnis J.

Nature. 2016 Jul 21;535(7612):425-9. Epub 2016 Jul 13.


Central Nervous System: (Immunological) Ivory Tower or Not?

Marin IA, Kipnis J.

Neuropsychopharmacology. 2017 Jan;42(1):28-35. doi: 10.1038/npp.2016.122. Epub 2016 Jul 11. Review.


Bugs and Brain: How Infection Makes You Feel Blue.

Herz J, Kipnis J.

Immunity. 2016 Apr 19;44(4):718-20. doi: 10.1016/j.immuni.2016.03.010.


Corrigendum: Structural and functional features of central nervous system lymphatic vessels.

Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J.

Nature. 2016 May 12;533(7602):278. doi: 10.1038/nature16999. Epub 2016 Feb 24. No abstract available.


Shedding light on IL-33 in the eye.

Gadani SP, Kipnis J.

J Exp Med. 2016 Feb 8;213(2):141. doi: 10.1084/jem.2132insight2. No abstract available.


Natural killers in the brain's nursery.

Gadani SP, Kipnis J.

Nat Neurosci. 2016 Feb;19(2):176-7. doi: 10.1038/nn.4227. No abstract available.


Understanding the Role of T Cells in CNS Homeostasis.

Ellwardt E, Walsh JT, Kipnis J, Zipp F.

Trends Immunol. 2016 Feb;37(2):154-65. doi: 10.1016/ Epub 2016 Jan 14. Review.


Revisiting the Mechanisms of CNS Immune Privilege.

Louveau A, Harris TH, Kipnis J.

Trends Immunol. 2015 Oct;36(10):569-77. doi: 10.1016/ Review.


Breaking bad blood: β2-microglobulin as a pro-aging factor in blood.

Filiano AJ, Kipnis J.

Nat Med. 2015 Aug;21(8):844-5. doi: 10.1038/nm.3926. No abstract available.


Dealing with Danger in the CNS: The Response of the Immune System to Injury.

Gadani SP, Walsh JT, Lukens JR, Kipnis J.

Neuron. 2015 Jul 1;87(1):47-62. doi: 10.1016/j.neuron.2015.05.019. Review.


Structural and functional features of central nervous system lymphatic vessels.

Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J.

Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1. Erratum in: Nature. 2016 May 12;533(7602):278.


Unexpected cellular players in Rett syndrome pathology.

Cronk JC, Derecki NC, Litvak V, Kipnis J.

Neurobiol Dis. 2016 Aug;92(Pt A):64-71. doi: 10.1016/j.nbd.2015.05.005. Epub 2015 May 14. Review.


MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J.

J Clin Invest. 2015 Jun;125(6):2547. doi: 10.1172/JCI82458. Epub 2015 May 4. No abstract available.


Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.

Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, Smirnov I, Baker W, Norris GT, Marin I, Coddington N, Wolf Y, Turner SD, Aderem A, Klibanov AL, Harris TH, Jung S, Litvak V, Kipnis J.

Immunity. 2015 Apr 21;42(4):679-91. doi: 10.1016/j.immuni.2015.03.013.


Brainless immunity no more.

Gadani SP, Kipnis J.

Nat Immunol. 2015 May;16(5):440-1. doi: 10.1038/ni.3145. No abstract available.


The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury.

Gadani SP, Walsh JT, Smirnov I, Zheng J, Kipnis J.

Neuron. 2015 Feb 18;85(4):703-9. doi: 10.1016/j.neuron.2015.01.013. Epub 2015 Feb 5.


MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J.

J Clin Invest. 2015 Feb;125(2):699-714. doi: 10.1172/JCI76210. Epub 2015 Jan 20. Erratum in: J Clin Invest. 2015 Jun;125(6):2547.


Regulatory T cells in central nervous system injury: a double-edged sword.

Walsh JT, Zheng J, Smirnov I, Lorenz U, Tung K, Kipnis J.

J Immunol. 2014 Nov 15;193(10):5013-22. doi: 10.4049/jimmunol.1302401. Epub 2014 Oct 15.


Interactions of innate and adaptive immunity in brain development and function.

Filiano AJ, Gadani SP, Kipnis J.

Brain Res. 2015 Aug 18;1617:18-27. doi: 10.1016/j.brainres.2014.07.050. Epub 2014 Aug 7. Review.


Microglia as a critical player in both developmental and late-life CNS pathologies.

Derecki NC, Katzmarski N, Kipnis J, Meyer-Luehmann M.

Acta Neuropathol. 2014 Sep;128(3):333-45. doi: 10.1007/s00401-014-1321-z. Epub 2014 Jul 24. Review.


T cells in the central nervous system: messengers of destruction or purveyors of protection?

Walsh JT, Watson N, Kipnis J.

Immunology. 2014 Mar;141(3):340-4. doi: 10.1111/imm.12187. Review.


Microglia - the brain's busy bees.

Cronk JC, Kipnis J.

F1000Prime Rep. 2013 Dec 3;5:53. doi: 10.12703/P5-53. Review.


From neurons to microglia, with complements.

Derecki NC, Kipnis J.

Nat Neurosci. 2013 Dec;16(12):1712-3. doi: 10.1038/nn.3579. No abstract available.


How do immune cells support and shape the brain in health, disease, and aging?

Schwartz M, Kipnis J, Rivest S, Prat A.

J Neurosci. 2013 Nov 6;33(45):17587-96. doi: 10.1523/JNEUROSCI.3241-13.2013. Review.


Learning and memory ... and the immune system.

Marin I, Kipnis J.

Learn Mem. 2013 Sep 19;20(10):601-6. doi: 10.1101/lm.028357.112. Review.


Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire.

Radjavi A, Smirnov I, Kipnis J.

Brain Behav Immun. 2014 Jan;35:58-63. doi: 10.1016/j.bbi.2013.08.013. Epub 2013 Sep 5.


Dynamics of the meningeal CD4(+) T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice.

Radjavi A, Smirnov I, Derecki N, Kipnis J.

Mol Psychiatry. 2014 May;19(5):531-3. doi: 10.1038/mp.2013.79. Epub 2013 Jun 11. No abstract available.


Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury.

Smirnov I, Walsh JT, Kipnis J.

Brain Behav Immun. 2013 Jul;31:177-82. doi: 10.1016/j.bbi.2012.12.015. Epub 2013 Jan 4.


The role of microglia in brain maintenance: implications for Rett syndrome.

Derecki NC, Cronk JC, Kipnis J.

Trends Immunol. 2013 Mar;34(3):144-50. doi: 10.1016/ Epub 2012 Oct 31. Review.


IL-4 in the brain: a cytokine to remember.

Gadani SP, Cronk JC, Norris GT, Kipnis J.

J Immunol. 2012 Nov 1;189(9):4213-9. doi: 10.4049/jimmunol.1202246. Review.


Pro-cognitive properties of T cells.

Kipnis J, Gadani S, Derecki NC.

Nat Rev Immunol. 2012 Sep;12(9):663-9. doi: 10.1038/nri3280. Epub 2012 Aug 20. Review.


Wild-type microglia arrest pathology in a mouse model of Rett syndrome.

Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J.

Nature. 2012 Mar 18;484(7392):105-9. doi: 10.1038/nature10907.


Phagocytic activity of neuronal progenitors regulates adult neurogenesis.

Lu Z, Elliott MR, Chen Y, Walsh JT, Klibanov AL, Ravichandran KS, Kipnis J.

Nat Cell Biol. 2011 Jul 31;13(9):1076-83. doi: 10.1038/ncb2299.


Regulatory T cells in CNS injury: the simple, the complex and the confused.

Walsh JT, Kipnis J.

Trends Mol Med. 2011 Oct;17(10):541-7. doi: 10.1016/j.molmed.2011.05.012. Epub 2011 Jul 7.

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