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Identification and Functional Characterization of Sugarcane Invertase Inhibitor (ShINH1): A Potential Candidate for Reducing Pre- and Post-harvest Loss of Sucrose in Sugarcane.

Shivalingamurthy SG, Anangi R, Kalaipandian S, Glassop D, King GF, Rae AL.

Front Plant Sci. 2018 May 3;9:598. doi: 10.3389/fpls.2018.00598. eCollection 2018.


Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects.

Walker AA, Rosenthal M, Undheim EEA, King GF.

J Vis Exp. 2018 Apr 21;(134). doi: 10.3791/57729.


Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes.

Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI.

J Biol Chem. 2018 Apr 27. pii: jbc.RA118.002553. doi: 10.1074/jbc.RA118.002553. [Epub ahead of print]


Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

Fernandez-Rojo MA, Deplazes E, Pineda SS, Brust A, Marth T, Wilhelm P, Martel N, Ramm GA, Mancera RL, Alewood PF, Woods GM, Belov K, Miles JJ, King GF, Ikonomopoulou MP.

Cell Death Discov. 2018 Feb 14;4:19. doi: 10.1038/s41420-018-0030-0. eCollection 2018 Dec.


The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens.

Walker AA, Mayhew ML, Jin J, Herzig V, Undheim EAB, Sombke A, Fry BG, Meritt DJ, King GF.

Nat Commun. 2018 Feb 22;9(1):755. doi: 10.1038/s41467-018-03091-5.


Giant fish-killing water bug reveals ancient and dynamic venom evolution in Heteroptera.

Walker AA, Hernández-Vargas MJ, Corzo G, Fry BG, King GF.

Cell Mol Life Sci. 2018 Feb 9. doi: 10.1007/s00018-018-2768-1. [Epub ahead of print]


The North American Society of Toxinology establishes formal affiliation with Toxicon.

Keyler DE, King GF.

Toxicon. 2018 Feb;142:A1. doi: 10.1016/j.toxicon.2017.11.009. Epub 2017 Nov 26. No abstract available.


Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

Lee JYP, Saez NJ, Cristofori-Armstrong B, Anangi R, King GF, Smith MT, Rash LD.

Br J Pharmacol. 2017 Nov 14. doi: 10.1111/bph.14089. [Epub ahead of print]


ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins.

Pineda SS, Chaumeil PA, Kunert A, Kaas Q, Thang MWC, Le L, Nuhn M, Herzig V, Saez NJ, Cristofori-Armstrong B, Anangi R, Senff S, Gorse D, King GF.

Bioinformatics. 2018 Mar 15;34(6):1074-1076. doi: 10.1093/bioinformatics/btx661.


Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.


Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery.

Robinson SD, Undheim EAB, Ueberheide B, King GF.

Expert Rev Proteomics. 2017 Oct;14(10):931-939. doi: 10.1080/14789450.2017.1377613. Epub 2017 Sep 13.


Revisiting venom of the sea anemone Stichodactyla haddoni: Omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus.

Madio B, Undheim EAB, King GF.

J Proteomics. 2017 Aug 23;166:83-92. doi: 10.1016/j.jprot.2017.07.007. Epub 2017 Jul 21.


Improved efficacy of an arthropod toxin expressing fungus against insecticide-resistant malaria-vector mosquitoes.

Bilgo E, Lovett B, Fang W, Bende N, King GF, Diabate A, St Leger RJ.

Sci Rep. 2017 Jun 13;7(1):3433. doi: 10.1038/s41598-017-03399-0.


Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.


Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.


Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.

Smith JJ, Herzig V, Ikonomopoulou MP, Dziemborowicz S, Bosmans F, Nicholson GM, King GF.

Toxins (Basel). 2017 May 5;9(5). pii: E155. doi: 10.3390/toxins9050155.


A Strategy for Production of Correctly Folded Disulfide-Rich Peptides in the Periplasm of E. coli.

Saez NJ, Cristofori-Armstrong B, Anangi R, King GF.

Methods Mol Biol. 2017;1586:155-180. doi: 10.1007/978-1-4939-6887-9_10.


Venom Profiling of a Population of the Theraphosid Spider Phlogius crassipes Reveals Continuous Ontogenetic Changes from Juveniles through Adulthood.

Santana RC, Perez D, Dobson J, Panagides N, Raven RJ, Nouwens A, Jones A, King GF, Fry BG.

Toxins (Basel). 2017 Mar 25;9(4). pii: E116. doi: 10.3390/toxins9040116.


Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20.


The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.


Melt With This Kiss: Paralyzing and Liquefying Venom of The Assassin Bug Pristhesancus plagipennis (Hemiptera: Reduviidae).

Walker AA, Madio B, Jin J, Undheim EA, Fry BG, King GF.

Mol Cell Proteomics. 2017 Apr;16(4):552-566. doi: 10.1074/mcp.M116.063321. Epub 2017 Jan 27.


Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.

Koehn LM, Noor NM, Dong Q, Er SY, Rash LD, King GF, Dziegielewska KM, Saunders NR, Habgood MD.

Version 2. F1000Res. 2016 Jul 26 [revised 2016 Jan 1];5:1822. doi: 10.12688/f1000research.9094.2. eCollection 2016.


Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.


Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.

Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF.

Toxicon. 2016 Dec 1;123:62-70. doi: 10.1016/j.toxicon.2016.10.013. Epub 2016 Oct 26.


Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data.

Mohanty B, Williams ML, Doak BC, Vazirani M, Ilyichova O, Wang G, Bermel W, Simpson JS, Chalmers DK, King GF, Mobli M, Scanlon MJ.

J Biomol NMR. 2016 Nov;66(3):195-208. Epub 2016 Oct 24.


Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus.

Matsubara FH, Meissner GO, Herzig V, Justa HC, Dias BC, Trevisan-Silva D, Gremski LH, Gremski W, Senff-Ribeiro A, Chaim OM, King GF, Veiga SS.

Insect Mol Biol. 2017 Feb;26(1):25-34. doi: 10.1111/imb.12268. Epub 2016 Oct 15.


Centipede venoms as a source of drug leads.

Undheim EA, Jenner RA, King GF.

Expert Opin Drug Discov. 2016 Dec;11(12):1139-1149. Epub 2016 Sep 19. Review.


Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28.


Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.

Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF.

Sci Rep. 2016 Jul 7;6:29538. doi: 10.1038/srep29538.


Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI.

J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.


Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.


Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.

Ariki NK, Muñoz LE, Armitage EL, Goodstein FR, George KG, Smith VL, Vetter I, Herzig V, King GF, Loening NM.

PLoS One. 2016 May 26;11(5):e0156291. doi: 10.1371/journal.pone.0156291. eCollection 2016.


Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides.

Undheim EA, Mobli M, King GF.

Bioessays. 2016 Jun;38(6):539-48. doi: 10.1002/bies.201500165. Epub 2016 May 11. Review.


Venoms of Heteropteran Insects: A Treasure Trove of Diverse Pharmacological Toolkits.

Walker AA, Weirauch C, Fry BG, King GF.

Toxins (Basel). 2016 Feb 12;8(2):43. doi: 10.3390/toxins8020043. Review.


Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating.

Deplazes E, Henriques ST, Smith JJ, King GF, Craik DJ, Mark AE, Schroeder CI.

Biochim Biophys Acta. 2016 Apr;1858(4):872-82. doi: 10.1016/j.bbamem.2016.02.002. Epub 2016 Feb 2.


Combination of Ambiguous and Unambiguous Data in the Restraint-driven Docking of Flexible Peptides with HADDOCK: The Binding of the Spider Toxin PcTx1 to the Acid Sensing Ion Channel (ASIC) 1a.

Deplazes E, Davies J, Bonvin AM, King GF, Mark AE.

J Chem Inf Model. 2016 Jan 25;56(1):127-38. doi: 10.1021/acs.jcim.5b00529. Epub 2015 Dec 24.


The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a.

Herzig V, King GF.

Toxins (Basel). 2015 Oct 26;7(10):4366-80. doi: 10.3390/toxins7104366.


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD.

Sci Rep. 2015 Oct 6;5:14763. doi: 10.1038/srep14763.


Widespread convergence in toxin resistance by predictable molecular evolution.

Ujvari B, Casewell NR, Sunagar K, Arbuckle K, Wüster W, Lo N, O'Meally D, Beckmann C, King GF, Deplazes E, Madsen T.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11911-6. doi: 10.1073/pnas.1511706112. Epub 2015 Sep 8.


PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

McCarthy CA, Rash LD, Chassagnon IR, King GF, Widdop RE.

Neuropharmacology. 2015 Dec;99:650-7. doi: 10.1016/j.neuropharm.2015.08.040. Epub 2015 Aug 29.


Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Saez NJ, Deplazes E, Cristofori-Armstrong B, Chassagnon IR, Lin X, Mobli M, Mark AE, Rash LD, King GF.

Br J Pharmacol. 2015 Oct;172(20):4985-95. doi: 10.1111/bph.13267. Epub 2015 Sep 22.


Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.

Chow CY, Cristofori-Armstrong B, Undheim EA, King GF, Rash LD.

Toxins (Basel). 2015 Jun 30;7(7):2494-513. doi: 10.3390/toxins7072494.


Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators.

Undheim EA, Grimm LL, Low CF, Morgenstern D, Herzig V, Zobel-Thropp P, Pineda SS, Habib R, Dziemborowicz S, Fry BG, Nicholson GM, Binford GJ, Mobli M, King GF.

Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.


Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.

Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ.

Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.


Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.

Nogueira ML, Sforça ML, Chin YK, Mobli M, Handler A, Gorbatyuk VY, Robson SA, King GF, Gueiros-Filho FJ, Zeri AC.

Biomol NMR Assign. 2015 Oct;9(2):387-91. doi: 10.1007/s12104-015-9615-1. Epub 2015 May 13.


Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint.

Undheim EA, Hamilton BR, Kurniawan ND, Bowlay G, Cribb BW, Merritt DJ, Fry BG, King GF, Venter DJ.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4026-31. doi: 10.1073/pnas.1424068112. Epub 2015 Mar 16.


Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.


Centipede venom: recent discoveries and current state of knowledge.

Undheim EA, Fry BG, King GF.

Toxins (Basel). 2015 Feb 25;7(3):679-704. doi: 10.3390/toxins7030679. Review.


Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.

Simons C, Rash LD, Crawford J, Ma L, Cristofori-Armstrong B, Miller D, Ru K, Baillie GJ, Alanay Y, Jacquinet A, Debray FG, Verloes A, Shen J, Yesil G, Guler S, Yuksel A, Cleary JG, Grimmond SM, McGaughran J, King GF, Gabbett MT, Taft RJ.

Nat Genet. 2015 Mar;47(3):304. doi: 10.1038/ng0315-304b. No abstract available.


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