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The novel C-terminal truncated 90-kDa isoform of topoisomerase IIα (TOP2α/90) is a determinant of etoposide resistance in K562 leukemia cells via heterodimerization with the TOP2α/170 isoform.

Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Elton TS, Yalowich JC.

Mol Pharmacol. 2018 Mar 7. pii: mol.117.111567. doi: 10.1124/mol.117.111567. [Epub ahead of print]


Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.

Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC.

J Pharmacol Exp Ther. 2017 Jan;360(1):152-163. Epub 2016 Nov 10.

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