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Items: 35

1.

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner.

Fedorka SR, So K, Al-Hamashi AA, Gad I, Shah R, Kholodovych V, Alqahtani HD, Taylor WR, Tillekeratne LMV.

Org Biomol Chem. 2018 Feb 7. doi: 10.1039/c7ob03086j. [Epub ahead of print]

PMID:
29411821
2.

Organizing Pneumonia related to Electronic Cigarette Use: A Case Report and Review of Literature.

Khan MS, Khateeb F, Akhtar J, Khan Z, Lal A, Kholodovych V, Hammersley J.

Clin Respir J. 2018 Feb 2. doi: 10.1111/crj.12775. [Epub ahead of print] Review.

PMID:
29392888
3.

Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.

Geng K, Kumar S, Kimani SG, Kholodovych V, Kasikara C, Mizuno K, Sandiford O, Rameshwar P, Kotenko SV, Birge RB.

Front Immunol. 2017 Nov 10;8:1521. doi: 10.3389/fimmu.2017.01521. eCollection 2017.

4.

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.

Huang C, Alapa M, Shu P, Nagarajan N, Wu C, Sadoshima J, Kholodovych V, Li H, Beuve A.

J Biol Chem. 2017 Sep 1;292(35):14362-14370. doi: 10.1074/jbc.M117.787390. Epub 2017 Jun 28.

PMID:
28659344
5.

The β1'-β2' Motif of the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Responsible for Conferring Open Conformation to the p66 Subunit by Displacing the Connection Domain from the Polymerase Cleft.

Pandey AK, Dixit U, Kholodovych V, Comollo TW, Pandey VN.

Biochemistry. 2017 Jul 11;56(27):3434-3442. doi: 10.1021/acs.biochem.7b00005. Epub 2017 Jun 28.

PMID:
28627879
6.

Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s).

Garbuzenko OB, Ivanova V, Kholodovych V, Reimer DC, Reuhl KR, Yurkow E, Adler D, Minko T.

Nanomedicine. 2017 Aug;13(6):1983-1992. doi: 10.1016/j.nano.2017.04.005. Epub 2017 Apr 19.

7.

Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity.

Kimani SG, Kumar S, Bansal N, Singh K, Kholodovych V, Comollo T, Peng Y, Kotenko SV, Sarafianos SG, Bertino JR, Welsh WJ, Birge RB.

Sci Rep. 2017 Mar 8;7:43908. doi: 10.1038/srep43908.

8.

Self-assembled cationic amphiphiles as antimicrobial peptides mimics: Role of hydrophobicity, linkage type, and assembly state.

Zhang Y, Algburi A, Wang N, Kholodovych V, Oh DO, Chikindas M, Uhrich KE.

Nanomedicine. 2017 Feb;13(2):343-352. doi: 10.1016/j.nano.2016.07.018. Epub 2016 Aug 9.

PMID:
27520722
9.

l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.

Hu L, Yang Y, Aloysius H, Albanyan H, Yang M, Liang JJ, Yu A, Shtukenberg A, Poloni LN, Kholodovych V, Tischfield JA, Goldfarb DS, Ward MD, Sahota A.

J Med Chem. 2016 Aug 11;59(15):7293-8. doi: 10.1021/acs.jmedchem.6b00647. Epub 2016 Jul 26.

10.

Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor.

Beuve A, Wu C, Cui C, Liu T, Jain MR, Huang C, Yan L, Kholodovych V, Li H.

J Proteomics. 2016 Apr 14;138:40-7. doi: 10.1016/j.jprot.2016.02.009. Epub 2016 Feb 18.

11.

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.

Rosenfeld JA, Reeves D, Brugler MR, Narechania A, Simon S, Durrett R, Foox J, Shianna K, Schatz MC, Gandara J, Afshinnekoo E, Lam ET, Hastie AR, Chan S, Cao H, Saghbini M, Kentsis A, Planet PJ, Kholodovych V, Tessler M, Baker R, DeSalle R, Sorkin LN, Kolokotronis SO, Siddall ME, Amato G, Mason CE.

Nat Commun. 2016 Feb 2;7:10164. doi: 10.1038/ncomms10164.

12.

Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction.

Heckler EJ, Kholodovych V, Jain M, Liu T, Li H, Beuve A.

PLoS One. 2015 Nov 30;10(11):e0143523. doi: 10.1371/journal.pone.0143523. eCollection 2015.

13.

Synthesis, biological evaluation and docking of novel bisamidinohydrazones as non-peptide inhibitors of furin.

Kibirev VK, Osadchuk TV, Kozachenko OP, Kholodovych V, Fedoryak D, Brovarets VS.

Ukr Biochem J. 2015 Jan-Feb;87(1):55-63.

PMID:
26036131
14.

Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes.

Martin AA, Tomasini M, Kholodovych V, Gu L, Sommerfeld SD, Uhrich KE, Murthy NS, Welsh WJ, Moghe PV.

J Funct Biomater. 2015 Apr 8;6(2):171-91. doi: 10.3390/jfb6020171.

15.

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo.

Lewis DR, Petersen LK, York AW, Zablocki KR, Joseph LB, Kholodovych V, Prud'homme RK, Uhrich KE, Moghe PV.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2693-8. doi: 10.1073/pnas.1424594112. Epub 2015 Feb 17.

16.

Human lutropin (hLH) and choriogonadotropin (CG) are assembled by different pathways: a model of hLH assembly.

Bernard MP, Lin W, Kholodovych V, Moyle WR.

J Biol Chem. 2014 May 16;289(20):14360-9. doi: 10.1074/jbc.M113.535609. Epub 2014 Apr 1.

17.

In silico design of anti-atherogenic biomaterials.

Lewis DR, Kholodovych V, Tomasini MD, Abdelhamid D, Petersen LK, Welsh WJ, Uhrich KE, Moghe PV.

Biomaterials. 2013 Oct;34(32):7950-9. doi: 10.1016/j.biomaterials.2013.07.011. Epub 2013 Jul 25.

18.

Exome sequencing in familial corticobasal degeneration.

Fekete R, Bainbridge M, Baizabal-Carvallo JF, Rivera A, Miller B, Du P, Kholodovych V, Powell S, Ondo W.

Parkinsonism Relat Disord. 2013 Nov;19(11):1049-52. doi: 10.1016/j.parkreldis.2013.06.016. Epub 2013 Jul 16.

19.

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information.

Sushko I, Novotarskyi S, Körner R, Pandey AK, Rupp M, Teetz W, Brandmaier S, Abdelaziz A, Prokopenko VV, Tanchuk VY, Todeschini R, Varnek A, Marcou G, Ertl P, Potemkin V, Grishina M, Gasteiger J, Schwab C, Baskin II, Palyulin VA, Radchenko EV, Welsh WJ, Kholodovych V, Chekmarev D, Cherkasov A, Aires-de-Sousa J, Zhang QY, Bender A, Nigsch F, Patiny L, Williams A, Tkachenko V, Tetko IV.

J Comput Aided Mol Des. 2011 Jun;25(6):533-54. doi: 10.1007/s10822-011-9440-2. Epub 2011 Jun 10.

20.

Logical Analysis of Data in Structure-Activity Investigation of Polymeric Gene Delivery.

Gubskaya AV, Bonates TO, Kholodovych V, Hammer P, Welsh WJ, Langer R, Kohn J.

Macromol Theory Simul. 2011 May 23;20(4):275-285.

21.

Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1.

Passic SR, Ferguson ML, Catalone BJ, Kish-Catalone T, Kholodovych V, Zhu W, Welsh W, Rando R, Howett MK, Wigdahl B, Labib M, Krebs FC.

Biomed Pharmacother. 2010 Dec;64(10):723-32. doi: 10.1016/j.biopha.2010.10.001. Epub 2010 Nov 4.

22.

Persistent interactions between biguanide-based compound NB325 and CXCR4 result in prolonged inhibition of human immunodeficiency virus type 1 infection.

Thakkar N, Pirrone V, Passic S, Keogan S, Zhu W, Kholodovych V, Welsh W, Rando R, Labib M, Wigdahl B, Krebs FC.

Antimicrob Agents Chemother. 2010 May;54(5):1965-72. doi: 10.1128/AAC.00934-09. Epub 2010 Mar 15.

23.

Predicting inhibitors of acetylcholinesterase by regression and classification machine learning approaches with combinations of molecular descriptors.

Chekmarev D, Kholodovych V, Kortagere S, Welsh WJ, Ekins S.

Pharm Res. 2009 Sep;26(9):2216-24. doi: 10.1007/s11095-009-9937-8. Epub 2009 Jul 15.

PMID:
19603258
24.

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.

Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG.

Drug Metab Dispos. 2009 Jun;37(6):1295-304. doi: 10.1124/dmd.108.025213. Epub 2009 Feb 27.

25.

Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection.

Thakkar N, Pirrone V, Passic S, Zhu W, Kholodovych V, Welsh W, Rando RF, Labib ME, Wigdahl B, Krebs FC.

Antimicrob Agents Chemother. 2009 Feb;53(2):631-8. doi: 10.1128/AAC.00866-08. Epub 2008 Dec 1.

26.

Computational discovery of novel low micromolar human pregnane X receptor antagonists.

Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S.

Mol Pharmacol. 2008 Sep;74(3):662-72. doi: 10.1124/mol.108.049437. Epub 2008 Jun 25.

27.

Shape signatures: new descriptors for predicting cardiotoxicity in silico.

Chekmarev DS, Kholodovych V, Balakin KV, Ivanenkov Y, Ekins S, Welsh WJ.

Chem Res Toxicol. 2008 Jun;21(6):1304-14. doi: 10.1021/tx800063r. Epub 2008 May 8.

28.

Prediction of Fibrinogen Adsorption for Biodegradable Polymers: Integration of Molecular Dynamics and Surrogate Modeling.

Gubskaya AV, Kholodovych V, Knight D, Kohn J, Welsh WJ.

Polymer (Guildf). 2007 Sep 10;48(19):5788-5801.

29.

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.

Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K.

Mol Pharmacol. 2007 Sep;72(3):592-603. Epub 2007 Jun 18.

30.

Volume learning algorithm significantly improved PLS model for predicting the estrogenic activity of xenoestrogens.

Kovalishyn VV, Kholodovych V, Tetko IV, Welsh WJ.

J Mol Graph Model. 2007 Sep;26(2):591-4. Epub 2007 Mar 19.

PMID:
17433745
31.

3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.

Peng Y, Keenan SM, Zhang Q, Kholodovych V, Welsh WJ.

J Med Chem. 2005 Mar 10;48(5):1620-9.

PMID:
15743203
32.

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.

Paranjpe PV, Chen Y, Kholodovych V, Welsh W, Stein S, Sinko PJ.

J Control Release. 2004 Nov 24;100(2):275-92.

PMID:
15544875
33.

Using surrogate modeling in the prediction of fibrinogen adsorption onto polymer surfaces.

Smith JR, Knight D, Kohn J, Rasheed K, Weber N, Kholodovych V, Welsh WJ.

J Chem Inf Comput Sci. 2004 May-Jun;44(3):1088-97.

PMID:
15154777
34.

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

Tabb MM, Kholodovych V, Grün F, Zhou C, Welsh WJ, Blumberg B.

Environ Health Perspect. 2004 Feb;112(2):163-9.

35.

Fluorogenic substrates for proteases based on intramolecular fluorescence energy transfer (IFETS).

Gershkovich AA, Kholodovych VV.

J Biochem Biophys Methods. 1996 Dec 30;33(3):135-62.

PMID:
9029259

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