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Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival.

Gumbleton M, Sudan R, Fernandes S, Engelman RW, Russo CM, Chisholm JD, Kerr WG.

Sci Signal. 2017 Oct 10;10(500). pii: eaam5353. doi: 10.1126/scisignal.aam5353.


Analysis of SHIP1 expression and activity in Crohn's disease patients.

Somasundaram R, Fernandes S, Deuring JJ, de Haar C, Kuipers EJ, Vogelaar L, Middleton FA, van der Woude CJ, Peppelenbosch MP, Kerr WG, Fuhler GM.

PLoS One. 2017 Aug 2;12(8):e0182308. doi: 10.1371/journal.pone.0182308. eCollection 2017.


MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling.

Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG, Kuchenbauer F, Lapidot T.

Leukemia. 2017 May;31(5):1247-1250. doi: 10.1038/leu.2017.50. Epub 2017 Feb 8. No abstract available.


LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.

Park MY, Sudan R, Srivastava N, Neelam S, Youngs C, Wang JW, Engelman RW, Kerr WG.

Sci Rep. 2016 Nov 8;6:36568. doi: 10.1038/srep36568.


Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.

Hoekstra E, Das AM, Willemsen M, Swets M, Kuppen PJ, van der Woude CJ, Bruno MJ, Shah JP, Ten Hagen TL, Chisholm JD, Kerr WG, Peppelenbosch MP, Fuhler GM.

Oncotarget. 2016 Nov 8;7(45):73525-73540. doi: 10.18632/oncotarget.12321.


A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.

Srivastava N, Iyer S, Sudan R, Youngs C, Engelman RW, Howard KT, Russo CM, Chisholm JD, Kerr WG.

JCI Insight. 2016 Jul 21;1(11). pii: e88544.


Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5'-phosphatase (SHIP).

Russo CM, Adhikari AA, Wallach DR, Fernandes S, Balch AN, Kerr WG, Chisholm JD.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5344-8. doi: 10.1016/j.bmcl.2015.09.034. Epub 2015 Sep 15.


miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.

Lind EF, Millar DG, Dissanayake D, Savage JC, Grimshaw NK, Kerr WG, Ohashi PS.

J Immunol. 2015 Nov 15;195(10):4632-40. doi: 10.4049/jimmunol.1302941. Epub 2015 Oct 7.


SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans.

Blanco-Menéndez N, Del Fresno C, Fernandes S, Calvo E, Conde-Garrosa R, Kerr WG, Sancho D.

J Immunol. 2015 Nov 1;195(9):4466-4478. doi: 10.4049/jimmunol.1402874. Epub 2015 Sep 28.


Role of SHIP1 in Invariant NKT Cell Development and Functions.

Anderson CK, Salter AI, Toussaint LE, Reilly EC, Fugère C, Srivastava N, Kerr WG, Brossay L.

J Immunol. 2015 Sep 1;195(5):2149-2156. doi: 10.4049/jimmunol.1500567. Epub 2015 Jul 31.


SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.

Fernandes S, Brooks R, Gumbleton M, Park MY, Russo CM, Howard KT, Chisholm JD, Kerr WG.

EBioMedicine. 2015 Mar 1;2(3):205-213.


SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice.

Gumbleton M, Vivier E, Kerr WG.

J Immunol. 2015 Mar 15;194(6):2847-54. doi: 10.4049/jimmunol.1402930. Epub 2015 Feb 16.


SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.

Iyer S, Brooks R, Gumbleton M, Kerr WG.

Stem Cells Dev. 2015 May 1;24(9):1073-81. doi: 10.1089/scd.2014.0501. Epub 2015 Feb 5.


Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi.

Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG.

Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902.


SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.

Iyer S, Viernes DR, Chisholm JD, Margulies BS, Kerr WG.

Stem Cells Dev. 2014 Oct 1;23(19):2336-51. doi: 10.1089/scd.2014.0122. Epub 2014 Jul 3.


Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice.

Park MY, Srivastava N, Sudan R, Viernes DR, Chisholm JD, Engelman RW, Kerr WG.

Mucosal Immunol. 2014 Nov;7(6):1429-1439. doi: 10.1038/mi.2014.32. Epub 2014 Apr 30.


SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.

Maxwell MJ, Srivastava N, Park MY, Tsantikos E, Engelman RW, Kerr WG, Hibbs ML.

Genes Immun. 2014 Apr;15(4):233-40. doi: 10.1038/gene.2014.9. Epub 2014 Mar 6.


The mouse that lost its appetite for human.

Kerr WG.

Blood. 2013 Dec 12;122(25):4003-4. doi: 10.1182/blood-2013-09-527614.


Discovery and development of small molecule SHIP phosphatase modulators.

Viernes DR, Choi LB, Kerr WG, Chisholm JD.

Med Res Rev. 2014 Jul;34(4):795-824. doi: 10.1002/med.21305. Epub 2013 Dec 2. Review.


Role of inositol poly-phosphatases and their targets in T cell biology.

Srivastava N, Sudan R, Kerr WG.

Front Immunol. 2013 Sep 23;4:288. doi: 10.3389/fimmu.2013.00288. Review.


Introduction to inositol phospholipid signaling in physiology and disease.

Kerr WG, Fernandes S.

Ann N Y Acad Sci. 2013 Mar;1280:v-vii. doi: 10.1111/nyas.12097. No abstract available.


Role of SHIP1 in bone biology.

Iyer S, Margulies BS, Kerr WG.

Ann N Y Acad Sci. 2013 Mar;1280:11-4. doi: 10.1111/nyas.12091. Review.


Role of SHIP1 in cancer and mucosal inflammation.

Fernandes S, Iyer S, Kerr WG.

Ann N Y Acad Sci. 2013 Mar;1280:6-10. doi: 10.1111/nyas.12038. Review.


Role of inositol phospholipid signaling in natural killer cell biology.

Gumbleton M, Kerr WG.

Front Immunol. 2013 Mar 6;4:47. doi: 10.3389/fimmu.2013.00047. eCollection 2013.


Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.

Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP.

J Immunol. 2013 Apr 15;190(8):3994-4004. doi: 10.4049/jimmunol.1200873. Epub 2013 Mar 11.


Quorum sensing contributes to activated IgM-secreting B cell homeostasis.

Montaudouin C, Anson M, Hao Y, Duncker SV, Fernandez T, Gaudin E, Ehrenstein M, Kerr WG, Colle JH, Bruhns P, Daëron M, Freitas AA.

J Immunol. 2013 Jan 1;190(1):106-14. doi: 10.4049/jimmunol.1200907. Epub 2012 Dec 3.


Mouse natural killer cell development and maturation are differentially regulated by SHIP-1.

Banh C, Miah SM, Kerr WG, Brossay L.

Blood. 2012 Nov 29;120(23):4583-90. doi: 10.1182/blood-2012-04-425009. Epub 2012 Oct 3.


Assessing inflammatory disease at mucosal surfaces in murine genetic models.

Engelman RW, Kerr WG.

Methods Mol Biol. 2012;900:433-41. doi: 10.1007/978-1-60761-720-4_21.


Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.

Collazo MM, Paraiso KH, Park MY, Hazen AL, Kerr WG.

Eur J Immunol. 2012 Jul;42(7):1785-95. doi: 10.1002/eji.201142092.


Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection.

Hadidi S, Antignano F, Hughes MR, Wang SK, Snyder K, Sammis GM, Kerr WG, McNagny KM, Zaph C.

Mucosal Immunol. 2012 Sep;5(5):535-43. doi: 10.1038/mi.2012.29. Epub 2012 Apr 25.


Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer.

Fuhler GM, Brooks R, Toms B, Iyer S, Gengo EA, Park MY, Gumbleton M, Viernes DR, Chisholm JD, Kerr WG.

Mol Med. 2012 Feb 10;18:65-75. doi: 10.2119/molmed.2011.00178.


Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment.

Hazen AL, Diks SH, Wahle JA, Fuhler GM, Peppelenbosch MP, Kerr WG.

J Proteome Res. 2011 Aug 5;10(8):3542-50. doi: 10.1021/pr2001594. Epub 2011 Jun 28.


Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention.

Fuhler GM, Diks SH, Peppelenbosch MP, Kerr WG.

Mol Med. 2011;17(7-8):790-8. doi: 10.2119/molmed.2011.00013. Epub 2011 Apr 28.


Inositol phospholipid signaling and the biology of natural killer cells.

Kerr WG, Colucci F.

J Innate Immun. 2011;3(3):249-57. doi: 10.1159/000323920. Epub 2011 Mar 22. Review.


Inhibitor and activator: dual functions for SHIP in immunity and cancer.

Kerr WG.

Ann N Y Acad Sci. 2011 Jan;1217:1-17. doi: 10.1111/j.1749-6632.2010.05869.x. Epub 2010 Dec 13. Review.


SHIP represses Th2 skewing by inhibiting IL-4 production from basophils.

Kuroda E, Antignano F, Ho VW, Hughes MR, Ruschmann J, Lam V, Kawakami T, Kerr WG, McNagny KM, Sly LM, Krystal G.

J Immunol. 2011 Jan 1;186(1):323-32. doi: 10.4049/jimmunol.1002778. Epub 2010 Dec 3.


SHIP deficiency causes Crohn's disease-like ileitis.

Kerr WG, Park MY, Maubert M, Engelman RW.

Gut. 2011 Feb;60(2):177-88. doi: 10.1136/gut.2009.202283. Epub 2010 Oct 12.


TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB.

Sci Signal. 2010 May 18;3(122):ra38. doi: 10.1126/scisignal.2000500.


SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation.

Fortenbery NR, Paraiso KH, Taniguchi M, Brooks C, Ibrahim L, Kerr WG.

J Immunol. 2010 May 1;184(9):5065-74. doi: 10.4049/jimmunol.0901862. Epub 2010 Apr 2.


SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

Brooks R, Fuhler GM, Iyer S, Smith MJ, Park MY, Paraiso KH, Engelman RW, Kerr WG.

J Immunol. 2010 Apr 1;184(7):3582-9. doi: 10.4049/jimmunol.0902844. Epub 2010 Mar 3.


SHIP limits immunoregulatory capacity in the T-cell compartment.

Collazo MM, Wood D, Paraiso KH, Lund E, Engelman RW, Le CT, Stauch D, Kotsch K, Kerr WG.

Blood. 2009 Mar 26;113(13):2934-44. doi: 10.1182/blood-2008-09-181164. Epub 2009 Jan 9.


SHIP is required for a functional hematopoietic stem cell niche.

Hazen AL, Smith MJ, Desponts C, Winter O, Moser K, Kerr WG.

Blood. 2009 Mar 26;113(13):2924-33. doi: 10.1182/blood-2008-02-138008. Epub 2008 Dec 12.


SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors.

Perez LE, Desponts C, Parquet N, Kerr WG.

PLoS One. 2008;3(10):e3565. doi: 10.1371/journal.pone.0003565. Epub 2008 Oct 29.


A role for SHIP in stem cell biology and transplantation.

Kerr WG.

Curr Stem Cell Res Ther. 2008 May;3(2):99-106. Review.


Analysis of apoptosis in hematopoietic stem cells by flow cytometry.

Kerr WG.

Methods Mol Biol. 2008;430:87-99. doi: 10.1007/978-1-59745-182-6_6.


Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease.

Paraiso KH, Ghansah T, Costello A, Engelman RW, Kerr WG.

J Immunol. 2007 Mar 1;178(5):2893-900.


s-SHIP associates with receptor complexes essential for pluripotent stem cell growth and survival.

Desponts C, Ninos JM, Kerr WG.

Stem Cells Dev. 2006 Oct;15(5):641-6.


Cutting edge: dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets.

Wahle JA, Paraiso KH, Costello AL, Goll EL, Sentman CL, Kerr WG.

J Immunol. 2006 Jun 15;176(12):7165-9.


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