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What can we learn from using formal patient-reported outcome instruments to assess pain, functional impairment, anxiety, and depression in US adults with hemophilia?

Buckner TW, Batt K, Cooper DL, Kempton CL.

Eur J Haematol. 2018 Apr;100 Suppl 1:3-4. doi: 10.1111/ejh.13026.


Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient-reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study.

Buckner TW, Batt K, Quon D, Witkop M, Recht M, Kessler C, Baumann K, Hernandez G, Wang M, Cooper DL, Kempton CL.

Eur J Haematol. 2018 Apr;100 Suppl 1:5-13. doi: 10.1111/ejh.13027.


Mitigating the effect of persistent postnatal depression on child outcomes through an intervention to treat depression and improve parenting: a randomised controlled trial.

Stein A, Netsi E, Lawrence PJ, Granger C, Kempton C, Craske MG, Nickless A, Mollison J, Stewart DA, Rapa E, West V, Scerif G, Cooper PJ, Murray L.

Lancet Psychiatry. 2018 Feb;5(2):134-144. doi: 10.1016/S2215-0366(18)30006-3.


Impact of pain and functional impairment in US adults with haemophilia: Patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study.

Kempton CL, Recht M, Neff A, Wang M, Buckner TW, Soni A, Quon D, Witkop M, Boggio L, Gut RZ, Cooper DL.

Haemophilia. 2017 Dec 8. doi: 10.1111/hae.13377. [Epub ahead of print]


Known-group validity of patient-reported outcome instruments and hemophilia joint health score v2.1 in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.

Buckner TW, Wang M, Cooper DL, Iyer NN, Kempton CL.

Patient Prefer Adherence. 2017 Oct 11;11:1745-1753. doi: 10.2147/PPA.S141392. eCollection 2017.


Current and emerging factor VIII replacement products for hemophilia A.

Cafuir LA, Kempton CL.

Ther Adv Hematol. 2017 Oct;8(10):303-313. doi: 10.1177/2040620717721458. Epub 2017 Aug 26. Review.


Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ) study.

Kempton CL, Wang M, Recht M, Neff A, Shapiro AD, Soni A, Kulkarni R, Buckner TW, Batt K, Iyer NN, Cooper DL.

Patient Prefer Adherence. 2017 Sep 19;11:1603-1612. doi: 10.2147/PPA.S141389. eCollection 2017.


Method to Increase Undergraduate Laboratory Student Confidence in Performing Independent Research.

Kempton CE, Weber KS, Johnson SM.

J Microbiol Biol Educ. 2017 Apr 21;18(1). pii: 18.1.18. doi: 10.1128/jmbe.v18i1.1230. eCollection 2017. No abstract available.


Construct validity of patient-reported outcome instruments in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.

Batt K, Recht M, Cooper DL, Iyer NN, Kempton CL.

Patient Prefer Adherence. 2017 Aug 9;11:1369-1380. doi: 10.2147/PPA.S141390. eCollection 2017.


Effect of late prophylaxis in hemophilia on joint status: a randomized trial.

Manco-Johnson MJ, Lundin B, Funk S, Peterfy C, Raunig D, Werk M, Kempton CL, Reding MT, Goranov S, Gercheva L, Rusen L, Uscatescu V, Pierdominici M, Engelen S, Pocoski J, Walker D, Hong W.

J Thromb Haemost. 2017 Nov;15(11):2115-2124. doi: 10.1111/jth.13811. Epub 2017 Oct 10.


Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients.

Collins PW, Quon DVK, Makris M, Chowdary P, Kempton CL, Apte SJ, Ramanan MV, Hay CRM, Drobic B, Hua Y, Babinchak TJ, Gomperts ED.

Haemophilia. 2018 Jan;24(1):104-112. doi: 10.1111/hae.13324. Epub 2017 Aug 17.


Exploring changes in distress among individuals with bleeding disorders: What is linked to improvements in distress?

Barry V, Lynch ME, Tran DQ, Antun A, DeBalsi A, Hicks D, Lasseter F, Mattis S, Ribeiro MJ, Stein SF, Kempton CL.

J Health Psychol. 2017 Mar 1:1359105317695877. doi: 10.1177/1359105317695877. [Epub ahead of print]


Intrusive thoughts and images of intentional harm to infants in the context of maternal postnatal depression, anxiety, and OCD.

Lawrence PJ, Craske MG, Kempton C, Stewart A, Stein A.

Br J Gen Pract. 2017 Aug;67(661):376-377. doi: 10.3399/bjgp17X692105. No abstract available.


Acquired hemophilia A: Updated review of evidence and treatment guidance.

Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM.

Am J Hematol. 2017 Jul;92(7):695-705. doi: 10.1002/ajh.24777. Epub 2017 Jun 5. Review.


Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.

Witkop M, Neff A, Buckner TW, Wang M, Batt K, Kessler CM, Quon D, Boggio L, Recht M, Baumann K, Gut RZ, Cooper DL, Kempton CL.

Haemophilia. 2017 Jul;23(4):556-565. doi: 10.1111/hae.13214. Epub 2017 Apr 16.


Moving from parked to neutral(izing).

Kempton CL.

Blood. 2017 Mar 9;129(10):1233-1234. doi: 10.1182/blood-2017-01-760538. No abstract available.


Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay.

Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH; Hemophilia Inhibitor Research Study Investigators.

J Thromb Haemost. 2016 Oct;14(10):1931-1940. doi: 10.1111/jth.13438. Epub 2016 Sep 17.


Physician trust and depression influence adherence to factor replacement: a single-centre cross-sectional study.

Tran DQ, Barry V, Antun A, Ribeiro M, Stein S, Kempton CL.

Haemophilia. 2017 Jan;23(1):98-104. doi: 10.1111/hae.13078. Epub 2016 Sep 30.


Interim results from a large multinational extension trial (guardian(™) 2) using turoctocog alfa for prophylaxis and treatment of bleeding in patients with severe haemophilia A.

Lentz SR, Cerqueira M, Janic D, Kempton C, Matytsina I, Misgav M, Oldenburg J, Ozelo M, Recht M, Rosholm A, Savic A, Suzuki T, Tiede A, Santagostino E.

Haemophilia. 2016 Sep;22(5):e445-9. doi: 10.1111/hae.12990. Epub 2016 Jun 13. No abstract available.


Expecting the Unexpected.

Antun A, Kempton CL.

J Oncol Pract. 2016 Jun;12(6):533-4. doi: 10.1200/JOP.2016.012690. No abstract available.


Prospective, multicenter study of postoperative deep-vein thrombosis in patients with haemophilia undergoing major orthopaedic surgery.

Buckner TW, Leavitt AD, Ragni M, Kempton CL, Eyster ME, Cuker A, Lentz SR, Ducore J, Leissinger C, Wang M, Key NS.

Thromb Haemost. 2016 Jul 4;116(1):42-9. doi: 10.1160/TH15-10-0802. Epub 2016 Mar 24.


A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII.

Eubanks J, Baldwin WH, Markovitz R, Parker ET, Cox C, Kempton CL, Meeks SL.

Blood. 2016 Apr 21;127(16):2028-34. doi: 10.1182/blood-2015-09-670034. Epub 2016 Jan 29.


Inhibitor recurrence after immune tolerance induction: a multicenter retrospective cohort study.

Antun A, Monahan PE, Manco-Johnson MJ, Callaghan MU, Kanin M, Knoll C, Carpenter SL, Davis JA, Guerrera MF, Kruse-Jarres R, Ragni MV, Witmer C, McCracken CE, Kempton CL.

J Thromb Haemost. 2015 Nov;13(11):1980-8. doi: 10.1111/jth.13143. Epub 2015 Oct 20.


Mitral valve repair in a Jehovah's witness with haemophilia A with high-titre inhibitor.

Tran DQ, Moss E, Murphy DA, Kempton CL.

Haemophilia. 2015 Nov;21(6):e523-5. doi: 10.1111/hae.12789. Epub 2015 Aug 17. No abstract available.


Distress in patients with bleeding disorders: a single institutional cross-sectional study.

Barry V, Lynch ME, Tran DQ, Antun A, Cohen HG, DeBalsi A, Hicks D, Mattis S, Ribeiro MJ, Stein SF, Truss CL, Tyson K, Kempton CL.

Haemophilia. 2015 Nov;21(6):e456-64. doi: 10.1111/hae.12748. Epub 2015 Jul 14.


Bone health in persons with haemophilia.

Kempton CL, Antoniucci DM, Rodriguez-Merchan EC.

Haemophilia. 2015 Sep;21(5):568-77. doi: 10.1111/hae.12736. Epub 2015 Jul 14. Review.


US Guidelines for immune tolerance induction in patients with haemophilia a and inhibitors.

Valentino LA, Kempton CL, Kruse-Jarres R, Mathew P, Meeks SL, Reiss UM; International Immune Tolerance Induction Study Investigators.

Haemophilia. 2015 Sep;21(5):559-67. doi: 10.1111/hae.12730. Epub 2015 Jun 2. Review.


Prophylaxis escalation in severe von Willebrand disease: a prospective study from the von Willebrand Disease Prophylaxis Network.

Abshire T, Cox-Gill J, Kempton CL, Leebeek FW, Carcao M, Kouides P, Donfield S, Berntorp E.

J Thromb Haemost. 2015 Sep;13(9):1585-9. doi: 10.1111/jth.12995. Epub 2015 Jul 14. Review.


Toward optimal therapy for inhibitors in hemophilia.

Kempton CL, Meeks SL.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):364-71. doi: 10.1182/asheducation-2014.1.364. Epub 2014 Nov 18. Review.


Changes in bleeding patterns in von Willebrand disease after institution of long-term replacement therapy: results from the von Willebrand Disease Prophylaxis Network.

Holm E, Abshire TC, Bowen J, Álvarez MT, Bolton-Maggs P, Carcao M, Federici AB, Gill JC, Halimeh S, Kempton C, Key NS, Kouides P, Lail A, Landorph A, Leebeek F, Makris M, Mannucci P, Mauser-Bunschoten EP, Nugent D, Valentino LA, Winikoff R, Berntorp E.

Blood Coagul Fibrinolysis. 2015 Jun;26(4):383-8. doi: 10.1097/MBC.0000000000000257.


Toward optimal therapy for inhibitors in hemophilia.

Kempton CL, Meeks SL.

Blood. 2014 Nov 27;124(23):3365-72. doi: 10.1182/blood-2014-05-577643. Review.


Reproducibility and consistency of in vitro nucleosome reconstitutions demonstrated by invitrosome isolation and sequencing.

Kempton CE, Heninger JR, Johnson SM.

PLoS One. 2014 Aug 5;9(8):e103752. doi: 10.1371/journal.pone.0103752. eCollection 2014.


Continuation of all-trans retinoic acid despite the development of scrotal ulcerations in a black male.

Sutherland J, Kempton CL, Curry MA.

J Oncol Pharm Pract. 2015 Oct;21(5):393-5. doi: 10.1177/1078155214536244. Epub 2014 May 29.


Use of factor VIII after inhibitor clearance in patients with moderate haemophilia A: a case series.

Tran DQ, Harvey RD, Meeks SL, Chapman R, Kempton CL.

Haemophilia. 2014 Jul;20(4):e344-6. doi: 10.1111/hae.12452. Epub 2014 Apr 21. No abstract available.


A study of prospective surveillance for inhibitors among persons with haemophilia in the United States.

Soucie JM, Miller CH, Kelly FM, Payne AB, Creary M, Bockenstedt PL, Kempton CL, Manco-Johnson MJ, Neff AT; Haemophilia Inhibitor Research Study Investigators.

Haemophilia. 2014 Mar;20(2):230-7. doi: 10.1111/hae.12302. Epub 2013 Nov 22.


The role of disease severity in influencing body mass index in people with haemophilia: a single-institutional cross-sectional study.

McNamara M, Antun A, Kempton CL.

Haemophilia. 2014 Mar;20(2):190-5. doi: 10.1111/hae.12279. Epub 2013 Oct 14.


Bone density in haemophilia: a single institutional cross-sectional study.

Kempton CL, Antun A, Antoniucci DM, Carpenter W, Ribeiro M, Stein S, Slovensky L, Elon L.

Haemophilia. 2014 Jan;20(1):121-8. doi: 10.1111/hae.12240. Epub 2013 Aug 1.


Prevalent inhibitors in haemophilia B subjects enrolled in the Universal Data Collection database.

Puetz J, Soucie JM, Kempton CL, Monahan PE; Hemophilia Treatment Center Network (HTCN) Investigators.

Haemophilia. 2014 Jan;20(1):25-31. doi: 10.1111/hae.12229. Epub 2013 Jul 16.


Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial.

Mannucci PM, Kempton C, Millar C, Romond E, Shapiro A, Birschmann I, Ragni MV, Gill JC, Yee TT, Klamroth R, Wong WY, Chapman M, Engl W, Turecek PL, Suiter TM, Ewenstein BM; rVWF Ad Hoc Study Group.

Blood. 2013 Aug 1;122(5):648-57. doi: 10.1182/blood-2013-01-479527. Epub 2013 Jun 18.


Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance.

Lewis KB, Hughes RJ, Epstein MS, Josephson NC, Kempton CL, Kessler CM, Key NS, Howard TE, Kruse-Jarres R, Lusher JM, Walsh CE, Watts RG, Ettinger RA, Pratt KP; PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators.

PLoS One. 2013 May 8;8(5):e61120. doi: 10.1371/journal.pone.0061120. Print 2013.


Physical activity and functional abilities in adult males with haemophilia: a cross-sectional survey from a single US haemophilia treatment centre.

Baumgardner J, Elon L, Antun A, Stein S, Ribeiro M, Slovensky L, Kempton CL.

Haemophilia. 2013 Jul;19(4):551-7. doi: 10.1111/hae.12134. Epub 2013 Apr 10.


Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor VIII in adults with severe hemophilia A (SPINART).

Manco-Johnson MJ, Kempton CL, Reding MT, Lissitchkov T, Goranov S, Gercheva L, Rusen L, Ghinea M, Uscatescu V, Rescia V, Hong W.

J Thromb Haemost. 2013 Jun;11(6):1119-27. doi: 10.1111/jth.12202. Erratum in: J Thromb Haemost. 2014 Jan;12(1):119-22.


A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.

Lane J, McLaren PJ, Dorrell L, Shianna KV, Stemke A, Pelak K, Moore S, Oldenburg J, Alvarez-Roman MT, Angelillo-Scherrer A, Boehlen F, Bolton-Maggs PH, Brand B, Brown D, Chiang E, Cid-Haro AR, Clotet B, Collins P, Colombo S, Dalmau J, Fogarty P, Giangrande P, Gringeri A, Iyer R, Katsarou O, Kempton C, Kuriakose P, Lin J, Makris M, Manco-Johnson M, Tsakiris DA, Martinez-Picado J, Mauser-Bunschoten E, Neff A, Oka S, Oyesiku L, Parra R, Peter-Salonen K, Powell J, Recht M, Shapiro A, Stine K, Talks K, Telenti A, Wilde J, Yee TT, Wolinsky SM, Martinson J, Hussain SK, Bream JH, Jacobson LP, Carrington M, Goedert JJ, Haynes BF, McMichael AJ, Goldstein DB, Fellay J; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI).

Hum Mol Genet. 2013 May 1;22(9):1903-10. doi: 10.1093/hmg/ddt033. Epub 2013 Jan 30.


Late immune tolerance induction in haemophilia A patients.

Meeks SL, Chapman RL, Kempton C, Dunn AL.

Haemophilia. 2013 May;19(3):445-8. doi: 10.1111/hae.12077. Epub 2013 Jan 7.


Pharmacokinetic properties of IB1001, an investigational recombinant factor IX, in patients with haemophilia B: repeat pharmacokinetic evaluation and sialylation analysis.

Martinowitz U, Shapiro A, Quon DV, Escobar M, Kempton C, Collins PW, Chowdary P, Makris M, Mannucci PM, Morfini M, Valentino LA, Gomperts E, Lee M.

Haemophilia. 2012 Nov;18(6):881-7. doi: 10.1111/j.1365-2516.2012.02897.x. Epub 2012 Jul 5.


Eradication of factor VIII inhibitors in patients with mild and moderate hemophilia A.

Kempton CL, Allen G, Hord J, Kruse-Jarres R, Pruthi RK, Walsh C, Young G, Soucie JM.

Am J Hematol. 2012 Sep;87(9):933-6. doi: 10.1002/ajh.23269. Epub 2012 Jun 26.


Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A.

Kempton CL, Abshire TC, Deveras RA, Hoots WK, Gill JC, Kessler CM, Key NS, Konkle BA, Kuriakose P, Macfarlane DE, Bergman G.

Haemophilia. 2012 Sep;18(5):798-804. doi: 10.1111/j.1365-2516.2012.02789.x. Epub 2012 Apr 19.


Screening for von Willebrand disease in children: a case-control study.

Bujnicki HC, Sidonio RF, Kempton C, Kouides PA, Kulkarni R, Nugent DJ, Yee DL, Moore CG, Ragni MV.

J Thromb Haemost. 2011 May;9(5):1086-9. doi: 10.1111/j.1538-7836.2011.04261.x. No abstract available.

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