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Items: 1 to 50 of 64

1.

Controlling of N-alkylpolyamine analogue metabolism by selective deuteration.

Ucal S, Häkkinen MR, Alanne AL, Alhonen L, Vepsäläinen J, Keinänen TA, Hyvönen MT.

Biochem J. 2018 Feb 14;475(3):663-676. doi: 10.1042/BCJ20170887.

PMID:
29301981
2.

Urinary Polyamines as Biomarkers for Ovarian Cancer.

Niemi RJ, Roine AN, Häkkinen MR, Kumpulainen PS, Keinänen TA, Vepsäläinen JJ, Lehtimäki T, Oksala NK, Mäenpää JU.

Int J Gynecol Cancer. 2017 Sep;27(7):1360-1366. doi: 10.1097/IGC.0000000000001031.

PMID:
28604456
3.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism.

Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV.

Biochem Biophys Res Commun. 2017 Feb 5;483(2):904-909. doi: 10.1016/j.bbrc.2017.01.032. Epub 2017 Jan 9.

PMID:
28082202
4.

Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer.

Thomas TJ, Thomas T, John S, Hsu HC, Yang P, Keinänen TA, Hyvönen MT.

Amino Acids. 2016 Oct;48(10):2293-302. doi: 10.1007/s00726-016-2300-6. Epub 2016 Jul 20.

PMID:
27438264
5.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Hyvönen MT, Ucal S, Pasanen M, Peräniemi S, Weisell J, Khomutov M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2016 May 15;473(10):1433-41. doi: 10.1042/BCJ20160134. Epub 2016 Mar 21.

PMID:
27001865
6.

[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].

Khomutov MA, Keinanen TA, Hyvonen MT, Weisell J, Vepsalainen J, Alhonen L, Kochetkov SN, Khomutov AR.

Bioorg Khim. 2015 Sep-Oct;41(5):612-8. Russian.

PMID:
26762100
7.

[Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme].

Keĭnanen TA, Khivonen T, Vepsalajnen Ĭ, Alhonen L, Homutov AR, Ianne Iu.

Bioorg Khim. 2014 Mar-Apr;40(2):170-7. Russian.

PMID:
25895336
8.

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA.

ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27.

PMID:
25689365
9.

Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells.

Ruiz-Pérez MV, Medina MÁ, Urdiales JL, Keinänen TA, Sánchez-Jiménez F.

J Biol Chem. 2015 Mar 6;290(10):6106-19. doi: 10.1074/jbc.M114.619197. Epub 2015 Jan 15.

10.

Detection of prostate cancer by an electronic nose: a proof of principle study.

Roine A, Veskimäe E, Tuokko A, Kumpulainen P, Koskimäki J, Keinänen TA, Häkkinen MR, Vepsäläinen J, Paavonen T, Lekkala J, Lehtimäki T, Tammela TL, Oksala NK.

J Urol. 2014 Jul;192(1):230-4. doi: 10.1016/j.juro.2014.01.113. Epub 2014 Feb 25.

PMID:
24582536
11.

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN.

Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Review.

12.

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.

Häkkinen MR, Roine A, Auriola S, Tuokko A, Veskimäe E, Keinänen TA, Lehtimäki T, Oksala N, Vepsäläinen J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 15;941:81-9. doi: 10.1016/j.jchromb.2013.10.009. Epub 2013 Oct 15.

PMID:
24185098
13.

Selective regulation of polyamine metabolism with methylated polyamine analogues.

Keinänen TA, Hyvönen MT, Alhonen L, Vepsäläinen J, Khomutov AR.

Amino Acids. 2014 Mar;46(3):605-20. Epub 2013 Oct 10. Review.

PMID:
24022706
14.

Charge deficient analogues of the natural polyamines.

Weisell J, Hyvönen MT, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

Curr Pharm Des. 2014;20(2):262-77. Review.

PMID:
23701551
15.

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

Hyvönen MT, Koponen T, Weisell J, Pietilä M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2013 Aug 1;453(3):467-74. doi: 10.1042/BJ20130263.

PMID:
23672317
16.

Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose.

Roine A, Tolvanen M, Sipiläinen M, Kumpulainen P, Helenius MA, Lehtimäki T, Vepsäläinen J, Keinänen TA, Häkkinen MR, Koskimäki J, Veskimäe E, Tuokko A, Visakorpi T, Tammela TL, Sioris T, Paavonen T, Lekkala J, Helle H, Oksala NK.

Future Oncol. 2012 Sep;8(9):1157-65. doi: 10.2217/fon.12.93.

PMID:
23030490
17.

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

Hyvönen MT, Weisell J, Khomutov AR, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2013 Jan;41(1):30-2. doi: 10.1124/dmd.112.047274. Epub 2012 Sep 28.

18.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

Smirnova OA, Isaguliants MG, Hyvonen MT, Keinanen TA, Tunitskaya VL, Vepsalainen J, Alhonen L, Kochetkov SN, Ivanov AV.

Biochimie. 2012 Sep;94(9):1876-83. doi: 10.1016/j.biochi.2012.04.023. Epub 2012 May 8.

PMID:
22579641
19.

Complex N-acetylation of triethylenetetramine.

Cerrada-Gimenez M, Weisell J, Hyvönen MT, Park MH, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2011 Dec;39(12):2242-9. doi: 10.1124/dmd.111.041798. Epub 2011 Aug 30.

20.

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Vepsäläinen J, Park JH, Khomutov AR, Alhonen L, Park MH.

Amino Acids. 2012 Feb;42(2-3):685-95. doi: 10.1007/s00726-011-0984-1. Epub 2011 Aug 23.

21.

A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.

Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ.

Amino Acids. 2012 Feb;42(2-3):899-911. doi: 10.1007/s00726-011-1005-0. Epub 2011 Aug 10.

PMID:
21830120
22.

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS.

Cerrada-Gimenez M, Häkkinen MR, Vepsäläinen J, Auriola S, Alhonen L, Keinänen TA.

Amino Acids. 2012 Feb;42(2-3):451-60. doi: 10.1007/s00726-011-1024-x. Epub 2011 Aug 5.

PMID:
21818565
23.

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Vepsäläinen J, Khomutov AR, Keinänen TA, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):485-93. doi: 10.1007/s00726-011-1027-7. Epub 2011 Aug 2.

PMID:
21809078
24.

[Novel metabolically stable functionally-active mimetic of spermidine].

Khomutov MA, Khivonen MT, Simonian AR, Vepsäläinen Ĭ, Alkhonen L, Kochetkov SN, Keinänen TA.

Bioorg Khim. 2011 Mar-Apr;37(2):253-8. Russian.

PMID:
21721258
25.

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Weisell J, Kochetkov SN, Vepsäläinen J, Alhonen L, Khomutov AR.

J Med Chem. 2011 Jul 14;54(13):4611-8. doi: 10.1021/jm200293r. Epub 2011 Jun 3.

PMID:
21639123
26.

Methylated polyamines as research tools.

Khomutov AR, Weisell J, Khomutov MA, Grigorenko NA, Simonian AR, Häkkinen MR, Keinänen TA, Hyvönen MT, Alhonen L, Kochetkov SN, Vepsäläinen J.

Methods Mol Biol. 2011;720:449-61. doi: 10.1007/978-1-61779-034-8_29.

PMID:
21318892
27.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

J Med Chem. 2010 Aug 12;53(15):5738-48. doi: 10.1021/jm100439p.

PMID:
20684609
28.

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Cerrada-Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvönen MT, Keinänen TA, Jänne J, Alhonen L.

Transgenic Res. 2011 Apr;20(2):387-96. doi: 10.1007/s11248-010-9422-5. Epub 2010 Jun 25.

PMID:
20577801
29.

Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L.

Pancreatology. 2010;10(2-3):208-21. doi: 10.1159/000243730. Epub 2010 May 7.

PMID:
20453551
30.

Transgenic animals modelling polyamine metabolism-related diseases.

Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA.

Essays Biochem. 2009 Nov 4;46:125-44. doi: 10.1042/bse0460009. Review.

PMID:
20095974
31.

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.

Häkkinen MR, Hyvönen MT, Auriola S, Casero RA Jr, Vepsäläinen J, Khomutov AR, Alhonen L, Keinänen TA.

Amino Acids. 2010 Feb;38(2):369-81. doi: 10.1007/s00726-009-0429-2. Epub 2009 Dec 10.

32.

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage.

Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA, Alhonen L.

Amino Acids. 2010 Feb;38(2):575-81. doi: 10.1007/s00726-009-0418-5. Epub 2009 Dec 3.

PMID:
19956991
33.

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.

Fashe TM, Keinänen TA, Grigorenko NA, Khomutov AR, Jänne J, Alhonen L, Pietilä M.

Amino Acids. 2010 Feb;38(2):583-90. doi: 10.1007/s00726-009-0421-x. Epub 2009 Dec 3.

PMID:
19956989
34.

Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.

Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR, Soininen P.

Amino Acids. 2010 Feb;38(2):501-7. doi: 10.1007/s00726-009-0409-6. Epub 2009 Dec 2.

PMID:
19953281
35.

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.

Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA, Thomas TJ.

Biomacromolecules. 2010 Jan 11;11(1):97-105. doi: 10.1021/bm900958c.

PMID:
19919070
36.

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J, Alhonen L.

J Cell Mol Med. 2010 Jun;14(6B):1683-92. doi: 10.1111/j.1582-4934.2009.00808.x. Epub 2009 Jun 16.

37.

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA.

Biochem J. 2009 Aug 13;422(2):321-8. doi: 10.1042/BJ20090737.

PMID:
19522702
38.

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.

Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L.

Biochem J. 2009 Jul 29;422(1):101-9. doi: 10.1042/BJ20090411.

39.

[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism].

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Verspalainen J, Alhonen L, Janne J.

Mol Biol (Mosk). 2009 Mar-Apr;43(2):274-85. Russian.

PMID:
19425496
40.

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2008 Sep 29;48(2):414-21. doi: 10.1016/j.jpba.2008.02.019. Epub 2008 Feb 26.

PMID:
18394842
41.

Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2007 Nov 30;45(4):625-34. Epub 2007 Sep 7.

PMID:
17945452
42.

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J.

J Biol Chem. 2007 Nov 30;282(48):34700-6. Epub 2007 Sep 27.

43.

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J.

Mini Rev Med Chem. 2007 Aug;7(8):813-20. Review.

PMID:
17692042
44.

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.

Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig KH, Jänne J, Alhonen L.

Amino Acids. 2007 Aug;33(2):323-30. Epub 2007 Apr 6.

PMID:
17410333
45.

Mechanisms of polyamine catabolism-induced acute pancreatitis.

Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L.

Biochem Soc Trans. 2007 Apr;35(Pt 2):326-30.

PMID:
17371271
46.

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J.

J Cell Mol Med. 2006 Oct-Dec;10(4):933-45.

47.

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J.

RNA. 2006 Aug;12(8):1569-82. Epub 2006 Jun 29.

48.

Genetic manipulation of polyamine catabolism in rodents.

Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E, Järvinen A.

J Biochem. 2006 Feb;139(2):155-60. Review.

PMID:
16452302
49.

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L.

Am J Pathol. 2006 Jan;168(1):115-22.

50.

Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.

Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE.

J Med Chem. 2006 Jan 12;49(1):399-406.

PMID:
16392825

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