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Items: 47


Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.

Bongard J, Lorenz M, Vetter IR, Stege P, Porfetye AT, Schmitz AL, Kaschani F, Wolf A, Koch U, Nussbaumer P, Klebl B, Kaiser M, Ehrmann M.

ACS Chem Biol. 2018 May 18;13(5):1307-1312. doi: 10.1021/acschembio.8b00101. Epub 2018 Apr 16.


Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants.

Husaini AM, Morimoto K, Chandrasekar B, Kelly S, Kaschani F, Palmero D, Jiang J, Kaiser M, Ahrazem O, Overkleeft HS, van der Hoorn RAL.

Plant Physiol. 2018 May;177(1):24-37. doi: 10.1104/pp.18.00250. Epub 2018 Mar 19.


Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production.

Santos RB, Chandrasekar B, Mandal MK, Kaschani F, Kaiser M, Both L, van der Hoorn RAL, Schiermeyer A, Abranches R.

Biotechnol J. 2018 Mar 12. doi: 10.1002/biot.201800050. [Epub ahead of print]


Protease activities triggered by Ralstonia solanacearum infection in susceptible and tolerant tomato lines.

Planas-Marquès M, Bernardo-Faura M, Paulus JK, Kaschani F, Kaiser M, Valls M, van der Hoorn R, Coll NS.

Mol Cell Proteomics. 2018 Mar 9. pii: mcp.RA117.000052. doi: 10.1074/mcp.RA117.000052. [Epub ahead of print]


Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in N. benthamiana.

Grosse-Holz F, Madeira L, Zahid MA, Songer M, Kourelis J, Fesenko M, Ninck S, Kaschani F, Kaiser M, van der Hoorn RAL.

Plant Biotechnol J. 2018 Mar 6. doi: 10.1111/pbi.12916. [Epub ahead of print]


An apoplastic peptide activates salicylic acid signalling in maize.

Ziemann S, van der Linde K, Lahrmann U, Acar B, Kaschani F, Colby T, Kaiser M, Ding Y, Schmelz E, Huffaker A, Holton N, Zipfel C, Doehlemann G.

Nat Plants. 2018 Mar;4(3):172-180. doi: 10.1038/s41477-018-0116-y. Epub 2018 Feb 26.


A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases.

Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM, Zenke FT, Kaiser M, Meyer H.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580. doi: 10.1002/anie.201711429. Epub 2018 Jan 15.


The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire.

Grosse-Holz F, Kelly S, Blaskowski S, Kaschani F, Kaiser M, van der Hoorn RAL.

Plant Biotechnol J. 2018 May;16(5):1068-1084. doi: 10.1111/pbi.12852. Epub 2017 Dec 17.


Turning-ON Proteasomes.

Krahn JH, Kaschani F, Kaiser M.

Cell Chem Biol. 2017 Jun 22;24(6):653-655. doi: 10.1016/j.chembiol.2017.06.005.


Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea.

Zweerink S, Kallnik V, Ninck S, Nickel S, Verheyen J, Blum M, Wagner A, Feldmann I, Sickmann A, Albers SV, Bräsen C, Kaschani F, Siebers B, Kaiser M.

Nat Commun. 2017 May 8;8:15352. doi: 10.1038/ncomms15352.


The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock.

de Montaigu A, Oeljeklaus J, Krahn JH, Suliman MNS, Halder V, de Ansorena E, Nickel S, Schlicht M, Plíhal O, Kubiasová K, Radová L, Kracher B, Tóth R, Kaschani F, Coupland G, Kombrink E, Kaiser M.

ACS Chem Biol. 2017 Jun 16;12(6):1466-1471. doi: 10.1021/acschembio.6b00978. Epub 2017 Apr 19.


Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.

Kovács J, Poór P, Kaschani F, Chandrasekar B, Hong TN, Misas-Villamil JC, Xin BT, Kaiser M, Overkleeft HS, Tari I, van der Hoorn RA.

Front Plant Sci. 2017 Feb 3;8:107. doi: 10.3389/fpls.2017.00107. eCollection 2017.


Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA.

Plant J. 2017 Apr;90(2):418-430. doi: 10.1111/tpj.13494. Epub 2017 Mar 14.


Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves.

Pružinská A, Shindo T, Niessen S, Kaschani F, Tóth R, Millar AH, van der Hoorn RA.

BMC Plant Biol. 2017 Jan 6;17(1):4. doi: 10.1186/s12870-016-0955-5.


Quantitative Proteomics Reveals Ecophysiological Effects of Light and Silver Stress on the Mixotrophic Protist Poterioochromonas malhamensis.

Beisser D, Kaschani F, Graupner N, Grossmann L, Jensen M, Ninck S, Schulz F, Rahmann S, Boenigk J, Kaiser M.

PLoS One. 2017 Jan 5;12(1):e0168183. doi: 10.1371/journal.pone.0168183. eCollection 2017.


Activity-Based Protein Profiling with Natural Product-Derived Chemical Probes in Human Cell Lysates.

Zweerink S, Pollmann T, Ninck S, Kaschani F, Kaiser M.

Methods Mol Biol. 2017;1491:23-46.


VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair.

van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H.

Mol Cell. 2016 Oct 6;64(1):189-198. doi: 10.1016/j.molcel.2016.08.037.


Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases.

Shindo T, Kaschani F, Yang F, Kovács J, Tian F, Kourelis J, Hong TN, Colby T, Shabab M, Chawla R, Kumari S, Ilyas M, Hörger AC, Alfano JR, van der Hoorn RA.

PLoS Pathog. 2016 Sep 7;12(9):e1005874. doi: 10.1371/journal.ppat.1005874. eCollection 2016 Sep.


Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.

Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V.

Antioxid Redox Signal. 2017 Apr 10;26(11):563-582. doi: 10.1089/ars.2016.6748. Epub 2016 Nov 14.


Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition.

Kaschani F, Wei Q, Dingemans J, van der Hoorn RA, Cornelis P, Kaiser M.

Bioorg Med Chem. 2016 Aug 1;24(15):3330-5. doi: 10.1016/j.bmc.2016.04.051. Epub 2016 Apr 26.


Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M.

Nat Chem Biol. 2015 Nov;11(11):862-9. doi: 10.1038/nchembio.1931. Epub 2015 Oct 5.


Functional Divergence of Two Secreted Immune Proteases of Tomato.

Ilyas M, Hörger AC, Bozkurt TO, van den Burg HA, Kaschani F, Kaiser M, Belhaj K, Smoker M, Joosten MH, Kamoun S, van der Hoorn RA.

Curr Biol. 2015 Aug 31;25(17):2300-6. doi: 10.1016/j.cub.2015.07.030. Epub 2015 Aug 20.


Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid.

Nickel S, Serwa RA, Kaschani F, Ninck S, Zweerink S, Tate EW, Kaiser M.

Chemistry. 2015 Jul 20;21(30):10721-8. doi: 10.1002/chem.201500934. Epub 2015 Jun 16.


Chemical proteomics versus leishmaniasis.

Ehrmann M, Kaschani F, Kaiser M.

Chem Biol. 2015 Mar 19;22(3):309-10. doi: 10.1016/j.chembiol.2015.03.001.


Peptidyl succinimidyl peptides as taspase 1 inhibitors.

van den Boom J, Mamić M, Baccelliere D, Zweerink S, Kaschani F, Knauer S, Bayer P, Kaiser M.

Chembiochem. 2014 Oct 13;15(15):2233-7. doi: 10.1002/cbic.201402108. Epub 2014 Aug 21.


Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA.

Mol Cell Proteomics. 2013 Sep;12(9):2481-96. doi: 10.1074/mcp.M112.026278. Epub 2013 May 29.


Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites.

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA.

PLoS Pathog. 2013 Mar;9(3):e1003281. doi: 10.1371/journal.ppat.1003281. Epub 2013 Mar 28.


A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB.

Lu H, Wang Z, Shabab M, Oeljeklaus J, Verhelst SH, Kaschani F, Kaiser M, Bogyo M, van der Hoorn RA.

Chem Biol. 2013 Feb 21;20(2):168-76. doi: 10.1016/j.chembiol.2012.11.007.


Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening.

Oeljeklaus J, Kaschani F, Kaiser M.

Angew Chem Int Ed Engl. 2013 Jan 28;52(5):1368-70. doi: 10.1002/anie.201207306. Epub 2012 Dec 20. No abstract available.


The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.

Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M.

Chem Biol. 2012 Dec 21;19(12):1546-55. doi: 10.1016/j.chembiol.2012.09.020.


Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection.

Misas-Villamil JC, Toenges G, Kolodziejek I, Sadaghiani AM, Kaschani F, Colby T, Bogyo M, van der Hoorn RA.

Plant J. 2013 Feb;73(4):689-700. doi: 10.1111/tpj.12062. Epub 2012 Dec 28.


Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases.

Kaschani F, Clerc J, Krahn D, Bier D, Hong TN, Ottmann C, Niessen S, Colby T, van der Hoorn RA, Kaiser M.

Angew Chem Int Ed Engl. 2012 May 21;51(21):5230-3. doi: 10.1002/anie.201107276. Epub 2012 Apr 5. No abstract available.


A maize cystatin suppresses host immunity by inhibiting apoplastic cysteine proteases.

van der Linde K, Hemetsberger C, Kastner C, Kaschani F, van der Hoorn RA, Kumlehn J, Doehlemann G.

Plant Cell. 2012 Mar;24(3):1285-300. doi: 10.1105/tpc.111.093732. Epub 2012 Mar 27.


Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana.

Gu C, Shabab M, Strasser R, Wolters PJ, Shindo T, Niemer M, Kaschani F, Mach L, van der Hoorn RA.

PLoS One. 2012;7(3):e32422. doi: 10.1371/journal.pone.0032422. Epub 2012 Mar 2.


Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stüber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RA.

Plant Physiol. 2012 Apr;158(4):1583-99. doi: 10.1104/pp.112.194001. Epub 2012 Feb 27.


Activity-based protein profiling of infected plants.

Kaschani F, Gu C, van der Hoorn RA.

Methods Mol Biol. 2012;835:47-59. doi: 10.1007/978-1-61779-501-5_3.


Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe.

Lenger J, Kaschani F, Lenz T, Dalhoff C, Villamor JG, Köster H, Sewald N, van der Hoorn RA.

Bioorg Med Chem. 2012 Jan 15;20(2):592-6. doi: 10.1016/j.bmc.2011.06.068. Epub 2011 Jun 29.


Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.

Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RA.

Bioorg Med Chem. 2012 Jan 15;20(2):597-600. doi: 10.1016/j.bmc.2011.06.040. Epub 2011 Jul 18.


A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis.

Nickel S, Kaschani F, Colby T, van der Hoorn RA, Kaiser M.

Bioorg Med Chem. 2012 Jan 15;20(2):601-6. doi: 10.1016/j.bmc.2011.06.041. Epub 2011 Jul 15.


A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction.

Kaschani F, Van der Hoorn RA.

Plant Signal Behav. 2011 Jan;6(1):109-12. Epub 2011 Jan 1.


Proteasome activity imaging and profiling characterizes bacterial effector syringolin A.

Kolodziejek I, Misas-Villamil JC, Kaschani F, Clerc J, Gu C, Krahn D, Niessen S, Verdoes M, Willems LI, Overkleeft HS, Kaiser M, van der Hoorn RA.

Plant Physiol. 2011 Jan;155(1):477-89. doi: 10.1104/pp.110.163733. Epub 2010 Nov 2.


An effector-targeted protease contributes to defense against Phytophthora infestans and is under diversifying selection in natural hosts.

Kaschani F, Shabab M, Bozkurt T, Shindo T, Schornack S, Gu C, Ilyas M, Win J, Kamoun S, van der Hoorn RA.

Plant Physiol. 2010 Dec;154(4):1794-804. doi: 10.1104/pp.110.158030. Epub 2010 Oct 12.


Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3.

Song J, Win J, Tian M, Schornack S, Kaschani F, Ilyas M, van der Hoorn RA, Kamoun S.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1654-9. doi: 10.1073/pnas.0809201106. Epub 2009 Jan 26.


Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana.

Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, van der Hoorn RA.

Mol Cell Proteomics. 2009 May;8(5):1082-93. doi: 10.1074/mcp.M800494-MCP200. Epub 2009 Jan 11.


Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, van der Hoorn RA.

Plant J. 2009 Jan;57(2):373-85. doi: 10.1111/j.1365-313X.2008.03683.x. Epub 2008 Oct 25.


Fungal effector protein AVR2 targets diversifying defense-related cys proteases of tomato.

Shabab M, Shindo T, Gu C, Kaschani F, Pansuriya T, Chintha R, Harzen A, Colby T, Kamoun S, van der Hoorn RA.

Plant Cell. 2008 Apr;20(4):1169-83. doi: 10.1105/tpc.107.056325. Epub 2008 Apr 30.


Small molecule approaches in plants.

Kaschani F, van der Hoorn R.

Curr Opin Chem Biol. 2007 Feb;11(1):88-98. Epub 2007 Jan 5. Review.


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