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Items: 1 to 50 of 143

1.

Therapeutic luminal coating of the intestine.

Lee Y, Deelman TE, Chen K, Lin DSY, Tavakkoli A, Karp JM.

Nat Mater. 2018 Jun 11. doi: 10.1038/s41563-018-0106-5. [Epub ahead of print]

PMID:
29891893
2.

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types.

Mead BE, Ordovas-Montanes J, Braun AP, Levy LE, Bhargava P, Szucs MJ, Ammendolia DA, MacMullan MA, Yin X, Hughes TK, Wadsworth MH 2nd, Ahmad R, Rakoff-Nahoum S, Carr SA, Langer R, Collins JJ, Shalek AK, Karp JM.

BMC Biol. 2018 Jun 5;16(1):62. doi: 10.1186/s12915-018-0527-2.

3.

Author Correction: Towards an arthritis flare-responsive drug delivery system.

Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM.

Nat Commun. 2018 May 11;9(1):1954. doi: 10.1038/s41467-018-04346-x.

4.

Progress and challenges towards targeted delivery of cancer therapeutics.

Rosenblum D, Joshi N, Tao W, Karp JM, Peer D.

Nat Commun. 2018 Apr 12;9(1):1410. doi: 10.1038/s41467-018-03705-y. Review.

5.

Towards an arthritis flare-responsive drug delivery system.

Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM.

Nat Commun. 2018 Apr 3;9(1):1275. doi: 10.1038/s41467-018-03691-1. Erratum in: Nat Commun. 2018 May 11;9(1):1954.

6.

Early animal model evaluation of an implantable contrast agent to enhance magnetic resonance imaging of arterial bypass vein grafts.

Mitsouras D, Tao M, de Vries MR, Trocha K, Miranda OR, Vemula PK, Ding K, Imanzadeh A, Schoen FJ, Karp JM, Ozaki CK, Rybicki FJ.

Acta Radiol. 2018 Jan 1:284185117753656. doi: 10.1177/0284185117753656. [Epub ahead of print]

PMID:
29378421
7.

Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex.

Hayama R, Sparks S, Hecht LM, Dutta K, Karp JM, Cabana CM, Rout MP, Cowburn D.

J Biol Chem. 2018 Mar 23;293(12):4555-4563. doi: 10.1074/jbc.AC117.001649. Epub 2018 Jan 26.

8.

Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release.

Warren C, Matsui T, Karp JM, Onikubo T, Cahill S, Brenowitz M, Cowburn D, Girvin M, Shechter D.

Nat Commun. 2017 Dec 20;8(1):2215. doi: 10.1038/s41467-017-02308-3.

9.

Focus on RNA interference: from nanoformulations to in vivo delivery.

Karp JM, Peer D.

Nanotechnology. 2018 Jan 5;29(1):010201. doi: 10.1088/1361-6528/aa98e3. No abstract available.

PMID:
29185433
10.

A Slick and Stretchable Surgical Adhesive.

Karp JM.

N Engl J Med. 2017 Nov 23;377(21):2092-2094. doi: 10.1056/NEJMcibr1709967. No abstract available.

PMID:
29166237
11.

Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells.

Tong Z, Martyn K, Yang A, Yin X, Mead BE, Joshi N, Sherman NE, Langer RS, Karp JM.

Biomaterials. 2018 Feb;154:60-73. doi: 10.1016/j.biomaterials.2017.10.038. Epub 2017 Oct 26.

PMID:
29120819
12.

Multiscale technologies for treatment of ischemic cardiomyopathy.

Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC.

Nat Nanotechnol. 2017 Sep 6;12(9):845-855. doi: 10.1038/nnano.2017.167. Review.

13.

Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.

Alvarez MM, Aizenberg J, Analoui M, Andrews AM, Bisker G, Boyden ES, Kamm RD, Karp JM, Mooney DJ, Oklu R, Peer D, Stolzoff M, Strano MS, Trujillo-de Santiago G, Webster TJ, Weiss PS, Khademhosseini A.

ACS Nano. 2017 Jun 27;11(6):5195-5214. doi: 10.1021/acsnano.7b01493. Epub 2017 May 19.

PMID:
28524668
14.

Isolation of Circulating Plasma Cells in Multiple Myeloma Using CD138 Antibody-Based Capture in a Microfluidic Device.

Qasaimeh MA, Wu YC, Bose S, Menachery A, Talluri S, Gonzalez G, Fulciniti M, Karp JM, Prabhala RH, Karnik R.

Sci Rep. 2017 Apr 4;7:45681. doi: 10.1038/srep45681.

15.

A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin.

Seong KY, Seo MS, Hwang DY, O'Cearbhaill ED, Sreenan S, Karp JM, Yang SY.

J Control Release. 2017 Nov 10;265:48-56. doi: 10.1016/j.jconrel.2017.03.041. Epub 2017 Mar 24.

PMID:
28344013
16.

Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease.

Holmberg FE, Seidelin JB, Yin X, Mead BE, Tong Z, Li Y, Karp JM, Nielsen OH.

EMBO Mol Med. 2017 May;9(5):558-570. doi: 10.15252/emmm.201607260. Review.

17.

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.

Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC.

Cancer Discov. 2017 Jul;7(7):750-765. doi: 10.1158/2159-8290.CD-16-0778. Epub 2017 Mar 8.

PMID:
28274958
18.

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells.

McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge ASB.

Cell Rep. 2017 Feb 21;18(8):1917-1929. doi: 10.1016/j.celrep.2017.01.066.

19.

Effects of FGFR2 kinase activation loop dynamics on catalytic activity.

Karp JM, Sparks S, Cowburn D.

PLoS Comput Biol. 2017 Feb 2;13(2):e1005360. doi: 10.1371/journal.pcbi.1005360. eCollection 2017 Feb.

20.

A Growth-Accommodating Implant for Paediatric Applications.

Feins EN, Lee Y, O'Cearbhaill ED, Vasilyev NV, Shimada S, Friehs I, Perrin D, Hammer PE, Yamauchi H, Marx G, Gosline A, Arabagi V, Karp JM, Del Nido PJ.

Nat Biomed Eng. 2017;1:818-825. doi: 10.1038/s41551-017-0142-5. Epub 2017 Oct 10.

21.

Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.

Firestone RS, Cameron SA, Karp JM, Arcus VL, Schramm VL.

ACS Chem Biol. 2017 Feb 17;12(2):464-473. doi: 10.1021/acschembio.6b00885. Epub 2016 Dec 27.

22.

Preparing the Pediatric Dentist for Palliative and End-of-life Care.

Sarvas EW, Schwantes SA, Karp JM.

Pediatr Dent. 2016;38(4):295-9.

PMID:
27557917
23.

Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation.

Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM.

Sci Rep. 2016 Jul 26;6:30263. doi: 10.1038/srep30263.

24.

Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering.

Ranganath SH, Tong Z, Levy O, Martyn K, Karp JM, Inamdar MS.

Stem Cell Reports. 2016 Jun 14;6(6):926-39. doi: 10.1016/j.stemcr.2016.05.003. Epub 2016 Jun 2.

25.

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex.

Raveh B, Karp JM, Sparks S, Dutta K, Rout MP, Sali A, Cowburn D.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2489-97. doi: 10.1073/pnas.1522663113. Epub 2016 Apr 18.

26.

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.

Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM.

Biomaterials. 2016 Jun;91:140-150. doi: 10.1016/j.biomaterials.2016.03.023. Epub 2016 Mar 17.

27.

Management of Red Teeth in an International Patient with X-Linked Adrenoleukodystrophy.

Petrova E, Miller WP, Myers SL, Karp JM.

Pediatr Dent. 2015 Nov-Dec;37(7):550-3.

PMID:
26883615
28.

Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue.

Fischer SCL, Levy O, Kroner E, Hensel R, Karp JM, Arzt E.

J Mech Behav Biomed Mater. 2016 Aug;61:87-95. doi: 10.1016/j.jmbbm.2016.01.014. Epub 2016 Jan 25.

29.

Engineering Stem Cell Organoids.

Yin X, Mead BE, Safaee H, Langer R, Karp JM, Levy O.

Cell Stem Cell. 2016 Jan 7;18(1):25-38. doi: 10.1016/j.stem.2015.12.005. Review.

30.

Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.

Ng KS, Kuncewicz TM, Karp JM.

Cell Metab. 2015 Oct 6;22(4):541-3. doi: 10.1016/j.cmet.2015.09.019.

31.

A light-reflecting balloon catheter for atraumatic tissue defect repair.

Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Casar Berazaluce AM, Bueno A, Lang N, Pereira MJ, Feins E, Wasserman S, O'Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, Del Nido PJ, Walsh CJ.

Sci Transl Med. 2015 Sep 23;7(306):306ra149. doi: 10.1126/scitranslmed.aaa2406. Epub 2015 Sep 23.

PMID:
26400910
32.

Stomaching Notch.

Yin X, Karp JM.

EMBO J. 2015 Oct 14;34(20):2489-91. doi: 10.15252/embj.201592859. Epub 2015 Sep 10. No abstract available.

33.

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease.

Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G, Langer R, Karp JM.

Sci Transl Med. 2015 Aug 12;7(300):300ra128. doi: 10.1126/scitranslmed.aaa5657.

34.

Cell therapy--showing cells the way home.

Heinelt M, Karp JM, Levy O.

Oncotarget. 2015 Jul 20;6(20):17857-8. No abstract available.

35.

Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair.

Lee Y, Xu C, Sebastin M, Lee A, Holwell N, Xu C, Miranda Nieves D, Mu L, Langer RS, Lin C, Karp JM.

Adv Healthc Mater. 2015 Nov 18;4(16):2587-96. doi: 10.1002/adhm.201500419. Epub 2015 Jul 27.

36.

Accelerating the Translation of Nanomaterials in Biomedicine.

Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C.

ACS Nano. 2015 Jul 28;9(7):6644-54. doi: 10.1021/acsnano.5b03569. Epub 2015 Jun 26. Review.

37.

Application of biomaterials to advance induced pluripotent stem cell research and therapy.

Tong Z, Solanki A, Hamilos A, Levy O, Wen K, Yin X, Karp JM.

EMBO J. 2015 Apr 15;34(8):987-1008. doi: 10.15252/embj.201490756. Epub 2015 Mar 12. Review.

38.

Crystallization of lysozyme with (R)-, (S)- and (RS)-2-methyl-2,4-pentanediol.

Stauber M, Jakoncic J, Berger J, Karp JM, Axelbaum A, Sastow D, Buldyrev SV, Hrnjez BJ, Asherie N.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):427-41. doi: 10.1107/S1399004714025061. Epub 2015 Feb 26.

39.

Erratum to: Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins.

Karp JM, Eryilmaz E, Cowburn D.

J Biomol NMR. 2015 May;62(1):119. doi: 10.1007/s10858-015-9915-x. No abstract available.

PMID:
25749870
40.

A small-molecule screen for enhanced homing of systemically infused cells.

Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM.

Cell Rep. 2015 Mar 3;10(8):1261-1268. doi: 10.1016/j.celrep.2015.01.057. Epub 2015 Feb 26.

41.

Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.

French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA.

Stem Cells Transl Med. 2015 Mar;4(3):217-23. doi: 10.5966/sctm.2014-0233. Epub 2015 Feb 3. Review.

42.

Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies.

Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ, Williams D, Kim HW, French A, Coffey PJ, Cooper-White JJ, Reeve B, Rao M, Snyder EY, Ng KS, Mead BE, Smith JA, Karp JM, Brindley DA, Wall I.

Cell Stem Cell. 2015 Jan 8;16(1):13-7. doi: 10.1016/j.stem.2014.12.013.

43.
44.

Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.

Davies BM, Rikabi S, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K, Judge A, MacLaren RE, Mathur A, Williams DJ, Wall I, Birchall M, Reeve B, Atala A, Barker RW, Cui Z, Furniss D, Bure K, Snyder EY, Karp JM, Price A, Carr A, Brindley DA.

J Tissue Eng. 2014 Sep 19;5:2041731414551764. doi: 10.1177/2041731414551764. eCollection 2014. Review.

45.

Simple battery armor to protect against gastrointestinal injury from accidental ingestion.

Laulicht B, Traverso G, Deshpande V, Langer R, Karp JM.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16490-5. doi: 10.1073/pnas.1418423111. Epub 2014 Nov 3.

46.

Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils.

Teo GS, Yang Z, Carman CV, Karp JM, Lin CP.

Stem Cells. 2015 Jan;33(1):265-77. doi: 10.1002/stem.1848.

47.

A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft.

Gajanayake T, Olariu R, Leclère FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM, Vemula PK, Rieben R, Vögelin E.

Sci Transl Med. 2014 Aug 13;6(249):249ra110. doi: 10.1126/scitranslmed.3008778.

48.

Bioengineering tools to elucidate and control the fate of transplanted stem cells.

Sridharan R, Karp JM, Zhao W.

Biochem Soc Trans. 2014 Jun;42(3):679-87. doi: 10.1042/BST20130276.

PMID:
24849237
49.

Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids.

Ankrum JA, Dastidar RG, Ong JF, Levy O, Karp JM.

Sci Rep. 2014 Apr 10;4:4645. doi: 10.1038/srep04645.

50.

Behavior guidance symposium Workshop B report - training implications.

Law CS, Karp JM.

Pediatr Dent. 2014 Mar-Apr;36(2):154-7.

PMID:
24717755

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