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A new RelB-dependent CD117+ CD172a+ murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.

Andreas N, Riemann M, Castro CN, Groth M, Koliesnik I, Engelmann C, Sparwasser T, Kamradt T, Haenold R, Weih F.

Eur J Immunol. 2018 Feb 27. doi: 10.1002/eji.201747332. [Epub ahead of print]


IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.

Kulkarni U, Herrmenau C, Win SJ, Bauer M, Kamradt T.

PLoS One. 2018 Feb 21;13(2):e0192304. doi: 10.1371/journal.pone.0192304. eCollection 2018.


The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.

Göpfert C, Andreas N, Weber F, Häfner N, Yakovleva T, Gaestel M, Kamradt T, Drube S.

J Immunol. 2018 Feb 1;200(3):1198-1206. doi: 10.4049/jimmunol.1700727. Epub 2017 Dec 29.


Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM.

Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013.


The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T.

J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556. Epub 2017 Sep 8.


Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis.

Ebbinghaus M, Natura G, Segond von Banchet G, Hensellek S, Böttcher M, Hoffmann B, Salah FS, Gajda M, Kamradt T, Schaible HG.

Sci Rep. 2017 Sep 4;7(1):10334. doi: 10.1038/s41598-017-10509-5.


Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging.

Hoffmann B, Svensson CM, Straßburger M, Gebser B, Irmler IM, Kamradt T, Peter Saluz H, Thilo Figge M.

Sci Rep. 2017 May 22;7(1):2217. doi: 10.1038/s41598-017-02389-6.


Time to follow up when comparing studies of pneumococcal vaccines.

Pletz MW, Kamradt T, Welte T.

Lancet Infect Dis. 2017 Mar;17(3):244-246. doi: 10.1016/S1473-3099(17)30051-8. Epub 2017 Jan 24. No abstract available.


Bacterial load of conditioned pressure ulcers is not a predictor for early flap failure in spinal cord injury.

Kamradt T, Klein S, Zimmermann S, Schröder-Braunstein J, Fürstenberg CH, Hensel C, Weidner N, Hug A.

Spinal Cord. 2017 Jun;55(6):535-539. doi: 10.1038/sc.2016.186. Epub 2017 Jan 10.


Were Antibody Titers the Right Parameter When Immunologically Comparing Pneumococcal Vaccines?

Pletz MW, Kamradt T, Forstner C, Welte T.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1447-1448. No abstract available.


MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.

Drube S, Kraft F, Dudeck J, Müller AL, Weber F, Göpfert C, Meininger I, Beyer M, Irmler I, Häfner N, Schütz D, Stumm R, Yakovleva T, Gaestel M, Dudeck A, Kamradt T.

J Immunol. 2016 Nov 1;197(9):3662-3668. Epub 2016 Sep 30.


Patients' safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Moghaddam A, Graeser V, Westhauser F, Dapunt U, Kamradt T, Woerner SM, Schmidmaier G.

Ther Clin Risk Manag. 2016 Sep 7;12:1387-93. doi: 10.2147/TCRM.S107398. eCollection 2016.


Immunometabolism and autoimmunity.

Freitag J, Berod L, Kamradt T, Sparwasser T.

Immunol Cell Biol. 2016 Nov;94(10):925-934. doi: 10.1038/icb.2016.77. Epub 2016 Aug 26. Review.


Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.

Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B.

Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16.


In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.

Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T.

Eur J Immunol. 2016 May;46(5):1193-202. doi: 10.1002/eji.201546104. Epub 2016 Jan 20.


Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

Llop-Guevara A, Porras M, Cendón C, Di Ceglie I, Siracusa F, Madarena F, Rinotas V, Gómez L, van Lent PL, Douni E, Chang HD, Kamradt T, Román J.

Arthritis Res Ther. 2015 Dec 10;17:356. doi: 10.1186/s13075-015-0866-0.


IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration.

Kulkarni U, Karsten CM, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig RJ, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser AE, Langer C, Huber-Lang M, Finkelman FD, Köhl J, Wong DM, Manz RA.

J Allergy Clin Immunol. 2016 May;137(5):1487-1497.e6. doi: 10.1016/j.jaci.2015.10.018. Epub 2015 Dec 2.


TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T.

Oncotarget. 2015 Oct 6;6(30):28833-50. doi: 10.18632/oncotarget.5008.


TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.

Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker HW.

J Pathol. 2015 Sep;237(1):62-71. doi: 10.1002/path.4559. Epub 2015 Jun 11.


Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.

Oncotarget. 2015 Mar 10;6(7):5354-68.


[Regulatory T cells and rheumatic diseases].

Humrich JY, Kamradt T, Riemekasten G.

Z Rheumatol. 2015 Feb;74(1):26-32. doi: 10.1007/s00393-014-1446-4. Review. German.


Towards the generation of B-cell receptor retrogenic mice.

Freitag J, Heink S, Roth E, Wittmann J, Jäck HM, Kamradt T.

PLoS One. 2014 Oct 8;9(10):e109199. doi: 10.1371/journal.pone.0109199. eCollection 2014.


18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis.

Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T.

Arthritis Res Ther. 2014 Jul 22;16(4):R155. doi: 10.1186/ar4670.


Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function.

Irmler IM, Gajda M, Kamradt T.

Ann Rheum Dis. 2014 Dec;73(12):2183-91. doi: 10.1136/annrheumdis-2013-204148. Epub 2013 Dec 10.


Tim-3 is differently expressed in genetically susceptible C57BL/6 and resistant BALB/c mice during oral infection with Toxoplasma gondii.

Berrocal Almanza LC, Muñoz M, Kühl AA, Kamradt T, Heimesaat MM, Liesenfeld O.

Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):211-21. doi: 10.1556/EuJMI.3.2013.3.10. Epub 2013 Sep 23.


A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis.

Kamradt T, Drube S.

Arthritis Res Ther. 2013;15(3):115.


Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response.

Müller U, Stenzel W, Piehler D, Grahnert A, Protschka M, Köhler G, Frey O, Held J, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G.

Int Immunol. 2013 Aug;25(8):459-70. doi: 10.1093/intimm/dxt003. Epub 2013 Mar 26.


Spinal cord injury: association with axonal peripheral neuropathy in severely paralysed limbs.

Kamradt T, Rasch C, Schuld C, Böttinger M, Mürle B, Hensel C, Fürstenberg CH, Weidner N, Rupp R, Hug A.

Eur J Neurol. 2013 May;20(5):843-8. doi: 10.1111/ene.12082. Epub 2013 Jan 11.


IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.

Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M.

J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10.


[Bad memories: understanding and removal of pathogenic consequences of immunological memory in inflammatory rheumatic diseases. The IMPAM consortium].

Kamradt T, Radbruch A, Chang HD.

Z Rheumatol. 2012 Aug;71(6):501-3. doi: 10.1007/s00393-011-0920-5. German.


[Recommendations of the Laboratory Commission of the German Society of Rheumatology (DGRh) on further training of rheumatologists in the field of rheumatological and immunological laboratory diagnostics].

Dörner T, Hartung K, Burmester GR, Genth E, Kamradt T, Mierau R, Specker C, von Hinüber U.

Z Rheumatol. 2012 Jun;71(4):328-9. doi: 10.1007/s00393-012-0976-x. German. No abstract available.


Multivariate analysis of flow cytometric data using decision trees.

Simon S, Guthke R, Kamradt T, Frey O.

Front Microbiol. 2012 Apr 2;3:114. doi: 10.3389/fmicb.2012.00114. eCollection 2012.


Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia.

Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M.

FASEB J. 2012 Jun;26(6):2424-36. doi: 10.1096/fj.11-191957. Epub 2012 Mar 13.


[Osteoimmunology - IMMUNOBONE - Understanding the interaction between bone and immune system].

Schett G, Pap T, Müller-Ladner U, Kamradt T.

Z Rheumatol. 2012 Feb;71(2):138-9. doi: 10.1007/s00393-012-0954-3. Review. German.


Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis.

Müller U, Piehler D, Stenzel W, Köhler G, Frey O, Held J, Grahnert A, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G.

Mucosal Immunol. 2012 May;5(3):299-310. doi: 10.1038/mi.2012.9. Epub 2012 Feb 15.


C-Kit controls IL-1β-induced effector functions in HMC-cells.

Drube S, Schmitz F, Göpfert C, Weber F, Kamradt T.

Eur J Pharmacol. 2012 Jan 30;675(1-3):57-62. doi: 10.1016/j.ejphar.2011.11.035. Epub 2011 Dec 8.


[Th1, Th17 and Th1+17 cells].

Chang HD, Kamradt T, Schulze-Koops H.

Z Rheumatol. 2011 Dec;70(10):862-5. doi: 10.1007/s00393-011-0779-5. German.


Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.

Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19317-22. doi: 10.1073/pnas.1105857108. Epub 2011 Nov 14.


[Intestinal microbiota as regulator of the immune system].

Chang HD, Kamradt T.

Z Rheumatol. 2011 Nov;70(9):790-2. doi: 10.1007/s00393-011-0907-2. German.


B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis.

Frey O, Bruns L, Morawietz L, Dunussi-Joannopoulos K, Kamradt T.

PLoS One. 2011;6(9):e24718. doi: 10.1371/journal.pone.0024718. Epub 2011 Sep 8.


[Adaptive immunity].

Kamradt T, Ferrari-Kühne K.

Dtsch Med Wochenschr. 2011 Aug;136(33):1678-83. doi: 10.1055/s-0031-1281577. Epub 2011 Aug 10. Review. German. No abstract available.


Diversity and flexibility of Th17 effector functions.

Kamradt T, Chang HD.

Arthritis Res Ther. 2011 Apr 18;13(2):106. doi: 10.1186/ar3296.


IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss.

Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY, Schett G.

J Immunol. 2011 Jun 1;186(11):6097-105. doi: 10.4049/jimmunol.1003487. Epub 2011 Apr 22.


Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.

Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito H, Nakae S.

PLoS One. 2011 Apr 11;6(4):e18404. doi: 10.1371/journal.pone.0018404.


Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT.

Walther M, Gebhardt P, Grosse-Gehling P, Würbach L, Irmler I, Preusche S, Khalid M, Opfermann T, Kamradt T, Steinbach J, Saluz HP.

Appl Radiat Isot. 2011 Jun;69(6):852-7. doi: 10.1016/j.apradiso.2011.02.040. Epub 2011 Mar 2.


PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.

Berod L, Heinemann C, Heink S, Escher A, Stadelmann C, Drube S, Wetzker R, Norgauer J, Kamradt T.

Eur J Immunol. 2011 Mar;41(3):833-44. doi: 10.1002/eji.201040504. Epub 2011 Feb 1.


Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ.

Frey O, Mitera T, Kelchtermans H, Schurgers E, Kamradt T, Matthys P.

J Autoimmun. 2011 Mar;36(2):161-9. doi: 10.1016/j.jaut.2010.12.006. Epub 2011 Jan 22.


[Biologics. Magic bullets - magic effects - magic costs? New therapeutics and their effects].

Frey O, Kamradt T.

Ophthalmologe. 2011 Jan;108(1):7-12. doi: 10.1007/s00347-010-2255-z. German.


Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny HP, Kamradt T, Naumann R, Müller W, Krieg T, Waskow C, Hartmann K, Roers A.

Blood. 2011 Feb 10;117(6):2012-21. doi: 10.1182/blood-2008-11-189605. Epub 2010 Dec 9.


IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells.

Lexberg MH, Taubner A, Albrecht I, Lepenies I, Richter A, Kamradt T, Radbruch A, Chang HD.

Eur J Immunol. 2010 Nov;40(11):3017-27. doi: 10.1002/eji.201040539.

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