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Items: 20


Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA.

Mol Metab. 2018 Feb 7. pii: S2212-8778(18)30096-6. doi: 10.1016/j.molmet.2018.02.001. [Epub ahead of print]


Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome.

Kraakman MJ, Kammoun HL, Dragoljevic D, Al-Sharea A, Lee MKS, Flynn MC, Stolz CJ, Guirguis AA, Lancaster GI, Chin-Dusting J, Curtis DJ, Murphy AJ.

Haematologica. 2018 Jan 25. pii: haematol.2017.181958. doi: 10.3324/haematol.2017.181958. [Epub ahead of print]


High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaam6084. doi: 10.1126/scitranslmed.aam6084.


Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.

Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.

PLoS One. 2017 Jun 20;12(6):e0179099. doi: 10.1371/journal.pone.0179099. eCollection 2017.


Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes.

Kraakman MJ, Lee MK, Al-Sharea A, Dragoljevic D, Barrett TJ, Montenont E, Basu D, Heywood S, Kammoun HL, Flynn M, Whillas A, Hanssen NM, Febbraio MA, Westein E, Fisher EA, Chin-Dusting J, Cooper ME, Berger JS, Goldberg IJ, Nagareddy PR, Murphy AJ.

J Clin Invest. 2017 Jun 1;127(6):2133-2147. doi: 10.1172/JCI92450. Epub 2017 May 15.


Is the risk of cardiovascular disease altered with anti-inflammatory therapies? Insights from rheumatoid arthritis.

Kraakman MJ, Dragoljevic D, Kammoun HL, Murphy AJ.

Clin Transl Immunology. 2016 May 20;5(5):e84. doi: 10.1038/cti.2016.31. eCollection 2016 May. Review.


PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

Lancaster GI, Kammoun HL, Kraakman MJ, Kowalski GM, Bruce CR, Febbraio MA.

Nat Commun. 2016 Feb 3;7:10626. doi: 10.1038/ncomms10626.


IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.


Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA.

Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.


Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice.

Jordy AB, Kraakman MJ, Gardner T, Estevez E, Kammoun HL, Weir JM, Kiens B, Meikle PJ, Febbraio MA, Henstridge DC.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E778-91. doi: 10.1152/ajpendo.00547.2014. Epub 2015 Feb 24.


The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

Lancaster GI, Kraakman MJ, Kammoun HL, Langley KG, Estevez E, Banerjee A, Grumont RJ, Febbraio MA, Gerondakis S.

PLoS One. 2014 Nov 6;9(11):e111524. doi: 10.1371/journal.pone.0111524. eCollection 2014.


Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?

Kraakman MJ, Murphy AJ, Jandeleit-Dahm K, Kammoun HL.

Front Immunol. 2014 Sep 26;5:470. doi: 10.3389/fimmu.2014.00470. eCollection 2014. Review.


Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.

Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D.

Nat Commun. 2014 Oct 13;5:5190. doi: 10.1038/ncomms6190.


Come on BAIBA light my fire.

Kammoun HL, Febbraio MA.

Cell Metab. 2014 Jan 7;19(1):1-2. doi: 10.1016/j.cmet.2013.12.007.


Adipose tissue inflammation in glucose metabolism.

Kammoun HL, Kraakman MJ, Febbraio MA.

Rev Endocr Metab Disord. 2014 Mar;15(1):31-44. doi: 10.1007/s11154-013-9274-4. Review.


Targeting gp130 to prevent inflammation and promote insulin action.

Kraakman MJ, Allen TL, Whitham M, Iliades P, Kammoun HL, Estevez E, Lancaster GI, Febbraio MA.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:170-5. doi: 10.1111/dom.12170. Review.


Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis.

Flamment M, Kammoun HL, Hainault I, Ferré P, Foufelle F.

Curr Opin Lipidol. 2010 Jun;21(3):239-46. doi: 10.1097/MOL.0b013e3283395e5c. Review.


Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice.

Lerat H, Kammoun HL, Hainault I, Mérour E, Higgs MR, Callens C, Lemon SM, Foufelle F, Pawlotsky JM.

J Biol Chem. 2009 Nov 27;284(48):33466-74. doi: 10.1074/jbc.M109.019810. Epub 2009 Oct 6.


Nutritional related liver disease: targeting the endoplasmic reticulum stress.

Kammoun HL, Hainault I, Ferré P, Foufelle F.

Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):575-82. doi: 10.1097/MCO.0b013e32833189db. Review.


GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F.

J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.

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