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Items: 23

1.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.

Afroz R, Cao Y, Rostam MA, Ta H, Xu S, Zheng W, Osman N, Kamato D, Little PJ.

Pharmacol Ther. 2018 Feb 15. pii: S0163-7258(18)30030-5. doi: 10.1016/j.pharmthera.2018.02.005. [Epub ahead of print] Review.

PMID:
29454855
2.

Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2.

Rostam MA, Shajimoon A, Kamato D, Mitra P, Piva T, Getachew R, Cao Y, Zheng W, Osman N, Little PJ.

J Pharmacol Exp Ther. 2018 Feb 9. pii: jpet.117.244483. doi: 10.1124/jpet.117.244483. [Epub ahead of print]

3.

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells.

Kamato D, Bhaskarala VV, Mantri N, Oh TG, Ling D, Janke R, Zheng W, Little PJ, Osman N.

PLoS One. 2017 Jul 18;12(7):e0180842. doi: 10.1371/journal.pone.0180842. eCollection 2017.

4.

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.

Asrafuzzaman M, Cao Y, Afroz R, Kamato D, Gray S, Little PJ.

Biomed Pharmacother. 2017 May;89:1242-1251. doi: 10.1016/j.biopha.2017.03.010. Epub 2017 Mar 17. Review.

PMID:
28320091
5.

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.

Chaplin R, Thach L, Hollenberg MD, Cao Y, Little PJ, Kamato D.

J Cell Commun Signal. 2017 Jun;11(2):117-125. doi: 10.1007/s12079-017-0375-9. Epub 2017 Feb 6. Review.

6.

Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis.

Sharifat N, Mohammad Zadeh G, Ghaffari MA, Dayati P, Kamato D, Little PJ, Babaahmadi-Rezaei H.

J Pharm Pharmacol. 2017 Jan;69(1):66-72. doi: 10.1111/jphp.12654. Epub 2016 Dec 1.

PMID:
27905105
7.

Gaq proteins: molecular pharmacology and therapeutic potential.

Kamato D, Mitra P, Davis F, Osman N, Chaplin R, Cabot PJ, Afroz R, Thomas W, Zheng W, Kaur H, Brimble M, Little PJ.

Cell Mol Life Sci. 2017 Apr;74(8):1379-1390. doi: 10.1007/s00018-016-2405-9. Epub 2016 Nov 4. Review.

PMID:
27815595
8.

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells.

Al Gwairi O, Osman N, Getachew R, Zheng W, Liang XL, Kamato D, Thach L, Little PJ.

Int J Biol Sci. 2016 Jul 18;12(9):1041-51. doi: 10.7150/ijbs.16134. eCollection 2016.

9.

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle.

Rostam MA, Kamato D, Piva TJ, Zheng W, Little PJ, Osman N.

Cell Signal. 2016 Aug;28(8):956-66. doi: 10.1016/j.cellsig.2016.05.002. Epub 2016 May 3.

PMID:
27153775
10.

Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response.

Bernard R, Getachew R, Kamato D, Thach L, Osman N, Chan V, Zheng W, Little PJ.

J Pharm Pharmacol. 2016 Mar;68(3):368-78. doi: 10.1111/jphp.12530. Epub 2016 Feb 17.

PMID:
26888375
11.

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11.

Kamato D, Thach L, Bernard R, Chan V, Zheng W, Kaur H, Brimble M, Osman N, Little PJ.

Front Cardiovasc Med. 2015 Mar 24;2:14. doi: 10.3389/fcvm.2015.00014. eCollection 2015. Review.

12.

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.

Little PJ, Hollenberg MD, Kamato D, Thomas W, Chen J, Wang T, Zheng W, Osman N.

Br J Pharmacol. 2016 Oct;173(20):2992-3000. doi: 10.1111/bph.13398. Epub 2016 Feb 16. Review.

13.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, Little PJ, Osman N.

Cell Signal. 2016 Jan;28(1):110-9. doi: 10.1016/j.cellsig.2015.11.003. Epub 2015 Nov 5.

PMID:
26548632
14.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier.

Kamato D, Rostam MA, Bernard R, Piva TJ, Mantri N, Guidone D, Zheng W, Osman N, Little PJ.

Cell Mol Life Sci. 2015 Feb;72(4):799-808. doi: 10.1007/s00018-014-1775-0. Epub 2014 Nov 12. Review.

PMID:
25384733
15.

Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.

Rostam MA, Piva TJ, Rezaei HB, Kamato D, Little PJ, Zheng W, Osman N.

Clin Exp Pharmacol Physiol. 2015 Feb;42(2):117-24. doi: 10.1111/1440-1681.12335. Review.

PMID:
25377120
16.

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells.

Kamato D, Rostam MA, Piva TJ, Babaahmadi Rezaei H, Getachew R, Thach L, Bernard R, Zheng W, Little PJ, Osman N.

J Pharm Pharmacol. 2014 Dec;66(12):1722-33. doi: 10.1111/jphp.12298. Epub 2014 Oct 14.

PMID:
25316549
17.

25 years of endothelin research: the next generation.

Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M.

Life Sci. 2014 Nov 24;118(2):77-86. doi: 10.1016/j.lfs.2014.07.035. Epub 2014 Aug 15.

18.

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle.

Al-aryahi S, Kamato D, Getachew R, Zheng W, Potocnik SJ, Cohen N, Guidone D, Osman N, Little PJ.

Cardiovasc Diabetol. 2014 Apr 15;13:80. doi: 10.1186/1475-2840-13-80.

19.

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, Zheng W, Little PJ, Osman N.

Cell Signal. 2013 Oct;25(10):2017-24. doi: 10.1016/j.cellsig.2013.06.001. Epub 2013 Jun 11. Review.

PMID:
23770288
20.

Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells.

Little PJ, Rostam MA, Piva TJ, Getachew R, Kamato D, Guidone D, Ballinger ML, Zheng W, Osman N.

J Pharm Pharmacol. 2013 Jul;65(7):1055-63. doi: 10.1111/jphp.12064. Epub 2013 Apr 24.

PMID:
23738733
21.

(S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.

Kamato D, Babaahmadi Rezaei H, Getachew R, Thach L, Guidone D, Osman N, Roufogalis B, Duke CC, Tran VH, Zheng W, Little PJ.

J Pharm Pharmacol. 2013 Jul;65(7):1026-36. doi: 10.1111/jphp.12060. Epub 2013 Mar 27.

PMID:
23738730
22.

Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors.

Kamato D, Burch ML, Osman N, Zheng W, Little PJ.

J Pharm Pharmacol. 2013 Apr;65(4):465-73. doi: 10.1111/j.2042-7158.2012.01577.x. Epub 2012 Aug 20. Review.

PMID:
23488775
23.

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle.

Rezaei HB, Kamato D, Ansari G, Osman N, Little PJ.

Clin Exp Pharmacol Physiol. 2012 Aug;39(8):661-7. doi: 10.1111/j.1440-1681.2011.05592.x. Review.

PMID:
21883378

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