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Items: 1 to 50 of 112

1.

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA.

Immunity. 2018 Apr 17;48(4):716-729.e8. doi: 10.1016/j.immuni.2018.03.015. Epub 2018 Apr 3.

PMID:
29625895
2.

ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.

Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM.

J Exp Med. 2018 Apr 2;215(4):1153-1168. doi: 10.1084/jem.20171352. Epub 2018 Feb 15.

PMID:
29449309
3.

Correction: STAT4 and T-bet control follicular helper T cell development in viral infections.

Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J.

J Exp Med. 2018 Mar 5;215(3):999. doi: 10.1084/jem.2017045702062018c. Epub 2018 Feb 13. No abstract available.

4.

Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.

Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM.

J Exp Med. 2018 Mar 5;215(3):877-893. doi: 10.1084/jem.20171435. Epub 2018 Feb 7.

PMID:
29436395
5.

Trials and Tribble-ations of tissue TRM cells.

Low JS, Kaech SM.

Nat Immunol. 2018 Feb;19(2):102-103. doi: 10.1038/s41590-017-0031-9. No abstract available.

PMID:
29348504
6.

STAT4 and T-bet control follicular helper T cell development in viral infections.

Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J.

J Exp Med. 2018 Jan 2;215(1):337-355. doi: 10.1084/jem.20170457. Epub 2017 Dec 6. Erratum in: J Exp Med. 2018 Feb 13;:.

PMID:
29212666
7.

Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response.

Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaan4767. doi: 10.1126/sciimmunol.aan4767.

PMID:
29054998
8.

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.

Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K.

Cancer Discov. 2017 Dec;7(12):1420-1435. doi: 10.1158/2159-8290.CD-17-0593. Epub 2017 Oct 12.

PMID:
29025772
9.

IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways.

Yeon SM, Halim L, Chandele A, Perry CJ, Kim SH, Kim SU, Byun Y, Yuk SH, Kaech SM, Jung YW.

Sci Rep. 2017 Sep 11;7(1):11155. doi: 10.1038/s41598-017-11492-7.

10.

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.

Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ.

PLoS Pathog. 2017 Aug 21;13(8):e1006544. doi: 10.1371/journal.ppat.1006544. eCollection 2017 Aug.

11.

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ.

Sci Immunol. 2016 Oct;1(5). pii: eaaf8612. Epub 2016 Nov 11.

12.

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.

Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V.

J Immunol. 2017 Aug 15;199(4):1250-1260. doi: 10.4049/jimmunol.1600941. Epub 2017 Jul 12.

13.

Metabolic Instruction of Immunity.

Buck MD, Sowell RT, Kaech SM, Pearce EL.

Cell. 2017 May 4;169(4):570-586. doi: 10.1016/j.cell.2017.04.004. Review.

14.

Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.

Ho PC, Kaech SM.

Curr Opin Immunol. 2017 Jun;46:38-44. doi: 10.1016/j.coi.2017.04.003. Epub 2017 Apr 27. Review.

PMID:
28458087
15.

Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency.

Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM.

Immunity. 2017 Apr 18;46(4):596-608. doi: 10.1016/j.immuni.2017.03.012. Epub 2017 Apr 11.

16.

Immunology: The chronicles of T-cell exhaustion.

Amezquita RA, Kaech SM.

Nature. 2017 Mar 9;543(7644):190-191. doi: 10.1038/nature21508. Epub 2017 Feb 22. No abstract available.

PMID:
28225757
17.

NK Cell Responses Redefine Immunological Memory.

Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC.

J Immunol. 2016 Oct 15;197(8):2963-2970. Review.

18.

ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells.

Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV.

J Clin Invest. 2016 Oct 3;126(10):3905-3916. doi: 10.1172/JCI85329. Epub 2016 Sep 12.

19.

Probing the Diversity of T Cell Dysfunction in Cancer.

Sowell RT, Kaech SM.

Cell. 2016 Sep 8;166(6):1362-1364. doi: 10.1016/j.cell.2016.08.058.

20.

IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.

Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS.

Sci Rep. 2016 Aug 1;6:30636. doi: 10.1038/srep30636.

21.

CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches.

Jung YW, Kim HG, Perry CJ, Kaech SM.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8278-83. doi: 10.1073/pnas.1602899113. Epub 2016 Jul 6.

22.

Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE.

Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC.

J Biol Chem. 2016 May 20;291(21):11230-40. doi: 10.1074/jbc.M115.713362. Epub 2016 Mar 18.

23.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A.

Nat Immunol. 2016 Apr;17(4):422-32. doi: 10.1038/ni.3410. Epub 2016 Mar 7.

24.

The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.

Laidlaw BJ, Craft JE, Kaech SM.

Nat Rev Immunol. 2016 Feb;16(2):102-11. doi: 10.1038/nri.2015.10. Epub 2016 Jan 19. Review.

25.

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.

Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM.

J Exp Med. 2015 Nov 16;212(12):2041-56. doi: 10.1084/jem.20150186. Epub 2015 Oct 26.

26.

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J.

Immunity. 2015 Oct 20;43(4):690-702. doi: 10.1016/j.immuni.2015.08.017. Epub 2015 Sep 22.

27.

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM.

Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27.

28.

Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.

Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM.

Nat Immunol. 2015 Aug;16(8):871-9. doi: 10.1038/ni.3224. Epub 2015 Jul 6.

29.

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity.

Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM.

Cell. 2015 May 7;161(4):750-61. doi: 10.1016/j.cell.2015.03.021.

30.

Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection.

Chen JH, Perry CJ, Tsui YC, Staron MM, Parish IA, Dominguez CX, Rosenberg DW, Kaech SM.

Nat Med. 2015 Apr;21(4):327-34. doi: 10.1038/nm.3831. Epub 2015 Mar 23.

31.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.

Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.

32.

Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS.

Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2.

33.

Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells.

Hu Y, Lee YT, Kaech SM, Garvy B, Cauley LS.

J Immunol. 2015 Mar 1;194(5):2407-14. doi: 10.4049/jimmunol.1402369. Epub 2015 Jan 30.

34.

Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.

Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC.

Aging (Albany NY). 2015 Jan;7(1):38-52.

35.

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.

Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM.

Elife. 2015 Jan 8;4:e04851. doi: 10.7554/eLife.04851.

36.

The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.

Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO, Kaech SM.

Immunity. 2014 Nov 20;41(5):802-14. doi: 10.1016/j.immuni.2014.10.013. Epub 2014 Nov 13.

37.

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC.

J Infect Dis. 2015 Apr 1;211(7):1174-84. doi: 10.1093/infdis/jiu573. Epub 2014 Nov 2.

38.

A central role for Notch in effector CD8(+) T cell differentiation.

Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D.

Nat Immunol. 2014 Dec;15(12):1143-51. doi: 10.1038/ni.3027. Epub 2014 Oct 26.

39.

CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.

Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM.

Immunity. 2014 Oct 16;41(4):633-45. doi: 10.1016/j.immuni.2014.09.007. Epub 2014 Oct 9.

40.

CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2.

Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S.

J Clin Invest. 2014 Oct;124(10):4549-63. doi: 10.1172/JCI76602. Epub 2014 Aug 26.

41.

The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation.

Gray SM, Kaech SM, Staron MM.

Immunol Rev. 2014 Sep;261(1):157-68. doi: 10.1111/imr.12205. Review.

42.
43.

T-cell TGF-β signaling abrogation restricts medulloblastoma progression.

Gate D, Danielpour M, Rodriguez J Jr, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3458-66. doi: 10.1073/pnas.1412489111. Epub 2014 Jul 31.

44.

Regulating the diverse outcomes of interferon's interference.

Marshall HD, Kaech SM.

Trends Immunol. 2014 Aug;35(8):353-4. doi: 10.1016/j.it.2014.07.002. Epub 2014 Jul 19.

45.

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM.

J Clin Invest. 2014 Aug;124(8):3455-68. doi: 10.1172/JCI66108. Epub 2014 Jul 8.

46.

Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.

Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM.

Cancer Res. 2014 Jun 15;74(12):3205-17. doi: 10.1158/0008-5472.CAN-13-3461. Epub 2014 Apr 15.

47.

TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.

Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM.

J Immunol. 2014 May 1;192(9):4221-32. doi: 10.4049/jimmunol.1302569. Epub 2014 Mar 21.

48.

Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells.

Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J.

Immunity. 2014 Mar 20;40(3):367-77. doi: 10.1016/j.immuni.2014.02.005. Epub 2014 Mar 13.

49.

Celebrating diversity in memory T cells.

Kaech SM.

J Immunol. 2014 Feb 1;192(3):837-9. doi: 10.4049/jimmunol.1303268. No abstract available.

50.

Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.

Slütter B, Pewe LL, Kaech SM, Harty JT.

Immunity. 2013 Nov 14;39(5):939-48. doi: 10.1016/j.immuni.2013.09.013.

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