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Items: 1 to 50 of 243


TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.

Cheng Y, Desse S, Martinez A, Worthen RJ, Jope RS, Beurel E.

Brain Behav Immun. 2018 Mar;69:556-567. doi: 10.1016/j.bbi.2018.02.003. Epub 2018 Feb 13.


Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

Pardo M, Cheng Y, Velmeshev D, Magistri M, Eldar-Finkelman H, Martinez A, Faghihi MA, Jope RS, Beurel E.

JCI Insight. 2017 Mar 23;2(6):e91782. doi: 10.1172/jci.insight.91782.


Stressed and Inflamed, Can GSK3 Be Blamed?

Jope RS, Cheng Y, Lowell JA, Worthen RJ, Sitbon YH, Beurel E.

Trends Biochem Sci. 2017 Mar;42(3):180-192. doi: 10.1016/j.tibs.2016.10.009. Epub 2016 Nov 19. Review.


Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome.

Pardo M, Beurel E, Jope RS.

Eur J Neurosci. 2017 Feb;45(4):490-498. doi: 10.1111/ejn.13446. Epub 2016 Nov 12.


Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling.

Beurel E, Grieco SF, Amadei C, Downey K, Jope RS.

Bipolar Disord. 2016 Sep;18(6):473-480. doi: 10.1111/bdi.12436. Epub 2016 Sep 30.


Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

Grieco SF, Velmeshev D, Magistri M, Eldar-Finkelman H, Faghihi MA, Jope RS, Beurel E.

World J Biol Psychiatry. 2017 Sep;18(6):445-456. doi: 10.1080/15622975.2016.1224927. Epub 2016 Oct 10.


Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition.

Grieco SF, Cheng Y, Eldar-Finkelman H, Jope RS, Beurel E.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jan 4;72:49-54. doi: 10.1016/j.pnpbp.2016.08.008. Epub 2016 Aug 16.


Lithium to the Rescue.

Jope RS, Nemeroff CB.

Cerebrum. 2016 Feb 1;2016. pii: cer-02-16. eCollection 2016 Jan-Feb.


Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior.

Cheng Y, Pardo M, Armini RS, Martinez A, Mouhsine H, Zagury JF, Jope RS, Beurel E.

Brain Behav Immun. 2016 Mar;53:207-222. doi: 10.1016/j.bbi.2015.12.012. Epub 2016 Jan 6.


GSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation.

Pardo M, Abrial E, Jope RS, Beurel E.

Genes Brain Behav. 2016 Mar;15(3):348-55. doi: 10.1111/gbb.12283. Epub 2016 Feb 12.


A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress.

Cheng Y, Jope RS, Beurel E.

BMC Neurosci. 2015 May 7;16:31. doi: 10.1186/s12868-015-0169-z.


Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.

Pardo M, King MK, Perez-Costas E, Melendez-Ferro M, Martinez A, Beurel E, Jope RS.

Front Behav Neurosci. 2015 Mar 4;9:55. doi: 10.3389/fnbeh.2015.00055. eCollection 2015.


Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.

Beurel E, Jope RS.

Transl Psychiatry. 2014 Dec 16;4:e488. doi: 10.1038/tp.2014.129. Review.


Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.

Beurel E, Grieco SF, Jope RS.

Pharmacol Ther. 2015 Apr;148:114-31. doi: 10.1016/j.pharmthera.2014.11.016. Epub 2014 Nov 27. Review.


Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.

Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS.

PLoS One. 2014 Jan 28;9(1):e86257. doi: 10.1371/journal.pone.0086257. eCollection 2014.


Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice.

Franklin AV, King MK, Palomo V, Martinez A, McMahon LL, Jope RS.

Biol Psychiatry. 2014 Feb 1;75(3):198-206. doi: 10.1016/j.biopsych.2013.08.003. Epub 2013 Sep 13.


Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome.

King MK, Jope RS.

Genes Brain Behav. 2013 Oct;12(7):723-31. doi: 10.1111/gbb.12071. Epub 2013 Aug 29.


Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.

King MK, Pardo M, Cheng Y, Downey K, Jope RS, Beurel E.

Pharmacol Ther. 2014 Jan;141(1):1-12. doi: 10.1016/j.pharmthera.2013.07.010. Epub 2013 Jul 31. Review.


Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Beurel E, Kaidanovich-Beilin O, Yeh WI, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS.

J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19.


Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium.

Yang JY, Deng W, Chen Y, Fan W, Baldwin KM, Jope RS, Wallace DC, Wang PH.

J Mol Cell Cardiol. 2013 Jun;59:167-75. doi: 10.1016/j.yjmcc.2013.02.016. Epub 2013 Mar 13.


The ups and downs of bipolar disorder research.

Jope RS, Nemeroff CB.

Biol Psychiatry. 2013 Apr 1;73(7):597-9. doi: 10.1016/j.biopsych.2012.12.014. No abstract available. Erratum in: Biol Psychiatry. 2013 May 15;73(10):1035.


DDX3 regulates DNA damage-induced apoptosis and p53 stabilization.

Sun M, Zhou T, Jonasch E, Jope RS.

Biochim Biophys Acta. 2013 Jun;1833(6):1489-97. doi: 10.1016/j.bbamcr.2013.02.026. Epub 2013 Mar 5.


Inflammatory T helper 17 cells promote depression-like behavior in mice.

Beurel E, Harrington LE, Jope RS.

Biol Psychiatry. 2013 Apr 1;73(7):622-30. doi: 10.1016/j.biopsych.2012.09.021. Epub 2012 Nov 20.


Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development.

Beurel E, Mines MA, Song L, Jope RS.

Bipolar Disord. 2012 Dec;14(8):822-30. doi: 10.1111/bdi.12023.


Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.

Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X.

Immunity. 2012 Nov 16;37(5):800-12. doi: 10.1016/j.immuni.2012.08.019. Epub 2012 Nov 8.


Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice.

Mines MA, Beurel E, Jope RS.

Eur J Pharmacol. 2013 Jan 5;698(1-3):252-8. doi: 10.1016/j.ejphar.2012.10.018. Epub 2012 Oct 23.


Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3.

Paul JR, Johnson RL, Jope RS, Gamble KL.

Neuroscience. 2012 Dec 13;226:1-9. doi: 10.1016/j.neuroscience.2012.08.047. Epub 2012 Sep 15.


Activation of the ATM-Snail pathway promotes breast cancer metastasis.

Sun M, Guo X, Qian X, Wang H, Yang C, Brinkman KL, Serrano-Gonzalez M, Jope RS, Zhou B, Engler DA, Zhan M, Wong ST, Fu L, Xu B.

J Mol Cell Biol. 2012 Oct;4(5):304-15. doi: 10.1093/jmcb/mjs048. Epub 2012 Aug 24.


Neurological functions of the masterswitch protein kinase - gsk-3.

Kaidanovich-Beilin O, Beaulieu JM, Jope RS, Woodgett JR.

Front Mol Neurosci. 2012 Apr 9;5:48. doi: 10.3389/fnmol.2012.00048. eCollection 2012. No abstract available.


Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice.

Mines MA, Jope RS.

Cell Signal. 2012 Jul;24(7):1398-405. doi: 10.1016/j.cellsig.2012.03.001. Epub 2012 Mar 10.


Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome.

Mines MA, Jope RS.

Front Mol Neurosci. 2011 Nov 1;4:35. doi: 10.3389/fnmol.2011.00035. eCollection 2011.


Functional significance of glycogen synthase kinase-3 regulation by serotonin.

Polter AM, Yang S, Jope RS, Li X.

Cell Signal. 2012 Jan;24(1):265-71. doi: 10.1016/j.cellsig.2011.09.009. Epub 2011 Sep 17.


Glycogen synthase kinase-3 in the etiology and treatment of mood disorders.

Jope RS.

Front Mol Neurosci. 2011 Aug 9;4:16. doi: 10.3389/fnmol.2011.00016. eCollection 2011.


Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3.

Mines MA, Beurel E, Jope RS.

Int J Alzheimers Dis. 2011;2011:861072. doi: 10.4061/2011/861072. Epub 2011 May 11.


Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice.

Beurel E, Song L, Jope RS.

Mol Psychiatry. 2011 Nov;16(11):1068-70. doi: 10.1038/mp.2011.47. Epub 2011 Apr 19. No abstract available.


Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.

Wang H, Brown J, Gu Z, Garcia CA, Liang R, Alard P, Beurel E, Jope RS, Greenway T, Martin M.

J Immunol. 2011 May 1;186(9):5217-26. doi: 10.4049/jimmunol.1002513. Epub 2011 Mar 21.


Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells.

Meares GP, Mines MA, Beurel E, Eom TY, Song L, Zmijewska AA, Jope RS.

Exp Cell Res. 2011 Jul 1;317(11):1621-8. doi: 10.1016/j.yexcr.2011.02.012. Epub 2011 Feb 26.


The role of DDX3 in regulating Snail.

Sun M, Song L, Zhou T, Gillespie GY, Jope RS.

Biochim Biophys Acta. 2011 Mar;1813(3):438-47. doi: 10.1016/j.bbamcr.2011.01.003. Epub 2011 Jan 12.


Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.

Beurel E, Yeh WI, Michalek SM, Harrington LE, Jope RS.

J Immunol. 2011 Feb 1;186(3):1391-8. doi: 10.4049/jimmunol.1003511. Epub 2010 Dec 29.


Is glycogen synthase kinase-3 a central modulator in mood regulation?

Li X, Jope RS.

Neuropsychopharmacology. 2010 Oct;35(11):2143-54. doi: 10.1038/npp.2010.105. Epub 2010 Jul 28. Review.


Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome.

Yuskaitis CJ, Beurel E, Jope RS.

Biochim Biophys Acta. 2010 Nov;1802(11):1006-12. doi: 10.1016/j.bbadis.2010.06.015. Epub 2010 Jul 1.


Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes.

Beurel E, Jope RS.

Neuroscience. 2010 Sep 1;169(3):1063-70. doi: 10.1016/j.neuroscience.2010.05.044. Epub 2010 May 27.


Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.

Polter A, Beurel E, Yang S, Garner R, Song L, Miller CA, Sweatt JD, McMahon L, Bartolucci AA, Li X, Jope RS.

Neuropsychopharmacology. 2010 Jul;35(8):1761-74. doi: 10.1038/npp.2010.43. Epub 2010 Mar 31.


GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.

Mines MA, Yuskaitis CJ, King MK, Beurel E, Jope RS.

PLoS One. 2010 Mar 16;5(3):e9706. doi: 10.1371/journal.pone.0009706.


Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

Beurel E, Michalek SM, Jope RS.

Trends Immunol. 2010 Jan;31(1):24-31. doi: 10.1016/ Epub 2009 Oct 14. Review.


Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.

Yuskaitis CJ, Mines MA, King MK, Sweatt JD, Miller CA, Jope RS.

Biochem Pharmacol. 2010 Feb 15;79(4):632-46. doi: 10.1016/j.bcp.2009.09.023.


XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3.

Sun M, Meares G, Song L, Jope RS.

Cell Signal. 2009 Dec;21(12):1857-65. doi: 10.1016/j.cellsig.2009.08.002. Epub 2009 Aug 19.


Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation.

Eom TY, Jope RS.

Biol Psychiatry. 2009 Sep 1;66(5):494-502. doi: 10.1016/j.biopsych.2009.04.015. Epub 2009 Jun 11.


GSK3 beta N-terminus binding to p53 promotes its acetylation.

Eom TY, Jope RS.

Mol Cancer. 2009 Mar 5;8:14. doi: 10.1186/1476-4598-8-14.

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