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A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway.

Freitas M, Ferreira F, Carvalho S, Silva F, Lopes P, Antunes L, Salta S, Diniz F, Santos LL, Videira JF, Henrique R, Jerónimo C.

J Transl Med. 2018 Feb 27;16(1):45. doi: 10.1186/s12967-018-1415-9.


Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival.

Oliveira AI, Xavier-Magalhães A, Moreira-Barbosa C, Magalhães H, Henrique R, Jerónimo C, Costa BM.

Biomark Med. 2018 Feb 13. doi: 10.2217/bmm-2017-0258. [Epub ahead of print]


MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.

Barros-Silva D, Costa-Pinheiro P, Duarte H, Sousa EJ, Evangelista AF, Graça I, Carneiro I, Martins AT, Oliveira J, Carvalho AL, Marques MM, Henrique R, Jerónimo C.

Cell Death Dis. 2018 Feb 7;9(2):167. doi: 10.1038/s41419-017-0241-y.


Methylation-Specific PCR.

Ramalho-Carvalho J, Henrique R, Jerónimo C.

Methods Mol Biol. 2018;1708:447-472. doi: 10.1007/978-1-4939-7481-8_23.


High immunoexpression of Ki67, EZH2, and SMYD3 in diagnostic prostate biopsies independently predicts outcome in patients with prostate cancer.

Lobo J, Rodrigues Â, Antunes L, Graça I, Ramalho-Carvalho J, Vieira FQ, Martins AT, Oliveira J, Jerónimo C, Henrique R.

Urol Oncol. 2017 Nov 22. pii: S1078-1439(17)30565-3. doi: 10.1016/j.urolonc.2017.10.028. [Epub ahead of print]


SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization.

Ferreira MJ, Pires-Luís AS, Vieira-Coimbra M, Costa-Pinheiro P, Antunes L, Dias PC, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C.

Epigenetics. 2017;12(12):1057-1064. doi: 10.1080/15592294.2017.1385685. Epub 2018 Jan 22.


Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models.

Ferreira LP, Gaspar VM, Henrique R, Jerónimo C, Mano JF.

Biotechnol J. 2017 Dec;12(12). doi: 10.1002/biot.201700079. Epub 2017 Sep 4. Review.


The Mediator Complex: At the Nexus of RNA Polymerase II Transcription.

Jeronimo C, Robert F.

Trends Cell Biol. 2017 Oct;27(10):765-783. doi: 10.1016/j.tcb.2017.07.001. Epub 2017 Aug 1. Review.


Is There a Role for Exosome-derived MicroRNAs in Detection of Renal Cell Tumors Using Urine Samples? Editorial to [European Urology Focus 2/2 (2016) 210-218].

Jerónimo C, Henrique R.

Eur Urol Focus. 2016 Dec 15;2(6):654-655. doi: 10.1016/j.euf.2016.01.001. Epub 2016 Jan 16. No abstract available.


Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel.

Pires-Luís AS, Costa-Pinheiro P, Ferreira MJ, Antunes L, Lobo F, Oliveira J, Henrique R, Jerónimo C.

J Transl Med. 2017 Jun 29;15(1):149. doi: 10.1186/s12967-017-1248-y.


Epigenetics in endometrial carcinogenesis - part 2: histone modifications, chromatin remodeling and noncoding RNAs.

Bartosch C, Lopes JM, Jerónimo C.

Epigenomics. 2017 Jun;9(6):873-892. doi: 10.2217/epi-2016-0167. Epub 2017 May 19. Review.


The role of pathology in the management of patients with endometrial carcinoma.

Bartosch C, Pires M, Jerónimo C, Lopes JM.

Future Oncol. 2017 May;13(11):1003-1020. doi: 10.2217/fon-2016-0570. Review.


Epigenetics in endometrial carcinogenesis - part 1: DNA methylation.

Bartosch C, Lopes JM, Jerónimo C.

Epigenomics. 2017 May;9(5):737-755. doi: 10.2217/epi-2016-0166. Epub 2017 May 4. Review.


Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes.

Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F.

Nucleic Acids Res. 2017 Jun 20;45(11):6417-6426. doi: 10.1093/nar/gkx242.


GC-MS metabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of renal cell carcinoma patients.

Monteiro M, Moreira N, Pinto J, Pires-Luís AS, Henrique R, Jerónimo C, Bastos ML, Gil AM, Carvalho M, Guedes de Pinho P.

J Cell Mol Med. 2017 Sep;21(9):2092-2105. doi: 10.1111/jcmm.13132. Epub 2017 Apr 4.


Behavior of prostate cancer cells in a nanohydroxyapatite/collagen bone scaffold.

Cruz-Neves S, Ribeiro N, Graça I, Jerónimo C, Sousa SR, Monteiro FJ.

J Biomed Mater Res A. 2017 Jul;105(7):2035-2046. doi: 10.1002/jbm.a.36070. Epub 2017 May 10.


The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells.

Monteiro FL, Vitorino R, Wang J, Cardoso H, Laranjeira H, Simões J, Caldas M, Henrique R, Amado F, Williams C, Jerónimo C, Helguero LA.

Cancer Lett. 2017 Jun 28;396:42-52. doi: 10.1016/j.canlet.2017.03.007. Epub 2017 Mar 11.


Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer.

Ramalho-Carvalho J, Graça I, Gomez A, Oliveira J, Henrique R, Esteller M, Jerónimo C.

J Hematol Oncol. 2017 Feb 6;10(1):43. doi: 10.1186/s13045-017-0415-1.


MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors.

Torres-Ferreira J, Ramalho-Carvalho J, Gomez A, Menezes FD, Freitas R, Oliveira J, Antunes L, Bento MJ, Esteller M, Henrique R, Jerónimo C.

Mol Cancer. 2017 Jan 31;16(1):26. doi: 10.1186/s12943-017-0604-0.


The epigenetics of testicular germ cell tumors: looking for novel disease biomarkers.

Costa AL, Lobo J, Jerónimo C, Henrique R.

Epigenomics. 2017 Feb;9(2):155-169. doi: 10.2217/epi-2016-0081. Epub 2017 Jan 18. Review.


MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma.

Padrão NA, Monteiro-Reis S, Torres-Ferreira J, Antunes L, Leça L, Montezuma D, Ramalho-Carvalho J, Dias PC, Monteiro P, Oliveira J, Henrique R, Jerónimo C.

Br J Cancer. 2017 Feb 28;116(5):634-639. doi: 10.1038/bjc.2016.454. Epub 2017 Jan 12.


Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1.

Ramalho-Carvalho J, Martins JB, Cekaite L, Sveen A, Torres-Ferreira J, Graça I, Costa-Pinheiro P, Eilertsen IA, Antunes L, Oliveira J, Lothe RA, Henrique R, Jerónimo C.

Cancer Lett. 2017 Jan 28;385:150-159. doi: 10.1016/j.canlet.2016.10.028. Epub 2016 Oct 27.


Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?

Lobo J, Pinto C, Freitas M, Pinheiro M, Vizcaino R, Oliva E, Teixeira MR, Jerónimo C, Bartosch C.

Virchows Arch. 2017 Mar;470(3):347-352. doi: 10.1007/s00428-016-2052-4. Epub 2016 Dec 3.


Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma.

Monteiro MS, Barros AS, Pinto J, Carvalho M, Pires-Luís AS, Henrique R, Jerónimo C, Bastos ML, Gil AM, Guedes de Pinho P.

Sci Rep. 2016 Nov 18;6:37275. doi: 10.1038/srep37275.


A Spiking Strategy for ChIP-chip Data Normalization in S. cerevisiae.

Jeronimo C, Robert F.

Methods Mol Biol. 2017;1528:211-227.


Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.

Luedeke M, Rinckleb AE, FitzGerald LM, Geybels MS, Schleutker J, Eeles RA, Teixeira MR, Cannon-Albright L, Ostrander EA, Weikert S, Herkommer K, Wahlfors T, Visakorpi T, Leinonen KA, Tammela TLJ, Cooper CS, Kote-Jarai Z, Edwards S, Goh CL, McCarthy F, Parker C, Flohr P, Paulo P, Jerónimo C, Henrique R, Krause H, Wach S, Lieb V, Rau TT, Vogel W, Kuefer R, Hofer MD, Perner S, Rubin MA, Agarwal AM, Easton DF, Al Olama AA, Benlloch S; PRACTICAL consortium, Hoegel J, Stanford JL, Maier C.

Hum Mol Genet. 2016 Dec 15;25(24):5490-5499. doi: 10.1093/hmg/ddw349.


Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

Herranz N, Dave N, Millanes-Romero A, Pascual-Reguant L, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Iturbide A, Di Croce L, García de Herreros A, Peiró S.

FEBS J. 2016 Dec;283(23):4263-4273. doi: 10.1111/febs.13922. Epub 2016 Oct 30.


Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.

Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F.

Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20.


Epigenetic modulators as therapeutic targets in prostate cancer.

Graça I, Pereira-Silva E, Henrique R, Packham G, Crabb SJ, Jerónimo C.

Clin Epigenetics. 2016 Sep 15;8:98. doi: 10.1186/s13148-016-0264-8. eCollection 2016. Review.


Prognostic significance of MST1R dysregulation in renal cell tumors.

Pires-Luís AS, Vieira-Coimbra M, Ferreira MJ, Ramalho-Carvalho J, Costa-Pinheiro P, Antunes L, Dias PC, Lobo F, Oliveira J, Graça I, Henrique R, Jerónimo C.

Am J Cancer Res. 2016 Aug 1;6(8):1799-811. eCollection 2016.


Decoding the usefulness of non-coding RNAs as breast cancer markers.

Amorim M, Salta S, Henrique R, Jerónimo C.

J Transl Med. 2016 Sep 15;14:265. doi: 10.1186/s12967-016-1025-3. Review.


Renal cell carcinoma: a critical analysis of metabolomic biomarkers emerging from current model systems.

Rodrigues D, Monteiro M, Jerónimo C, Henrique R, Belo L, Bastos ML, Guedes de Pinho P, Carvalho M.

Transl Res. 2017 Feb;180:1-11. doi: 10.1016/j.trsl.2016.07.018. Epub 2016 Aug 2. Review.


Testicular Germ Cell Tumors Go Epigenetics: Will miR-371a-3p Replace Classical Serum Biomarkers?

Henrique R, Jerónimo C.

Eur Urol. 2017 Feb;71(2):221-222. doi: 10.1016/j.eururo.2016.08.013. Epub 2016 Aug 16. No abstract available.


Comprehensive Analysis of Secreted Protein, Acidic and Rich in Cysteine in Prostate Carcinogenesis: Development of a 3D Nanostructured Bone-Like Model.

Ribeiro N, Costa-Pinheiro P, Henrique R, Gomez-Lazaro M, Pereira MP, Mansur AAP, Mansur HS, Jerónimo C, Sousa SR, Monteiro FJ.

J Biomed Nanotechnol. 2016 Aug;12(8):1667-78.


Retraction Notice to: Lysyl Oxidase-like 2 Deaminates Lysine 4 in Histone H3.

Herranz N, Dave N, Millanes-Romero A, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Di Croce L, García de Herreros A, Peiró S.

Mol Cell. 2016 Jul 7;63(1):180. doi: 10.1016/j.molcel.2016.06.013. No abstract available.


Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.

Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E.

Am J Surg Pathol. 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684.


Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.

Almeida-Rios D, Graça I, Vieira FQ, Ramalho-Carvalho J, Pereira-Silva E, Martins AT, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C.

Oncotarget. 2016 Aug 16;7(33):53018-53028. doi: 10.18632/oncotarget.10061.


Deciphering the function of non-coding RNAs in prostate cancer.

Ramalho-Carvalho J, Fromm B, Henrique R, Jerónimo C.

Cancer Metastasis Rev. 2016 Jun;35(2):235-62. doi: 10.1007/s10555-016-9628-y. Review.


Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants.

Jeronimo C, Robert F.

Bioessays. 2016 May;38(5):420-6. doi: 10.1002/bies.201500122. Epub 2016 Mar 15.


The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain.

Jeronimo C, Collin P, Robert F.

J Mol Biol. 2016 Jun 19;428(12):2607-2622. doi: 10.1016/j.jmb.2016.02.006. Epub 2016 Feb 12. Review.


Biomarkers in bladder cancer: A metabolomic approach using in vitro and ex vivo model systems.

Rodrigues D, Jerónimo C, Henrique R, Belo L, de Lourdes Bastos M, de Pinho PG, Carvalho M.

Int J Cancer. 2016 Jul 15;139(2):256-68. doi: 10.1002/ijc.30016. Epub 2016 Feb 23. Review.


NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer.

Silva MP, Barros-Silva JD, Vieira J, Lisboa S, Torres L, Correia C, Vieira-Coimbra M, Martins AT, Jerónimo C, Henrique R, Paulo P, Teixeira MR.

Genes Chromosomes Cancer. 2016 Apr;55(4):365-74. doi: 10.1002/gcc.22340. Epub 2016 Jan 22.


Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.

Bartosch C, Monteiro-Reis S, Almeida-Rios D, Vieira R, Castro A, Moutinho M, Rodrigues M, Graça I, Lopes JM, Jerónimo C.

Oncotarget. 2016 Jan 12;7(2):1144-54. doi: 10.18632/oncotarget.6691.


Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication.

Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C.

Epigenetics. 2015;10(11):1033-43. doi: 10.1080/15592294.2015.1103578.


Diagnostic and prognostic epigenetic biomarkers in cancer.

Costa-Pinheiro P, Montezuma D, Henrique R, Jerónimo C.

Epigenomics. 2015;7(6):1003-15. doi: 10.2217/epi.15.56. Epub 2015 Oct 7. Review.


Endometrial Endometrioid Carcinoma Metastases Show Decreased ER-Alpha and PR-A Expression Compared to Matched Primary Tumors.

Bartosch C, Monteiro-Reis S, Vieira R, Pereira A, Rodrigues M, Jerónimo C, Lopes JM.

PLoS One. 2015 Aug 7;10(8):e0134969. doi: 10.1371/journal.pone.0134969. eCollection 2015.


Identification of Two Novel HOXB13 Germline Mutations in Portuguese Prostate Cancer Patients.

Maia S, Cardoso M, Pinto P, Pinheiro M, Santos C, Peixoto A, Bento MJ, Oliveira J, Henrique R, Jerónimo C, Teixeira MR.

PLoS One. 2015 Jul 15;10(7):e0132728. doi: 10.1371/journal.pone.0132728. eCollection 2015.


Uncovering potential downstream targets of oncogenic GRPR overexpression in prostate carcinomas harboring ETS rearrangements.

Santos J, Mesquita D, Barros-Silva JD, Jerónimo C, Henrique R, Morais A, Paulo P, Teixeira MR.

Oncoscience. 2015 Mar 17;2(5):497-507. eCollection 2015.


SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3.

Vieira FQ, Costa-Pinheiro P, Almeida-Rios D, Graça I, Monteiro-Reis S, Simões-Sousa S, Carneiro I, Sousa EJ, Godinho MI, Baltazar F, Henrique R, Jerónimo C.

Oncotarget. 2015 May 30;6(15):13644-57.


MicroRNA-375 plays a dual role in prostate carcinogenesis.

Costa-Pinheiro P, Ramalho-Carvalho J, Vieira FQ, Torres-Ferreira J, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C.

Clin Epigenetics. 2015 Apr 10;7:42. doi: 10.1186/s13148-015-0076-2. eCollection 2015.

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