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Items: 1 to 50 of 186

1.

Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones: Total Synthesis of Indolizidine 209D.

Ho HE, James MJ, O'Brien P, Taylor RJK, Unsworth WP.

Org Lett. 2018 Mar 2;20(5):1439-1443. doi: 10.1021/acs.orglett.8b00225. Epub 2018 Feb 9.

PMID:
29425045
2.

Increasing Catalyst Efficiency in C-H Activation Catalysis.

Gensch T, James MJ, Dalton T, Glorius F.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2296-2306. doi: 10.1002/anie.201710377. Epub 2018 Jan 29. Review.

PMID:
29205745
3.

Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.

Demasi M, Cleland LG, Cook-Johnson RJ, Caughey GE, James MJ.

J Biol Chem. 2017 Sep 22;292(38):15993. doi: 10.1074/jbc.A117.305944. No abstract available.

4.

Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals.

Klauck FJR, James MJ, Glorius F.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12336-12339. doi: 10.1002/anie.201706896. Epub 2017 Aug 29.

PMID:
28762257
5.

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C.

J Med Chem. 2017 Jun 22;60(12):5120-5145. doi: 10.1021/acs.jmedchem.7b00475. Epub 2017 Jun 8.

6.

Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II.

James MJ, Grant ND, O'Brien P, Taylor RJ, Unsworth WP.

Org Lett. 2016 Dec 16;18(24):6256-6259. Epub 2016 Nov 30.

PMID:
27978692
7.

Silica-Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica.

Clarke AK, James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13798-13802. doi: 10.1002/anie.201608263. Epub 2016 Sep 30.

PMID:
27689850
8.

Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor.

James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9671-5. doi: 10.1002/anie.201605337. Epub 2016 Jul 20.

PMID:
27435296
9.

Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones.

Liddon JT, James MJ, Clarke AK, O'Brien P, Taylor RJ, Unsworth WP.

Chemistry. 2016 Jun 20;22(26):8777-80. doi: 10.1002/chem.201601836. Epub 2016 May 19.

10.

Nutritional regulation of long-chain PUFA biosynthetic genes in rainbow trout (Oncorhynchus mykiss).

Gregory MK, Collins RO, Tocher DR, James MJ, Turchini GM.

Br J Nutr. 2016 May 28;115(10):1721-9. doi: 10.1017/S0007114516000830. Epub 2016 Mar 18.

PMID:
26987422
11.

Structure Property Relationships of Carboxylic Acid Isosteres.

Lassalas P, Gay B, Lasfargeas C, James MJ, Tran V, Vijayendran KG, Brunden KR, Kozlowski MC, Thomas CJ, Smith AB 3rd, Huryn DM, Ballatore C.

J Med Chem. 2016 Apr 14;59(7):3183-203. doi: 10.1021/acs.jmedchem.5b01963. Epub 2016 Mar 30.

12.

Synthesis of Spirocyclic Indolenines.

James MJ, O'Brien P, Taylor RJ, Unsworth WP.

Chemistry. 2016 Feb 24;22(9):2856-81. doi: 10.1002/chem.201503835. Epub 2015 Dec 14. Review.

PMID:
26661053
13.

Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles.

James MJ, Clubley RE, Palate KY, Procter TJ, Wyton AC, O'Brien P, Taylor RJ, Unsworth WP.

Org Lett. 2015 Sep 4;17(17):4372-5. doi: 10.1021/acs.orglett.5b02216. Epub 2015 Aug 21.

PMID:
26293968
14.

Plasma n-3 fatty acids and clinical outcomes in recent-onset rheumatoid arthritis.

Proudman SM, Cleland LG, Metcalf RG, Sullivan TR, Spargo LD, James MJ.

Br J Nutr. 2015 Sep 28;114(6):885-90. doi: 10.1017/S0007114515002718. Epub 2015 Aug 18.

PMID:
26283657
15.

Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds.

James MJ, Cuthbertson JD, O'Brien P, Taylor RJ, Unsworth WP.

Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7640-3. doi: 10.1002/anie.201501812. Epub 2015 May 8.

PMID:
25960013
16.

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.

Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB 3rd, Ballatore C, Brunden KR.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4980-2. doi: 10.1016/j.bmcl.2015.03.002. Epub 2015 Mar 14.

17.

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.

Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC.

Nat Commun. 2014 Oct 28;5:5359. doi: 10.1038/ncomms6359.

18.
19.

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.

Cumming JG, Debreczeni JÉ, Edfeldt F, Evertsson E, Harrison M, Holdgate GA, James MJ, Lamont SG, Oldham K, Sullivan JE, Wells SL.

J Med Chem. 2015 Jan 8;58(1):278-93. doi: 10.1021/jm501038s. Epub 2014 Oct 9.

PMID:
25255283
20.

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.

Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB 3rd, Brunden KR, Ballatore C.

ACS Med Chem Lett. 2014 Jul 24;5(9):1015-20. doi: 10.1021/ml5002085. eCollection 2014 Sep 11.

21.

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.

Ballatore C, Gay B, Huang L, Robinson KH, James MJ, Trojanowski JQ, Lee VM, Brunden KR, Smith AB 3rd.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4171-5. doi: 10.1016/j.bmcl.2014.07.047. Epub 2014 Jul 23.

22.

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.

Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB 3rd, Brunden KR, Ballatore C.

J Med Chem. 2014 Jul 24;57(14):6116-27. doi: 10.1021/jm5005623. Epub 2014 Jul 3.

23.

Pitfalls in the use of randomised controlled trials for fish oil studies with cardiac patients.

James MJ, Sullivan TR, Metcalf RG, Cleland LG.

Br J Nutr. 2014 Sep 14;112(5):812-20. doi: 10.1017/S0007114514001408. Epub 2014 Jun 16.

PMID:
24933212
24.

Functional characterization of the duck and turkey fatty acyl elongase enzymes ELOVL5 and ELOVL2.

Gregory MK, James MJ.

J Nutr. 2014 Aug;144(8):1234-9. doi: 10.3945/jn.114.194159. Epub 2014 Jun 11.

PMID:
24919687
25.

MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.

Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB 3rd.

ACS Med Chem Lett. 2013 Jul 23;4(9):886-9. doi: 10.1021/ml400233e. eCollection 2013 Sep 12.

26.

RE: Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial.

Cleland LG, Proudman SM, James MJ.

J Natl Cancer Inst. 2014 Apr;106(4):dju022. doi: 10.1093/jnci/dju022. Epub 2014 Mar 31. No abstract available.

PMID:
24685932
27.

Fruit self-thinning: a trait to consider for genetic improvement of apple tree.

Celton JM, Kelner JJ, Martinez S, Bechti A, Khelifi Touhami A, James MJ, Durel CE, Laurens F, Costes E.

PLoS One. 2014 Mar 13;9(3):e91016. doi: 10.1371/journal.pone.0091016. eCollection 2014.

28.

U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery.

Metcalf RG, Skuladottir GV, Indridason OS, Sullivan TR, Bjorgvinsdottir L, Sanders P, Arnar DO, Gibson RA, Heidarsdottir R, Cleland LG, Palsson R, Farquharson AL, Young GD, James MJ.

Eur J Clin Nutr. 2014 Jan;68(1):114-8. doi: 10.1038/ejcn.2013.215. Epub 2013 Oct 30.

PMID:
24169465
29.

Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use.

Proudman SM, James MJ, Spargo LD, Metcalf RG, Sullivan TR, Rischmueller M, Flabouris K, Wechalekar MD, Lee AT, Cleland LG.

Ann Rheum Dis. 2015 Jan;74(1):89-95. doi: 10.1136/annrheumdis-2013-204145. Epub 2013 Sep 30.

PMID:
24081439
30.

Signal peptide etiquette during assembly of a complex respiratory enzyme.

James MJ, Coulthurst SJ, Palmer T, Sargent F.

Mol Microbiol. 2013 Oct;90(2):400-14. doi: 10.1111/mmi.12373. Epub 2013 Sep 8.

31.

Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2.

Gregory MK, Cleland LG, James MJ.

J Lipid Res. 2013 Oct;54(10):2851-7. doi: 10.1194/jlr.M041368. Epub 2013 Jul 21.

32.

The CD11b-integrin (ITGAM) and systemic lupus erythematosus.

Fagerholm SC, MacPherson M, James MJ, Sevier-Guy C, Lau CS.

Lupus. 2013 Jun;22(7):657-63. doi: 10.1177/0961203313491851. Review.

PMID:
23753600
33.

Fish oil administration in older adults with cardiovascular disease or cardiovascular risk factors: is there potential for adverse events? A systematic review of the literature.

Villani AM, Crotty M, Cleland LG, James MJ, Fraser RJ, Cobiac L, Miller MD.

Int J Cardiol. 2013 Oct 9;168(4):4371-5. doi: 10.1016/j.ijcard.2013.05.054. Epub 2013 Jun 3. Review. No abstract available.

PMID:
23742929
34.

Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature.

Villani AM, Crotty M, Cleland LG, James MJ, Fraser RJ, Cobiac L, Miller MD.

BMC Geriatr. 2013 May 1;13:41. doi: 10.1186/1471-2318-13-41. Review.

35.

Effect of dietary canola oil on long-chain omega-3 fatty acid content in broiler hearts.

Gregory MK, Geier MS, Gibson RA, James MJ.

J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):235-8. doi: 10.1111/jpn.12072. Epub 2013 Mar 19.

PMID:
23510129
36.

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.

Crowe A, James MJ, Lee VM, Smith AB 3rd, Trojanowski JQ, Ballatore C, Brunden KR.

J Biol Chem. 2013 Apr 19;288(16):11024-37. doi: 10.1074/jbc.M112.436006. Epub 2013 Feb 26.

37.

Functional characterization of the chicken fatty acid elongases.

Gregory MK, Geier MS, Gibson RA, James MJ.

J Nutr. 2013 Jan;143(1):12-6. doi: 10.3945/jn.112.170290. Epub 2012 Nov 21.

PMID:
23173174
38.

Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.

Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB 3rd, Lee VM, Ballatore C, Brunden KR.

ACS Chem Neurosci. 2012 Nov 21;3(11):928-40. doi: 10.1021/cn3000795. Epub 2012 Jul 27.

39.

Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer).

Tu WC, Mühlhäusler BS, James MJ, Stone DA, Gibson RA.

Comp Biochem Physiol B Biochem Mol Biol. 2013 Jan;164(1):29-37. doi: 10.1016/j.cbpb.2012.10.001. Epub 2012 Oct 18.

PMID:
23085323
40.

An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer).

Tu WC, Mühlhäusler BS, James MJ, Stone DA, Gibson RA.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):176-82. doi: 10.1016/j.bbrc.2012.05.110. Epub 2012 May 26.

PMID:
22640739
41.

Osteoarthritis. Omega-3 fatty acids and synovitis in osteoarthritic knees.

Cleland LG, James MJ.

Nat Rev Rheumatol. 2012 Apr 17;8(6):314-5. doi: 10.1038/nrrheum.2012.60. No abstract available.

PMID:
22508432
42.

Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities.

Tu WC, Cook-Johnson RJ, James MJ, Mühlhäusler BS, Stone DA, Gibson RA.

Biotechnol Lett. 2012 Jul;34(7):1283-96. doi: 10.1007/s10529-012-0891-x. Epub 2012 Mar 4.

PMID:
22391738
43.

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE.

Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9.

44.

Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis.

Gregory MK, Gibson RA, Cook-Johnson RJ, Cleland LG, James MJ.

PLoS One. 2011;6(12):e29662. doi: 10.1371/journal.pone.0029662. Epub 2011 Dec 22.

45.

Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.

Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ.

J Neurosci. 2011 Oct 5;31(40):14436-49. doi: 10.1523/JNEUROSCI.3836-11.2011.

46.

Effect of dietary fish oil on atrial fibrillation after cardiac surgery.

Farquharson AL, Metcalf RG, Sanders P, Stuklis R, Edwards JR, Gibson RA, Cleland LG, Sullivan TR, James MJ, Young GD.

Am J Cardiol. 2011 Sep 15;108(6):851-6. doi: 10.1016/j.amjcard.2011.04.036. Epub 2011 Jul 15.

PMID:
21762871
47.

Metastasis of a cecal adenocarcinoma to the prostate five years after a right hemicolectomy: a case report.

Youssef FR, Hunt L, Meiring PD, Taraporewalla DR, Gupta R, James MJ.

J Med Case Rep. 2011 Jun 21;5:223. doi: 10.1186/1752-1947-5-223.

48.

Fatty acid desaturase 2 promoter mutation is not responsible for Δ6-desaturase deficiency.

Gregory MK, Lester SE, Cook-Johnson RJ, Gibson RA, Proudman SM, Cleland LG, James MJ.

Eur J Hum Genet. 2011 Nov;19(11):1202-4. doi: 10.1038/ejhg.2011.104. Epub 2011 Jun 1.

49.

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB 3rd, Lee VM.

Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14.

50.

Atrial protective effects of n-3 polyunsaturated fatty acids: a long-term study in ovine chronic heart failure.

Lau DH, Psaltis PJ, Carbone A, Kelly DJ, Mackenzie L, Worthington M, Metcalf RG, Kuklik P, Nelson AJ, Zhang Y, Wong CX, Brooks AG, Saint DA, James MJ, Edwards J, Young GD, Worthley SG, Sanders P.

Heart Rhythm. 2011 Apr;8(4):575-82. doi: 10.1016/j.hrthm.2010.12.009. Epub 2010 Dec 8.

PMID:
21145429

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