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Items: 46


The origin of chromosomal replication is asymmetrically positioned on the mycobacterial nucleoid and the timing of its firing depends on HupB.

Hołówka J, Trojanowski D, Janczak M, Jakimowicz D, Zakrzewska-Czerwińska J.

J Bacteriol. 2018 Mar 12. pii: JB.00044-18. doi: 10.1128/JB.00044-18. [Epub ahead of print]


HupB Is a Bacterial Nucleoid-Associated Protein with an Indispensable Eukaryotic-Like Tail.

Hołówka J, Trojanowski D, Ginda K, Wojtaś B, Gielniewski B, Jakimowicz D, Zakrzewska-Czerwińska J.

MBio. 2017 Nov 7;8(6). pii: e01272-17. doi: 10.1128/mBio.01272-17.


C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity.

Strzalka A, Szafran MJ, Strick T, Jakimowicz D.

Nucleic Acids Res. 2017 Nov 16;45(20):11908-11924. doi: 10.1093/nar/gkx827.


The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria.

Ginda K, Santi I, Bousbaine D, Zakrzewska-Czerwińska J, Jakimowicz D, McKinney J.

Mol Microbiol. 2017 Aug;105(3):453-468. doi: 10.1111/mmi.13712. Epub 2017 Jun 22.


Multifork chromosome replication in slow-growing bacteria.

Trojanowski D, Hołówka J, Ginda K, Jakimowicz D, Zakrzewska-Czerwińska J.

Sci Rep. 2017 Mar 6;7:43836. doi: 10.1038/srep43836.


Unique Function of the Bacterial Chromosome Segregation Machinery in Apically Growing Streptomyces - Targeting the Chromosome to New Hyphal Tubes and its Anchorage at the Tips.

Kois-Ostrowska A, Strzałka A, Lipietta N, Tilley E, Zakrzewska-Czerwińska J, Herron P, Jakimowicz D.

PLoS Genet. 2016 Dec 15;12(12):e1006488. doi: 10.1371/journal.pgen.1006488. eCollection 2016 Dec.


The Coordinated Positive Regulation of Topoisomerase Genes Maintains Topological Homeostasis in Streptomyces coelicolor.

Szafran MJ, Gongerowska M, Gutkowski P, Zakrzewska-Czerwińska J, Jakimowicz D.

J Bacteriol. 2016 Oct 7;198(21):3016-3028. Print 2016 Nov 1.


ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation.

Donczew M, Mackiewicz P, Wróbel A, Flärdh K, Zakrzewska-Czerwińska J, Jakimowicz D.

Open Biol. 2016 Apr;6(4):150263. doi: 10.1098/rsob.150263. Epub 2016 Apr 27.


Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin.

Wolański M, Łebkowski T, Kois-Ostrowska A, Zettler J, Apel AK, Jakimowicz D, Zakrzewska-Czerwińska J.

Appl Microbiol Biotechnol. 2016 Apr;100(7):3147-64. doi: 10.1007/s00253-015-7196-7. Epub 2015 Dec 5.


Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

Baronian G, Ginda K, Berry L, Cohen-Gonsaud M, Zakrzewska-Czerwińska J, Jakimowicz D, Molle V.

PLoS One. 2015 Mar 25;10(3):e0119907. doi: 10.1371/journal.pone.0119907. eCollection 2015.


Choreography of the Mycobacterium replication machinery during the cell cycle.

Trojanowski D, Ginda K, Pióro M, Hołówka J, Skut P, Jakimowicz D, Zakrzewska-Czerwińska J.

MBio. 2015 Feb 17;6(1):e02125-14. doi: 10.1128/mBio.02125-14.


Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.

Wolański M, Jakimowicz D, Zakrzewska-Czerwińska J.

J Bacteriol. 2014 Aug 15;196(16):2901-11. doi: 10.1128/JB.01706-14. Epub 2014 Jun 9. Review.


A highly processive topoisomerase I: studies at the single-molecule level.

Szafran MJ, Strick T, Strzałka A, Zakrzewska-Czerwińska J, Jakimowicz D.

Nucleic Acids Res. 2014 Jul;42(12):7935-46. doi: 10.1093/nar/gku494. Epub 2014 May 31.


Topoisomerase I (TopA) is recruited to ParB complexes and is required for proper chromosome organization during Streptomyces coelicolor sporulation.

Szafran M, Skut P, Ditkowski B, Ginda K, Chandra G, Zakrzewska-Czerwińska J, Jakimowicz D.

J Bacteriol. 2013 Oct;195(19):4445-55. doi: 10.1128/JB.00798-13. Epub 2013 Aug 2.


Dynamic interplay of ParA with the polarity protein, Scy, coordinates the growth with chromosome segregation in Streptomyces coelicolor.

Ditkowski B, Holmes N, Rydzak J, Donczew M, Bezulska M, Ginda K, Kedzierski P, Zakrzewska-Czerwińska J, Kelemen GH, Jakimowicz D.

Open Biol. 2013 Mar 27;3(3):130006. doi: 10.1098/rsob.130006.


[Bacterial type I topoisomerases - biological function and potential use as targets for antibiotic treatments].

Szafran M, Zakrzewska-Czerwińska J, Jakimowicz D.

Postepy Hig Med Dosw (Online). 2013 Mar 4;67:130-42. Review. Polish.


ParA of Mycobacterium smegmatis co-ordinates chromosome segregation with the cell cycle and interacts with the polar growth determinant DivIVA.

Ginda K, Bezulska M, Ziółkiewicz M, Dziadek J, Zakrzewska-Czerwińska J, Jakimowicz D.

Mol Microbiol. 2013 Mar;87(5):998-1012. doi: 10.1111/mmi.12146. Epub 2013 Jan 28.


AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication.

Wolański M, Jakimowicz D, Zakrzewska-Czerwińska J.

Open Biol. 2012 Jul;2(7):120097. doi: 10.1098/rsob.120097.


Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?

Jakimowicz D, van Wezel GP.

Mol Microbiol. 2012 Aug;85(3):393-404. doi: 10.1111/j.1365-2958.2012.08107.x. Epub 2012 Jun 11. Review.


The level of AdpA directly affects expression of developmental genes in Streptomyces coelicolor.

Wolanski M, Donczew R, Kois-Ostrowska A, Masiewicz P, Jakimowicz D, Zakrzewska-Czerwinska J.

J Bacteriol. 2011 Nov;193(22):6358-65. doi: 10.1128/JB.05734-11. Epub 2011 Sep 16.


[Solving the mysteries of the bacterial cell - application of novel techniques in fluorescence microscopy].

Donczew M, Ginda K, Zakrzewska-Czerwińska J, Jakimowicz D.

Postepy Hig Med Dosw (Online). 2011 Feb 22;65:114-23. Review. Polish.


Replisome trafficking in growing vegetative hyphae of Streptomyces coelicolor A3(2).

Wolánski M, Wali R, Tilley E, Jakimowicz D, Zakrzewska-Czerwinska J, Herron P.

J Bacteriol. 2011 Mar;193(5):1273-5. doi: 10.1128/JB.01326-10. Epub 2010 Dec 30.


The actinobacterial signature protein ParJ (SCO1662) regulates ParA polymerization and affects chromosome segregation and cell division during Streptomyces sporulation.

Ditkowski B, Troć P, Ginda K, Donczew M, Chater KF, Zakrzewska-Czerwińska J, Jakimowicz D.

Mol Microbiol. 2010 Dec;78(6):1403-15. doi: 10.1111/j.1365-2958.2010.07409.x. Epub 2010 Oct 18.


SMC protein-dependent chromosome condensation during aerial hyphal development in Streptomyces.

Kois A, Swiatek M, Jakimowicz D, Zakrzewska-Czerwińska J.

J Bacteriol. 2009 Jan;191(1):310-9. doi: 10.1128/JB.00513-08. Epub 2008 Oct 17.


Characterization of the mycobacterial chromosome segregation protein ParB and identification of its target in Mycobacterium smegmatis.

Jakimowicz D, Brzostek A, Rumijowska-Galewicz A, Zydek P, Dołzbłasz A, Smulczyk-Krawczyszyn A, Zimniak T, Wojtasz L, Zawilak-Pawlik A, Kois A, Dziadek J, Zakrzewska-Czerwińska J.

Microbiology. 2007 Dec;153(Pt 12):4050-60.


[Chromosome segregation and cell division during the growth and differentiation of Streptomyces].

Jakimowicz D.

Postepy Hig Med Dosw (Online). 2007 Oct 12;61:565-75. Review. Polish.


Alignment of multiple chromosomes along helical ParA scaffolding in sporulating Streptomyces hyphae.

Jakimowicz D, Zydek P, Kois A, Zakrzewska-Czerwińska J, Chater KF.

Mol Microbiol. 2007 Aug;65(3):625-41.


Regulation of the initiation of chromosomal replication in bacteria.

Zakrzewska-Czerwińska J, Jakimowicz D, Zawilak-Pawlik A, Messer W.

FEMS Microbiol Rev. 2007 Jul;31(4):378-87. Epub 2007 Apr 25. Review.


Replisome localization in vegetative and aerial hyphae of Streptomyces coelicolor.

Ruban-Ośmiałowska B, Jakimowicz D, Smulczyk-Krawczyszyn A, Chater KF, Zakrzewska-Czerwińska J.

J Bacteriol. 2006 Oct;188(20):7311-6.


Cluster of DnaA boxes involved in regulation of Streptomyces chromosome replication: from in silico to in vivo studies.

Smulczyk-Krawczyszyn A, Jakimowicz D, Ruban-Osmialowska B, Zawilak-Pawlik A, Majka J, Chater K, Zakrzewska-Czerwinska J.

J Bacteriol. 2006 Sep;188(17):6184-94.


Developmental control of a parAB promoter leads to formation of sporulation-associated ParB complexes in Streptomyces coelicolor.

Jakimowicz D, Mouz S, Zakrzewska-Czerwinska J, Chater KF.

J Bacteriol. 2006 Mar;188(5):1710-20.


Developmental-stage-specific assembly of ParB complexes in Streptomyces coelicolor hyphae.

Jakimowicz D, Gust B, Zakrzewska-Czerwinska J, Chater KF.

J Bacteriol. 2005 May;187(10):3572-80.


Architecture of bacterial replication initiation complexes: orisomes from four unrelated bacteria.

Zawilak-Pawlik A, Kois A, Majka J, Jakimowicz D, Smulczyk-Krawczyszyn A, Messer W, Zakrzewska-Czerwińska J.

Biochem J. 2005 Jul 15;389(Pt 2):471-81.


Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

Gust B, Chandra G, Jakimowicz D, Yuqing T, Bruton CJ, Chater KF.

Adv Appl Microbiol. 2004;54:107-28. Review. No abstract available.


SCP1, a 356,023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2).

Bentley SD, Brown S, Murphy LD, Harris DE, Quail MA, Parkhill J, Barrell BG, McCormick JR, Santamaria RI, Losick R, Yamasaki M, Kinashi H, Chen CW, Chandra G, Jakimowicz D, Kieser HM, Kieser T, Chater KF.

Mol Microbiol. 2004 Mar;51(6):1615-28.


[Segregation of genetic material in prokaryotic cells].

Jakimowicz D, Zakrzewska-Czerwińska J.

Postepy Biochem. 2002;48(4):242-51. Review. Polish. No abstract available.


[Initiation of chromosome replication in prokaryotes and eurkaryotes].

Jakimowicz D, Zakrzewska-Czerwińska J.

Postepy Biochem. 2000;46(4):282-90. Review. Polish. No abstract available.


Initiation of the Streptomyces chromosome replication.

Zakrzewska-Czerwińska J, Jakimowicz D, Majka J, Messer W, Schrempf H.

Antonie Van Leeuwenhoek. 2000 Dec;78(3-4):211-21. No abstract available.


Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA.

Zawilak A, Cebrat S, Mackiewicz P, Król-Hulewicz A, Jakimowicz D, Messer W, Gosciniak G, Zakrzewska-Czerwinska J.

Nucleic Acids Res. 2001 Jun 1;29(11):2251-9.


Bacterial replication initiator DnaA. Rules for DnaA binding and roles of DnaA in origin unwinding and helicase loading.

Messer W, Blaesing F, Jakimowicz D, Krause M, Majka J, Nardmann J, Schaper S, Seitz H, Speck C, Weigel C, Wegrzyn G, Welzeck M, Zakrzewska-Czerwinska J.

Biochimie. 2001 Jan;83(1):5-12. Review.


Architecture of the Streptomyces lividans DnaA protein-replication origin complexes.

Jakimowicz D, Majkadagger J, Konopa G, Wegrzyn G, Messer W, Schrempf H, Zakrzewska-Czerwińska J.

J Mol Biol. 2000 May 5;298(3):351-64.


Structure and regulation of the dnaA promoter region in three Streptomyces species.

Jakimowicz D, Majka J, Lis B, Konopa G, Wegrzyn G, Messer W, Schrempf H, Zakrzewska-Czerwinska J.

Mol Gen Genet. 2000 Jan;262(6):1093-102.


Interactions of the Streptomyces lividans initiator protein DnaA with its target.

Majka J, Jakimowicz D, Messer W, Schrempf H, Lisowski M, Zakrzewska-Czerwińska J.

Eur J Biochem. 1999 Mar;260(2):325-35.


Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein.

Jakimowicz D, Majka J, Messer W, Speck C, Fernandez M, Martin MC, Sanchez J, Schauwecker F, Keller U, Schrempf H, Zakrzewska-Czerwińska J.

Microbiology. 1998 May;144 ( Pt 5):1281-90.


Glutathione S-transferase fusion proteins as an affinity reagent for rapid isolation of specific sequence directly from genomic DNA.

Majka J, Jakimowicz D, Zarko-Postawka M, Zakrzewska-Czerwinska J.

Nucleic Acids Res. 1997 Jun 15;25(12):2537-8.

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