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Items: 1 to 50 of 224

1.

Mechanistic Investigations of Diarrhea Toxicity Induced by anti-HER2/3 Combination Therapy.

Moisan A, Michielin F, Jacob W, Kronenberg S, Wilson S, Avignon B, Gérard R, Benmansour F, McIntyre C, Meneses-Lorente G, Hasmann M, Schneeweiss A, Weisser M, Adessi C.

Mol Cancer Ther. 2018 Apr 13. pii: molcanther.1268.2017. doi: 10.1158/1535-7163.MCT-17-1268. [Epub ahead of print]

PMID:
29654069
2.

Thoracic aortic aneurysm complicated by secondary aortoesophageal fistula after thoracic endovascular aortic repair : a case report.

Spitaels R, Jacob W, Janssens F, Schurmans P, Vanmoerkerke L, Walgraeve D, Coenegrachts JL.

Acta Gastroenterol Belg. 2017 Oct-Dec;80(4):527-525.

PMID:
29560649
3.

Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer.

Schneeweiss A, Park-Simon TW, Albanell J, Lassen U, Cortés J, Dieras V, May M, Schindler C, Marmé F, Cejalvo JM, Martinez-Garcia M, Gonzalez I, Lopez-Martin J, Welt A, Levy C, Joly F, Michielin F, Jacob W, Adessi C, Moisan A, Meneses-Lorente G, Racek T, James I, Ceppi M, Hasmann M, Weisser M, Cervantes A.

Invest New Drugs. 2018 Jan 19. doi: 10.1007/s10637-018-0562-4. [Epub ahead of print]

PMID:
29349598
4.

89Zr-Lumretuzumab PET Imaging before and during HER3 Antibody Lumretuzumab Treatment in Patients with Solid Tumors.

Bensch F, Lamberts LE, Smeenk MM, Jorritsma-Smit A, Lub-de Hooge MN, Terwisscha van Scheltinga AGT, de Jong JR, Gietema JA, Schröder CP, Thomas M, Jacob W, Abiraj K, Adessi C, Meneses-Lorente G, James I, Weisser M, Brouwers AH, de Vries EGE.

Clin Cancer Res. 2017 Oct 15;23(20):6128-6137. doi: 10.1158/1078-0432.CCR-17-0311. Epub 2017 Jul 21.

5.

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy.

Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Rüttinger D.

J Immunother Cancer. 2017 Jul 18;5(1):53. doi: 10.1186/s40425-017-0257-y. Review.

6.

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity.

Meulendijks D, Jacob W, Voest EE, Mau-Sorensen M, Martinez-Garcia M, Taus A, Fleitas T, Cervantes A, Lolkema MP, Langenberg MHG, De Jonge MJ, Sleijfer S, Han JY, Calles A, Felip E, Kim SW, Schellens JHM, Wilson S, Thomas M, Ceppi M, Meneses-Lorente G, James I, Vega-Harring S, Dua R, Nguyen M, Steiner L, Adessi C, Michielin F, Bossenmaier B, Weisser M, Lassen UN.

Clin Cancer Res. 2017 Sep 15;23(18):5406-5415. doi: 10.1158/1078-0432.CCR-17-0812. Epub 2017 Jun 9.

PMID:
28600476
7.

Accelerating drug development by efficiently using emerging PK/PD data from an adaptable entry-into-human trial: example of lumretuzumab.

Meneses-Lorente G, McIntyre C, Hsu JC, Thomas M, Jacob W, Adessi C, Weisser M.

Cancer Chemother Pharmacol. 2017 Jun;79(6):1239-1247. doi: 10.1007/s00280-017-3328-3. Epub 2017 May 11.

PMID:
28497320
8.

Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer.

Collins D, Jacob W, Cejalvo JM, Ceppi M, James I, Hasmann M, Crown J, Cervantes A, Weisser M, Bossenmaier B.

PLoS One. 2017 May 11;12(5):e0177331. doi: 10.1371/journal.pone.0177331. eCollection 2017.

9.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M.

Hum Mol Genet. 2016 Dec 15;25(24):5365-5382. doi: 10.1093/hmg/ddw352.

PMID:
27794539
10.

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.

Driscoll DR, Karim SA, Sano M, Gay DM, Jacob W, Yu J, Mizukami Y, Gopinathan A, Jodrell DI, Evans TR, Bardeesy N, Hall MN, Quattrochi BJ, Klimstra DS, Barry ST, Sansom OJ, Lewis BC, Morton JP.

Cancer Res. 2016 Dec 1;76(23):6911-6923. Epub 2016 Oct 6.

11.

Retail Clinics: Bringing Health Care to the Neighborhood.

Jacob W.

Prof Case Manag. 2016 Sep-Oct;21(5):260-2. doi: 10.1097/NCM.0000000000000180. No abstract available.

PMID:
27472182
12.

Performance of manual hyperinflation: consistency and modification of the technique by intensive care unit nurses during physiotherapy.

Dennis DM, Duncan CN, Pinder M, Budgeon CA, Jacob WJ.

J Clin Nurs. 2016 Aug;25(15-16):2295-304. doi: 10.1111/jocn.13190. Epub 2016 Apr 27.

PMID:
27118297
13.

Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2.

Athanasopoulos PS, Jacob W, Neumann S, Kutsch M, Wolters D, Tan EK, Bichler Z, Herrmann C, Heumann R.

Biol Chem. 2016 Jun 1;397(6):541-54. doi: 10.1515/hsz-2015-0189.

PMID:
26894577
14.

First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.

Meulendijks D, Jacob W, Martinez-Garcia M, Taus A, Lolkema MP, Voest EE, Langenberg MH, Fleitas Kanonnikoff T, Cervantes A, De Jonge MJ, Sleijfer S, Soerensen MM, Thomas M, Ceppi M, Meneses-Lorente G, James I, Adessi C, Michielin F, Abiraj K, Bossenmaier B, Schellens JH, Weisser M, Lassen UN.

Clin Cancer Res. 2016 Feb 15;22(4):877-85. doi: 10.1158/1078-0432.CCR-15-1683. Epub 2015 Oct 13.

15.

Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5.

Jacob W, Rosenzweig D, Vázquez-Martin C, Duce SL, Cohen PT.

Biochem J. 2015 Feb 15;466(1):163-76. doi: 10.1042/BJ20140428.

PMID:
25437352
16.

Ventilation - how often are we correct?

Dennis D, Jacob W, van Heerden PV.

Anaesth Intensive Care. 2012 Jul;40(4):638-42.

17.

Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.

Jacob W, Marsch R, Marsicano G, Lutz B, Wotjak CT.

Neurobiol Learn Mem. 2012 Jul;98(1):47-55. doi: 10.1016/j.nlm.2012.04.008. Epub 2012 May 8.

PMID:
22579951
18.

Ventilator versus manual hyperinflation in clearing sputum in ventilated intensive care unit patients.

Dennis D, Jacob W, Budgeon C.

Anaesth Intensive Care. 2012 Jan;40(1):142-9.

19.

A survey of the use of ventilator hyperinflation in Australian tertiary intensive care units.

Dennis DM, Jacob WJ, Samuel FD.

Crit Care Resusc. 2010 Dec;12(4):262-8.

PMID:
21143087
20.

Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission.

Jacob W, Yassouridis A, Marsicano G, Monory K, Lutz B, Wotjak CT.

Genes Brain Behav. 2009 Oct;8(7):685-98. doi: 10.1111/j.1601-183X.2009.00512.x. Epub 2009 May 28.

21.

The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning.

Jacob W, Gravius A, Pietraszek M, Nagel J, Belozertseva I, Shekunova E, Malyshkin A, Greco S, Barberi C, Danysz W.

Neuropharmacology. 2009 Aug;57(2):97-108. doi: 10.1016/j.neuropharm.2009.04.011. Epub 2009 May 6.

PMID:
19426746
22.

Forest pathology for the last century: an overview of the symposium.

Walla JA, Jacob WR, Schmidt RA.

Phytopathology. 2003 Aug;93(8):1037-8. doi: 10.1094/PHYTO.2003.93.8.1037. No abstract available.

23.

Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.

Kessler MS, Murgatroyd C, Bunck M, Czibere L, Frank E, Jacob W, Horvath C, Muigg P, Holsboer F, Singewald N, Spengler D, Landgraf R.

Eur J Neurosci. 2007 Nov;26(10):2857-64.

PMID:
18001282
24.

The endocannabinoid system controls key epileptogenic circuits in the hippocampus.

Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B.

Neuron. 2006 Aug 17;51(4):455-66.

25.

Anxiety and hippocampus volume in the rat.

Kalisch R, Schubert M, Jacob W, Kessler MS, Hemauer R, Wigger A, Landgraf R, Auer DP.

Neuropsychopharmacology. 2006 May;31(5):925-32.

26.

Determination of tumour prognosis based on angiogenesis-related vascular patterns measured by fractal and syntactic structure analysis.

Weyn B, Tjalma WA, Vermeylen P, van Daele A, Van Marck E, Jacob W.

Clin Oncol (R Coll Radiol). 2004 Jun;16(4):307-16.

PMID:
15214656
27.

Learned association of allocentric and egocentric information in the hippocampus.

Hölscher C, Jacob W, Mallot HA.

Exp Brain Res. 2004 Sep;158(2):233-40. Epub 2004 Apr 7.

PMID:
15069593
28.

Reward modulates neuronal activity in the hippocampus of the rat.

Hölscher C, Jacob W, Mallot HA.

Behav Brain Res. 2003 Jun 16;142(1-2):181-91.

PMID:
12798280
29.

Regulation of mitochondrial contact sites in neonatal, juvenile and diabetic hearts.

Ziegelhöffer-Mihalovicová B, Ziegelhöffer A, Ravingerová T, Kolár F, Jacob W, Tribulová N.

Mol Cell Biochem. 2002 Jul;236(1-2):37-44.

PMID:
12190119
30.

Validation of nuclear texture, density, morphometry and tissue syntactic structure analysis as prognosticators of cervical carcinoma.

Weyn B, Tjalma W, Van De Wouwer G, Van Daele A, Scheunders P, Jacob W, Van Marck E.

Anal Quant Cytol Histol. 2000 Oct;22(5):373-82.

PMID:
11064813
31.

Data representation and reduction for chromatin texture in nuclei from premalignant prostatic, esophageal, and colonic lesions.

Weyn B, Jacob W, da Silva VD, Montironi R, Hamilton PW, Thompson D, Bartels HG, Van Daele A, Dillon K, Bartels PH.

Cytometry. 2000 Oct 1;41(2):133-8.

PMID:
11002269
32.

Value of morphometry, texture analysis, densitometry, and histometry in the differential diagnosis and prognosis of malignant mesothelioma.

Weyn B, Van De Wouwer G, Koprowski M, Van Daele A, Dhaene K, Scheunders P, Jacob W, Van Marck E.

J Pathol. 1999 Dec;189(4):581-9.

PMID:
10629562
33.

Wavelets as chromatin texture descriptors for the automated identification of neoplastic nuclei.

Van De Wouwer G, Weyn B, Scheunders P, Jacob W, Van Marck E, Van Dyck D.

J Microsc. 2000 Jan;197(Pt 1):25-35.

34.

Computer-assisted differential diagnosis of malignant mesothelioma based on syntactic structure analysis.

Weyn B, van de Wouwer G, Kumar-Singh S, van Daele A, Scheunders P, van Marck E, Jacob W.

Cytometry. 1999 Jan 1;35(1):23-9.

PMID:
10554177
35.

Analytical electron microscopy of silver halide photographic systems

Oleshko VP, Gijbels RH, Jacob WA.

Micron. 2000 Jan;31(1):55-95.

PMID:
10568231
36.

Modulation of mitochondrial contact sites formation in immature rat heart.

Ziegelhöffer-Mihalovicová B, Kolár F, Jacob W, Tribulová N, Uhrík B, Ziegelhöffer A.

Gen Physiol Biophys. 1998 Dec;17(4):385-90.

PMID:
10191423
37.

Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies.

Steeghs K, Oerlemans F, de Haan A, Heerschap A, Verdoodt L, de Bie M, Ruitenbeek W, Benders A, Jost C, van Deursen J, Tullson P, Terjung R, Jap P, Jacob W, Pette D, Wieringa B.

Mol Cell Biochem. 1998 Jul;184(1-2):183-94.

PMID:
9746321
38.

Combined characterization of composite tabular silver halide microcrystals by cryo-EFTEM/EELS and cryo-STEM/EDX techniques.

Oleshko VP, Gijbels RH, Van Daele AJ, Jacob WA, Xu YE, Wang SE, Park IY, Kang TS.

Microsc Res Tech. 1998 Jul 15;42(2):108-22.

PMID:
9728882
39.

Automated breast tumor diagnosis and grading based on wavelet chromatin texture description.

Weyn B, van de Wouwer G, van Daele A, Scheunders P, van Dyck D, van Marck E, Jacob W.

Cytometry. 1998 Sep 1;33(1):32-40.

PMID:
9725556
40.

Apoptosis and related proteins in different stages of human atherosclerotic plaques.

Kockx MM, De Meyer GR, Muhring J, Jacob W, Bult H, Herman AG.

Circulation. 1998 Jun 16;97(23):2307-15.

41.

A closed culture system for the ex vivo transduction and expansion of human T lymphocytes.

Robinet E, Certoux JM, Ferrand C, Maples P, Hardwick A, Cahn JY, Reynolds CW, Jacob W, Hervé P, Tiberghien P.

J Hematother. 1998 Jun;7(3):205-15.

PMID:
9621254
42.

Atomic force microscopy: influence of air drying and fixation on the morphology and viscoelasticity of cultured cells.

Weyn B, Kalle W, Kumar-Singh S, Van Marck E, Tanke H, Jacob W.

J Microsc. 1998 Feb;189(Pt 2):172-80.

43.

Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes.

Contassot E, Ferrand C, Certoux JM, Reynolds CW, Jacob W, Chiang Y, Cahn JY, Hervé P, Tiberghien P.

Hum Gene Ther. 1998 Jan 1;9(1):73-80.

PMID:
9458244
44.
45.

Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts.

Bakker AC, Webster P, Jacob WA, Andrews NW.

J Cell Sci. 1997 Sep;110 ( Pt 18):2227-38.

46.

Use of donor T-lymphocytes expressing herpes-simplex thymidine kinase in allogeneic bone marrow transplantation: a phase I-II study.

Tiberghien P, Cahn JY, Brion A, Deconinck E, Racadot E, Hervé P, Milpied N, Lioure B, Gluckman E, Bordigoni P, Jacob W, Chiang Y, Marcus S, Reynolds C, Longo D.

Hum Gene Ther. 1997 Mar 20;8(5):615-24. No abstract available.

PMID:
9095412
47.

Diagnostic classification through the study of linguistic dimensions.

Jacob W, Mudersbach K, van der Ploeg HM.

Psychol Rep. 1996 Dec;79(3 Pt 1):951-9.

PMID:
8969105
48.

[Utilization of herpes simplex virus-1 thymidine kinase gene in stem cell transplantation therapy].

Tiberghien P, Cahn JY, Ferrand C, Milpied N, Contassot E, Angonin R, Sallard D, Robinet E, Reynolds CW, Certoux JM, Rousseau E, Jacob W, Hervé WJ.

Hematol Cell Ther. 1996 Oct;38(5):464. French. No abstract available.

PMID:
9044823
49.

Luminal foam cell accumulation is associated with smooth muscle cell death in the intimal thickening of human saphenous vein grafts.

Kockx MM, De Meyer GR, Bortier H, de Meyere N, Muhring J, Bakker A, Jacob W, Van Vaeck L, Herman A.

Circulation. 1996 Sep 15;94(6):1255-62.

50.

Biotin- or digoxigenin-conjugated nucleotides bind to matrix vesicles in atherosclerotic plaques.

Kockx MM, Muhring J, Bortier H, De Meyer GR, Jacob W.

Am J Pathol. 1996 Jun;148(6):1771-7.

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