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Items: 1 to 50 of 162

1.

Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.

Renkonen-Sinisalo L, Seppälä TT, Järvinen HJ, Mecklin JP.

Dis Colon Rectum. 2017 Aug;60(8):792-799. doi: 10.1097/DCR.0000000000000802.

PMID:
28682964
2.

Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis.

Nieminen TT, Pavicic W, Porkka N, Kankainen M, Järvinen HJ, Lepistö A, Peltomäki P.

Oncotarget. 2016 Oct 25;7(43):70685-70698. doi: 10.18632/oncotarget.12206.

3.

[Diagnosis and treatment of Lynch syndrome].

Seppälä T, Pylvänäinen K, Renkonen-Sinisalo L, Böhm J, Kuopio T, Järvinen HJ, Mecklin JP.

Duodecim. 2016;132(3):233-40. Review. Finnish.

PMID:
26951027
4.

Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation.

Niskakoski A, Kaur S, Staff S, Renkonen-Sinisalo L, Lassus H, Järvinen HJ, Mecklin JP, Bützow R, Peltomäki P.

Epigenetics. 2014 Dec;9(12):1577-87. doi: 10.4161/15592294.2014.983374.

5.

Comparison of proctocolectomy and ileal pouch-anal anastomosis to colectomy and ileorectal anastomosis in familial adenomatous polyposis.

Koskenvuo L, Mustonen H, Renkonen-Sinisalo L, Järvinen HJ, Lepistö A.

Fam Cancer. 2015 Jun;14(2):221-7. doi: 10.1007/s10689-014-9773-9.

PMID:
25504366
6.

Reply: To PMID 24941021.

Nieminen TT, Mecklin JP, Järvinen HJ, Peltomäki P.

Gastroenterology. 2015 Jan;148(1):259. doi: 10.1053/j.gastro.2014.11.028. Epub 2014 Nov 22. No abstract available.

PMID:
25451653
7.

Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis.

Pavicic W, Nieminen TT, Gylling A, Pursiheimo JP, Laiho A, Gyenesei A, Järvinen HJ, Peltomäki P.

Genes Chromosomes Cancer. 2014 Oct;53(10):857-64. doi: 10.1002/gcc.22197. Epub 2014 Jun 20.

PMID:
24946964
8.

Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency.

Nieminen TT, O'Donohue MF, Wu Y, Lohi H, Scherer SW, Paterson AD, Ellonen P, Abdel-Rahman WM, Valo S, Mecklin JP, Järvinen HJ, Gleizes PE, Peltomäki P.

Gastroenterology. 2014 Sep;147(3):595-598.e5. doi: 10.1053/j.gastro.2014.06.009. Epub 2014 Jun 15.

9.

Risk of cancer and secondary proctectomy after colectomy and ileorectal anastomosis in familial adenomatous polyposis.

Koskenvuo L, Renkonen-Sinisalo L, Järvinen HJ, Lepistö A.

Int J Colorectal Dis. 2014 Feb;29(2):225-30. doi: 10.1007/s00384-013-1796-4. Epub 2013 Nov 30.

PMID:
24292488
10.

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.

Niskakoski A, Kaur S, Renkonen-Sinisalo L, Lassus H, Järvinen HJ, Mecklin JP, Bützow R, Peltomäki P.

Int J Cancer. 2013 Dec 1;133(11):2596-608. doi: 10.1002/ijc.28287. Epub 2013 Jun 21.

11.

Colorectal surveillance in Lynch syndrome families.

de Vos tot Nederveen Cappel WH, Järvinen HJ, Lynch PM, Engel C, Mecklin JP, Vasen HF.

Fam Cancer. 2013 Jun;12(2):261-5. doi: 10.1007/s10689-013-9631-1. Review.

PMID:
23525799
12.

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts.

Vasen HF, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, Bernstein I, Bertario L, Burn J, Capella G, Colas C, Engel C, Frayling IM, Genuardi M, Heinimann K, Hes FJ, Hodgson SV, Karagiannis JA, Lalloo F, Lindblom A, Mecklin JP, Møller P, Myrhoj T, Nagengast FM, Parc Y, Ponz de Leon M, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Sijmons RH, Tejpar S, Thomas HJ, Rahner N, Wijnen JT, Järvinen HJ, Möslein G; Mallorca group.

Gut. 2013 Jun;62(6):812-23. doi: 10.1136/gutjnl-2012-304356. Epub 2013 Feb 13.

13.

Does preoperative radiotherapy with postoperative chemotherapy increase acute side-effects and postoperative complications of total mesorectal excision? Report of the randomized Finnish rectal cancer trial.

Salmenkylä S, Kouri M, Österlund P, Pukkala E, Luukkonen P, Hyöty M, Pääkkönen M, Mäkelä J, Mustonen H, Järvinen HJ; Finnish Rectal Cancer Trial Group.

Scand J Surg. 2012;101(4):275-82.

PMID:
23238504
14.

Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.

Lotsari JE, Gylling A, Abdel-Rahman WM, Nieminen TT, Aittomäki K, Friman M, Pitkänen R, Aarnio M, Järvinen HJ, Mecklin JP, Kuopio T, Peltomäki P.

Breast Cancer Res. 2012 Jun 12;14(3):R90.

15.

Uroepithelial and kidney carcinoma in Lynch syndrome.

Aarnio M, Säily M, Juhola M, Gylling A, Peltomäki P, Järvinen HJ, Mecklin JP.

Fam Cancer. 2012 Sep;11(3):395-401. doi: 10.1007/s10689-012-9526-6.

PMID:
22476430
16.

BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.

Nieminen TT, Abdel-Rahman WM, Ristimäki A, Lappalainen M, Lahermo P, Mecklin JP, Järvinen HJ, Peltomäki P.

Gastroenterology. 2011 Jul;141(1):e23-6. doi: 10.1053/j.gastro.2011.03.063. Epub 2011 Jun 1. No abstract available.

PMID:
21640116
17.

Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome.

Aktan-Collan KI, Kääriäinen HA, Kolttola EM, Pylvänäinen K, Järvinen HJ, Haukkala AH, Mecklin JP.

Fam Cancer. 2011 Mar;10(1):43-50. doi: 10.1007/s10689-010-9386-x.

PMID:
20857224
18.

[Treatment of pseudomyxoma peritonei is developing].

Lepistö A, Osterlund P, Järvinen HJ.

Duodecim. 2010;126(14):1693-9. Review. Finnish.

PMID:
20804088
19.

Risk of cancer in patients with chronic pouchitis after restorative proctocolectomy for ulcerative colitis.

Vento P, Lepistö A, Kärkkäinen P, Ristimäki A, Haglund C, Järvinen HJ.

Colorectal Dis. 2011 Jan;13(1):58-66. doi: 10.1111/j.1463-1318.2009.02058.x.

PMID:
19832871
20.

Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia.

Nieminen TT, Gylling A, Abdel-Rahman WM, Nuorva K, Aarnio M, Renkonen-Sinisalo L, Järvinen HJ, Mecklin JP, Bützow R, Peltomäki P.

Clin Cancer Res. 2009 Sep 15;15(18):5772-83. doi: 10.1158/1078-0432.CCR-09-0506. Epub 2009 Sep 1.

21.

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, Peltomäki P, Aaltonen LA, Mecklin JP.

J Clin Oncol. 2009 Oct 1;27(28):4793-7. doi: 10.1200/JCO.2009.23.7784. Epub 2009 Aug 31.

PMID:
19720893
22.

Primary sclerosing cholangitis: outcome of patients undergoing restorative proctocolecetomy for ulcerative colitis.

Lepistö A, Kivistö S, Kivisaari L, Arola J, Järvinen HJ.

Int J Colorectal Dis. 2009 Oct;24(10):1169-74. doi: 10.1007/s00384-009-0773-4. Epub 2009 Jul 28.

PMID:
19636573
23.

Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds.

Grindedal EM, Renkonen-Sinisalo L, Vasen H, Evans G, Sala P, Blanco I, Gronwald J, Apold J, Eccles DM, Sánchez AA, Sampson J, Järvinen HJ, Bertario L, Crawford GC, Stormorken AT, Maehle L, Moller P.

J Med Genet. 2010 Feb;47(2):99-102. doi: 10.1136/jmg.2009.068130. Epub 2009 Jul 26.

PMID:
19635727
24.

Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery.

Nieuwenhuis MH, Bülow S, Björk J, Järvinen HJ, Bülow C, Bisgaard ML, Vasen HF.

Dis Colon Rectum. 2009 Jul;52(7):1259-63. doi: 10.1007/DCR.0b013e3181a0d33b.

PMID:
19571702
25.

Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis.

Lepistö A, Kiviluoto T, Halttunen J, Järvinen HJ.

Endoscopy. 2009 Jun;41(6):504-9. doi: 10.1055/s-0029-1214719. Epub 2009 Jun 16.

PMID:
19533554
26.

Survival of patients with pseudomyxoma peritonei treated by serial debulking.

Järvinen P, Järvinen HJ, Lepistö A.

Colorectal Dis. 2010 Sep;12(9):868-72. doi: 10.1111/j.1463-1318.2009.01947.x. Epub 2009 Jun 10.

PMID:
19519686
27.

[Rectal cancer].

Lepistö A, Osterlund P, Kouri M, Järvinen HJ.

Duodecim. 2009;125(8):857-65. Finnish.

PMID:
19492703
28.

[Colonic carcinoma].

Osterlund P, Lepistö A, Järvinen HJ.

Duodecim. 2009;125(6):619-28. Finnish.

PMID:
19413169
29.

Large genomic rearrangements and germline epimutations in Lynch syndrome.

Gylling A, Ridanpää M, Vierimaa O, Aittomäki K, Avela K, Kääriäinen H, Laivuori H, Pöyhönen M, Sallinen SL, Wallgren-Pettersson C, Järvinen HJ, Mecklin JP, Peltomäki P.

Int J Cancer. 2009 May 15;124(10):2333-40. doi: 10.1002/ijc.24230.

30.

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome.

Burn J, Bishop DT, Mecklin JP, Macrae F, Möslein G, Olschwang S, Bisgaard ML, Ramesar R, Eccles D, Maher ER, Bertario L, Jarvinen HJ, Lindblom A, Evans DG, Lubinski J, Morrison PJ, Ho JW, Vasen HF, Side L, Thomas HJ, Scott RJ, Dunlop M, Barker G, Elliott F, Jass JR, Fodde R, Lynch HT, Mathers JC; CAPP2 Investigators.

N Engl J Med. 2008 Dec 11;359(24):2567-78. doi: 10.1056/NEJMoa0801297. Erratum in: N Engl J Med. 2009 Apr 2;360(14):1470.

31.

Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors.

Gylling AH, Nieminen TT, Abdel-Rahman WM, Nuorva K, Juhola M, Joensuu EI, Järvinen HJ, Mecklin JP, Aarnio M, Peltomäki PT.

Carcinogenesis. 2008 Jul;29(7):1351-9. doi: 10.1093/carcin/bgn133. Epub 2008 Jun 12.

PMID:
18550572
32.

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.

Watson P, Vasen HFA, Mecklin JP, Bernstein I, Aarnio M, Järvinen HJ, Myrhøj T, Sunde L, Wijnen JT, Lynch HT.

Int J Cancer. 2008 Jul 15;123(2):444-449. doi: 10.1002/ijc.23508.

33.

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer.

Siltanen S, Syrjäkoski K, Fagerholm R, Ikonen T, Lipman P, Mallott J, Holli K, Tammela TL, Järvinen HJ, Mecklin JP, Aittomäki K, Blomqvist C, Bailey-Wilson JE, Nevanlinna H, Aaltonen LA, Schleutker J, Vahteristo P.

Eur J Hum Genet. 2008 Aug;16(8):983-91. doi: 10.1038/ejhg.2008.43. Epub 2008 Mar 12.

34.

Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch-anal anastomosis.

Lepistö A, Kärkkäinen P, Järvinen HJ.

Inflamm Bowel Dis. 2008 Jun;14(6):775-9. doi: 10.1002/ibd.20384.

PMID:
18253951
35.

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

Mecklin JP, Aarnio M, Läärä E, Kairaluoma MV, Pylvänäinen K, Peltomäki P, Aaltonen LA, Järvinen HJ.

Gastroenterology. 2007 Oct;133(4):1093-8. Epub 2007 Aug 14.

PMID:
17919485
36.

Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing.

Aktan-Collan K, Haukkala A, Pylvänäinen K, Järvinen HJ, Aaltonen LA, Peltomäki P, Rantanen E, Kääriäinen H, Mecklin JP.

J Med Genet. 2007 Nov;44(11):732-8. Epub 2007 Jul 14.

37.

Background mutation frequency in microsatellite-unstable colorectal cancer.

Sammalkorpi H, Alhopuro P, Lehtonen R, Tuimala J, Mecklin JP, Järvinen HJ, Jiricny J, Karhu A, Aaltonen LA.

Cancer Res. 2007 Jun 15;67(12):5691-8.

38.

Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis.

Lepistö A, Sarna S, Tiitinen A, Järvinen HJ.

Br J Surg. 2007 Apr;94(4):478-82.

PMID:
17310506
39.

Utility of computed tomographic colonography in surveillance for hereditary nonpolyposis colorectal cancer syndrome.

Renkonen-Sinisalo L, Kivisaari A, Kivisaari L, Sarna S, Järvinen HJ.

Fam Cancer. 2007;6(1):135-40.

PMID:
17273816
40.

Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study.

Gylling A, Abdel-Rahman WM, Juhola M, Nuorva K, Hautala E, Järvinen HJ, Mecklin JP, Aarnio M, Peltomäki P.

Gut. 2007 Jul;56(7):926-33. Epub 2007 Jan 31.

41.

Vuoden 2006 Matti Ayräpään palkinto Lauri Aaltoselle.

Järvinen HJ.

Duodecim. 2006;122(18):2189-91. Finnish. No abstract available.

PMID:
17115640
42.

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome.

Renkonen-Sinisalo L, Bützow R, Leminen A, Lehtovirta P, Mecklin JP, Järvinen HJ.

Int J Cancer. 2007 Feb 15;120(4):821-4.

43.

Numbers of mutations to different types of colorectal cancer.

Calabrese P, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D.

BMC Cancer. 2005 Oct 3;5:126.

44.

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.

Alhopuro P, Ylisaukko-Oja SK, Koskinen WJ, Bono P, Arola J, Järvinen HJ, Mecklin JP, Atula T, Kontio R, Mäkitie AA, Suominen S, Leivo I, Vahteristo P, Aaltonen LM, Aaltonen LA.

J Med Genet. 2005 Sep;42(9):694-8.

45.

Surveillance in Lynch syndrome.

Mecklin JP, Järvinen HJ.

Fam Cancer. 2005;4(3):267-71. Review.

PMID:
16136388
46.

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Alhopuro P, Parker AR, Lehtonen R, Enholm S, Järvinen HJ, Mecklin JP, Karhu A, Eshleman JR, Aaltonen LA.

Hum Mutat. 2005 Oct;26(4):393.

PMID:
16134146
47.

Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.

Renkonen ET, Nieminen P, Abdel-Rahman WM, Moisio AL, Järvelä I, Arte S, Järvinen HJ, Peltomäki P.

J Clin Oncol. 2005 Aug 20;23(24):5651-9.

PMID:
16110024
48.

Fate of the rectum after colectomy with ileorectal anastomosis in ulcerative colitis.

Lepistö A, Järvinen HJ.

Scand J Surg. 2005;94(1):40-2.

PMID:
15865115
49.

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.

Abdel-Rahman WM, Ollikainen M, Kariola R, Järvinen HJ, Mecklin JP, Nyström-Lahti M, Knuutila S, Peltomäki P.

Oncogene. 2005 Feb 24;24(9):1542-51.

PMID:
15674332
50.

[From animal models to human trials of Peutz-Jeghers syndrome].

Udd L, Katajisto P, Rossi D, Lepistö A, Lahesmaa AM, Ylikorkala A, Järvinen HJ, Ristimäki A, Mäkelä T.

Duodecim. 2004;120(19):2353-4. Finnish. No abstract available.

PMID:
15565989

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