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Items: 1 to 50 of 682

1.

Host defense against oral microbiota by bone-damaging T cells.

Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H.

Nat Commun. 2018 Feb 16;9(1):701. doi: 10.1038/s41467-018-03147-6.

2.

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.

Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.

Nat Commun. 2018 Feb 14;9(1):672. doi: 10.1038/s41467-018-03051-z.

3.

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.

Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.

Sci Rep. 2018 Jan 31;8(1):2021. doi: 10.1038/s41598-018-19769-1.

4.

HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.

Liu S, Lee JS, Jie C, Park MH, Iwakura Y, Patel Y, Soni M, Reisman D, Chen H.

Cancer Res. 2018 Jan 30. pii: canres.2761.2017. doi: 10.1158/0008-5472.CAN-17-2761. [Epub ahead of print]

PMID:
29382706
5.

IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.

Yoshida K, Murayama MA, Shimizu K, Tang C, Katagiri N, Matsuo K, Fukai F, Iwakura Y.

Biochem Biophys Res Commun. 2018 Feb 12;496(3):934-940. doi: 10.1016/j.bbrc.2018.01.116. Epub 2018 Feb 2.

PMID:
29366788
6.

NK Cells Control Tumor-Promoting Function of Neutrophils in Mice.

Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.

Cancer Immunol Res. 2018 Jan 23. doi: 10.1158/2326-6066.CIR-17-0204. [Epub ahead of print]

PMID:
29362222
7.

Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice.

Takemiya T, Fumizawa K, Yamagata K, Iwakura Y, Kawakami M.

Front Behav Neurosci. 2017 Oct 23;11:202. doi: 10.3389/fnbeh.2017.00202. eCollection 2017.

8.

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.

Lamprinaki D, Beasy G, Zhekova A, Wittmann A, James S, Dicks J, Iwakura Y, Saijo S, Wang X, Chow CW, Roberts I, Korcsmaros T, Mayer U, Wileman T, Kawasaki N.

Front Immunol. 2017 Oct 25;8:1397. doi: 10.3389/fimmu.2017.01397. eCollection 2017.

9.

β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.

Kamiya T, Tang C, Kadoki M, Oshima K, Hattori M, Saijo S, Adachi Y, Ohno N, Iwakura Y.

Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.86. [Epub ahead of print]

PMID:
29068000
10.

Production of low-molecular weight soluble yeast β-glucan by an acid degradation method.

Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Kanzaki K, Iwakura Y, Ohno N.

Int J Biol Macromol. 2018 Feb;107(Pt B):2269-2278. doi: 10.1016/j.ijbiomac.2017.10.094. Epub 2017 Oct 16.

PMID:
29051097
11.

Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B.

Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15.

PMID:
29026003
12.

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c.

PMID:
28985207
13.

IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.

Deloer S, Nakamura R, Kikuchi M, Moriyasu T, Kalenda YDJ, Mohammed ES, Senba M, Iwakura Y, Yoshida H, Hamano S.

Parasitol Int. 2017 Dec;66(6):817-823. doi: 10.1016/j.parint.2017.09.011. Epub 2017 Sep 18.

PMID:
28927906
14.

Interleukin-17A-Deficient Mice Are Highly Susceptible to Toxoplasma gondii Infection Due to Excessively Induced T. gondii HSP70 and Interferon Gamma Production.

Moroda M, Takamoto M, Iwakura Y, Nakayama J, Aosai F.

Infect Immun. 2017 Nov 17;85(12). pii: e00399-17. doi: 10.1128/IAI.00399-17. Print 2017 Dec.

PMID:
28893913
15.

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

J Immunol. 2017 Oct 15;199(8):2921-2929. doi: 10.4049/jimmunol.1700655. Epub 2017 Sep 6.

PMID:
28877988
16.

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.

Wang J, Ge P, Qiang L, Tian F, Zhao D, Chai Q, Zhu M, Zhou R, Meng G, Iwakura Y, Gao GF, Liu CH.

Nat Commun. 2017 Aug 15;8(1):244. doi: 10.1038/s41467-017-00279-z.

17.

Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, Smith JR, Caspi RR, Rosenzweig HL.

Clin Exp Immunol. 2017 Dec;190(3):293-303. doi: 10.1111/cei.13021. Epub 2017 Aug 30.

PMID:
28763100
18.

An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR.

Immunity. 2017 Jul 18;47(1):148-158.e5. doi: 10.1016/j.immuni.2017.06.014. Epub 2017 Jul 11.

PMID:
28709803
19.

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

Maruyama K, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.

Cell Rep. 2017 Jun 27;19(13):2730-2742. doi: 10.1016/j.celrep.2017.06.002.

20.

Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.

Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H.

Neurosci Lett. 2017 Jul 27;654:99-106. doi: 10.1016/j.neulet.2017.06.005. Epub 2017 Jun 21.

PMID:
28645787
21.

Quantification of bleeding volume using computed tomography and clinical complications after percutaneous renal biopsy.

Chikamatsu Y, Matsuda K, Takeuchi Y, Kagaya S, Ojima Y, Fukami H, Sato H, Saito A, Iwakura Y, Nagasawa T.

Clin Kidney J. 2017 Feb;10(1):9-15. doi: 10.1093/ckj/sfw131. Epub 2017 Jan 25.

22.

Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.

J Neurosci. 2017 Jul 26;37(30):7125-7139. doi: 10.1523/JNEUROSCI.2519-16.2017. Epub 2017 Jun 21.

23.

Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons.

Namba H, Nagano T, Jodo E, Eifuku S, Horie M, Takebayashi H, Iwakura Y, Sotoyama H, Takei N, Nawa H.

J Neurochem. 2017 Jun 13. doi: 10.1111/jnc.14097. [Epub ahead of print]

PMID:
28608461
24.

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241.

25.

Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method.

Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Kanzaki K, Okita K, Iwakura Y, Ohno N.

Int J Biol Macromol. 2017 Nov;104(Pt A):367-376. doi: 10.1016/j.ijbiomac.2017.06.036. Epub 2017 Jun 8.

PMID:
28602993
26.

Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.

Zhang C, Feng J, Du J, Zhuo Z, Yang S, Zhang W, Wang W, Zhang S, Iwakura Y, Meng G, Fu YX, Hou B, Tang H.

Cell Mol Immunol. 2017 May 15. doi: 10.1038/cmi.2017.22. [Epub ahead of print]

PMID:
28504245
27.

Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.

Kanemaru K, Nakamura Y, Totoki K, Fukuyama T, Shoji M, Kaneko H, Shiratori K, Yoneda A, Inoue T, Iwakura Y, Kabashima K, Fukami K.

Cell Death Differ. 2017 Jun;24(6):1079-1090. doi: 10.1038/cdd.2017.56. Epub 2017 Apr 21.

PMID:
28430185
28.

Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis.

Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.

Sci Rep. 2017 Apr 7;7:46322. doi: 10.1038/srep46322.

29.

Megakaryocytes compensate for Kit insufficiency in murine arthritis.

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA.

J Clin Invest. 2017 May 1;127(5):1714-1724. doi: 10.1172/JCI84598. Epub 2017 Apr 4.

30.

Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons.

Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa H.

PLoS One. 2017 Mar 28;12(3):e0174780. doi: 10.1371/journal.pone.0174780. eCollection 2017.

31.

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.

Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L, Zhang Q, Zhang R.

Circ Res. 2017 Mar 31;120(7):1116-1129. doi: 10.1161/CIRCRESAHA.116.310260. Epub 2017 Feb 13.

PMID:
28193608
32.

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation.

Furukawa K, Fuse I, Iwakura Y, Sotoyama H, Hanyu O, Nawa H, Sone H, Takei N.

Cardiovasc Diabetol. 2017 Feb 8;16(1):20. doi: 10.1186/s12933-017-0505-y.

33.

Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice.

Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K.

Eur J Immunol. 2017 Apr;47(4):704-712. doi: 10.1002/eji.201646814. Epub 2017 Feb 22.

PMID:
28127756
34.

Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice.

Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.

Eur J Immunol. 2017 Apr;47(4):685-691. doi: 10.1002/eji.201646699. Epub 2017 Jan 11.

PMID:
28012161
35.

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.

Immunity. 2016 Dec 20;45(6):1299-1310. doi: 10.1016/j.immuni.2016.11.010.

36.

Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection.

Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.

Immun Inflamm Dis. 2016 Aug 24;4(4):401-412. eCollection 2016 Dec.

37.

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.

Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14097-14102. Epub 2016 Nov 21.

38.

Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.

Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.

J Immunol. 2017 Jan 1;198(1):61-70. Epub 2016 Nov 16.

39.

Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.

Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.

Stem Cells. 2017 Apr;35(4):989-1002. doi: 10.1002/stem.2524. Epub 2016 Nov 11.

PMID:
27753160
40.

Activated Intrarenal Renin Angiotensin Systems Is the Primary Source of Progressing Renal Damage in Primary Aldosteronism.

Satoh F, Iwakura Y, Morimoto R, Ono Y, Tezuka Y, Omata K, Nezu M, Igarashi Y, Kudo M, Ito S.

J Am Soc Hypertens. 2016 Jul;10 Suppl 1:e9. doi: 10.1016/j.jash.2016.06.026. No abstract available.

PMID:
27677148
41.

Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae.

Murakami T, Hatano S, Yamada H, Iwakura Y, Yoshikai Y.

J Infect Dis. 2016 Dec 1;214(11):1752-1761. Epub 2016 Sep 20.

PMID:
27651419
42.

IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis.

Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y.

Innate Immun. 2016 Nov;22(8):588-597. doi: 10.1177/1753425916664125. Epub 2016 Sep 22.

PMID:
27554052
43.

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2016 Aug;65(8):2462. doi: 10.2337/db16-ec08a. No abstract available.

44.

The potential for repositioning antithyroid agents as antiasthma drugs.

Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.

J Allergy Clin Immunol. 2016 Nov;138(5):1458-1461.e8. doi: 10.1016/j.jaci.2016.04.047. Epub 2016 Jun 15. No abstract available.

PMID:
27444178
45.

IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.

Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.

Cancer Sci. 2016 Sep;107(9):1206-14. doi: 10.1111/cas.13005. Epub 2016 Sep 1.

46.

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.

Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.

J Biol Chem. 2016 Aug 19;291(34):17629-38. doi: 10.1074/jbc.M116.741256. Epub 2016 Jun 29.

47.

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation.

Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M.

Immunity. 2016 Jun 21;44(6):1422-33. doi: 10.1016/j.immuni.2016.05.010. Epub 2016 Jun 14.

48.

IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.

Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M.

Exp Dermatol. 2017 Feb;26(2):137-144. doi: 10.1111/exd.13115. Epub 2016 Nov 16.

PMID:
27305096
49.

Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.

Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.

J Immunol. 2016 Jul 1;197(1):278-87. doi: 10.4049/jimmunol.1502485. Epub 2016 May 18.

50.

Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.

Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S.

Innate Immun. 2016 Jul;22(5):316-24. doi: 10.1177/1753425916645392. Epub 2016 Apr 26.

PMID:
27189427

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