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Items: 1 to 50 of 873

1.

Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.

Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, Dairiki R, Kawakita Y, Mizojiri R, Ito Y, Asano M, Maezaki H, Nakayama Y, Kaishima M, Hayashi K, Teratani M, Miyakawa S, Iwatani M, Miyamoto M, Klein MG, Lane W, Snell G, Tjhen R, He X, Pulukuri S, Nomura T.

EMBO Mol Med. 2018 May 16. pii: e8289. doi: 10.15252/emmm.201708289. [Epub ahead of print]

2.

Phosphine Induced Dimerization of Propargyl Alcohols Leading to Allyl Propargyl Ethers.

Iwai K, Yokoyama S, Asahara H, Nishiwaki N.

J Oleo Sci. 2018 May 15. doi: 10.5650/jos.ess17277. [Epub ahead of print]

3.

A Aceruloplasminemia Patient with Abnormal Compound Heterozygous Mutations Who Developed Neurological Dysfunction during Phlebotomy Therapy: A Case Report.

Watanabe M, Ohyama K, Suzuki M, Nosaki Y, Hara T, Iwai K, Kono S, Miyajima H, Mokuno K.

Intern Med. 2018 Apr 27. doi: 10.2169/internalmedicine.9855-17. [Epub ahead of print]

4.

Difference in contributions to the team's score in female wheelchair basketball at the 2016 Rio Paralympics by physical capability classification.

Doi T, Mutsuzaki H, Tachibana K, Wadano Y, Iwai K.

J Phys Ther Sci. 2018 Apr;30(4):500-503. doi: 10.1589/jpts.30.500. Epub 2018 Apr 13.

5.

Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization.

Fujita H, Tokunaga A, Shimizu S, Whiting AL, Aguilar-Alonso F, Takagi K, Walinda E, Sasaki Y, Shimokawa T, Mizushima T, Ohki I, Ariyoshi M, Tochio H, Bernal F, Shirakawa M, Iwai K.

Cell Rep. 2018 Apr 24;23(4):1192-1204. doi: 10.1016/j.celrep.2018.03.112.

6.

Crucial Role of Linear Ubiquitin Chain Assembly Complex-Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development.

Sasaki Y, Iwai K.

J Immunol. 2018 May 15;200(10):3438-3449. doi: 10.4049/jimmunol.1701526. Epub 2018 Apr 13.

PMID:
29654209
7.

Potential signaling pathways as therapeutic targets for overcoming chemoresistance in mucinous ovarian cancer.

Niiro E, Morioka S, Iwai K, Yamada Y, Ogawa K, Kawahara N, Kobayashi H.

Biomed Rep. 2018 Mar;8(3):215-223. doi: 10.3892/br.2018.1045. Epub 2018 Jan 17.

8.

[A case of Alexander disease with dropped head syndrome].

Maeda K, Iwai K, Kobayashi Y, Tsuji H, Yoshida T, Kobayashi Y.

Rinsho Shinkeigaku. 2018 Mar 28;58(3):198-201. doi: 10.5692/clinicalneurol.cn-001116. Epub 2018 Mar 28. Japanese.

PMID:
29491332
9.

Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins.

Ogura M, Endo R, Ishikawa H, Takeda Y, Uchida T, Iwai K, Kobayashi K, Ishimori K.

J Inorg Biochem. 2018 May;182:238-248. doi: 10.1016/j.jinorgbio.2018.01.007. Epub 2018 Jan 9.

PMID:
29449016
10.

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R.

Stem Cell Reports. 2018 Feb 13;10(2):356-365. doi: 10.1016/j.stemcr.2017.12.001. Epub 2018 Jan 11.

11.

Preoperative assessment of pleural adhesion by Four-Dimensional Ultra-Low-Dose Computed Tomography (4D-ULDCT) with Adaptive Iterative Dose Reduction using Three-Dimensional processing (AIDR-3D).

Hashimoto M, Nagatani Y, Oshio Y, Nitta N, Yamashiro T, Tsukagoshi S, Ushio N, Mayumi M, Kimoto T, Igarashi T, Yoshigoe M, Iwai K, Tanaka K, Sato S, Sonoda A, Otani H, Murata K, Hanaoka J; investigators of ACTIve study group.

Eur J Radiol. 2018 Jan;98:179-186. doi: 10.1016/j.ejrad.2017.11.011. Epub 2017 Nov 21.

PMID:
29279160
12.

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

Tamiya H, Kim H, Klymenko O, Kim H, Feng Y, Zhang T, Han JY, Murao A, Snipas SJ, Jilaveanu L, Brown K, Kluger H, Zhang H, Iwai K, Ronai ZA.

J Clin Invest. 2018 Jan 2;128(1):517-530. doi: 10.1172/JCI95410. Epub 2017 Dec 11.

13.

Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.

Kuriyama N, Ozaki E, Mizuno T, Ihara M, Mizuno S, Koyama T, Matsui D, Watanabe I, Akazawa K, Takeda K, Takada A, Inaba M, Yamada S, Motoyama K, Takeshita W, Iwai K, Hashiguchi K, Kobayashi D, Kondo M, Tamura A, Yamada K, Nakagawa M, Watanabe Y.

J Alzheimers Dis. 2018;61(1):145-155. doi: 10.3233/JAD-170466.

PMID:
29154273
14.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

15.

Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis.

Kobayashi H, Ogawa K, Kawahara N, Iwai K, Niiro E, Morioka S, Yamada Y.

Free Radic Res. 2017 Oct;51(9-10):755-764. doi: 10.1080/10715762.2017.1383605. Epub 2017 Oct 11.

PMID:
28931330
16.

Genetic Variants of RAMP2 and CLR are Associated with Stroke.

Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, Endoh K, Furusyo N, Ikezaki H, Suzuki S, Hosono A, Mikami H, Nakamura Y, Kubo M, Wakai K.

J Atheroscler Thromb. 2017 Dec 1;24(12):1267-1281. doi: 10.5551/jat.41517. Epub 2017 Sep 14.

17.

Comparison of the Different Definition Criteria for the Diagnosis of Amniotic Fluid Embolism.

Kobayashi H, Akasaka J, Naruse K, Sado T, Tsunemi T, Niiro E, Iwai K.

J Clin Diagn Res. 2017 Jul;11(7):QC18-QC21. doi: 10.7860/JCDR/2017/26746.10283. Epub 2017 Jul 1.

18.

Isolation of Extracellular Vesicles in Saliva Using Density Gradient Ultracentrifugation.

Iwai K, Yamamoto S, Yoshida M, Shiba K.

Methods Mol Biol. 2017;1660:343-350. doi: 10.1007/978-1-4939-7253-1_27.

PMID:
28828669
19.

Droplet microfluidics for synthetic biology.

Gach PC, Iwai K, Kim PW, Hillson NJ, Singh AK.

Lab Chip. 2017 Oct 11;17(20):3388-3400. doi: 10.1039/c7lc00576h. Review.

20.

The conceptual advances of carcinogenic sequence model in high-grade serous ovarian cancer.

Kobayashi H, Iwai K, Niiro E, Morioka S, Yamada Y, Ogawa K, Kawahara N.

Biomed Rep. 2017 Sep;7(3):209-213. doi: 10.3892/br.2017.955. Epub 2017 Jul 27.

21.

Congenital fiber-type disproportion presenting as ventricular fibrillation.

Iwai K, Yoshida Y, Kazuta T, Suzuki T, Kuki I.

Pediatr Int. 2017 Sep;59(9):1025-1027. doi: 10.1111/ped.13339. Epub 2017 Aug 7. No abstract available.

PMID:
28786238
22.

Changes in skin structure of the Zip13-KO mouse by Makomo (Zizania latifolia) feeding.

Yamauchi T, Hirose T, Sato K, Iwai K, Takahashi N, Minaguchi J, Ueno T, Tangkawattana P, Takehana K.

J Vet Med Sci. 2017 Sep 29;79(9):1563-1568. doi: 10.1292/jvms.17-0206. Epub 2017 Aug 4.

23.

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.

Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8574-8579. doi: 10.1073/pnas.1702615114. Epub 2017 Jul 25.

24.

3D Printed "Earable" Smart Devices for Real-Time Detection of Core Body Temperature.

Ota H, Chao M, Gao Y, Wu E, Tai LC, Chen K, Matsuoka Y, Iwai K, Fahad HM, Gao W, Nyein HYY, Lin L, Javey A.

ACS Sens. 2017 Jul 28;2(7):990-997. doi: 10.1021/acssensors.7b00247. Epub 2017 Jul 19.

PMID:
28721726
25.

Current status of tertiary debulking surgery and prognosis after secondary debulking surgery for recurrent Müllerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402).

Hirakawa T, Minaguchi T, Itani Y, Kasamatsu Y, Murase S, Sakurada S, Nagano H, Takehara K, Tsuruta T, Arakawa A, Kawano K, Tsubamoto H, Ushiwaka T, Mori T, Iwai K, Saito M, Morisawa H, Saito F, Yoshida K, Kaneuchi M, Sato H, Ito K, Nasu K.

World J Surg Oncol. 2017 Jul 17;15(1):132. doi: 10.1186/s12957-017-1200-x.

26.

Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan.

Kihira T, Okamoto K, Sakurai I, Arakawa Y, Wakayama I, Takamiya K, Okumura R, Iinuma Y, Iwai K, Kokubo Y, Yoshida S.

Intern Med. 2017;56(12):1497-1506. doi: 10.2169/internalmedicine.56.8038. Epub 2017 Jun 15.

27.

Skin-mucous membrane disorder and therapeutic effect of pegylated liposomal doxorubicin in recurrent ovarian cancer.

Yamada Y, Kawaguchi R, Ito F, Iwai K, Niiro E, Shigetomi H, Tanase Y, Kobayashi H.

J Obstet Gynaecol Res. 2017 Jul;43(7):1194-1199. doi: 10.1111/jog.13334. Epub 2017 May 19.

PMID:
28544386
28.

2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.

Kurasawa O, Homma M, Oguro Y, Miyazaki T, Mori K, Uchiyama N, Iwai K, Ohashi A, Hara H, Yoshida S, Cho N.

Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670. doi: 10.1016/j.bmc.2017.04.044. Epub 2017 May 2.

PMID:
28533114
29.

Influence of Oral Appliances for Mandibular Advancement on Dentitions Using a Strain Gauge Analysis: A Pilot Study.

Ueda H, Matsumura Y, Horihata A, Concepcion C, Iwai K, Tanimoto K.

Sleep Disord. 2017;2017:9097305. doi: 10.1155/2017/9097305. Epub 2017 Apr 3.

30.

Synthesis of Functionalized 3-Cyanoisoxazoles Using a Dianionic Reagent.

Iwai K, Asahara H, Nishiwaki N.

J Org Chem. 2017 May 19;82(10):5409-5415. doi: 10.1021/acs.joc.7b00811. Epub 2017 May 9.

PMID:
28471185
31.

"Direct MPR": A Useful Tool for Oblique CT Fluoroscopy-Assisted Puncture.

Sato R, Aramaki T, Yoza K, Iwai K, Moriguchi M, Asakura K, Endo M, Ito T.

Cardiovasc Intervent Radiol. 2017 Aug;40(8):1261-1266. doi: 10.1007/s00270-017-1642-0. Epub 2017 Apr 24.

PMID:
28439625
32.

Successful Long-term Management with a Single Administration of Tri-weekly Nab-paclitaxel in a Patient with Advanced Gastric Cancer with Peritoneal Dissemination.

Matano D, Moriwaki T, Tange Y, Niisato Y, Yamaura M, Nagase M, Suganuma D, Takagi Taketa K, Iwai K, Enami C, Yamamoto Y, Hyodo I.

Intern Med. 2017;56(8):921-923. doi: 10.2169/internalmedicine.56.7783. Epub 2017 Apr 15.

33.

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

Kurasawa O, Oguro Y, Miyazaki T, Homma M, Mori K, Iwai K, Hara H, Skene R, Hoffman I, Ohashi A, Yoshida S, Ishikawa T, Cho N.

Bioorg Med Chem. 2017 Apr 1;25(7):2133-2147. doi: 10.1016/j.bmc.2017.02.021. Epub 2017 Feb 16.

PMID:
28284870
34.

Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity.

Kuriyama N, Inaba M, Ozaki E, Yoneda Y, Matsui D, Hashiguchi K, Koyama T, Iwai K, Watanabe I, Tanaka R, Omichi C, Mizuno S, Kurokawa M, Horii M, Niwa F, Iwasa K, Yamada S, Watanabe Y.

Arch Gerontol Geriatr. 2017 May - Jun;70:201-208. doi: 10.1016/j.archger.2017.02.005. Epub 2017 Feb 10.

PMID:
28214401
35.

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI.

PLoS Pathog. 2017 Jan 19;13(1):e1006162. doi: 10.1371/journal.ppat.1006162. eCollection 2017 Jan.

36.

Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling.

Oi-Kano Y, Iwasaki Y, Nakamura T, Watanabe T, Goto T, Kawada T, Watanabe K, Iwai K.

J Nutr Biochem. 2017 Feb;40:209-218. doi: 10.1016/j.jnutbio.2016.11.009. Epub 2016 Nov 23.

PMID:
27951473
37.

Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment.

Watanabe I, Kuriyama N, Miyatani F, Nomura R, Naka S, Nakano K, Ihara M, Iwai K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Tamura A, Mizuno T, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Tanaka T, Kanamura N, Friedland RP, Watanabe Y.

Sci Rep. 2016 Dec 9;6:38561. doi: 10.1038/srep38561.

38.
39.

Survival of mature T cells depends on signaling through HOIP.

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K, Yasutomo K.

Sci Rep. 2016 Oct 27;6:36135. doi: 10.1038/srep36135.

40.

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, Tajima S, Goda N, Iwai K, Fukuda S, Yamaguti K, Kuratsune H, Soga T, Watanabe Y, Kataoka Y.

Sci Rep. 2016 Oct 11;6:34990. doi: 10.1038/srep34990.

41.

Asymmetrical and smaller size of trunk muscles in combat sports athletes with lumbar intervertebral disc degeneration.

Iwai K, Koyama K, Okada T, Nakazato K, Takahashi R, Matsumoto S, Yamamoto Y, Hiranuma K.

Springerplus. 2016 Sep 1;5(1):1474. doi: 10.1186/s40064-016-3155-8. eCollection 2016.

42.

Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.

Irokawa H, Tachibana T, Watanabe T, Matsuyama Y, Motohashi H, Ogasawara A, Iwai K, Naganuma A, Kuge S.

Sci Rep. 2016 Sep 16;6:33536. doi: 10.1038/srep33536.

43.

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.

Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.

44.

A draft genome of the brown alga, Cladosiphon okamuranus, S-strain: a platform for future studies of 'mozuku' biology.

Nishitsuji K, Arimoto A, Iwai K, Sudo Y, Hisata K, Fujie M, Arakaki N, Kushiro T, Konishi T, Shinzato C, Satoh N, Shoguchi E.

DNA Res. 2016 Dec;23(6):561-570. Epub 2016 Aug 8.

45.

Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.

Hirayama T, Okaniwa M, Banno H, Kakei H, Ohashi A, Ohori M, Nambu T, Iwai K, Kawamoto T, Yokota A, Miyamoto M, Ishikawa T.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4296-300. doi: 10.1016/j.bmcl.2016.07.038. Epub 2016 Jul 19.

PMID:
27476141
46.

[Maintenance of cellular and body iron homeostasis].

Takeda Y, Iwai K.

Nihon Rinsho. 2016 Jul;74(7):1094-102. Japanese.

PMID:
27455797
47.

A Rapid and Simple LC-MS Method Using Collagen Marker Peptides for Identification of the Animal Source of Leather.

Kumazawa Y, Taga Y, Iwai K, Koyama Y.

J Agric Food Chem. 2016 Aug 3;64(30):6051-7. doi: 10.1021/acs.jafc.6b02132. Epub 2016 Jul 20.

PMID:
27397145
48.

Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein.

Kobayashi K, Nakagaki M, Ishikawa H, Iwai K, O'Brian MR, Ishimori K.

Biochemistry. 2016 Jul 26;55(29):4047-54. doi: 10.1021/acs.biochem.6b00512. Epub 2016 Jul 13.

PMID:
27379473
49.

Isolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations.

Iwai K, Minamisawa T, Suga K, Yajima Y, Shiba K.

J Extracell Vesicles. 2016 May 17;5:30829. doi: 10.3402/jev.v5.30829. eCollection 2016.

50.

Clinical and imaging findings of progressive supranuclear palsy with predominant cerebellar ataxia.

Shimohata T, Kanazawa M, Yoshida M, Saito Y, Iwai K, Yasuda T, Inukai A, Takahashi H, Nishizawa M, Aiba I.

Mov Disord. 2016 May;31(5):760-2. doi: 10.1002/mds.26618. Epub 2016 Mar 31. No abstract available.

PMID:
27030358

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